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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene-environment interactions.
Michaela E Johnson, Larisa Bobrovskaya
Neurotoxicology 2014 Dec;
PMID: 25514659 [PubMed - as supplied by publisher]

Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease.
Jesse E Hanson, Jean-Francois Pare, Lunbin Deng, Yoland Smith, Qiang Zhou
Neurobiol Dis 2014 Dec; 74C:254-262
PMID: 25484285 [PubMed - as supplied by publisher]

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy.
Victor S Van Laar, Nikita Roy, Annie Liu, Swati Rajprohat, Beth Arnold, April A Dukes, Cory D Holbein, Sarah B Berman
Neurobiol Dis 2014 Dec; 74C:180-193
PMID: 25478815 [PubMed - as supplied by publisher]

Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity.
X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang, H Lou
Neuroscience 2014 Nov; 286C:131-140
PMID: 25449120 [PubMed - as supplied by publisher]

Comparative pathway and network analysis of brain transcriptome changes during adult aging and in Parkinson's disease.
Enrico Glaab, Reinhard Schneider
Neurobiol Dis 2014 Nov; 74C:1-13
PMID: 25447234 [PubMed - as supplied by publisher]

PINK1 Catalytic Activity is Regulated by Phosphorylation on Serines 228 and 402.
Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais
J Biol Chem 2014 Dec;
PMID: 25527497 [PubMed - as supplied by publisher]

MS-275 Inhibits Aroclor 1254-Induced SH-SY5Y Neuronal Cell Toxicity by Preventing the Formation of the HDAC3/REST Complex on the Synapsin-1 Promoter.
Luigi Formisano, Natascia Guida, Giusy Laudati, Luigi Mascolo, Gianfranco Di Renzo, Lorella M T Canzoniero
J Pharmacol Exp Ther 2015 Feb; 352(2):236-43
PMID: 25467131 [PubMed - as supplied by publisher]

Complex Network-Driven View of Genomic Mechanisms Underlying Parkinson's Disease: Analyses in Dorsal Motor Vagal Nucleus, Locus Coeruleus, and Substantia Nigra.
Beatriz Raposo Corradini, Priscila Iamashita, Edilaine Tampellini, José Marcelo Farfel, Lea Tenenholz Grinberg, Carlos Alberto Moreira-Filho
Biomed Res Int 2014 ; 2014:543673
PMID: 25525598 [PubMed - as supplied by publisher]

Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Sungwoo Park, Seon-Guk Choi, Seung-Min Yoo, Jin H Son, Yong-Keun Jung
Autophagy 2014 Nov; 10(11):1906-20
PMID: 25483962 [PubMed - as supplied by publisher]

Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes.
Ian Martin, Leire Abalde-Atristain, Jungwoo Wren Kim, Ted M Dawson, Valina L Dawson
Fly (Austin) 2014 Jul; 8(3):165-9
PMID: 25483009 [PubMed - as supplied by publisher]

Modulatory effect of Decalepis hamiltonii on ethanol-induced toxicity in transgenic Drosophila model of Parkinson's disease.
Samaneh Reiszadeh Jahromi, Mohammad Haddadi, T Shivanandappa, S R Ramesh
Neurochem Int 2014 Nov; 80C:1-6
PMID: 25451756 [PubMed - as supplied by publisher]

Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's Disease.
Janelle Drouin-Ouellet, Isabelle St-Amour, Martine Saint-Pierre, Jérôme Lamontagne-Proulx, Jasna Kriz, Roger A Barker, Francesca Cicchetti
Int J Neuropsychopharmacol 2014 Dec;
PMID: 25522431 [PubMed - as supplied by publisher]

Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
Nathan C Rowland, Philip A Starr, Paul S Larson, Jill L Ostrem, William J Marks, Daniel A Lim
Mov Disord 2014 Dec;
PMID: 25521796 [PubMed - as supplied by publisher]

Detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients.
Monique Antoinette David, Mourad Tayebi
Front Neurol 2014 ; 5:251
PMID: 25520699 [PubMed - as supplied by publisher]

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.
Feng Zhang, Dan Xu, Ling Yuan, Yiming Sun, Zhiheng Xu
Nat Commun 2014 ; 5:5815
PMID: 25519973 [PubMed - as supplied by publisher]

Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease.
Zhe Yu, Ting Wang, Jun Xu, Wei Wang, Guifang Wang, Chao Chen, Lili Zheng, Li Pan, Dianrong Gong, Xueli Li, Huaiqian Qu, Fang Li, Bin Zhang, Weidong Le, Fabin Han
J Hum Genet 2014 Dec;
PMID: 25518742 [PubMed - as supplied by publisher]

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.
Michel Belyk, Shelly Jo Kraft, Steven Brown
J Hum Genet 2014 Dec;
PMID: 25518740 [PubMed - as supplied by publisher]

Additional noradrenergic depletion aggravates forelimb akinesia and abnormal subthalamic nucleus activity in a rat model of Parkinson's disease.
Yong Wang, Xiang Chen, Tao Wang, Yi Na Sun, Ling Na Han, Li Bo Li, Li Zhang, Zhong Heng Wu, Chen Huang, Jian Liu
Life Sci 2014 Dec; 119(1-2):18-27
PMID: 25445222 [PubMed - as supplied by publisher]

Correction: Cell-Permeable Parkin Proteins Suppress Parkinson Disease-Associated Phenotypes in Cultured Cells and Animals.
PLoS One 2014 ; 9(12):e116242
PMID: 25517621 [PubMed - as supplied by publisher]

Therapeutic strategies in Parkinson's disease: what we have learned from animal models.
Jorge S Valadas, Melissa Vos, Patrik Verstreken
Ann N Y Acad Sci 2014 Dec;
PMID: 25515068 [PubMed - as supplied by publisher]

?-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila.
Gonçalo M Poças, Joana Branco-Santos, Federico Herrera, Tiago Fleming Outeiro, Pedro M Domingos
Hum Mol Genet 2014 Dec;
PMID: 25452431 [PubMed - as supplied by publisher]

Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats.
Cheng-Long Xie, Wen-Wen Wang, Su-Fang Zhang, Ming-Lu Yuan, Jun-Yi Che, Jing Gan, Lu Song, Wei-En Yuan, Zhen-Guo Liu
Sci Rep 2014 ; 4:7506
PMID: 25511986 [PubMed - as supplied by publisher]

An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.
XiaoQin Yuan, YongPing Chen, Bei Cao, Bi Zhao, QianQian Wei, XiaoYan Guo, Yuan Yang, LiXing Yuan, HuiFang Shang
Parkinsonism Relat Disord 2014 Dec;
PMID: 25511328 [PubMed - as supplied by publisher]

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.
Rasajna Nadella, Merja H Voutilainen, Mart Saarma, Juan A Gonzalez-Barrios, Bertha A Leon-Chavez, Judith M Dueñas Jiménez, Sergio H Dueñas Jiménez, Lourdes Escobedo, Daniel Martinez-Fong
J Neuroinflammation 2014 Dec; 11(1):209
PMID: 25511018 [PubMed - as supplied by publisher]

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing ?-synuclein.
Iddo Magen, Regina Ostritsky, Franziska Richter, Chunni Zhu, Sheila M Fleming, Vincent Lemesre, Alistair J Stewart, Bruce H Morimoto, Illana Gozes, Marie-Françoise Chesselet
Pharmacol Res Perspect 2014 Oct; 2(5):e00065
PMID: 25505609 [PubMed - as supplied by publisher]

Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra.
Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Drouin
PLoS Genet 2014 Dec; 10(12):e1004863
PMID: 25501001 [PubMed - as supplied by publisher]

Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Ruth Chia, Sara Haddock, Alexandra Beilina, Iakov N Rudenko, Adamantios Mamais, Alice Kaganovich, Yan Li, Ravindran Kumaran, Michael A Nalls, Mark R Cookson
Nat Commun 2014 ; 5:5827
PMID: 25500533 [PubMed - as supplied by publisher]

Disturbed mitochondrial dynamics and neurodegenerative disorders.
Florence Burté, Valerio Carelli, Patrick F Chinnery, Patrick Yu-Wai-Man
Nat Rev Neurol 2014 Dec;
PMID: 25486875 [PubMed - as supplied by publisher]

Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles.
D M Yurek, U Hasselrot, W A Cass, O Sesenoglu-Laird, L Padegimas, M J Cooper
Neuroscience 2015 Jan; 284:500-12
PMID: 25453772 [PubMed - as supplied by publisher]

The ongoing pursuit of neuroprotective therapies in Parkinson disease.
Dilan Athauda, Thomas Foltynie
Nat Rev Neurol 2014 Dec;
PMID: 25447485 [PubMed - as supplied by publisher]

Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy.
Yu-Chin Su, Xing Guo, Xin Qi
Biochim Biophys Acta 2015 Jan; 1852(1):12-21
PMID: 25446991 [PubMed - as supplied by publisher]

Evolution of Prodromal Clinical Markers of Parkinson Disease in a GBA Mutation-Positive Cohort.
Michelle Beavan, Alisdair McNeill, Christos Proukakis, Derralynn A Hughes, Atul Mehta, Anthony H V Schapira
JAMA Neurol 2014 Dec;
PMID: 25506732 [PubMed - as supplied by publisher]

Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease.
Nino Spataro, Francesc Calafell, Laura Cervera, Ferran Casals, Javier Pagonabarraga, Berta Pascual-Sedano, Antònia Campolongo, Jaime Kulisevsky, Alberto Lleó, Arcadi Navarro, Jordi Clarimón, Elena Bosch
Hum Mol Genet 2014 Dec;
PMID: 25504046 [PubMed - as supplied by publisher]

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Amaia M Arranz, Lore Delbroek, Kristof Van Kolen, Marco R Guimarães, Wim Mandemakers, Guy Daneels, Samer Matta, Sara Calafate, Hamdy Shaban, Pieter Baatsen, Pieter-Jan De Bock, Kris Gevaert, Pieter Vanden Berghe, Patrik Verstreken, Bart De Strooper, Diederik Moechars
J Cell Sci 2014 Dec;
PMID: 25501810 [PubMed - as supplied by publisher]

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M Griggs, Laura Zavala-Flores, Elsa M Reyes-Reyes, Javier Seravalli, Lia A Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franco
Neurobiol Dis 2014 Dec;
PMID: 25497688 [PubMed - as supplied by publisher]

Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson¿s disease ¿ a multicenter study.
Malin von Otter, Petra Bergström, Aldo Quattrone, Elvira De Marco, Grazia Annesi, Peter Söderkvist, Stephanie Wettinger, Marek Drozdzik, Monika Bialecka, Hans Nissbrandt, Christine Klein, Michael Nilsson, Ola Hammarsten, Staffan Nilsson, Henrik Zetterberg
BMC Med Genet 2014 Dec; 15(1):131
PMID: 25496089 [PubMed - as supplied by publisher]

Association between two ?-2-macroglobulin gene polymorphisms and Parkinson's disease: a meta-analysis.
Guo Xingzhi, Tang Peng, Li Xiaoqing, Chong Li, Zhang Xin, Li Rui
Int J Neurosci 2014 Dec; :1-19
PMID: 25495992 [PubMed - as supplied by publisher]

Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.
Wagdy K B Khalil, Naglaa Assaf, Shaimaa A ElShebiney, Neveen A Salem
Neurochem Int 2014 Dec;
PMID: 25481089 [PubMed - as supplied by publisher]

Neurotransmitter receptor density changes in Pitx3(ak) mice - A model relevant to Parkinson's disease.
J N Cremer, K Amunts, J Graw, M Piel, F Rösch, K Zilles
Neuroscience 2014 Nov; 285C:11-23
PMID: 25451278 [PubMed - as supplied by publisher]

The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure.
Matthew J Benskey, Fredric P Manfredsson, Keith J Lookingland, John L Goudreau
Neurotoxicology 2014 Nov; 46C:1-11
PMID: 25447324 [PubMed - as supplied by publisher]

Differential Co-Expression between ?-Synuclein and IFN-? Signaling Genes across Development and in Parkinson's Disease.
Noa Liscovitch, Leon French
PLoS One 2014 ; 9(12):e115029
PMID: 25493648 [PubMed - as supplied by publisher]

Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?
Rachel Saunders-Pullman, Anat Mirelman, Cuiling Wang, Roy N Alcalay, Marta San Luciano, Robert Ortega, Deborah Raymond, Helen Mejia-Santana, Laurie Ozelius, Lorraine Clark, Avi Orr-Utreger, Karen Marder, Nir Giladi, Susan B Bressman
Ann Clin Transl Neurol 2014 Sep; 1(9):670-8
PMID: 25493281 [PubMed - as supplied by publisher]

Motor phenotype of LRRK2-associated Parkinson's disease: A tunisian longitudinal study.
Fatma Nabli, Samia Ben Sassi, Rim Amouri, John E Duda, Matthew J Farrer, Fayçal Hentati
Mov Disord 2014 Dec;
PMID: 25487881 [PubMed - as supplied by publisher]

Autophagy functions on EMT in gastrulation of avian embryo.
Wen-Hui Lu, Guang Wang, Yan Li, Shuai Li, Xiao-Yu Song, Xiao-Yu Wang, Manli Chuai, Kenneth Ka Ho Lee, Liu Cao, Xuesong Yang
Cell Cycle 2014 Sep; 13(17):2752-64
PMID: 25486362 [PubMed - as supplied by publisher]

Behavioral phenotyping of parkin-deficient mice: looking for early preclinical features of Parkinson's disease.
Daniel Rial, Adalberto A Castro, Nuno Machado, Pedro Garção, Francisco Q Gonçalves, Henrique B Silva, Angelo R Tomé, Attila Köfalvi, Olga Corti, Rita Raisman-Vozari, Rodrigo A Cunha, Rui D Prediger
PLoS One 2014 ; 9(12):e114216
PMID: 25486126 [PubMed - as supplied by publisher]

TNF-? regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells.
Paresh Prajapati, Sripada Lakshmi, Kritarth Singh, Khyati Bhatelia, Rochika Singh, Rajesh Singh
Biochim Biophys Acta 2014 Dec;
PMID: 25481834 [PubMed - as supplied by publisher]

Biotherapies for Parkinson disease.
P Remy
Rev Neurol (Paris) 2014 Dec; 170(12):763-9
PMID: 25459116 [PubMed - as supplied by publisher]

GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.
Piotr Hadaczek, Gusheng Wu, Nitasha Sharma, Agnieszka Ciesielska, Krystof Bankiewicz, Amy L Davidow, Zi-Hua Lu, John Forsayeth, Robert W Ledeen
Exp Neurol 2015 Jan; 263:177-89
PMID: 25448159 [PubMed - as supplied by publisher]

Autophagy and ethanol neurotoxicity.
Jia Luo
Autophagy 2014 Nov; :0
PMID: 25484085 [PubMed - as supplied by publisher]

Gene therapy for Parkinson's disease: still a hot topic?
Jeffrey H Kordower
Neuropsychopharmacology 2015 Jan; 40(1):255-6
PMID: 25482182 [PubMed - as supplied by publisher]

PINK1 signalling in cancer biology.
Ciara H O'Flanagan, Cora O'Neill
Biochim Biophys Acta 2014 Dec; 1846(2):590-598
PMID: 25450579 [PubMed - as supplied by publisher]

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with ?-Synuclein Pathology.
Gabrielle R Wilson, Joe C H Sim, Catriona McLean, Maila Giannandrea, Charles A Galea, Jessica R Riseley, Sarah E M Stephenson, Elizabeth Fitzpatrick, Stefan A Haas, Kate Pope, Kirk J Hogan, Ronald G Gregg, Catherine J Bromhead, David S Wargowski, Christopher H Lawrence, Paul A James, Andrew Churchyard, Yujing Gao, Dean G Phelan, Greta Gillies, Nicholas Salce, Lynn Stanford, Ashley P L Marsh, Maria L Mignogna, Susan J Hayflick, Richard J Leventer, Martin B Delatycki, George D Mellick, Vera M Kalscheuer, Patrizia D'Adamo, Melanie Bahlo, David J Amor, Paul J Lockhart
Am J Hum Genet 2014 Dec; 95(6):729-35
PMID: 25434005 [PubMed - as supplied by publisher]

