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What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

Impulse Control Disorder

Vision/Visual hallucination



Orthostatic Hypotension


Imaging Studies

Clinical Studies



Treating Parkinson’s

Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

Deep Brain Stimulation

Physical, Occupational and Speech Therapy



Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

Hospice/End of Life/Palliative Care

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Computational analysis of the LRRK2 interactome.
Claudia Manzoni, Paul Denny, Ruth C Lovering, Patrick A Lewis
PeerJ 2015 ; 3:e778
PMID: 25737818 [PubMed - as supplied by publisher]

Patterns of Tau and ?-Synuclein Pathology in the Visual System.
Jasmin Rahimi, Ivan Milenkovic, Gabor G Kovacs
J Parkinsons Dis 2015 Mar;
PMID: 25737267 [PubMed - as supplied by publisher]

The endosomal pathway in Parkinson's disease.
Rebecca M Perrett, Zoi Alexopoulou, George K Tofaris
Mol Cell Neurosci 2015 Feb;
PMID: 25701813 [PubMed - as supplied by publisher]

Cholinesterase inhibitors for rarer dementias associated with neurological conditions.
Ying Li, Shan Hai, Yan Zhou, Bi Rong Dong
Cochrane Database Syst Rev 2015 Mar; 3:CD009444
PMID: 25734590 [PubMed - as supplied by publisher]

Heterogeneity among patients with Parkinson's disease: Cluster analysis and genetic association.
Ling-Yan Ma, Piu Chan, Zhu-Qin Gu, Fang-Fei Li, Tao Feng
J Neurol Sci 2015 Feb;
PMID: 25732803 [PubMed - as supplied by publisher]

N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: an investigation into the interaction of Parkin and Drp1 proteins.
Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzadeh
Brain Res Bull 2015 Feb;
PMID: 25732239 [PubMed - as supplied by publisher]

Adenoviral-Mediated Expression of G2019S LRRK2 Induces Striatal Pathology in a Kinase-Dependent Manner in a Rat Model of Parkinson's Disease.
Elpida Tsika, An Phu Tran Nguyen, Julien Dusonchet, Philippe Colin, Bernard L Schneider, Darren J Moore
Neurobiol Dis 2015 Feb;
PMID: 25731749 [PubMed - as supplied by publisher]

Overexpression of GRK6 rescues l-DOPA-induced signaling abnormalities in the dopamine-depleted striatum of hemiparkinsonian rats.
M Rafiuddin Ahmed, Evgeny Bychkov, Seunghyi Kook, Lilia Zurkovsky, Kevin N Dalby, Eugenia V Gurevich
Exp Neurol 2015 Feb; 266C:42-54
PMID: 25687550 [PubMed - as supplied by publisher]

Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-thiazolidinone in MPTP induced Parkinsonism model in mice.
Zhili Ren, Nan Yang, Chao Ji, Ji Zheng, Tao Wang, Yanyong Liu, Pingping Zuo
Neuropharmacology 2015 Feb; 93C:209-218
PMID: 25680233 [PubMed - as supplied by publisher]

Glutathione transferases and neurodegenerative diseases.
Anna Paola Mazzetti, Maria Carmela Fiorile, Alessandra Primavera, Mario Lo Bello
Neurochem Int 2015 Feb; 82C:10-18
PMID: 25661512 [PubMed - as supplied by publisher]

Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesia.
Sean Austin O Lim, Rong Xia, Yunmin Ding, Lisa Won, William J Ray, Stephen A Hitchcock, Daniel S McGehee, Un Jung Kang
Neurobiol Dis 2015 Feb; 76C:67-76
PMID: 25661301 [PubMed - as supplied by publisher]

A new gene for Parkinson's disease: should we care?
Andrew Singleton
Lancet Neurol 2015 Mar; 14(3):238-9
PMID: 25728432 [PubMed - as supplied by publisher]

A yeast model of the Parkinson´s disease-associated protein Parkin.
Clara Pereira, Vitor Costa, L Miguel Martins, Lucília Saraiva
Exp Cell Res 2015 Feb;
PMID: 25728007 [PubMed - as supplied by publisher]

Genetic testing for spinocerebellar ataxias in patients diagnosed as Parkinson's disease in bangladesh.
M S Rahman, M A Sarkar, M F Rahman, S K Paul, S Y Nagai, M J Uddin, T Toda
Mymensingh Med J 2015 Jan; 24(1):44-51
PMID: 25725667 [PubMed - as supplied by publisher]

