What can we learn by studying genetics and Parkinson's? PDF-funded researchers Drs. Mata and Zabetian share their progress six years after launching the first large-scale survey of PD genetics in Latin America.
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Genetics and PD
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Linking Genes to Neurological Clinical Practice: The Genomic Basis for Neurorehabilitation.
Allon Goldberg, Catherine L Curtis, Jeffrey A Kleim
J Neurol Phys Ther 2014 Nov;
PMID: 25415554 [PubMed - as supplied by publisher]
Monkey-based research on human disease: the implications of genetic differences.
Altern Lab Anim 2014 Nov; 42(5):287-317
PMID: 25413291 [PubMed - as supplied by publisher]
p62 Deficiency Enhances ?-Synuclein Pathology in Mice.
Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi
Brain Pathol 2014 Oct;
PMID: 25412696 [PubMed - as supplied by publisher]
The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy.
Joe H Pogson, Rachael M Ivatt, Alvaro Sanchez-Martinez, Roberta Tufi, Emma Wilson, Heather Mortiboys, Alexander J Whitworth
PLoS Genet 2014 Nov; 10(11):e1004815
PMID: 25412178 [PubMed - as supplied by publisher]
Glutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease.
Taye H Hamza, Erin M Hill-Burns, William K Scott, Jeffrey M Vance, Stewart A Factor, Cyrus P Zabetian, Haydeh Payami
PLoS Genet 2014 Nov; 10(11):e1004774
PMID: 25411979 [PubMed - as supplied by publisher]
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.
Ianai Fishbein, Yien-Ming Kuo, Benoit I Giasson, Robert L Nussbaum
Brain 2014 Dec; 137(Pt 12):3235-47
PMID: 25351739 [PubMed - as supplied by publisher]
CSF biomarkers and clinical progression of Parkinson disease.
Sara Hall, Yulia Surova, Annika Ohrfelt, Henrik Zetterberg, Daniel Lindqvist, Oskar Hansson
Neurology 2014 Nov;
PMID: 25411441 [PubMed - as supplied by publisher]
Syntaxin 5-Dependent Retrograde Transport to the Golgi is Required for AAV Transduction.
Mathieu E Nonnenmacher, Jean-Christophe Cintrat, Daniel Gillet, Thomas Weber
J Virol 2014 Nov;
PMID: 25410859 [PubMed - as supplied by publisher]
PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.
Agne Kazlauskaite, Miratul M K Muqit
FEBS J 2014 Oct;
PMID: 25345844 [PubMed - as supplied by publisher]
Generation of functional organs from stem cells.
Yunying Liu, Ru Yang, Zuping He, Wei-Qiang Gao
Cell Regen (Lond) 2013 ; 2(1):1
PMID: 25408873 [PubMed - as supplied by publisher]
Neuroprotection by Saponins.
Aijing Sun, Xianxiang Xu, Junsheng Lin, Xiuling Cui, Ruian Xu
Phytother Res 2014 Nov;
PMID: 25408503 [PubMed - as supplied by publisher]
Successful GPi stimulation in genetic Parkinson's disease caused by mosaicism of alpha-synuclein gene duplication: first description.
C Perandones, N Aráoz Olivos, G B Raina, L A Pellene, J C Giugni, D S Calvo, M Radrizzani, F Piedimonte, F E Micheli
J Neurol 2014 Nov;
PMID: 25408368 [PubMed - as supplied by publisher]
MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.
Woori Kim, Haneul Noh, Yenarae Lee, Jeha Jeon, Arthi Shanmugavadivu, Donna L McPhie, Kwang-Soo Kim, Bruce M Cohen, Hyemyung Seo, Kai C Sonntag
Mol Neurobiol 2014 Nov;
PMID: 25407931 [PubMed - as supplied by publisher]
Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.
Briana R De Miranda, Katriana A Popichak, Sean L Hammond, James A Miller, Stephen Safe, Ronald B Tjalkens
Toxicol Sci 2014 Nov;
PMID: 25406165 [PubMed - as supplied by publisher]
Effects of sevoflurane on leucine-rich repeat kinase 2-associated Drosophila model of Parkinson's disease.
Zhiming Shan, Song Cai, Tao Zhang, Liting Kuang, Qi Wang, Huanhuan Xiu, Jing Wen, Huaiyu Gu, Kangqing Xu
Mol Med Rep 2014 Nov;
PMID: 25406035 [PubMed - as supplied by publisher]
Identification of Potential Drugs for Parkinson's Disease Based on a Sub-Pathway Method.
