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Rejuvenation Res 2014 Jun;
Authors: Ben A Bahr
New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help against several disease states of which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumulation events. Shoji-Kawata et al. describe a new autophagy-inducing peptide, Tat-beclin 1, that enhances the clearance of polyglutamine aggregates related to Huntington's disease and, interestingly, it suppresses viral and bacterial infections. Savolainen et al. describe a prolyl oligopeptidase inhibitor that reduces ?-synuclein species related to Parkinson's disease and other ?-synucleinopathies, and the inhibitor caused a concomitant increase in autophagic activation markers. Previous studies also linked the autophagy-lysosomal pathway to the protective clearing of A? peptides of Alzheimer's disease and tau species of tauopathies. Enhancing autophagic-lysosomal efficiency may provide a therapeutic avenue for diverse types of proteinopathies, including the most common neurodegenerative disorders of the elderly.
PMID: 24953230 [PubMed - as supplied by publisher]