What can we learn by studying genetics and Parkinson's? PDF-funded researchers Drs. Mata and Zabetian share their progress six years after launching the first large-scale survey of PD genetics in Latin America.
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The Parkinson's Disease-Associated Protein ?-Synuclein Disrupts Stress Signaling - A Possible Implication for Methamphetamine Use?
Shaoxiao Wang, Stephan N Witt
Microb Cell 2014 Apr; 1(4):131-132
PMID: 25343141 [PubMed - as supplied by publisher]
Noradrenergic regulation of glial activation: molecular mechanisms and therapeutic implications.
David Braun, Jose L M Madrigal, Douglas L Feinstein
Curr Neuropharmacol 2014 Jul; 12(4):342-52
PMID: 25342942 [PubMed - as supplied by publisher]
Histone Hyperacetylation Upregulates PKC? in Dopaminergic Neurons to Induce Cell Death: Relevance to Epigenetic Mechanisms of Neurodegeneration in Parkinson's Disease.
Huajun Jin, Arthi Kanthasamy, Dilshan S Harischandra, Naveen Kondru, Anamitra Ghosh, Nikhil Panicker, Vellareddy Anantharam, Ajay Rana, Anumantha G Kanthasamy
J Biol Chem 2014 Oct;
PMID: 25342743 [PubMed - as supplied by publisher]
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.
Hyo-Kyoung Choi, Youngsok Choi, HeeBum Kang, Eun-Jin Lim, Soo-Yeon Park, Hyun-Seob Lee, Ji-Min Park, Jisook Moon, Yoon-Jung Kim, Insup Choi, Eun-Hye Joe, Kyung-Chul Choi, Ho-Geun Yoon
Hum Mol Genet 2014 Oct;
PMID: 25305081 [PubMed - as supplied by publisher]
Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.
Suzana Gispert, Nadine Brehm, Jonas Weil, Kay Seidel, Udo Rüb, Beatrice Kern, Michael Walter, Jochen Roeper, Georg Auburger
Hum Mol Genet 2014 Oct;
PMID: 25296918 [PubMed - as supplied by publisher]
Computational Study of Human Tyrosine Hydroxylase Mutants to Uphold [4-(Propan-2-yl) Phenyl]Carbamic Acid as a Potential Inhibitor.
Muhammad S Nawaz, Zahida Parveen, Liyong Wang, Sajid Rashid, Muhammad Q Fatmi, Mohammad A Kamal
CNS Neurol Disord Drug Targets 2014 ; 13(7):1169-74
PMID: 25230230 [PubMed - as supplied by publisher]
The impact of dementia development concurrent with Parkinson's disease: a new perspective.
Alyce Russell, Alesya Drozdova, Wei Wang, Meghan Thomas
CNS Neurol Disord Drug Targets 2014 ; 13(7):1160-8
PMID: 25230219 [PubMed - as supplied by publisher]
A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress.
Peter Bou Dib, Bettina Gnägi, Fiona Daly, Virginie Sabado, Damla Tas, Dominique A Glauser, Peter Meister, Emi Nagoshi
PLoS Genet 2014 Oct; 10(10):e1004718
PMID: 25340742 [PubMed - as supplied by publisher]
Mucuna pruriens (Velvet bean) Rescues Motor, Olfactory, Mitochondrial and Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic Model of Parkinson's Disease.
Simone Poddighe, Francescaelena De Rose, Roberto Marotta, Roberta Ruffilli, Maura Fanti, Pietro Paolo Secci, Maria Cristina Mostallino, Maria Dolores Setzu, Maria Antonietta Zuncheddu, Ignazio Collu, Paolo Solla, Francesco Marrosu, Sanjay Kasture, Elio Acquas, Anna Liscia
PLoS One 2014 ; 9(10):e110802
PMID: 25340511 [PubMed - as supplied by publisher]
Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum.
Yue Huang, Cheng Chang, Jiewen Zhang, Xiaoqun Gao
Neural Regen Res 2012 Dec; 7(34):2653-62
PMID: 25337111 [PubMed - as supplied by publisher]
Differentiation of rhesus adipose stem cells into dopaminergic neurons.
Yan Zhou, Maosheng Sun, Hongjun Li, Min Yan, Tianhong Xie
Neural Regen Res 2012 Dec; 7(34):2645-52
PMID: 25337110 [PubMed - as supplied by publisher]
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.
Yvette C Wong, Erika L F Holzbaur
Proc Natl Acad Sci U S A 2014 Oct; 111(42):E4439-48
PMID: 25294927 [PubMed - as supplied by publisher]
Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-derived Human Neurons.