Ai-Guo Sun, Ai-Qi Lin, Shao-Yue Huang, Di Huo, Chao-Hua Cong
Int J Neurosci 2014 Nov; :1-18
PMID: 25405535 [PubMed - as supplied by publisher]
Role of Glucose Metabolism and ATP in Maintaining PINK1 Levels During Parkin-mediated Mitochondrial Damage Responses.
Schuyler Lee, Conggang Zhang, Xuedong Liu
J Biol Chem 2014 Nov;
PMID: 25404737 [PubMed - as supplied by publisher]
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Jeanne E McKeon, Di Sha, Lian Li, Lih-Shen Chin
Cell Mol Life Sci 2014 Nov;
PMID: 25403879 [PubMed - as supplied by publisher]
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.
Jaclyn Nicole Le Grand, Laura Gonzalez-Cano, Maria Angeliki Pavlou, Jens C Schwamborn
Cell Mol Life Sci 2014 Nov;
PMID: 25403878 [PubMed - as supplied by publisher]
Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases.
Ronald Gstir, Simon Schafferer, Marcel Scheideler, Matthias Misslinger, Matthias Griehl, Nina Daschil, Christian Humpel, Gerald J Obermair, Claudia Schmuckermair, Joerg Striessnig, Bernhard E Flucher, Alexander Hüttenhofer
RNA 2014 Dec; 20(12):1929-43
PMID: 25344396 [PubMed - as supplied by publisher]
?-synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: Implications in the pathogenesis of Parkinson's disease.
Aritri Bir, Oishimaya Sen, Shruti Anand, Vineet Kumar Khemka, Priyanjalee Banerjee, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti
J Neurochem 2014 Oct;
PMID: 25319443 [PubMed - as supplied by publisher]
Higher Frequency of Certain Cancers in LRRK2 G2019S Mutation Carriers With Parkinson Disease: A Pooled Analysis.
Ilir Agalliu, Marta San Luciano, Anat Mirelman, Nir Giladi, Bjorg Waro, Jan Aasly, Rivka Inzelberg, Sharon Hassin-Baer, Eitan Friedman, Javier Ruiz-Martinez, Jose Felix Marti-Masso, Avi Orr-Urtreger, Susan Bressman, Rachel Saunders-Pullman
JAMA Neurol 2014 Nov;
PMID: 25401981 [PubMed - as supplied by publisher]
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.
Lorraine V Kalia, Anthony E Lang, Lili-Naz Hazrati, Shinsuke Fujioka, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ross, Vivianna M Van Deerlin, John Q Trojanowski, Howard I Hurtig, Roy N Alcalay, Karen S Marder, Lorraine N Clark, Carles Gaig, Eduardo Tolosa, Javier Ruiz-Martínez, Jose F Marti-Masso, Isidre Ferrer, Adolfo López de Munain, Samuel M Goldman, Birgitt Schüle, J William Langston, Jan O Aasly, Maria T Giordana, Vincenzo Bonifati, Andreas Puschmann, Margherita Canesi, Gianni Pezzoli, Andre Maues De Paula, Kazuko Hasegawa, Charles Duyckaerts, Alexis Brice, A Jon Stoessl, Connie Marras
JAMA Neurol 2014 Nov;
PMID: 25401511 [PubMed - as supplied by publisher]
A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.
Mikko Muona, Samuel F Berkovic, Leanne M Dibbens, Karen L Oliver, Snezana Maljevic, Marta A Bayly, Tarja Joensuu, Laura Canafoglia, Silvana Franceschetti, Roberto Michelucci, Salla Markkinen, Sarah E Heron, Michael S Hildebrand, Eva Andermann, Frederick Andermann, Antonio Gambardella, Paolo Tinuper, Laura Licchetta, Ingrid E Scheffer, Chiara Criscuolo, Alessandro Filla, Edoardo Ferlazzo, Jamil Ahmad, Adeel Ahmad, Betul Baykan, Edith Said, Meral Topcu, Patrizia Riguzzi, Mary D King, Cigdem Ozkara, Danielle M Andrade, Bernt A Engelsen, Arielle Crespel, Matthias Lindenau, Ebba Lohmann, Veronica Saletti, João Massano, Michael Privitera, Alberto J Espay, Birgit Kauffmann, Michael Duchowny, Rikke S Møller, Rachel Straussberg, Zaid Afawi, Bruria Ben-Zeev, Kaitlin E Samocha, Mark J Daly, Steven Petrou, Holger Lerche, Aarno Palotie, Anna-Elina Lehesjoki
Nat Genet 2014 Nov;
PMID: 25401298 [PubMed - as supplied by publisher]
ATF3 Protects Pulmonary Resident Cells from Acute Lung Injury by Preventing Keap-1-mediated Nrf2 Degradation in a DJ-1-dependent manner.
