What can we learn by studying genetics and Parkinson's? PDF-funded researchers Drs. Mata and Zabetian share their progress six years after launching the first large-scale survey of PD genetics in Latin America.
PDF Grant Programs
Are you interested in furthering Parkinson's science? View PDF's open grant programs.
2012 Research Grants
In 2012, the Parkinson’s Disease Foundation (PDF) funded $5.3 million in Parkinson’s research awards. Recipients were chosen by members of our Scientific Advisory Board, which is made up of leading scientists joined by representatives of the Parkinson’s Advocates in Research program.
[+] Research Centers
Research Centers | $2.38 Million
Allow talented scientists the flexibility and long-term support to collaborate on basic, translational and clinical research.
Columbia University Medical Center
Rush University Medical Center
Weill Cornell Medical Center
[+] International Research Grants
International Research Grants | $1.16 Million
Promote innovative research projects that have high potential to significantly advance the knowledge of Parkinson’s.
Stability of Tetrameric Alpha-synuclein as a Biomarker in Parkinson’s Disease
Tim Bartels, M.Sc., Ph.D., and Dennis J. Selkoe, M.D., Harvard Medical School and Brigham and Women’s Hospital
Evaluating the Role of Mitochondrial Dynamics in Parkinson's Disease in an In Vivo Vertebrate Model: Real-Time Live Imaging of Mitochondrial Dynamics in Dopamine Neurons in Whole Zebrafish*
Sarah B. Berman, Ph.D., M.D., and Edward Burton M.D., D.Phil., F.R.C.P., University of Pittsburgh
Impact of Low- and High-Frequency Electrical Stimulation on the Inputs, Integrative Properties and Output of the Subthalamic Nucleus*
Mark D. Bevan, Ph.D., Northwestern University
Dissecting the Different Properties of Human Alphasynuclein Between Dopamine and Nondopamine Neurons in Vivo
Linan Chen, M.D., Ph.D., and Xiaoxi Zhuang, Ph.D., University of Chicago
Cellular Mechanisms of Semaphorin 3E-Plexin-D1 Signaling in Basal Ganglia Circuitry Formation and Neurodegenerative Diseases
Chenghua Gu, D.V.M., Ph.D., Harvard Medical School
Identification and Characterization of a Novel Gene for Parkinsonism
Paul Lockhart, Ph.D., and Gabrielle Wilson, Ph.D., Bruce Lefroy Centre, Murdoch Childrens Research Institute, Royal Children's Hospital
Small Aromatic Molecules as Novel Inhibitors of Alpha-Synuclein Aggregation*
Daniel Segal, Ph.D., Tel Aviv University, Israel
Cyclic GMP Signaling and Experimental Parkinsonism
Anthony R. West, Ph.D., and Kuei-Yuan Tseng, M.D., Ph.D., Rosalind Franklin University
Identification of Genes for Parkinson's in an Isolated Greek Community and a Greek Population Cohort*
Georgia Xiromerisiou, Ph.D., M.D., University of Thessaly, Greece, and Henry Houlden, M.D., M.R.C.P., Ph.D., University College, London, England
[+] Fellowship and Career Development Awards
Fellowship and Career Development Awards | $1.38 Million
Prepare leaders in Parkinson’s research and clinical practice.
Research Fellowship Projects | $190,000
Regulation of Alpha-synuclein mRNA Translation in SNCA Expressing Neurons
Ianai Fishbein, Ph.D., Institute for Human Genetics, University of California, San Francisco
Dopaminergic Neuron Subtype Differences in OXPHOS Capacity and Mitophagy in Response to mtDNA Damage
Alicia Pickrell, Ph.D., Division of Intramural Research, National Institute of Neurological Disorders and Stroke (NINDS)
The Role of Parkin in Regulating Mitochondrial Dynamics and Homeostasis in Cortical and Dopaminergic Neurons*
Victor Van Laar, Ph.D., University of Pittsburgh
Locus Coeruleus as a Substrate for Parkinsonian Cognitive Inflexibility*
Elena Vazey, Ph.D., Medical University of South Carolina
Clinical Training Fellowships | $822,000
Rush University Medical Center
Houman Homayoun, M.D.
Gian Pal, M.D.
Sheila Rane, M.D.
Columbia University Medical Center
David Arkadir, M.D., Ph.D.
Christopher W. Hess, M.D.
Ruben Martinez, M.D.
Madeline Sharp, M.D.
Sirinan Tazen, M.D.
Tuhin Virmani, M.D., Ph.D.
Brenton Wright, M.D.