In vitro studies in VCP-associated multisystem proteinopathy suggest altered mitochondrial bioenergetics.
Angèle Nalbandian, Katrina J Llewellyn, Arianna Gomez, Naomi Walker, Hailing Su, Andrew Dunnigan, Marilyn Chwa, Jouni Vesa, M Cristina Kenney, Virginia E Kimonis
Mitochondrion 2015 Feb;
PMID: 25724235 [PubMed - as supplied by publisher]

P-glycoprotein in autoimmune rheumatic diseases.
M García-Carrasco, C Mendoza-Pinto, S Macias Díaz, M Vera-Recabarren, L Vázquez de Lara, S Méndez Martínez, P Soto-Santillán, R González-Ramírez, A Ruiz-Arguelles
Autoimmun Rev 2015 Feb;
PMID: 25712147 [PubMed - as supplied by publisher]

Progress in unraveling the genetic etiology of Parkinson disease in a genomic era.
Aline Verstraeten, Jessie Theuns, Christine Van Broeckhoven
Trends Genet 2015 Mar; 31(3):140-149
PMID: 25703649 [PubMed - as supplied by publisher]

CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
Manabu Funayama, Kenji Ohe, Taku Amo, Norihiko Furuya, Junji Yamaguchi, Shinji Saiki, Yuanzhe Li, Kotaro Ogaki, Maya Ando, Hiroyo Yoshino, Hiroyuki Tomiyama, Kenya Nishioka, Kazuko Hasegawa, Hidemoto Saiki, Wataru Satake, Kaoru Mogushi, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, Tatsushi Toda, Yoshikuni Mizuno, Yasuo Uchiyama, Kinji Ohno, Nobutaka Hattori
Lancet Neurol 2015 Mar; 14(3):274-82
PMID: 25662902 [PubMed - as supplied by publisher]

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an ?-synuclein-based rat model for Parkinson's disease.
Anke Van der Perren, Francesca Macchi, Jaan Toelen, Marianne S Carlon, Michael Maris, Henriette de Loor, Dirk R J Kuypers, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2015 Mar; 36(3):1559-68
PMID: 25660193 [PubMed - as supplied by publisher]

Myricitrin alleviates MPP(+)-induced mitochondrial dysfunction in a DJ-1-dependent manner in SN4741 cells.
Zhibiao Cai, Weijun Zeng, Kai Tao, Fangfang Lu, Guodong Gao, Qian Yang
Biochem Biophys Res Commun 2015 Mar; 458(2):227-33
PMID: 25623535 [PubMed - as supplied by publisher]

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2015 Mar; 36(3):1543-58
PMID: 25599874 [PubMed - as supplied by publisher]

Chaperone Mediated Autophagy to the Rescue: A New-Fangled Target for the Treatment of Neurodegenerative Diseases.
Maria Xilouri, Leonidas Stefanis
Mol Cell Neurosci 2015 Feb;
PMID: 25724482 [PubMed - as supplied by publisher]

Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP(+)-treated MN9D cells in vitro.
M Sivasubramanian, N Kanagaraj, S T Dheen, S S W Tay
Neuroscience 2015 Jan; 290C:636-648
PMID: 25637806 [PubMed - as supplied by publisher]

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.
Kei Okatsu, Mayumi Kimura, Toshihiko Oka, Keiji Tanaka, Noriyuki Matsuda
J Cell Sci 2015 Mar; 128(5):964-78
PMID: 25609704 [PubMed - as supplied by publisher]

Association between HLA rs3129882 polymorphism and Parkinson's disease: a meta-analysis.
R-L Zhu, X-C Lu, L-J Tang, B-S Huang, W Yu, S Li, L-X Li
Eur Rev Med Pharmacol Sci 2015 Feb; 19(3):423-32
PMID: 25720714 [PubMed - as supplied by publisher]

Postmortem Alzheimer's Disease Hippocampi Show Oxidative Phosphorylation Gene Expression Opposite that of Isolated Pyramidal Neurons.
Ann C Rice, Amy C Ladd, James P Bennett Jr
J Alzheimers Dis 2015 Feb;
PMID: 25720395 [PubMed - as supplied by publisher]