Yuexin Shan, Ali Akram, Hajera Amatullah, Dun Yuan Zhou, Patrciai Gali, Tatiana Maron-Gutierrez, Adrian González-López, Louis Zhou, Patricia R M Rocco, David Hwang, Guillermo M Albaiceta, Jack J Haitsma, Claudia C Dos Santos
Antioxid Redox Signal 2014 Nov;
PMID: 25401197 [PubMed - as supplied by publisher]
Dual life of TPPP/p25 evolved in physiological and pathological conditions.
Judit Oláh, Judit Ovádi
Biochem Soc Trans 2014 Dec; 42(6):1762-7
PMID: 25399603 [PubMed - as supplied by publisher]
Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor.
Jaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, Karen J Coffman, Jayasankar Jasti, Ravi G Kurumbail, Travis T Wager, Patrick R Verhoest, G Stephen Noell, Yi Chen, Elie Needle, Zdenek Berger, Stefanus J Steyn, Christopher Houle, Warren D Hirst, Paul Galatsis
J Med Chem 2014 Nov;
PMID: 25353650 [PubMed - as supplied by publisher]
Cytoskeletal Alterations and Biomechanical Properties of parkin-Mutant Human Primary Fibroblasts.
Daniele Vergara, Marzia M Ferraro, Mariafrancesca Cascione, Loretta L Del Mercato, Stefano Leporatti, Anna Ferretta, Paola Tanzarella, Consiglia Pacelli, Angelo Santino, Michele Maffia, Tiziana Cocco, Ross Rinaldi, Antonio Gaballo
Cell Biochem Biophys 2014 Nov;
PMID: 25399302 [PubMed - as supplied by publisher]
GSK-3? dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and ?-synuclein.
J J Credle, J L George, J Wills, V Duka, K Shah, Y-C Lee, O Rodriguez, T Simkins, M Winter, D Moechars, T Steckler, J Goudreau, D I Finkelstein, A Sidhu
Cell Death Differ 2014 Nov;
PMID: 25394490 [PubMed - as supplied by publisher]
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
A R Esteves, M G-Fernandes, D Santos, C Januário, S M Cardoso
Mol Neurobiol 2014 Nov;
PMID: 25394383 [PubMed - as supplied by publisher]
Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation.
Diana F Lázaro, Eva F Rodrigues, Ramona Langohr, Hedieh Shahpasandzadeh, Thales Ribeiro, Patrícia Guerreiro, Ellen Gerhardt, Katharina Kröhnert, Jochen Klucken, Marcos D Pereira, Blagovesta Popova, Niels Kruse, Brit Mollenhauer, Silvio O Rizzoli, Gerhard H Braus, Karin M Danzer, Tiago F Outeiro
PLoS Genet 2014 Nov; 10(11):e1004741
PMID: 25393002 [PubMed - as supplied by publisher]
The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
Madeleine E Sharp, Elise Caccappolo, Helen Mejia-Santana, Ming-X Tang, Llency Rosado, Martha Orbe Reilly, Diana Ruiz, Elan D Louis, Cynthia Comella, Martha Nance, Susan Bressman, William K Scott, Caroline Tanner, Cheryl Waters, Stanley Fahn, Lucien Cote, Blair Ford, Michael Rezak, Kevin Novak, Joseph H Friedman, Ronald Pfeiffer, Haydeh Payami, Eric Molho, Stuart A Factor, John Nutt, Carmen Serrano, Maritza Arroyo, Michael W Pauciulo, William C Nichols, Lorraine N Clark, Roy N Alcalay, Karen S Marder
Mov Disord 2014 Nov;
PMID: 25393808 [PubMed - as supplied by publisher]
ATP13A2/PARK9 Regulates Secretion of Exosomes and ?-Synuclein.
Taiji Tsunemi, Kana Hamada, Dimitri Krainc
J Neurosci 2014 Nov; 34(46):15281-7
PMID: 25392495 [PubMed - as supplied by publisher]
The role of the LRRK2 gene in Parkinsonism.
Jie-Qiong Li, Lan Tan, Jin-Tai Yu
Mol Neurodegener 2014 Nov; 9(1):47
PMID: 25391693 [PubMed - as supplied by publisher]
Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
Adrian Flierl, Luís M A Oliveira, Lisandro J Falomir-Lockhart, Sally K Mak, Jayne Hesley, Frank Soldner, Donna J Arndt-Jovin, Rudolf Jaenisch, J William Langston, Thomas M Jovin, Birgitt Schüle
PLoS One 2014 ; 9(11):e112413
PMID: 25390032 [PubMed - as supplied by publisher]
Clinicopathologic and Genetic Studies of 2 Patients With Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids.