Yong Ren, Houbo Jiang, Zhixing Hu, Kevin Fan, Jun Wang, Stephen Janoschka, Xiaomin Wang, Shaoyu Ge, Jian Feng
Stem Cells 2014 Oct;
PMID: 25332110 [PubMed - as supplied by publisher]
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.
Mol Genet Genomics 2014 Oct;
PMID: 25332075 [PubMed - as supplied by publisher]
Nonmotor Symptoms in LRRK2 G2019S Associated Parkinson's Disease.
Carles Gaig, Dolores Vilas, Jon Infante, María Sierra, Inés García-Gorostiaga, Mariateresa Buongiorno, Mario Ezquerra, Maria José Martí, Francesc Valldeoriola, Miquel Aguilar, Matilde Calopa, Jorge Hernandez-Vara, Eduardo Tolosa
PLoS One 2014 ; 9(10):e108982
PMID: 25330404 [PubMed - as supplied by publisher]
Identification of a set of endogenous reference genes for miRNA expression studies in Parkinson's disease blood samples.
Alice Serafin, Luisa Foco, Hagen Blankenburg, Anne Picard, Stefano Zanigni, Alessandra Zanon, Peter P Pramstaller, Andrew A Hicks, Christine Schwienbacher
BMC Res Notes 2014 ; 7:715
PMID: 25304816 [PubMed - as supplied by publisher]
Disease Penetrance of Late-Onset Parkinsonism: A Meta-analysis.
Joanne Trinh, Ilaria Guella, Matthew James Farrer
JAMA Neurol 2014 Oct;
PMID: 25330418 [PubMed - as supplied by publisher]
Families with Wilson's disease in subsequent generations: Clinical and genetic analysis.
Karolina Dzie?yc, Tomasz Litwin, Grzegorz Chabik, Karolina Gramza, Anna Cz?onkowska
Mov Disord 2014 Oct;
PMID: 25327413 [PubMed - as supplied by publisher]
Altered synaptic architecture and glycosylated synaptomatrix composition in a Drosophila classic galactosemia disease model.
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie
Dis Model Mech 2014 Oct;
PMID: 25326312 [PubMed - as supplied by publisher]
miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650.
Marlen Hesse, Christoph Arenz
Expert Opin Ther Pat 2014 Nov; 24(11):1271-6
PMID: 25307171 [PubMed - as supplied by publisher]
A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype.
Michael Veitinger, Rudolf Oehler, Ellen Umlauf, Roland Baumgartner, Georg Schmidt, Christopher Gerner, Rita Babeluk, Johannes Attems, Goran Mitulovic, Eduard Rappold, John Lamont, Maria Zellner
Acta Neuropathol 2014 Nov; 128(5):665-77
PMID: 25248508 [PubMed - as supplied by publisher]
Hyperhomocysteinemia and neurologic disorders: a review.
Ramin Ansari, Ali Mahta, Eric Mallack, Jin Jun Luo
J Clin Neurol 2014 Oct; 10(4):281-8
PMID: 25324876 [PubMed - as supplied by publisher]
Potential of caveolae in the therapy of cardiovascular and neurological diseases.
Gemma Navarro, Dasiel O Borroto-Escuela, Kjell Fuxe, Rafael Franco
Front Physiol 2014 ; 5:370
PMID: 25324780 [PubMed - as supplied by publisher]
Parkinson Disease Genetics: A "Continuum" From Mendelian to Multifactorial Inheritance.
S Petrucci, F Consoli, E M Valente
Curr Mol Med 2014 Oct;
PMID: 25323865 [PubMed - as supplied by publisher]
A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus.
Bridget A Culleton, Patrick Lall, Gemma K Kinsella, Sean Doyle, John McCaffrey, David A Fitzpatrick, Ann M Burnell
Cell Stress Chaperones 2014 Oct;
PMID: 25318690 [PubMed - as supplied by publisher]
Revisiting the Roco G protein cycle.
Susanne Terheyden, Franz Y Ho, Bernd Karl Gilsbach, Alfred Wittinghofer, Arjan Kortholt
Biochem J 2014 Oct;
PMID: 25317655 [PubMed - as supplied by publisher]
Driving neural regeneration through the mammalian target of rapamycin.
Neural Regen Res 2014 Aug; 9(15):1413-7
PMID: 25317149 [PubMed - as supplied by publisher]
Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.
Vinay K Godena, Nicholas Brookes-Hocking, Annekathrin Moller, Gary Shaw, Matthew Oswald, Rosa M Sancho, Christopher C J Miller, Alexander J Whitworth, Kurt J De Vos
Nat Commun 2014 ; 5:5245
PMID: 25316291 [PubMed - as supplied by publisher]
Repression of rRNA transcription by PARIS contributes to Parkinson's Disease.
