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Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson's disease: a meta-analysis.
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Neurol Sci 2014 Jun;
Authors: Ruixia Zhu, Ying Zhu, Xu Liu, Zhiyi He
Fibroblast growth factor 20 (FGF20) widely expressed in the substantia nigra is a neurotrophic factor and enhances the survival of midbrain dopaminergic neurons. Genetic association between variants in FGF20 gene (rs1721100) and PD has been reported, however, the results have been conflicting. A total of 3,463 PD patients and 4,606 controls from 5 case-control studies, which were identified by searching Web of Science, Embase and PubMed database up to March 2014, were collected for this meta-analysis. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model (GG versus CG+GG; OR†=†1.15, 95†% CI 1.02-1.29, p†=†0.02) but not under a dominant model (CG+GG versus CC; OR†=†1.03, 95†% CI 0.93-1.13, p†=†0.57). These findings suggest that rs1721100 GG genotype within FGF20 gene is a risk factor for PD. To our knowledge, this is the first meta-analysis to access to the association of FGF20 gene rs1721100 polymorphism with PD risk.
PMID: 24942208 [PubMed - as supplied by publisher]