Min-Yu Lan, Jia-Shou Liu, Chiung-Chih Chang, Ying-Fa Chen, Cheng-San Su, Cheng-Huei Peng, Yung-Yee Chang
Alzheimer Dis Assoc Disord 2014 Nov;
PMID: 25390884 [PubMed - as supplied by publisher]
Commentary on "Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice".
Elena Popugaeva, Ilya Bezprozvanny
Front Cell Neurosci 2014 ; 8:351
PMID: 25389389 [PubMed - as supplied by publisher]
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Shohei Shinozaki, Kyungho Chang, Michihiro Sakai, Nobuyuki Shimizu, Marina Yamada, Tomokazu Tanaka, Harumasa Nakazawa, Fumito Ichinose, Yoshitsugu Yamada, Akihito Ishigami, Hideki Ito, Yasuyoshi Ouchi, Marlene E Starr, Hiroshi Saito, Kentaro Shimokado, Jonathan S Stamler, Masao Kaneki
Sci Signal 2014 ; 7(351):ra106
PMID: 25389371 [PubMed - as supplied by publisher]
Mutational analysis of angiogenin gene in Parkinson's disease.
Meng-Ling Chen, Ruey-Meei Wu, Chun-Hwei Tai, Chin-Hsien Lin
PLoS One 2014 ; 9(11):e112661
PMID: 25386690 [PubMed - as supplied by publisher]
Effects of titanium dioxide nanoparticles on ?-synuclein aggregation and the ubiquitin-proteasome system in dopaminergic neurons.
Jie Wu, Hongjun Xie
Artif Cells Nanomed Biotechnol 2014 Nov; :1-5
PMID: 25386730 [PubMed - as supplied by publisher]
Predicting cognitive decline in Parkinson's disease: can we ask the genes?
Fabiola De Marchi, Miryam Carecchio, Roberto Cantello, Cristoforo Comi
Front Neurol 2014 ; 5:224
PMID: 25386162 [PubMed - as supplied by publisher]
Clinical heterogeneity in Progressive Supranuclear Palsy: Challenges to diagnosis, pathogenesis and future therapies.
Anthony E Lang
Mov Disord 2014 Nov;
PMID: 25384577 [PubMed - as supplied by publisher]
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.
William M Johnson, Chen Yao, Sandra L Siedlak, Wenzhang Wang, Xiongwei Zhu, Guy A Caldwell, Amy L Wilson-Delfosse, John J Mieyal, Shu G Chen
Hum Mol Genet 2014 Oct;
PMID: 25355420 [PubMed - as supplied by publisher]
Alpha-synuclein and tau: teammates in neurodegeneration?
Simon Moussaud, Daryl R Jones, Elisabeth L Moussaud-Lamodière, Marion Delenclos, Owen A Ross, Pamela J McLean
Mol Neurodegener 2014 ; 9:43
PMID: 25352339 [PubMed - as supplied by publisher]
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Dayne A Beccano-Kelly, Mattia Volta, Lise N Munsie, Sarah A Paschall, Igor Tatarnikov, Kimberley Co, Patrick Chou, Li-Ping Cao, Sabrina Bergeron, Emma Mitchell, Heather Han, Heather L Melrose, Lucia Tapia, Lynn A Raymond, Matthew J Farrer, Austen J Milnerwood
Hum Mol Genet 2014 Oct;
PMID: 25343991 [PubMed - as supplied by publisher]
Efficient Differentiation of Human Embryonic Stem Cells Toward Dopaminergic Neurons Using Recombinant LMX1A Factor.
Ali Fathi, Hassan Rasouli, Meghdad Yeganeh, Ghassem Hosseini Salekdeh, Hossein Baharvand
Mol Biotechnol 2014 Nov;
PMID: 25380985 [PubMed - as supplied by publisher]
Correlates of cerebrospinal fluid levels of oligomeric- and total-?-synuclein in premotor, motor and dementia stages of Parkinson's disease.
Yaroslau Compta, Tony Valente, Josep Saura, Bàrbara Segura, Alex Iranzo, Mònica Serradell, Carme Junqué, Eduard Tolosa, Francesc Valldeoriola, Esteban Muñoz, Joan Santamaria, Ana Cámara, Manel Fernández, Juan Fortea, Mariateresa Buongiorno, José Luis Molinuevo, Núria Bargalló, María José Martí
J Neurol 2014 Nov;
PMID: 25380583 [PubMed - as supplied by publisher]
Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models.