Hojin Kang, Joo-Ho Shin
Neurobiol Dis 2014 Oct;
PMID: 25315684 [PubMed - as supplied by publisher]
Could the detection of visual disturbances associated with Parkinson's disease genes in flies lead to new treatments for the disease?
Alex R Wade, Christopher Jh Elliott
Neurodegener Dis Manag 2014 Aug; 4(4):291-3
PMID: 25313984 [PubMed - as supplied by publisher]
Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease.
L-H You, F Li, L Wang, S-E Zhao, S-M Wang, L-L Zhang, L-H Zhang, X-L Duan, P Yu, Y-Z Chang
Neuroscience 2014 Oct;
PMID: 25301748 [PubMed - as supplied by publisher]
Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers.
M Caesar, S Felk, J O Aasly, F Gillardon
Neuroscience 2014 Oct;
PMID: 25301747 [PubMed - as supplied by publisher]
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis.
Alban Ordureau, Shireen A Sarraf, David M Duda, Jin-Mi Heo, Mark P Jedrychowski, Vladislav O Sviderskiy, Jennifer L Olszewski, James T Koerber, Tiao Xie, Sean A Beausoleil, James A Wells, Steven P Gygi, Brenda A Schulman, J Wade Harper
Mol Cell 2014 Oct;
PMID: 25284222 [PubMed - as supplied by publisher]
Pharmacogenetics of drug response in Parkinson's disease.
Eleonora D?olji?, Ivana Novakovi?, Maja Krajinovic, Ivan Grbatini?, Vladimir Kosti?
Int J Neurosci 2014 Oct;
PMID: 25226559 [PubMed - as supplied by publisher]
Clinical applications involving CNS gene transfer.
Boris Kantor, Thomas McCown, Paola Leone, Steven J Gray
Adv Genet 2014 ; 87:71-124
PMID: 25311921 [PubMed - as supplied by publisher]
The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease.
Ja Pyszko, Jb Strosznajder
Folia Neuropathol 2014 ; 52(3):260-9
PMID: 25310737 [PubMed - as supplied by publisher]
Mesenchymal stem cells: potential in treatment of neurodegenerative diseases.
Tanmay Tanna, Vatsal Sachan
Curr Stem Cell Res Ther 2014 ; 9(6):513-21
PMID: 25248677 [PubMed - as supplied by publisher]
Elevated levels of cerebrospinal fluid ?-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers.
Jan O Aasly, Krisztina K Johansen, Gunnar Brønstad, Bjørg J Warø, Nour K Majbour, Shiji Varghese, Fatimah Alzahmi, Katerina E Paleologou, Dena A M Amer, Abdulmonem Al-Hayani, Omar M A El-Agnaf
Front Aging Neurosci 2014 ; 6:248
PMID: 25309429 [PubMed - as supplied by publisher]
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Dayne A Beccano-Kelly, Naila Kuhlmann, Igor Tatarnikov, Mattia Volta, Lise N Munsie, Patrick Chou, Li-Ping Cao, Heather Han, Lucia Tapia, Matthew J Farrer, Austen J Milnerwood
Front Cell Neurosci 2014 ; 8:301
PMID: 25309331 [PubMed - as supplied by publisher]
An association study between Heme oxygenase-1 genetic variants and Parkinson's disease.
Pedro Ayuso, Carmen Martínez, Pau Pastor, Oswaldo Lorenzo-Betancor, Antonio Luengo, Félix J Jiménez-Jiménez, Hortensia Alonso-Navarro, José A G Agúndez, Elena García-Martín
Front Cell Neurosci 2014 ; 8:298
PMID: 25309329 [PubMed - as supplied by publisher]
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease.
J Schapansky, J D Nardozzi, M J LaVoie
Neuroscience 2014 Oct;
PMID: 25284317 [PubMed - as supplied by publisher]
Increased plasma oligomeric alpha-synuclein in patients with lysosomal storage diseases.
S N Pchelina, E P Nuzhnyi, A K Emelyanov, T M Boukina, T S Usenko, M A Nikolaev, G N Salogub, A F Yakimovskii, E Yu Zakharova
Neurosci Lett 2014 Sep; 583C:188-193
PMID: 25265039 [PubMed - as supplied by publisher]
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Brian P Dranka, Alison Gifford, Donna McAllister, Jacek Zielonka, Joy Joseph, Crystal L O'Hara, Cheryl L Stucky, Anumantha G Kanthasamy, Balaraman Kalyanaraman
Neurosci Lett 2014 Sep; 583C:159-164
PMID: 25263790 [PubMed - as supplied by publisher]
Mitogen- and stress-activated protein kinase 1 is required for specific signaling responses in dopamine-denervated mouse striatum, but is not necessary for l-DOPA-induced dyskinesia.