Compound Heterozygosity of Low-Frequency Promoter Deletions and Rare Loss-of-Function Mutations in TXNL4A Causes Burn-McKeown Syndrome.
Dagmar Wieczorek, William G Newman, Thomas Wieland, Tea Berulava, Maria Kaffe, Daniela Falkenstein, Christian Beetz, Elisabeth Graf, Thomas Schwarzmayr, Sofia Douzgou, Jill Clayton-Smith, Sarah B Daly, Simon G Williams, Sanjeev S Bhaskar, Jill E Urquhart, Beverley Anderson, James O'Sullivan, Odile Boute, Jasmin Gundlach, Johanna Christina Czeschik, Anthonie J van Essen, Filiz Hazan, Sarah Park, Anne Hing, Alma Kuechler, Dietmar R Lohmann, Kerstin U Ludwig, Elisabeth Mangold, Laura Steenpaß, Michael Zeschnigk, Johannes R Lemke, Charles Marques Lourenco, Ute Hehr, Eva-Christina Prott, Melanie Waldenberger, Anne C Böhmer, Bernhard Horsthemke, Raymond T O'Keefe, Thomas Meitinger, John Burn, Hermann-Josef Lüdecke, Tim M Strom
Am J Hum Genet 2014 Dec; 95(6):698-707
PMID: 25434003 [PubMed - as supplied by publisher]

Increased DJ-1 in Urine Exosome of Korean Males with Parkinson's Disease.
Dong Hwan Ho, Sanghak Yi, Hyemyung Seo, Ilhong Son, Wongi Seol
Biomed Res Int 2014 ; 2014:704678
PMID: 25478574 [PubMed - as supplied by publisher]

PLD3 is accumulated on neuritic plaques in Alzheimer's disease brains.
Jun-Ichi Satoh, Yoshihiro Kino, Yoji Yamamoto, Natsuki Kawana, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arima
Alzheimers Res Ther 2014 ; 6(9):70
PMID: 25478031 [PubMed - as supplied by publisher]

Biomarkers in biological fluids for dementia with Lewy bodies.
Sebastian Schade, Brit Mollenhauer
Alzheimers Res Ther 2014 ; 6(5-8):72
PMID: 25478030 [PubMed - as supplied by publisher]

Gut microbiota are related to Parkinson's disease and clinical phenotype.
Filip Scheperjans, Velma Aho, Pedro A B Pereira, Kaisa Koskinen, Lars Paulin, Eero Pekkonen, Elena Haapaniemi, Seppo Kaakkola, Johanna Eerola-Rautio, Marjatta Pohja, Esko Kinnunen, Kari Murros, Petri Auvinen
Mov Disord 2014 Dec;
PMID: 25476529 [PubMed - as supplied by publisher]

Molecular Imaging in Genetics.
José Leite, Roberta Hespanhol, Carlos Alberto Buchpiguel
Neuroimaging Clin N Am 2015 Feb; 25(1):17-29
PMID: 25476510 [PubMed - as supplied by publisher]

Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls.
Jon Infante, Carlos Prieto, María Sierra, Pascual Sánchez-Juan, Isabel González-Aramburu, Coro Sánchez-Quintana, José Berciano, Onofre Combarros, Jesús Sainz
Neurobiol Aging 2014 Nov;
PMID: 25475535 [PubMed - as supplied by publisher]

Genetic variability of the retromer cargo recognition complex in parkinsonism.
Emil K Gustavsson, Ilaria Guella, Joanne Trinh, Chelsea Szu-Tu, Alex Rajput, Ali H Rajput, John C Steele, Martin McKeown, Beom S Jeon, Jan O Aasly, Matthew J Farrer
Mov Disord 2014 Dec;
PMID: 25475142 [PubMed - as supplied by publisher]

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans.
Neda Masoudi, Pablo Ibanez-Cruceyra, Sarah-Lena Offenburger, Alexander Holmes, Anton Gartner
PLoS Genet 2014 Dec; 10(12):e1004767
PMID: 25474638 [PubMed - as supplied by publisher]

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering.
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai
PLoS Genet 2014 Dec; 10(12):e1004861
PMID: 25474007 [PubMed - as supplied by publisher]

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43.
Nicole F Liachko, Pamela J McMillan, Timothy J Strovas, Elaine Loomis, Lynne Greenup, Jill R Murrell, Bernardino Ghetti, Murray A Raskind, Thomas J Montine, Thomas D Bird, James B Leverenz, Brian C Kraemer
PLoS Genet 2014 Dec; 10(12):e1004803
PMID: 25473830 [PubMed - as supplied by publisher]