Flies with Parkinson's disease.
Roeland Vanhauwaert, Patrik Verstreken
Exp Neurol 2015 Feb;
PMID: 25708988 [PubMed - as supplied by publisher]

Nitric Oxide Induction of Parkin Translocation in PTEN-Induced Putative Kinase 1 (PINK1) Deficiency: Functional Role of Neuronal Nitric Oxide Synthase During Mitophagy.
Ji-Young Han, Min-Ji Kang, Kyung-Hee Kim, Pyung-Lim Han, Hyun-Seok Kim, Ji-Young Ha, Jin H Son
J Biol Chem 2015 Feb;
PMID: 25716315 [PubMed - as supplied by publisher]

Chemogenomic Profiling of Endogenous PARK2 Expression Using a Genome-Edited Coincidence Reporter.
Samuel A Hasson, Adam I Fogel, Chunxin Wang, Ryan MacArthur, Rajarshi Guha, Sabrina Heman-Ackah, Scott Martin, Richard J Youle, James Inglese
ACS Chem Biol 2015 Feb;
PMID: 25689131 [PubMed - as supplied by publisher]

Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson's disease.
B Macchi, D R Paola, F Marino-Merlo, M R Felice, S Cuzzocrea, A Mastino
CNS Neurol Disord Drug Targets 2015 Feb;
PMID: 25714978 [PubMed - as supplied by publisher]

Current update on synopsis of miRNA Dysregulation in Neurological Disorders.
M A Kamal, G Mushtaq, N H Greig
CNS Neurol Disord Drug Targets 2015 Feb;
PMID: 25714967 [PubMed - as supplied by publisher]

Parkin Structure and Function.
Marjan Seirafi, Guennadi Kozlov, Kalle Gehring
FEBS J 2015 Feb;
PMID: 25712550 [PubMed - as supplied by publisher]

Pharmacogenetic considerations in the treatment of Parkinson's disease.
Mateusz Kurzawski, Monika Bia?ecka, Marek Dro?dzik
Neurodegener Dis Manag 2015 Feb; 5(1):27-35
PMID: 25711452 [PubMed - as supplied by publisher]

Genome-wide association data classification and SNPs selection using two-stage quality-based Random Forests.
Thanh-Tung Nguyen, Joshua Huang, Qingyao Wu, Thuy Nguyen, Mark Li
BMC Genomics 2015 ; 16 Suppl 2:S5
PMID: 25708662 [PubMed - as supplied by publisher]

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.
Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh
Pathol Int 2015 Feb;
PMID: 25707882 [PubMed - as supplied by publisher]

Head injury, potential interaction with genes, and risk for Parkinson's disease.
Jianjun Gao, Rui Liu, Edward Zhao, Xuemei Huang, Michael A Nalls, Andrew B Singleton, Honglei Chen
Parkinsonism Relat Disord 2015 Mar; 21(3):292-6
PMID: 25603768 [PubMed - as supplied by publisher]

Function and dysfunction of leucine-rich repeat kinase 2 (LRRK2): Parkinson's disease and beyond.
Jae Ryul Bae, Byoung Dae Lee
BMB Rep 2015 Feb;
PMID: 25703537 [PubMed - as supplied by publisher]

The neuropathology of traumatic brain injury.
Ann C Mckee, Daniel H Daneshvar
Handb Clin Neurol 2015 ; 127:45-66
PMID: 25702209 [PubMed - as supplied by publisher]

Pathologic and therapeutic implications for the cell biology of parkin.
Rakshita A Charan, Matthew J LaVoie
Mol Cell Neurosci 2015 Feb;
PMID: 25697646 [PubMed - as supplied by publisher]

Induction of NQO1 and Neuroprotection by a Novel Compound KMS04014 in Parkinson's Disease Models.
Hyo Jin Son, Ji Hyun Choi, Ji Ae Lee, Dong Jin Kim, Kye Jung Shin, Onyou Hwang
J Mol Neurosci 2015 Feb;
PMID: 25702135 [PubMed - as supplied by publisher]

USP8 and PARK2/parkin-mediated mitophagy.
Thomas M Durcan, Edward A Fon
Autophagy 2015 Feb; :0
PMID: 25700639 [PubMed - as supplied by publisher]

PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.
Ghazaleh Ashrafi, Thomas L Schwarz
Autophagy 2015 Jan; 11(1):187-9
PMID: 25607607 [PubMed - as supplied by publisher]