Cristina Alcacer, Fanny Charbonnier-Beaupel, Jean-Christophe Corvol, Jean-Antoine Girault, Denis Hervé
Neurosci Lett 2014 Sep; 583C:76-80
PMID: 25233866 [PubMed - as supplied by publisher]
Association of Microtubule associated protein tau/Saitohin (MAPT/STH) MAPT_238bp/STH Q7R polymorphisms and Parkinson's disease: A meta-analysis.
Shan-Shan Lu, Feng-Feng Gong, Fang Feng, Cai-Yun Hu, Zhen-Zhong Qian, Yi-Le Wu, Hui-Yun Yang, Ye-Huan Sun
Biochem Biophys Res Commun 2014 Oct;
PMID: 25305495 [PubMed - as supplied by publisher]
Rab11 modulates ?-synuclein mediated defects in synaptic transmission and behaviour.
Carlo Breda, Marie L Nugent, Jasper G Estranero, Charalambos P Kyriacou, Tiago F Outeiro, Joern R Steinert, Flaviano Giorgini
Hum Mol Genet 2014 Oct;
PMID: 25305083 [PubMed - as supplied by publisher]
Epigenome-Wide Association Study for Parkinson's Disease.
Kerry Moore, Amy Jayne McKnight, David Craig, Francis O'Neill
Neuromolecular Med 2014 Oct;
PMID: 25304910 [PubMed - as supplied by publisher]
A Nucleoprotein-Enriched Diet Suppresses Dopaminergic Neuronal Cell Loss and Motor Deficit in Mice with MPTP-Induced Parkinson's Disease.
Keisuke Kiriyama, Hirokazu Ohtaki, Natsuki Kobayashi, Norimitsu Murai, Minako Matsumoto, Shun Sasaki, Chika Sawa, Kazue Satoh, Masaji Matsunaga, Seiji Shioda
J Mol Neurosci 2014 Oct;
PMID: 25303858 [PubMed - as supplied by publisher]
The role of SNCA and MAPT in Parkinson disease and LRRK2 parkinsonism in the Tunisian Arab-Berber population.
J Trinh, E K Gustavsson, I Guella, C Vilariño-Güell, D Evans, M Encarnacion, H Sherman, F Hentati, M J Farrer
Eur J Neurol 2014 Nov; 21(11):e91-2
PMID: 25303626 [PubMed - as supplied by publisher]
Pre-existing immunity to AAV2 limits transgene expression following intracerebral AAV2-based gene delivery in a 6-OHDA model of Parkinson's disease.
Shorena Janelidze, Ulrika Nordström, Sebastian Kügler, Patrik Brundin
J Gene Med 2014 Oct;
PMID: 25303717 [PubMed - as supplied by publisher]
Synaptojanin 1 Mutation in Parkinson's Disease Brings Further Insight into the Neuropathological Mechanisms.
Valérie Drouet, Suzanne Lesage
Biomed Res Int 2014 ; 2014:289728
PMID: 25302295 [PubMed - as supplied by publisher]
Dopaminergic Neuron-Like Cells Derived from Bone Marrow Mesenchymal Stem Cells by Lmx1? and Neurturin Overexpression for Autologous Cytotherapy in Hemiparkinsonian Rhesus Monkeys.
Wan-Pu Wang, Zhan-Long He, Shuai-Yao Lu, Min Yan, Yan Zhou, Tian-Hong Xie, Na Yin, Wen-Ju Wang, Dong-Hong Tang, Hong-Jun Li, Mao-Sheng Sun
Curr Stem Cell Res Ther 2014 Oct;
PMID: 25300822 [PubMed - as supplied by publisher]
Neural cell adhesion molecules belonging to the family of leucine-rich repeat proteins.
Malene Winther, Peter S Walmod
Adv Neurobiol 2014 ; 8:315-95
PMID: 25300143 [PubMed - as supplied by publisher]
Identifying distinct candidate genes for early Parkinson's disease by analysis of gene expression in whole blood.
Ai-Guo Sun, Jing Wang, Yao-Zhong Shan, Wen-Jiao Yu, Xin Li, Chao-Hua Cong, Xin Wang
Neuro Endocrinol Lett 2014 Sep; 35(5):398-404
PMID: 25275262 [PubMed - as supplied by publisher]
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?
Gurdeep Marwarha, Othman Ghribi
Exp Gerontol 2014 Sep;
PMID: 25261765 [PubMed - as supplied by publisher]
Should genetic testing for SCAs be included in the diagnostic workup for MSA?