Min Sik Choi, Tomohiro Nakamura, Seung-Je Cho, Xuemei Han, Emily A Holland, Jing Qu, Gregory A Petsko, John R Yates, Robert C Liddington, Stuart A Lipton
J Neurosci 2014 Nov; 34(45):15123-31
PMID: 25378175 [PubMed - as supplied by publisher]
Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells.
Xiaohua Jin, Qian Liu, Lili Jia, Meng Li, Xuan Wang
Cell Mol Neurobiol 2014 Nov;
PMID: 25377066 [PubMed - as supplied by publisher]
Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin.
Thomas R Caulfield, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Daniel F A R Dourado, Samuel C Flores, Wolfdieter Springer
PLoS Comput Biol 2014 Nov; 10(11):e1003935
PMID: 25375667 [PubMed - as supplied by publisher]
Analysis of Thr12Met and Ala1144Thr Mutations of the ATP13A2 Gene in Parkinson's Disease Patients in Xinjiang Uygur and Han Ethnic Groups.
Guihua Li, Zhenzhong Zhang, Huan Xia, Xinling Yang
Med Sci Monit 2014 ; 20:2177-82
PMID: 25374329 [PubMed - as supplied by publisher]
Large-scale identification of coregulated enhancer networks in the adult human brain.
Marit W Vermunt, Peter Reinink, Jeroen Korving, Ewart de Bruijn, Paul M Creyghton, Onur Basak, Geert Geeven, Pim W Toonen, Nico Lansu, Charles Meunier, Sebastiaan van Heesch, , Hans Clevers, Wouter de Laat, Edwin Cuppen, Menno P Creyghton
Cell Rep 2014 Oct; 9(2):767-79
PMID: 25373911 [PubMed - as supplied by publisher]
Efficient Conversion of Spermatogonial Stem Cells to Phenotypic and Functional Dopaminergic Neurons via the PI3K/Akt and P21/Smurf2/Nolz1 Pathway.
Hao Yang, Yang Liu, Yanan Hai, Ying Guo, Shi Yang, Zheng Li, Wei-Qiang Gao, Zuping He
Mol Neurobiol 2014 Nov;
PMID: 25373443 [PubMed - as supplied by publisher]
Hes3 is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release.
Jimmy Masjkur, Carina Arps-Forker, Steven Walter Poser, Polyxeni Nikolakopoulou, Louiza Toutouna, Ramu Chenna, Triantafyllos Chavakis, Antonis Chatzigeorgiou, Lan-Sun Chen, Anna Dubrovska, Pratik Choudhary, Ingo Uphues, Michael Mark, Stefan R Bornstein, Andreas Androutsellis-Theotokis
J Biol Chem 2014 Nov;
PMID: 25371201 [PubMed - as supplied by publisher]
Bioinformatic analysis of microRNA expression in Parkinson's disease.
Bin Hao, Xin Chen, Dongwei Dai, Chao Zou, Xi Wu, Jianchun Chen
Mol Med Rep 2014 Nov;
PMID: 25371140 [PubMed - as supplied by publisher]
Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network.
Guiyou Liu, Xinjie Bao, Yongshuai Jiang, Mingzhi Liao, Qinghua Jiang, Rennan Feng, Liangcai Zhang, Guoda Ma, Zugen Chen, Guangyu Wang, Renzhi Wang, Bin Zhao, Keshen Li
Mol Neurobiol 2014 Nov;
PMID: 25370933 [PubMed - as supplied by publisher]
MCP-1 and CCR2 gene polymorphisms in Parkinson's disease in a Han Chinese cohort.
Liang Gao, Hongmei Tang, Kun Nie, Limin Wang, Jiehao Zhao, Rong Gan, Jing Huang, Shujun Feng, Ruiming Zhu, Zhenpeng Duan, Youwen Zhang, Xin Zhao, Yuhu Zhang, Lijuan Wang
Neurol Sci 2014 Nov;
PMID: 25370917 [PubMed - as supplied by publisher]
Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.
Ying Liu, Yan-Yan Chen, Hui Liu, Ci-Jiang Yao, Xiao-Xia Zhu, Dao-Jun Chen, Jin Yang, You-Jin Lu, Ji-Yu Cao
Neurol Sci 2014 Nov;
PMID: 25370916 [PubMed - as supplied by publisher]
Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs.
Jing Yao, Jiaojiao Huang, Tang Hai, Xianlong Wang, Guosong Qin, Hongyong Zhang, Rong Wu, Chunwei Cao, Jianzhong Jeff Xi, Zengqiang Yuan, Jianguo Zhao
Sci Rep 2014 ; 4:6926
PMID: 25370805 [PubMed - as supplied by publisher]
Head injury, ?-synuclein genetic variability and Parkinson's disease.