Design, synthesis, and evaluation of a selective chemosensor for leucine-rich repeat kinase 2.
David A Szalewski, Jon R Beck, Cliff I Stains
Bioorg Med Chem Lett 2014 Dec; 24(24):5648-51
PMID: 25467152 [PubMed - as supplied by publisher]

102 supplementation with estradiol cypionate at the onset of a synchronized proestrus alters the uterine gene expression of suckled anestrous beef cows.
M F Sá Filho, G Pugliesi, A M Gonella-Diaza, M Sponchiado, M F Mendanha, R S Ramos, S C S Andrade, G Gasperin, M D Goissis, F S Mesquita, L L Coutinho, P S Baruselli, M Binelli
Reprod Fertil Dev 2014 Dec; 27(1):144
PMID: 25472151 [PubMed - as supplied by publisher]

UCH-L1 S18Y Variant and Risk of Parkinson's Disease in Asian Populations: An Updated Meta-Analysis.
Ruixia Zhu, Ying Zhu, Xu Liu, Zhiyi He
Neurodegener Dis 2014 Dec;
PMID: 25471998 [PubMed - as supplied by publisher]

Zirconium oxide ceramic foam: a promising supporting biomaterial for massive production of glial cell line-derived neurotrophic factor.
Zhong-Wei Liu, Wen-Qiang Li, Jun-Kui Wang, Xian-Cang Ma, Chen Liang, Peng Liu, Zheng Chu, Yong-Hui Dang
J Zhejiang Univ Sci B 2014 Dec; 15(12):1013-22
PMID: 25471830 [PubMed - as supplied by publisher]

Noninvasive Bioluminescence Imaging of ?-Synuclein Oligomerization in Mouse Brain Using Split Firefly Luciferase Reporters.
Sarah-Ann Aelvoet, Abdelilah Ibrahimi, Francesca Macchi, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
J Neurosci 2014 Dec; 34(49):16518-32
PMID: 25471588 [PubMed - as supplied by publisher]

Brain-derived neurotrophic factor expression increases after enzyme replacement therapy in Gaucher disease.
Filippo Vairo, Fernanda Sperb-Ludwig, Matheus Wilke, Kristiane Michellin-Tirelli, Cristina Netto, Eurico Camargo Neto, Ida Vanessa Doederlein Schwartz
J Neuroimmunol 2014 Nov;
PMID: 25468270 [PubMed - as supplied by publisher]

Analysis of Parkinson's disease pathophysiology using an integrated genomics-bioinformatics approach.
Li M Fu, Katherine A Fu
Pathophysiology 2014 Nov;
PMID: 25466606 [PubMed - as supplied by publisher]

Parkinson's disease, genetic variability and the Faroe Islands.
Maria Skaalum Petersen, Ilaria Guella, Sara Bech, Emil Gustavsson, Matthew J Farrer
Parkinsonism Relat Disord 2014 Nov;
PMID: 25466404 [PubMed - as supplied by publisher]

miRNA expression is highly sensitive to a drug therapy in Parkinson's disease.
Anelya Kh Alieva, Elena V Filatova, Aleksey V Karabanov, Sergey N Illarioshkin, Svetlana A Limborska, Maria I Shadrina, Petr A Slominsky
Parkinsonism Relat Disord 2014 Oct;
PMID: 25465742 [PubMed - as supplied by publisher]

The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease.
Lorraine Iacovitti, Xiaotao Wei, Jingli Cai, Eric W Kostuk, Ruihe Lin, Alexander Gorodinsky, Philip Roman, Gretchen Kusek, Sonal S Das, Audrey Dufour, Terina N Martinez, Kuldip D Dave
PLoS One 2014 ; 9(12):e113151
PMID: 25462571 [PubMed - as supplied by publisher]

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1.
Richard G Carroll, Emilie Hollville, Seamus J Martin
Cell Rep 2014 Nov; 9(4):1538-53
PMID: 25456142 [PubMed - as supplied by publisher]