Han-Joon Kim, Beom S Jeon, Junghwan Shin, Woong-Woo Lee, Hyeyoung Park, Yu Jin Jung, Gwanhee Ehm
Neurology 2014 Oct;
PMID: 25298309 [PubMed - as supplied by publisher]
Aldehyde dehydrogenase (ALDH) in Alzheimer's and Parkinson's disease.
Edna Grünblatt, Peter Riederer
J Neural Transm 2014 Oct;
PMID: 25298080 [PubMed - as supplied by publisher]
A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.
Ji Ae Lee, Ji Hyun Kim, Seo Yeon Woo, Hyo Jin Son, Se Hee Han, Bo Ko Jang, Ji Won Choi, Dong Jin Kim, Ki Duk Park, Onyou Hwang
Br J Pharmacol 2014 Oct;
PMID: 25297649 [PubMed - as supplied by publisher]
Mutant ?-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels.
Mahalakshmi Subramaniam, Daniel Althof, Suzana Gispert, Jochen Schwenk, Georg Auburger, Akos Kulik, Bernd Fakler, Jochen Roeper
J Neurosci 2014 Oct; 34(41):13586-99
PMID: 25297088 [PubMed - as supplied by publisher]
An exome study of Parkinson's disease in Sardinia, a Mediterranean genetic isolate.
Marialuisa Quadri, Xu Yang, Giovanni Cossu, Simone Olgiati, Valeria M Saddi, Guido J Breedveld, Limei Ouyang, Jingchu Hu, Na Xu, Josja Graafland, Valeria Ricchi, Daniela Murgia, Leonor Correia Guedes, Claudio Mariani, Maria J Marti, Patrizia Tarantino, Rosanna Asselta, Francesc Valldeoriola, Monica Gagliardi, Gianni Pezzoli, Mario Ezquerra, Aldo Quattrone, Joaquim Ferreira, Grazia Annesi, Stefano Goldwurm, Eduardo Tolosa, Ben A Oostra, Maurizio Melis, Jun Wang, Vincenzo Bonifati
Neurogenetics 2014 Oct;
PMID: 25294124 [PubMed - as supplied by publisher]
Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases.
William B Pratt, Jason E Gestwicki, Yoichi Osawa, Andrew P Lieberman
Annu Rev Pharmacol Toxicol 2014 Sep;
PMID: 25292434 [PubMed - as supplied by publisher]
Novel alleles of the Drosophila LRRK2 homolog reveal a crucial role in endolysosomal functions and autophagy in vivo.
Mark W Dodson, Lok K Leung, Mohiddin Lone, Michael A Lizzio, Ming Guo
Dis Model Mech 2014 Oct;
PMID: 25288684 [PubMed - as supplied by publisher]
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
, M C Cornelis, E M Byrne, T Esko, M A Nalls, A Ganna, N Paynter, K L Monda, N Amin, K Fischer, F Renstrom, J S Ngwa, V Huikari, A Cavadino, I M Nolte, A Teumer, K Yu, P Marques-Vidal, R Rawal, A Manichaikul, M K Wojczynski, J M Vink, J H Zhao, G Burlutsky, J Lahti, V Mikkilä, R N Lemaitre, J Eriksson, S K Musani, T Tanaka, F Geller, J Luan, J Hui, R Mägi, M Dimitriou, M E Garcia, W-K Ho, M J Wright, L M Rose, P K E Magnusson, N L Pedersen, D Couper, B A Oostra, A Hofman, M A Ikram, H W Tiemeier, A G Uitterlinden, F J A van Rooij, I Barroso, I Johansson, L Xue, M Kaakinen, L Milani, C Power, H Snieder, R P Stolk, S E Baumeister, R Biffar, F Gu, F Bastardot, Z Kutalik, D R Jacobs, N G Forouhi, E Mihailov, L Lind, C Lindgren, K Michaëlsson, A Morris, M Jensen, K-T Khaw, R N Luben, J J Wang, S Männistö, M-M Perälä, M Kähönen, T Lehtimäki, J Viikari, D Mozaffarian, K Mukamal, B M Psaty, A Döring, A C Heath, G W Montgomery, N Dahmen, T Carithers, K L Tucker, L Ferrucci, H A Boyd, M Melbye, J L Treur, D Mellström, J J Hottenga, I Prokopenko, A Tönjes, P Deloukas, S Kanoni, M Lorentzon, D K Houston, Y Liu, J Danesh, A Rasheed, M A Mason, A B Zonderman, L Franke, B S Kristal, , , , J Karjalainen, D R Reed, H-J Westra, M K Evans, D Saleheen, T B Harris, G Dedoussis, G Curhan, M Stumvoll, J Beilby, L R Pasquale, B Feenstra, S Bandinelli, J M Ordovas, A T Chan, U Peters, C Ohlsson, C Gieger, N G Martin, M Waldenberger, D S Siscovick, O Raitakari, J G Eriksson, P Mitchell, D J Hunter, P Kraft, E B Rimm, D I Boomsma, I B Borecki, R J F Loos, N J Wareham, P Vollenweider, N Caporaso, H J Grabe, M L Neuhouser, B H R Wolffenbuttel, F B Hu, E Hyppönen, M-R Järvelin, L A Cupples, P W Franks, P M Ridker, C M van Duijn, G Heiss, A Metspalu, K E North, E Ingelsson, J A Nettleton, R M van Dam, D I Chasman
Mol Psychiatry 2014 Oct;
PMID: 25288136 [PubMed - as supplied by publisher]
Primary familial brain calcification: Genetic analysis and clinical spectrum.