A Bird's-Eye View of Alzheimer's Disease Research: Reflecting Different Perspectives of Indexers, Authors, or Citers in Mapping the Field.
Dahee Lee, Won Chul Kim, Andreas Charidimou, Min Song
J Alzheimers Dis 2015 Feb;
PMID: 25697702 [PubMed - as supplied by publisher]

Targeting histone deacetylases: a novel approach in Parkinson's disease.
Sorabh Sharma, Rajeev Taliyan
Parkinsons Dis 2015 ; 2015:303294
PMID: 25694842 [PubMed - as supplied by publisher]

The transfection of BDNF to dopamine neurons potentiates the effect of dopamine d3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease.
Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Ruiz
PLoS One 2015 ; 10(2):e0117391
PMID: 25693197 [PubMed - as supplied by publisher]

Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: A meta-analysis.
Wei Han, Yingli Liu, Yingjun Mi, Jing Zhao, Dianwu Liu, Qingbao Tian
Am J Med Genet B Neuropsychiatr Genet 2015 Mar; 168(2):123-34
PMID: 25656566 [PubMed - as supplied by publisher]

Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease.
Jose A Santiago, Judith A Potashkin
Proc Natl Acad Sci U S A 2015 Feb; 112(7):2257-62
PMID: 25646437 [PubMed - as supplied by publisher]

Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.
James M Gruschus, Zhiping Jiang, Thai Leong Yap, Stephanie A Hill, Alexander Grishaev, Grzegorz Piszczek, Ellen Sidransky, Jennifer C Lee
Biochem Biophys Res Commun 2015 Feb; 457(4):561-6
PMID: 25600808 [PubMed - as supplied by publisher]

Multiple system atrophy: the application of genetics in understanding etiology.
Monica Federoff, Lucia V Schottlaender, Henry Houlden, Andrew Singleton
Clin Auton Res 2015 Feb;
PMID: 25687905 [PubMed - as supplied by publisher]

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.
R S Desikan, A J Schork, Y Wang, A Witoelar, M Sharma, L K McEvoy, D Holland, J B Brewer, C-H Chen, W K Thompson, D Harold, J Williams, M J Owen, M C O'Donovan, M A Pericak-Vance, R Mayeux, J L Haines, L A Farrer, G D Schellenberg, P Heutink, A B Singleton, A Brice, N W Wood, J Hardy, M Martinez, S H Choi, A DeStefano, M A Ikram, J C Bis, A Smith, A L Fitzpatrick, L Launer, C van Duijn, S Seshadri, I D Ulstein, D Aarsland, T Fladby, S Djurovic, B T Hyman, J Snaedal, H Stefansson, K Stefansson, T Gasser, O A Andreassen, A M Dale
Mol Psychiatry 2015 Feb;
PMID: 25687773 [PubMed - as supplied by publisher]

Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson?s disease.
Shaoxia Wang, Haoran Jing, Hongyun Yang, Zhidong Liu, Hong Guo, Lijuan Chai, Limin Hu
J Ethnopharmacol 2015 Feb;
PMID: 25666429 [PubMed - as supplied by publisher]

Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies.
Urmi Sengupta, Marcos J Guerrero-Muñoz, Diana L Castillo-Carranza, Cristian A Lasagna-Reeves, Julia E Gerson, Adriana A Paulucci-Holthauzen, Shashirekha Krishnamurthy, Malika Farhed, George R Jackson, Rakez Kayed
Biol Psychiatry 2015 Jan;
PMID: 25676491 [PubMed - as supplied by publisher]

Validity of the MPTP-Treated Mouse as a Model for Parkinson's Disease.
Cornelius J H M Klemann, Gerard J M Martens, Geert Poelmans, Jasper E Visser
Mol Neurobiol 2015 Feb;
PMID: 25676140 [PubMed - as supplied by publisher]

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice.
Zhi-Zhong Chen, Chien-Ming Wang, Guan-Chiun Lee, Ho-Chiang Hsu, Tzu-Ling Wu, Chia-Wei Lin, Chih-Kang Ma, Guey-Jen Lee-Chen, Hei-Jen Huang, Hsiu Mei Hsieh-Li
Neurochem Res 2015 Feb;
PMID: 25672822 [PubMed - as supplied by publisher]

