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Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population.
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Parkinsonism Relat Disord 2014 Jun;
Authors: Teeratorn Pulkes, Chutima Papsing, Ammarin Thakkinstian, Sunsanee Pongpakdee, Kongkiat Kulkantrakorn, Suchat Hanchaiphiboolkul, Somsak Tiamkao, Pairoj Boonkongchuen
LRRK2 p.R1628P (c.4883G†>†C) is associated with Parkinson's disease (PD) in Chinese and Thais. However, some studies in other East Asian ethnic groups did not observe this association. Carriers of p.R1628P are about 3-5% Chinese and Thais. In contrast, Japanese, Koreans and Malays are much less prevalent (0-<1%). The contradictory results may be caused by insufficient sample sizes especially studies in ethnic groups with low prevalence, which, theoretically need a much larger sample size. We conducted a case-control Thai PD study with appropriate size in order to support the role of p.R1628P related to susceptibility to PD.
PMID: 24997548 [PubMed - as supplied by publisher]