Ilaria Taglia, Andrea Mignarri, Simone Olgiati, Elisabetta Menci, Patrizia L Petrocelli, Guido J Breedveld, Cesa Scaglione, Paolo Martinelli, Antonio Federico, Vincenzo Bonifati, Maria Teresa Dotti
Mov Disord 2014 Oct;
PMID: 25284758 [PubMed - as supplied by publisher]
MiRNA Profile in the Substantia Nigra of Parkinson's Disease and Healthy Subjects.
Lucía F Cardo, Eliecer Coto, René Ribacoba, Manuel Menéndez, Germán Moris, Esther Suárez, Victoria Alvarez
J Mol Neurosci 2014 Oct;
PMID: 25284245 [PubMed - as supplied by publisher]
The Melanocortin 1 Receptor (Mc1r) Variants Do Not Account for the Co-occurrence of Parkinson's Disease and Malignant Melanoma.
Sandra Elincx-Benizri, Rivka Inzelberg, Lior Greenbaum, Oren S Cohen, Gilad Yahalom, Yael Laitman, Ruth Djaldetti, Yael Orlev, Alon Scope, Esther Azizi, Eitan Friedman, Sharon Hassin-Baer
J Mol Neurosci 2014 Oct;
PMID: 25284244 [PubMed - as supplied by publisher]
An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders.
Yang Yang, Shuai Jiang, Juanjuan Yan, Yue Li, Zhenlong Xin, Yan Lin, Yan Qu
Cytokine Growth Factor Rev 2014 Sep;
PMID: 25280871 [PubMed - as supplied by publisher]
Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease.
Jose A Santiago, Clemens R Scherzer, Judith A Potashkin
PLoS One 2014 ; 9(10):e109042
PMID: 25279756 [PubMed - as supplied by publisher]
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song Lu
Exp Neurol 2014 Sep;
PMID: 25263579 [PubMed - as supplied by publisher]
Parkinson's disease and age: The obvious but largely unexplored link.
Rashed Abdullah, Indranil Basak, Ketan S Patil, Guido Alves, Jan Petter Larsen, Simon Geir Møller
Exp Gerontol 2014 Sep;
PMID: 25261764 [PubMed - as supplied by publisher]
E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity.
Jacob W Zyskind, Ying Wang, Giyong Cho, Jenhao H Ting, Dennis L Kolson, David R Lynch, Kelly L Jordan-Sciutto
J Neurochem 2014 Oct;
PMID: 25279448 [PubMed - as supplied by publisher]
Meta-analyses of seven GIGYF2 polymorphisms with Parkinson's disease.
Dongjun Dai, Yunliang Wang, Xingyu Zhou, Jianmin Tao, Danjie Jiang, Hanlin Zhou, Yi Jiang, Guanghui Pan, Ping Ru, Huihui Ji, Jinfeng Li, Yuzheng Zhang, Honglei Yin, Mingqing Xu, Shiwei Duan
Biomed Rep 2014 Nov; 2(6):886-892
PMID: 25279164 [PubMed - as supplied by publisher]
Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson's Disease Model.
Xin-Shan Liu, Jin-Feng Li, Shan-Shan Wang, Yu-Tong Wang, Yu-Zhen Zhang, Hong-Lei Yin, Shuang Geng, Hui-Cui Gong, Bing Han, Yun-Liang Wang
Biomed Res Int 2014 ; 2014:909657
PMID: 25276829 [PubMed - as supplied by publisher]
Mendelian randomization of serum urate and parkinson disease progression.
Kelly Claire Simon, Shirley Eberly, Xiang Gao, David Oakes, Caroline M Tanner, Ira Shoulson, Stanley Fahn, Michael A Schwarzschild, Alberto Ascherio,
Ann Neurol 2014 Sep;
PMID: 25257975 [PubMed - as supplied by publisher]
Erratum to: Do CSF levels of t-Tau, p-Tau and ?1-42 amyloid correlate with dopaminergic system impairment in patients with a clinical diagnosis of Parkinson disease? A (123)I-FP-CIT study in the early stages of the disease.