P C Lee, Y Bordelon, J Bronstein, J S Sinsheimer, M Farrer, B Ritz
Eur J Neurol 2014 Nov;
PMID: 25370538 [PubMed - as supplied by publisher]
Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.
Phillip M Rappold, Mei Cui, Jonathan C Grima, Rebecca Z Fan, Karen L de Mesy-Bentley, Linan Chen, Xiaoxi Zhuang, William J Bowers, Kim Tieu
Nat Commun 2014 ; 5:5244
PMID: 25370169 [PubMed - as supplied by publisher]
EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.
Johanna Huttenlocher, Rejko Krüger, Philipp Capetian, Katja Lohmann, Kathrin Brockmann, Ilona Csoti, Christine Klein, Daniela Berg, Thomas Gasser, Michael Bonin, Olaf Riess, Peter Bauer
J Med Genet 2014 Nov;
PMID: 25368108 [PubMed - as supplied by publisher]
Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.
Sayinthen Vivekanantham, Savan Shah, Rizwan Dewji, Abbas Dewji, Chetan Khatri, Rele Ologunde
Int J Neurosci 2014 Nov; :1-17
PMID: 25364880 [PubMed - as supplied by publisher]
Mutual exacerbation of PGC-1? deregulation and ?-synuclein oligomerization.
Judith Eschbach, Björn von Einem, Kathrin Müller, Hanna Bayer, Annika Scheffold, Bradley E Morrison, K Lenhard Rudolph, Dietmar R Thal, Anke Witting, Patrick Weydt, Markus Otto, Michael Fauler, Birgit Liss, Pamela J McLean, Albert R La Spada, Albert C Ludolph, Jochen H Weishaupt, Karin M Danzer
Ann Neurol 2014 Nov;
PMID: 25363075 [PubMed - as supplied by publisher]
Selegiline promotes NOTCH-JAGGED signaling in astrocytes of the peri-infarct region and improves the functional integrity of the neurovascular unit in a rat model of focal ischemia.
Sándor Nardai, Arpád Dobolyi, Gabriella Pál, Judit Skopál, Nándor Pintér, Kinga Lakatos, Béla Merkely, Zoltán Nagy
Restor Neurol Neurosci 2014 Oct;
PMID: 25361607 [PubMed - as supplied by publisher]
LRRK2 Transport Is Regulated by Its Novel Interacting Partner Rab32.
Dieter Waschbüsch, Helen Michels, Swantje Strassheim, Edith Ossendorf, Daniel Kessler, Christian Johannes Gloeckner, Angelika Barnekow
PLoS One 2014 ; 9(10):e111632
PMID: 25360523 [PubMed - as supplied by publisher]
Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice.
Sara E Gombash, Christopher J Cowley, Julie A Fitzgerald, Jodie C E Hall, Christian Mueller, Fedias L Christofi, Kevin D Foust
Front Mol Neurosci 2014 ; 7:81
PMID: 25360081 [PubMed - as supplied by publisher]
Deep Brain Stimulation of the Thalamic Ventral Lateral Anterior Nucleus for DYT6 Dystonia.
Hideo Mure, Ryoma Morigaki, Hidetaka Koizumi, Shinya Okita, Toshitaka Kawarai, Ryosuke Miyamoto, Ryuji Kaji, Shinji Nagahiro, Satoshi Goto
Stereotact Funct Neurosurg 2014 Oct; 92(6):393-396
PMID: 25359437 [PubMed - as supplied by publisher]
LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.
Hui-Fang Liu, Song Lu, Philip Wing-Lok Ho, Ho-Man Tse, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, Jessica Wing-Man Ho, David B Ramsden, Zhong-Jun Zhou, Shu-Leong Ho
Ann Clin Transl Neurol 2014 Mar; 1(3):199-208
PMID: 25356398 [PubMed - as supplied by publisher]
Evaluation of Levodopa and Carbidopa Antioxidant Activity in Normal Human Lymphocytes In Vitro: Implication for Oxidative Stress in Parkinson's Disease.
Monica Colamartino, Massimo Santoro, Guglielmo Duranti, Stefania Sabatini, Roberta Ceci, Antonella Testa, Luca Padua, Renata Cozzi
Neurotox Res 2014 Oct;
PMID: 25355370 [PubMed - as supplied by publisher]
Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.
Shuang Sun, Yan Zhao, Guojiang Jin, Hui Kang
Neurol Sci 2014 Oct;
PMID: 25354657 [PubMed - as supplied by publisher]
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.