Modulation of tau phosphorylation by environmental copper.
Kellen Voss, Christopher Harris, Martina Ralle, Megan Duffy, Charles Murchison, Joseph F Quinn
Transl Neurodegener 2014 ; 3(1):24
PMID: 25671100 [PubMed - as supplied by publisher]

Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.
Julie Vallortigara, Sindhoo Rangarajan, David Whitfield, Amani Alghamdi, David Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Clive Ballard, Alan Thomas, John O'Brien, Dag Aarsland, Paul Francis
F1000Res 2014 ; 3:108
PMID: 25671083 [PubMed - as supplied by publisher]

DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1.
Raquel Requejo-Aguilar, Irene Lopez-Fabuel, Daniel Jimenez-Blasco, Emilio Fernandez, Angeles Almeida, Juan P Bolaños
Biochem J 2015 Feb;
PMID: 25670069 [PubMed - as supplied by publisher]

Trends in mitochondrial therapeutics for neurological disease.
Ana Leitão-Rocha, Pedro Guedes-Dias, Brígida R Pinho, Jorge M A Oliveira
Curr Med Chem 2015 Feb;
PMID: 25666789 [PubMed - as supplied by publisher]

The E3 Ubiquitin ligase parkin is recruited to the 26S proteasome via the proteasomal ubiquitin receptor Rpn13.
Miguel A Aguileta, Jelena Korac, Thomas M Durcan, Jean-François Trempe, Michael Haber, Kalle Gehring, Suzanne Elsasser, Oliver Waidmann, Edward A Fon, Koraljka Husnjak
J Biol Chem 2015 Feb;
PMID: 25666615 [PubMed - as supplied by publisher]

Moving activity and wakefulness-sleep cycle changes in a mouse MPTP model of Parkinson's disease].
A I Manolov, V V Dolgikh, Iu V Ukraintseva, I M Zavalko, A V Revishchin, G V Pavlova, T S Pronina, M V Ugriumov, V B Dorokhov, V M Koval'zon
Ross Fiziol Zh Im I M Sechenova 2014 Nov; 100(11):1252-60
PMID: 25665403 [PubMed - as supplied by publisher]

The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.
Faris Yaghmoor, Ahmed Noorsaeed, Samar Alsaggaf, Waleed Aljohani, Henrieta Scholtzova, Allal Boutajangout, Thomas Wisniewski
J Alzheimers Dis Parkinsonism 2014 Nov; 4(5)
PMID: 25664220 [PubMed - as supplied by publisher]

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.
Gary W Beecham, Dennis W Dickson, William K Scott, Eden R Martin, Gerard Schellenberg, Karen Nuytemans, Eric B Larson, Joseph D Buxbaum, John Q Trojanowski, Vivianna M Van Deerlin, Howard I Hurtig, Deborah C Mash, Thomas G Beach, Juan C Troncoso, Olga Pletnikova, Matthew P Frosch, Bernardino Ghetti, Tatiana M Foroud, Lawrence S Honig, Karen Marder, Jean Paul Vonsattel, Samuel M Goldman, Harry V Vinters, Owen A Ross, Zbigniew K Wszolek, Liyong Wang, Derek M Dykxhoorn, Margaret A Pericak-Vance, Thomas J Montine, James B Leverenz, Ted M Dawson, Jeffery M Vance
Neurology 2015 Feb;
PMID: 25663231 [PubMed - as supplied by publisher]

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric ?-Synuclein.
Cristine Betzer, A James Movius, Min Shi, Wei-Ping Gai, Jing Zhang, Poul Henning Jensen
PLoS One 2015 ; 10(2):e0116473
PMID: 25659148 [PubMed - as supplied by publisher]

A Recurrent Mutation in PARK2 Is Associated with Familial Lung Cancer.
Donghai Xiong, Yian Wang, Elena Kupert, Claire Simpson, Susan M Pinney, Colette R Gaba, Diptasri Mandal, Ann G Schwartz, Ping Yang, Mariza de Andrade, Claudio Pikielny, Jinyoung Byun, Yafang Li, Dwight Stambolian, Margaret R Spitz, Yanhong Liu, Christopher I Amos, Joan E Bailey-Wilson, Marshall Anderson, Ming You
Am J Hum Genet 2015 Feb; 96(2):301-8
PMID: 25640678 [PubMed - as supplied by publisher]