Agostino Chiaravalloti, Alessandro Stefani, Alessandro Fiorentini, Annamaria Lacanfora, Paolo Stanzione, Orazio Schillaci
Eur J Nucl Med Mol Imaging 2014 Nov; 41(11):2165-6
PMID: 25236909 [PubMed - as supplied by publisher]
Acute increase of ?-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.
David J Busch, Paul A Oliphint, Rylie B Walsh, Susan M L Banks, Wendy S Woods, Julia M George, Jennifer R Morgan
Mol Biol Cell 2014 Oct;
PMID: 25273557 [PubMed - as supplied by publisher]
Cholesterol in brain disease: sometimes determinant and frequently implicated.
Mauricio G Martín, Frank Pfrieger, Carlos G Dotti
EMBO Rep 2014 Oct; 15(10):1036-1052
PMID: 25223281 [PubMed - as supplied by publisher]
Clinical workout for the early detection of cognitive decline and dementia.
Eur J Clin Nutr 2014 Oct;
PMID: 25271010 [PubMed - as supplied by publisher]
Compound heterozygous PNPLA6 mutations cause Boucher-Neuhäuser syndrome with late-onset ataxia.
A Deik, B Johannes, J C Rucker, E Sánchez, S E Brodie, E Deegan, K Landy, Y Kajiwara, S Scelsa, R Saunders-Pullman, C Paisán-Ruiz
J Neurol 2014 Sep;
PMID: 25267340 [PubMed - as supplied by publisher]
Neurotoxin-Induced Pathway Perturbation in Human Neuroblastoma SH-EP Cells.
Jin Hwan Do
Mol Cells 2014 Sep; 37(9):672-84
PMID: 25234470 [PubMed - as supplied by publisher]
Sporadic inclusion-body myositis: A degenerative muscle disease associated with aging, impaired muscle protein homeostasis and abnormal mitophagy.
Valerie Askanas, W King Engel, Anna Nogalska
Biochim Biophys Acta 2014 Sep;
PMID: 25241263 [PubMed - as supplied by publisher]
Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL.
Xiao-Yun Liu, Maria E Gonzalez-Toledo, Austin Fagan, Yanying Liu, Wei-Ming Duan, Siyuan Zhang, Bin Li, Chun-Shu Piao, Li-Ru Zhao
Neurobiol Dis 2014 Sep;
PMID: 25251607 [PubMed - as supplied by publisher]
Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP.
Joon Ho Moon, Ji Ho Kim, Hyung-Jun Im, Dong Soo Lee, Eun Jung Park, Kilyoung Song, Hyun Ju Oh, Su Bin Hyun, Sang Chul Kang, Hyunil Kim, Hyo Eun Moon, Hyung Woo Park, Hong Jae Lee, Eun Ji Kim, Seokjoong Kim, Byeong Chun Lee, Sun Ha Paek
Exp Neurobiol 2014 Sep; 23(3):258-65
PMID: 25258574 [PubMed - as supplied by publisher]
An activated sympathetic nervous system affects white adipocyte differentiation and lipolysis in a rat model of Parkinson's disease.
XiangZhi Meng, RuiPan Zheng, Ying Zhang, MingLiang Qiao, Li Liu, Peng Jing, LuLu Wang, Jing Liu, Yan Gao
J Neurosci Res 2014 Sep;
PMID: 25257318 [PubMed - as supplied by publisher]
Air pollution and your brain: what do you need to know right now.
Lilian Calderón-Garcidueñas, Ana Calderón-Garcidueñas, Ricardo Torres-Jardón, José Avila-Ramírez, Randy J Kulesza, Amedeo D Angiulli
Prim Health Care Res Dev 2014 Sep; :1-17
PMID: 25256239 [PubMed - as supplied by publisher]
Dopamine signaling leads to loss of polycomb repression and aberrant gene activation in experimental parkinsonism.
Erik Södersten, Michael Feyder, Mads Lerdrup, Ana-Luisa Gomes, Hanna Kryh, Giada Spigolon, Jocelyne Caboche, Gilberto Fisone, Klaus Hansen
PLoS Genet 2014 Sep; 10(9):e1004574
PMID: 25254549 [PubMed - as supplied by publisher]
ß-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network.
Bérangère Deleglise, Sebastien Magnifico, Eric Duplus, Pauline Vaur, Vanessa Soubeyre, Morgane Belle, Maeva Vignes, Jean-Louis Viovy, Etienne Jacotot, Jean-Michel Peyrin, Bernard Brugg
Acta Neuropathol Commun 2014 Sep; 2(1):145
PMID: 25253021 [PubMed - as supplied by publisher]
LRRK2 Pathobiology in Parkinson's Disease.