Yusuke Kageyama, Masahiko Hoshijima, Kinya Seo, Djahida Bedja, Polina Sysa-Shah, Shaida A Andrabi, Weiran Chen, Ahmet Höke, Valina L Dawsn, Ted M Dawson, Kathleen Gabrielson, David A Kass, Miho Iijima, Hiromi Sesaki
EMBO J 2014 Oct;
PMID: 25349190 [PubMed - as supplied by publisher]
Genetic Movement Disorders in Patients of Jewish Ancestry.
Rivka Inzelberg, Sharon Hassin-Baer, Joseph Jankovic
JAMA Neurol 2014 Oct;
PMID: 25347348 [PubMed - as supplied by publisher]
Gene Expression Analysis Approach to Establish Possible Links between Parkinson's Disease, Cancer and Cardiovascular Diseases.
S Karim, Z Mirza, M A Kamal, A M Abuzenadah, M H Al-Qahtani
CNS Neurol Disord Drug Targets 2014 Oct;
PMID: 25345512 [PubMed - as supplied by publisher]
The Parkinson's Disease-Associated Protein ?-Synuclein Disrupts Stress Signaling - A Possible Implication for Methamphetamine Use?
Shaoxiao Wang, Stephan N Witt
Microb Cell 2014 Apr; 1(4):131-132
PMID: 25343141 [PubMed - as supplied by publisher]
Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications.
David Braun, Jose L M Madrigal, Douglas L Feinstein
Curr Neuropharmacol 2014 Jul; 12(4):342-52
PMID: 25342942 [PubMed - as supplied by publisher]
Histone Hyperacetylation Upregulates PKC? in Dopaminergic Neurons to Induce Cell Death: Relevance to Epigenetic Mechanisms of Neurodegeneration in Parkinson's Disease.
Huajun Jin, Arthi Kanthasamy, Dilshan S Harischandra, Naveen Kondru, Anamitra Ghosh, Nikhil Panicker, Vellareddy Anantharam, Ajay Rana, Anumantha G Kanthasamy
J Biol Chem 2014 Oct;
PMID: 25342743 [PubMed - as supplied by publisher]
A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress.
Peter Bou Dib, Bettina Gnägi, Fiona Daly, Virginie Sabado, Damla Tas, Dominique A Glauser, Peter Meister, Emi Nagoshi
PLoS Genet 2014 Oct; 10(10):e1004718
PMID: 25340742 [PubMed - as supplied by publisher]
Mucuna pruriens (Velvet bean) Rescues Motor, Olfactory, Mitochondrial and Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic Model of Parkinson's Disease.
Simone Poddighe, Francescaelena De Rose, Roberto Marotta, Roberta Ruffilli, Maura Fanti, Pietro Paolo Secci, Maria Cristina Mostallino, Maria Dolores Setzu, Maria Antonietta Zuncheddu, Ignazio Collu, Paolo Solla, Francesco Marrosu, Sanjay Kasture, Elio Acquas, Anna Liscia
PLoS One 2014 ; 9(10):e110802
PMID: 25340511 [PubMed - as supplied by publisher]
Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-derived Human Neurons.
Yong Ren, Houbo Jiang, Zhixing Hu, Kevin Fan, Jun Wang, Stephen Janoschka, Xiaomin Wang, Shaoyu Ge, Jian Feng
Stem Cells 2014 Oct;
PMID: 25332110 [PubMed - as supplied by publisher]
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.
Mol Genet Genomics 2014 Oct;
PMID: 25332075 [PubMed - as supplied by publisher]
Nonmotor Symptoms in LRRK2 G2019S Associated Parkinson's Disease.
Carles Gaig, Dolores Vilas, Jon Infante, María Sierra, Inés García-Gorostiaga, Mariateresa Buongiorno, Mario Ezquerra, Maria José Martí, Francesc Valldeoriola, Miquel Aguilar, Matilde Calopa, Jorge Hernandez-Vara, Eduardo Tolosa
PLoS One 2014 ; 9(10):e108982
PMID: 25330404 [PubMed - as supplied by publisher]
Disease Penetrance of Late-Onset Parkinsonism: A Meta-analysis.
Joanne Trinh, Ilaria Guella, Matthew James Farrer
JAMA Neurol 2014 Oct;
PMID: 25330418 [PubMed - as supplied by publisher]
Families with Wilson's disease in subsequent generations: Clinical and genetic analysis.
Karolina Dzie?yc, Tomasz Litwin, Grzegorz Chabik, Karolina Gramza, Anna Cz?onkowska
Mov Disord 2014 Oct;
PMID: 25327413 [PubMed - as supplied by publisher]
Altered synaptic architecture and glycosylated synaptomatrix composition in a Drosophila classic galactosemia disease model.