Lithium prevents parkinsonian behavioral and striatal phenotypes in an aged parkin mutant transgenic mouse model.
Christopher A Lieu, Colleen M Dewey, Shankar J Chinta, Anand Rane, Subramanian Rajagopalan, Sean Batir, Yong-Hwan Kim, Julie K Andersen
Brain Res 2014 Oct; 1591C:111-117
PMID: 25452026 [PubMed - as supplied by publisher]

Synthetic prions and other human neurodegenerative proteinopathies.
Nhat Tran Thanh Le, Joanna Narkiewicz, Suzana Auli?, Giulia Salzano, Hoa Thanh Tran, Denis Scaini, Fabio Moda, Gabriele Giachin, Giuseppe Legname
Virus Res 2014 Oct;
PMID: 25449570 [PubMed - as supplied by publisher]

The therapeutic potential of interleukin-10 in neuroimmune diseases.
A J Kwilasz, P M Grace, P Serbedzija, S F Maier, L R Watkins
Neuropharmacology 2014 Nov;
PMID: 25446571 [PubMed - as supplied by publisher]

The nicotinic cholinergic system function in the human brain.
Frauke Nees
Neuropharmacology 2014 Nov;
PMID: 25446570 [PubMed - as supplied by publisher]

?-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).
Guillaume Daniel, Alessandra Musso, Elpida Tsika, Aris Fiser, Liliane Glauser, Olga Pletnikova, Bernard L Schneider, Darren J Moore
Neurobiol Dis 2014 Oct; 73C:229-243
PMID: 25461191 [PubMed - as supplied by publisher]

Do genetic factors protect against Parkinson's disease? What I can learn from my healthy grandma.
Khashayar Dashtipour
Med Hypotheses 2014 Oct; 83(6):637-639
PMID: 25459129 [PubMed - as supplied by publisher]

Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.
Nicole K Polinski, Sara E Gombash, Fredric P Manfredsson, Jack W Lipton, Christopher J Kemp, Allyson Cole-Strauss, Nicholas M Kanaan, Kathy Steece-Collier, Nathan C Kuhn, Susan L Wohlgenant, Caryl E Sortwell
Neurobiol Aging 2014 Oct;
PMID: 25457558 [PubMed - as supplied by publisher]

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.
Jose A Morales-Garcia, Diana Aguilar-Morante, Elena Hernandez-Encinas, Sandra Alonso-Gil, Carmen Gil, Ana Martinez, Angel Santos, Ana Perez-Castillo
Neurobiol Aging 2014 Oct;
PMID: 25457552 [PubMed - as supplied by publisher]

RIT2 polymorphism is associated with Parkinson's disease in a Han Chinese population.
Kun Nie, Shu-Jun Feng, Hong-Mei Tang, Gui-Xian Ma, Rong Gan, Xin Zhao, Jie-Hao Zhao, Li-Min Wang, Zhi-Heng Huang, Jing Huang, Liang Gao, You-Wen Zhang, Rui-Ming Zhu, Zhen-Peng Duan, Yu-Hu Zhang, Li-Juan Wang
Neurobiol Aging 2014 Oct;
PMID: 25457028 [PubMed - as supplied by publisher]

A network approach to clinical intervention in neurodegenerative diseases.
Jose A Santiago, Judith A Potashkin
Trends Mol Med 2014 Oct; 20(12):694-703
PMID: 25455073 [PubMed - as supplied by publisher]

Clinical and electrophysiological features in a French family presenting with seipinopathy.
Yolaine Ollivier, Armelle Magot, Philippe Latour, Julie Perrier, Sandra Mercier, Thierry Maisonobe, Yann Péréon
Neuromuscul Disord 2014 Oct;
PMID: 25454168 [PubMed - as supplied by publisher]

The causative gene of parkinsonism and its medical treatment strategy.
Masatoshi Inden
Yakugaku Zasshi 2014 ; 134(12):1253-8
PMID: 25452235 [PubMed - as supplied by publisher]

Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets.
Rita Marreiros, Andreas Müller-Schiffmann, Verian Bader, Suganya Selvarajah, Debendranath Dey, Vishwanath R Lingappa, Carsten Korth
Virus Res 2014 Oct;
PMID: 25451064 [PubMed - as supplied by publisher]