Summer Student Fellowship Projects | $45,000
LRRK2-dependent Olfactory Deficits in Mice
Rachel Bailey, mentor Jada Lewis, Ph.D., University of Florida
Small Molecule Modulation of the Unfolded Protein Response as a Novel Therapeutic Avenue in the Treatment of Parkinson's Disease
Joel Credle, mentor Anita Sidhu, Ph.D., Georgetown University
CD200/CD200R-mediated Neuroinflammation in Parkinsonism
Collin Flanagan, mentor J. Timothy Greenamyre, M.D., Ph.D., University of Pittsburgh School of Medicine
Comparative Effectiveness Study to Evaluate In-Home Telemedicine as a Means to Increase Access to Sub-specialty Care for Individuals with Parkinson's Disease
Benjamin George, mentor E. Ray Dorsey, M.D.,M.B.A., Johns Hopkins University
Effect of p11 Inhibition on D1 and D2 Dopamine
Darya Khazanova, mentor Michael G. Kaplitt, Ph.D., M.D., Weill Cornell Medical College
Dopamine Receptor Expression and Function in the External Globus Pallidus
David Klein, mentor C. Savio Chan, Ph.D., Northwestern University
Study of the Roles and Mechanisms of PINK1 and Parkin in Mitophagy
Paul Lebot, mentor Serge Przedborski, M.D., Ph.D., Columbia University Medical Center
The Molecular Interaction of Non-catechol Drugs with Dopamine D1 Receptors: Towards Improved Therapy for Parkinson’s Disease
Sang Min Lee, mentor Richard Mailman, Ph.D., The Pennsylvania State University College of Medicine
Interactions Between Tyrosine Hydroxylase and 14-3-3 Protein
Ewa Nowara, mentor S. Colette Daubner, Ph.D., University of Texas Health Science Center at San Antonio
Mild Cognitive Impairment and Health-Related Quality of Life in Non-demented Parkinson's Disease Patients
William Reginold, mentor Connie Marras, M.D., Ph.D., Toronto Western Hospital
Dissecting the Role of c-Abl in Parkinson's
Andi Shahu, mentor Ted Dawson, M.D., Ph.D., Johns Hopkins University School of Medicine Neuropsychological Predictors of Disease
Progression in Early Onset Parkinson’s Disease
Megha Subramanian, mentor Paul J. Eslinger, Ph.D., The Pennsylvania State University College of Medicine
The Characterization of Autophagy in MPP+-induced
Eric Tsai, mentor Karen O'Malley, Ph.D., Washington University School of Medicine in St. Louis
Molecular Mechanisms by Which Excess Synuclein Impairs Synapse Function: Implications for Parkinson’s
Alexandra van Brummen, mentor Jennifer Morgan, Ph.D., The University of Texas at Austin
Protection of Dissociated Rat Substantia Nigra Cultures from MPP+ Toxicity by a Combination of Neurotrophic Factors
Stephanie Wyrostek, mentor Michael J. Zigmond, Ph.D., University of Pittsburgh
Collaborative Fellowships | $105,000
PDF-AANF Clinician-Scientist Development Award | $55,000 (per year for three years)
(co-sponsored by American Academy of Neurology Foundation)
Mechanisms of Cell Type-Specific Vulnerability in Synucleinopathy: A Yeast Stem Cell Dual Discovery Platform
Vikram Khurana, M.D., Ph.D., Massachusetts General Hospital
PDF-PSG Mentored Clinical Research Award | $50,000
(Funded by a grant from PDF to the Parkinson Study Group)
Neurophysiology Adaptations to Tango Dancing in Individuals with Parkinson's Disease
Kristen Pickett, Ph.D., mentors Gammon Earhart, M.D., and Joel Perlmutter, M.D., Washington University School of Medicine in St. Louis
[+] Advancing Parkinson's Treatments Grants
Advancing Parkinson's Treatments Grants | $200,000
Facilitate the movement of treatments from “bench to bedside.”
Innovations Awards | $150,000
Training of New Parkinson’s Clinical Research Investigators through PSG Annual Meeting
Parkinson Study Group
Datamining to Better Understand Parkinson’s Disease Progression, Treatment Response, Complications and Outcomes
Parkinson Study Group
Conference Awards | $50,000
Cognitive Assessment for Parkinson's Disease in Multi-Cultural/Linguistic Populations
Ignacio Mata, Ph.D., James. B. Leverenz, M.D., G. Stennis Watson, Ph.D., and Cyrus P. Zabetian, M.D., M.S., University of Washington
Impulse Control Disorders in Parkinson’s
Antonio Strafella, M.D., Ph.D., F.R.C.P.C., University of Toronto, and Mark A. Stacy, M.D., Duke University
Additional grant to be named
[+] Côté Clinical Genetics Initiative
Côté Clinical Genetics Initiative | $200,000
Identifying Genetic Causes Underlying Early-onset Parkinson’s Disease
Coro Paisán-Ruiz, Ph.D., mentor Joseph D. Buxbaum, Ph.D., Mount Sinai School of Medicine
Parkinson Disease in a Minority Inner City Population: Clinical Phenotypes and Genetic Etiologies, Focus on Afro-Caribbean Populations
Jose C. Cabassa, M.D., mentor Rachel Saunders-Pullman, M.D., M.P.H., SUNY Downstate Medical Center and Beth Israel Medical Center, Einstein College of Medicine
Localization of Alpha-synuclein in Mitochondrial-associated ER Membranes (MAM): A New Insight into the Pathogenesis of PD
Cristina Guardia-Laguarta, Ph.D., mentor Serge Przedborski, M.D., Ph.D., Columbia University Medical Center
Mutant Glucocerebrosidase Causes Dysfunctional Chaperone-mediated Autophagy and Alpha-synuclein Accumulation in Patient Fibroblast-derived Dopaminergic Neurons
Sheng-Han Kuo, M.D., Ph.D., mentor David Sulzer, Ph.D., Columbia University Medical Center
*Denotes second year of funding