Ian Martin, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson
J Neurochem 2014 Sep;
PMID: 25251388 [PubMed - as supplied by publisher]
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.
Adanna G Alexander, Vanessa Marfil, Chris Li
Front Genet 2014 ; 5:279
PMID: 25250042 [PubMed - as supplied by publisher]
Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.
Andrii Domanskyi, Heike Alter, Miriam A Vogt, Peter Gass, Ilya A Vinnikov
Front Cell Neurosci 2014 ; 8:275
PMID: 25249938 [PubMed - as supplied by publisher]
Glucocerebrosidase mutations in primary parkinsonism.
Rosanna Asselta, Valeria Rimoldi, Chiara Siri, Roberto Cilia, Ilaria Guella, Silvana Tesei, Giulia Soldà, Gianni Pezzoli, Stefano Duga, Stefano Goldwurm
Parkinsonism Relat Disord 2014 Sep;
PMID: 25249066 [PubMed - as supplied by publisher]
Focusing Brain Therapeutic Interventions in Space and Time for Parkinson's Disease.
S Little, P Brown
Curr Biol 2014 Sep; 24(18):R898-R909
PMID: 25247369 [PubMed - as supplied by publisher]
LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson's Disease in the Malaysian Population.
Aroma Agape Gopalai, Shen-Yang Lim, Jing Yi Chua, Shelisa Tey, Thien Thien Lim, Norlinah Mohamed Ibrahim, Ai Huey Tan, Gaik Bee Eow, Zariah Abdul Aziz, Santhi Datuk Puvanarajah, Shanthi Viswanathan, Irene Looi, Soo Kun Lim, Li Ping Tan, Yip Boon Chong, Chong Tin Tan, Yi Zhao, E K Tan, Azlina Ahmad-Annuar
Biomed Res Int 2014 ; 2014:867321
PMID: 25243190 [PubMed - as supplied by publisher]
Parkin (PARK 2) Mutations Are Rare in Czech Patients with Early-Onset Parkinson's Disease.
Ondrej Fiala, Daniela Zahorakova, Lenka Pospisilova, Jana Kucerova, Milada Matejckova, Pavel Martasek, Jan Roth, Evzen Ruzicka
PLoS One 2014 ; 9(9):e107585
PMID: 25238391 [PubMed - as supplied by publisher]
Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease is Phase Specific: Implication of its Therapeutic Effectiveness.
Limamanen Phom, Bovito Achumi, Debasmita Pankaj Alone, Murali Muralidhara, Sarat Chandra Yenisetti
Rejuvenation Res 2014 Sep;
PMID: 25238331 [PubMed - as supplied by publisher]
Mutant of leucine-rich repeat kinase 2 is not associated with non-motor symptoms in Chinese Parkinson's disease patients.
Maolin Hao, Ning Pan, Qinghua Zhang, Xiaohong Wang
Int J Clin Exp Med 2014 ; 7(8):2253-7
PMID: 25232417 [PubMed - as supplied by publisher]
Unique Functional and Structural Properties of the LRRK2 ATP-Binding Pocket.
Zhiyong Liu, Robert A Galemmo, Kyle B Fraser, Mark S Moehle, Saurabh Sen, Laura A Volpicelli-Daley, Lawrence J DeLucas, Larry J Ross, Jacob Valiyaveettil, Omar Moukha-Chafiq, Ashish K Pathak, Sam Ananthan, Hollis Kezar, E Lucile White, Vandana Gupta, Joseph A Maddry, Mark J Suto, Andrew B West
J Biol Chem 2014 Sep;
PMID: 25228699 [PubMed - as supplied by publisher]
Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study.
Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Leslie A Scarffe, Valina L Dawson, Owen A Ross, Wolfdieter Springer, Ted M Dawson, Zbigniew K Wszolek
Parkinsonism Relat Disord 2014 Sep;
PMID: 25226871 [PubMed - as supplied by publisher]
Protective role of olesoxime against wild type alpha-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells.
C Gouarné, J Tracz, M Giraudon Paoli, V Deluca, M Seimandi, G Tardif, M Xilouri, L Stefanis, T Bordet, R M Pruss
Br J Pharmacol 2014 Sep;
PMID: 25220617 [PubMed - as supplied by publisher]
Mutations in Niemann Pick type C gene are risk factor for Alzheimer's disease.
Nikola Kresojevi?, Valerija Dobri?i?, Marina Svetel, Vladimir Kosti?
Med Hypotheses 2014 Sep;
PMID: 25220527 [PubMed - as supplied by publisher]