The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.
Feng Gao, Dong Chen, Jianmin Si, Qingsong Hu, Zhenghong Qin, Ming Fang, Guanghui Wang
Hum Mol Genet 2015 Jan;
PMID: 25612572 [PubMed - as supplied by publisher]

A new prion disease: relationship with central and peripheral amyloidoses.
Simon Mead, Mary M Reilly
Nat Rev Neurol 2015 Feb; 11(2):90-97
PMID: 25623792 [PubMed - as supplied by publisher]

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.
Reina N Fuji, Michael Flagella, Miriam Baca, Marco A S Baptista, Jens Brodbeck, Bryan K Chan, Brian K Fiske, Lee Honigberg, Adrian M Jubb, Paula Katavolos, Donna W Lee, Sock-Cheng Lewin-Koh, Tori Lin, Xingrong Liu, Shannon Liu, Joseph P Lyssikatos, Jennifer O'Mahony, Mike Reichelt, Merone Roose-Girma, Zejuan Sheng, Todd Sherer, Ashley Smith, Margaret Solon, Zachary K Sweeney, Jacqueline Tarrant, Alison Urkowitz, Søren Warming, Murat Yaylaoglu, Shuo Zhang, Haitao Zhu, Anthony A Estrada, Ryan J Watts
Sci Transl Med 2015 Feb; 7(273):273ra15
PMID: 25653221 [PubMed - as supplied by publisher]

Environmental modulations of the number of midbrain dopamine neurons in adult mice.
Doris Tomas, Augustinus H Prijanto, Emma L Burrows, Anthony J Hannan, Malcolm K Horne, Tim D Aumann
J Vis Exp 2015 ; (95)
PMID: 25650697 [PubMed - as supplied by publisher]

Cognitive profile of LRRK2-related Parkinson's disease.
Sindhu Srivatsal, Brenna Cholerton, James B Leverenz, Zbigniew K Wszolek, Ryan J Uitti, Dennis W Dickson, Daniel Weintraub, John Q Trojanowski, Vivianna M Van Deerlin, Joseph F Quinn, Kathryn A Chung, Amie L Peterson, Stewart A Factor, Cathy Wood-Siverio, Jennifer G Goldman, Glenn T Stebbins, Bryan Bernard, Beate Ritz, Rebecca Rausch, Alberto J Espay, Fredy J Revilla, Johnna Devoto, Liana S Rosenthal, Ted M Dawson, Marilyn S Albert, Ignacio F Mata, Shu-Ching Hu, Kathleen S Montine, Catherine Johnson, Thomas J Montine, Karen L Edwards, Jing Zhang, Cyrus P Zabetian
Mov Disord 2015 Feb;
PMID: 25650144 [PubMed - as supplied by publisher]

A visual review of the interactome of LRRK2: Using deep-curated molecular interactions data to represent biology.
Pablo Porras, Margaret Duesbury, Antonio Fabregat, Marius Ueffing, Sandra Orchard, Christian Johannes Gloeckner, Henning Hermjakob
Proteomics 2015 Feb;
PMID: 25648416 [PubMed - as supplied by publisher]

Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models.
Shaik Mohammad Naushad, Sana Venkata Vijayalakshmi, Yedluri Rupasree, Nadella Kumudini, Sampathkumar Sowganthika, Janardhanan Venketlakshmi Naidu, M Janaki Ramaiah, Dunna Nageswara Rao, Vijay Kumar Kutala
Mol Biol Rep 2015 Feb;
PMID: 25648260 [PubMed - as supplied by publisher]

Impaired intracellular trafficking defines early Parkinson's disease.
Benjamin H M Hunn, Stephanie J Cragg, J Paul Bolam, Maria-Grazia Spillantini, Richard Wade-Martins
Trends Neurosci 2015 Jan;
PMID: 25639775 [PubMed - as supplied by publisher]

Phosphorylated ¿-synuclein in Parkinson¿s disease: correlation depends on disease severity.
Tessandra Stewart, Vesna Sossi, Jan O Aasly, Zbigniew K Wszolek, Ryan J Uitti, Kazuko Hasegawa, Teruo Yokoyama, Cyrus P Zabetian, James B Leverenz, Alexander Stoessl, Yu Wang, Carmen Ginghina, Changqin Liu, Kevin C Cain, Peggy Auinger, Un Kang, Poul Jensen, Min Shi, Jing Zhang
Acta Neuropathol Commun 2015 Jan; 3(1):7
PMID: 25637461 [PubMed - as supplied by publisher]

LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease.
Michelle Rothaug, Stijn Stroobants, Michaela Schweizer, Judith Peters, Friederike Zunke, Mirka Allerding, Rudi D Hooge, Paul Saftig, Judith Blanz
Acta Neuropathol Commun 2015 Jan; 3(1):6
PMID: 25637286 [PubMed - as supplied by publisher]

Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease].
Hongying Hao, Ming Shao, Jing An, Chushuang Chen, Xiuli Feng, Shu Xie, Zhuqin Gu, Biao Chen
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2015 Feb; 32(1):1-5
PMID: 25636089 [PubMed - as supplied by publisher]

SnapShot: Genetics of Parkinson's Disease.
José Brás, Rita Guerreiro, John Hardy
Cell 2015 Jan; 160(3):570-570.e1
PMID: 25635463 [PubMed - as supplied by publisher]

Neurofilament assembly and function during neuronal development.
Adi Laser-Azogui, Micha Kornreich, Eti Malka-Gibor, Roy Beck
Curr Opin Cell Biol 2015 Jan; 32C:92-101
PMID: 25635910 [PubMed - as supplied by publisher]

Novel GCH1 variant in Dopa-responsive dystonia and Parkinson's disease.
A J Lewthwaite, T D Lambert, E B Rolfe, S Olgiati, M Quadri, E J Simons, K E Morrison, V Bonifati, D J Nicholl
Parkinsonism Relat Disord 2015 Jan;
PMID: 25634433 [PubMed - as supplied by publisher]

Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders.
Susan Searles Nielsen, Harvey Checkoway, Susan R Criswell, Federico M Farin, Patricia L Stapleton, Lianne Sheppard, Brad A Racette
Parkinsonism Relat Disord 2015 Jan;
PMID: 25634431 [PubMed - as supplied by publisher]

A cybrid cell model for the assessment of the link between mitochondrial deficits and sporadic Parkinson's disease.
Daniela M Arduíno, A Raquel Esteves, Russell H Swerdlow, Sandra M Cardoso
Methods Mol Biol 2015 ; 1265:415-24
PMID: 25634293 [PubMed - as supplied by publisher]

Centella asiatica Attenuates Amyloid-?-Induced Oxidative Stress and Mitochondrial Dysfunction.
Nora E Gray, Harini Sampath, Jonathan A Zweig, Joseph F Quinn, Amala Soumyanath
J Alzheimers Dis 2015 Jan;
PMID: 25633675 [PubMed - as supplied by publisher]

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
Christian N Cunningham, Joshua M Baughman, Lilian Phu, Joy S Tea, Christine Yu, Mary Coons, Donald S Kirkpatrick, Baris Bingol, Jacob E Corn
Nat Cell Biol 2015 Feb; 17(2):160-9
PMID: 25621951 [PubMed - as supplied by publisher]

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.
Benjamin S Gillers, Aditi Chiplunkar, Haytham Aly, Tomas Valenta, Konrad Basler, Vincent M Christoffels, Igor R Efimov, Bastiaan J Boukens, Stacey Rentschler
Circ Res 2015 Jan; 116(3):398-406
PMID: 25599332 [PubMed - as supplied by publisher]

Neurotoxin Mechanisms and Processes Relevant to Parkinson's Disease: An Update.
Juan Segura-Aguilar, Richard M Kostrzewa
Neurotox Res 2015 Jan;
PMID: 25631236 [PubMed - as supplied by publisher]

The MC1R melanoma risk variant p.R160W is associated with Parkinson's disease.
Gemma Tell-Marti, Joan Anton Puig-Butille, Miriam Potrony, Celia Badenas, Josep Malvehy, María José Martí, Mario Ezquerra, Rubén Fernández-Santiago, Susana Puig
Ann Neurol 2015 Jan;
PMID: 25631192 [PubMed - as supplied by publisher]

Bolivian kindred with combined spinocerebellar ataxia types 2 and 10.
J F Baizabal-Carvallo, G Xia, P Botros, J Laguna, T Ashizawa, J Jankovic
Acta Neurol Scand 2015 Jan;
PMID: 25630585 [PubMed - as supplied by publisher]