Inflammation is genetically implicated in Parkinson's disease.
N Dzamko, C L Geczy, G M Halliday
Neuroscience 2014 Oct;
PMID: 25450953 [PubMed - as supplied by publisher]

Loss of NEIL1 causes defects in olfactory function in mice.
Chandrika Canugovi, Magdalena Misiak, Morten Scheibye-Knudsen, Deborah L Croteau, Mark P Mattson, Vilhelm A Bohr
Neurobiol Aging 2014 Oct;
PMID: 25448603 [PubMed - as supplied by publisher]

Ten Years and Counting: Moving Leucine-Rich Repeat Kinase 2 Inhibitors to the Clinic.
Andrew B West
Mov Disord 2014 Dec;
PMID: 25448543 [PubMed - as supplied by publisher]

The Addiction-Related Gene ANKK1 in Parkinsonian Patients with Impulse Control Disorder.
Janet Hoenicka, Pedro J García-Ruiz, Guillermo Ponce, Antonio Herranz, Dolores Martínez-Rubio, Estela Pérez-Santamarina, Francesc Palau
Neurotox Res 2014 Dec;
PMID: 25447970 [PubMed - as supplied by publisher]

Neurogranin binds ?-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.
Andrew O Koob, Gideon M Shaked, Andreas Bender, Alejandro Bisquertt, Edward Rockenstein, Eliezer Masliah
Brain Res 2014 Oct; 1591C:102-110
PMID: 25446004 [PubMed - as supplied by publisher]

Neuronal mitophagy: long-distance delivery or eating locally?
Bingwei Lu
Curr Biol 2014 Oct; 24(20):R1006-8
PMID: 25442848 [PubMed - as supplied by publisher]

Inhibiting Lateral Habenula Improves L-DOPA-induced Dyskinesia.
Matthieu F Bastide, Brice de la Crompe, Evelyne Doudnikoff, Pierre-Olivier Fernagut, Christian E Gross, Nicolas Mallet, Thomas Boraud, Erwan Bézard
Biol Psychiatry 2014 Sep;
PMID: 25442003 [PubMed - as supplied by publisher]

Neurogenetic Disorders in the Basque Population.
José Félix Martí Massó, Juan José Zarranz, David Otaegui, Adolfo López de Munain
Ann Hum Genet 2014 Dec;
PMID: 25440984 [PubMed - as supplied by publisher]

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.
Marc Brehme, Cindy Voisine, Thomas Rolland, Shinichiro Wachi, James H Soper, Yitan Zhu, Kai Orton, Adriana Villella, Dan Garza, Marc Vidal, Hui Ge, Richard I Morimoto
Cell Rep 2014 Nov; 9(3):1135-50
PMID: 25437566 [PubMed - as supplied by publisher]

Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling.
Jean-Francois Poulin, Jian Zou, Janelle Drouin-Ouellet, Kwang-Youn A Kim, Francesca Cicchetti, Rajeshwar B Awatramani
Cell Rep 2014 Nov; 9(3):930-43
PMID: 25437550 [PubMed - as supplied by publisher]

Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease.
Roy N Alcalay, Helen Mejia-Santana, Anat Mirelman, Rachel Saunders-Pullman, Deborah Raymond, Christina Palmese, Elise Caccappolo, Laurie Ozelius, Avi Orr-Urtreger, Lorraine Clark, Nir Giladi, Susan Bressman, Karen Marder,
Parkinsonism Relat Disord 2014 Nov;
PMID: 25434972 [PubMed - as supplied by publisher]

Inhibition of HDAC6 Modifies Tau Inclusion Body Formation and Impairs Autophagic Clearance.
Janina Leyk, Olaf Goldbaum, Monika Noack, Christiane Richter-Landsberg
J Mol Neurosci 2014 Dec;
PMID: 25434725 [PubMed - as supplied by publisher]

Genetics of leprosy: Expected and unexpected developments and perspectives.
Monica E D Sauer, Heloisa Salomão, Geovana B Ramos, Helena R S D Espindula, Rafael S A Rodrigues, Wilian C Macedo, Renata H M Sindeaux, Marcelo T Mira
Clin Dermatol 2015 Jan-Feb; 33(1):99-107
PMID: 25432815 [PubMed - as supplied by publisher]