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie
Dis Model Mech 2014 Oct;
PMID: 25326312 [PubMed - as supplied by publisher]
miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650.
Marlen Hesse, Christoph Arenz
Expert Opin Ther Pat 2014 Nov; 24(11):1271-6
PMID: 25307171 [PubMed - as supplied by publisher]
Hyperhomocysteinemia and neurologic disorders: a review.
Ramin Ansari, Ali Mahta, Eric Mallack, Jin Jun Luo
J Clin Neurol 2014 Oct; 10(4):281-8
PMID: 25324876 [PubMed - as supplied by publisher]
Potential of caveolae in the therapy of cardiovascular and neurological diseases.
Gemma Navarro, Dasiel O Borroto-Escuela, Kjell Fuxe, Rafael Franco
Front Physiol 2014 ; 5:370
PMID: 25324780 [PubMed - as supplied by publisher]
Parkinson Disease Genetics: A "Continuum" From Mendelian to Multifactorial Inheritance.
S Petrucci, F Consoli, E M Valente
Curr Mol Med 2014 Oct;
PMID: 25323865 [PubMed - as supplied by publisher]
A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus.
Bridget A Culleton, Patrick Lall, Gemma K Kinsella, Sean Doyle, John McCaffrey, David A Fitzpatrick, Ann M Burnell
Cell Stress Chaperones 2014 Oct;
PMID: 25318690 [PubMed - as supplied by publisher]
Revisiting the Roco G protein cycle.
Susanne Terheyden, Franz Y Ho, Bernd Karl Gilsbach, Alfred Wittinghofer, Arjan Kortholt
Biochem J 2014 Oct;
PMID: 25317655 [PubMed - as supplied by publisher]
Driving neural regeneration through the mammalian target of rapamycin.
Neural Regen Res 2014 Aug; 9(15):1413-7
PMID: 25317149 [PubMed - as supplied by publisher]
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.
Vinay K Godena, Nicholas Brookes-Hocking, Annekathrin Moller, Gary Shaw, Matthew Oswald, Rosa M Sancho, Christopher C J Miller, Alexander J Whitworth, Kurt J De Vos
Nat Commun 2014 ; 5:5245
PMID: 25316291 [PubMed - as supplied by publisher]
Repression of rRNA transcription by PARIS contributes to Parkinson's Disease.
Hojin Kang, Joo-Ho Shin
Neurobiol Dis 2014 Oct;
PMID: 25315684 [PubMed - as supplied by publisher]
Could the detection of visual disturbances associated with Parkinson's disease genes in flies lead to new treatments for the disease?
Alex R Wade, Christopher Jh Elliott
Neurodegener Dis Manag 2014 Aug; 4(4):291-3
PMID: 25313984 [PubMed - as supplied by publisher]
Clinical applications involving CNS gene transfer.
Boris Kantor, Thomas McCown, Paola Leone, Steven J Gray
Adv Genet 2014 ; 87:71-124
PMID: 25311921 [PubMed - as supplied by publisher]
The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease.
Ja Pyszko, Jb Strosznajder
Folia Neuropathol 2014 ; 52(3):260-9
PMID: 25310737 [PubMed - as supplied by publisher]
Elevated levels of cerebrospinal fluid ?-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers.
Jan O Aasly, Krisztina K Johansen, Gunnar Brønstad, Bjørg J Warø, Nour K Majbour, Shiji Varghese, Fatimah Alzahmi, Katerina E Paleologou, Dena A M Amer, Abdulmonem Al-Hayani, Omar M A El-Agnaf
Front Aging Neurosci 2014 ; 6:248
PMID: 25309429 [PubMed - as supplied by publisher]
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Dayne A Beccano-Kelly, Naila Kuhlmann, Igor Tatarnikov, Mattia Volta, Lise N Munsie, Patrick Chou, Li-Ping Cao, Heather Han, Lucia Tapia, Matthew J Farrer, Austen J Milnerwood
Front Cell Neurosci 2014 ; 8:301
PMID: 25309331 [PubMed - as supplied by publisher]
An association study between Heme oxygenase-1 genetic variants and Parkinson's disease.
Pedro Ayuso, Carmen Martínez, Pau Pastor, Oswaldo Lorenzo-Betancor, Antonio Luengo, Félix J Jiménez-Jiménez, Hortensia Alonso-Navarro, José A G Agúndez, Elena García-Martín
Front Cell Neurosci 2014 ; 8:298
PMID: 25309329 [PubMed - as supplied by publisher]