Quantitative Expression Proteomics and Phosphoproteomics Profile of Brain from PINK1 Knockout Mice: Insights into Mechanisms of Familial Parkinson Disease.
Judy Triplett, Zhaoshu Zhang, Rukhsana Sultana, Jian Cai, Jon B Klein, Hansruedi Büeler, D Allan Butterfield
J Neurochem 2015 Jan;
PMID: 25626353 [PubMed - as supplied by publisher]

The Effects of Two Polymorphisms on p21cip1 Function and Their Association with Alzheimer's Disease in a Population of European Descent.
Sharon C Yates, Amen Zafar, Erzsebet M Rabai, James B Foxall, Sheila Nagy, Karen E Morrison, Carl Clarke, Margaret M Esiri, Sharon Christie, A David Smith, Zsuzsanna Nagy
PLoS One 2015 ; 10(1):e0114050
PMID: 25625488 [PubMed - as supplied by publisher]

Polygenic determinants of Parkinson's disease in a Chinese population.
Ji-Feng Guo, Kai Li, Ri-Li Yu, Qi-Yin Sun, Lei Wang, Ling-Yan Yao, Ya-Cen Hu, Zhan-Yun Lv, Lin-Zi Luo, Lu Shen, Hong Jiang, Xin-Xiang Yan, Qian Pan, Kun Xia, Bei-Sha Tang
Neurobiol Aging 2015 Jan;
PMID: 25623333 [PubMed - as supplied by publisher]

Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis.
Alberto Capurro, Liviu-Gabriel Bodea, Patrick Schaefer, Ruth Luthi-Carter, Victoria M Perreau
Front Neurosci 2014 ; 8:441
PMID: 25620908 [PubMed - as supplied by publisher]

Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Qi Shi, Li-Na Chen, Bao-Yun Zhang, Kang Xiao, Wei Zhou, Cao Chen, Xiao-Mei Zhang, Chan Tian, Chen Gao, Jing Wang, Jun Han, Xiao-Ping Dong
Mol Cell Proteomics 2015 Jan;
PMID: 25616867 [PubMed - as supplied by publisher]

Amyloid ? oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Kirsten L Viola, William L Klein
Acta Neuropathol 2015 Feb; 129(2):183-206
PMID: 25604547 [PubMed - as supplied by publisher]

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease.
Alicia M Pickrell, Richard J Youle
Neuron 2015 Jan; 85(2):257-273
PMID: 25611507 [PubMed - as supplied by publisher]

A53T Human ?-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration.
Linan Chen, Zhiguo Xie, Susie Turkson, Xiaoxi Zhuang
J Neurosci 2015 Jan; 35(3):890-905
PMID: 25609609 [PubMed - as supplied by publisher]

Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Jing Yan, Ahmad Almilaji, Evi Schmid, Bernat Elvira, Derya R Shimshek, Herman van der Putten, Carsten A Wagner, Ekaterina Shumilina, Florian Lang
FASEB J 2015 Jan;
PMID: 25609428 [PubMed - as supplied by publisher]

The reduction of vascular disease risk mutations contributes to longevity in the Chinese population.
Yong-Han He, Xiang Lu, Ming-Xin Bi, Li-Qin Yang, Liang-You Xu, Qing-Peng Kong
Meta Gene 2014 Dec; 2:761-8
PMID: 25606459 [PubMed - as supplied by publisher]

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.
Hye Jin Yun, Hyejung Kim, Inhwa Ga, Hakjin Oh, Dong Hwan Ho, Jiyoung Kim, Hyemyung Seo, Ilhong Son, Wongi Seol
J Biochem 2015 Jan;
PMID: 25605758 [PubMed - as supplied by publisher]

Rare variants in ?-Amyloid precursor protein (APP) and Parkinson's disease.
Eva C Schulte, Akio Fukumori, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann
Eur J Hum Genet 2015 Jan;
PMID: 25604855 [PubMed - as supplied by publisher]

CHIP is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Amy Marie Palubinsky, Jeannette Nicole Stankowski, Alixandra Cozette Kale, Simona G Codreanu, Robert J Singer, Daniel C Liebler, Gregg D Stanwood, BethAnn Marie McLaughlin
Antioxid Redox Signal 2015 Jan;
PMID: 25602369 [PubMed - as supplied by publisher]

Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]