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Sheng-Han Kuo, M.D.

“The PDF Côté Award [in Clinical Genetics] helped me to start my research.”

Sheng-Han Kuo, M.D.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

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Vision/Visual hallucination



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Imaging Studies

Clinical Studies



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Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

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Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

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High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Nadya Pyatigorskaya, Michael Sharman, Jean-Christophe Corvol, Romain Valabregue, Lydia Yahia-Cherif, Fabrice Poupon, Florence Cormier-Dequaire, Hartwig Siebner, Stephan Klebe, Marie Vidailhet, Alexis Brice, Stephane Lehéricy
Mov Disord 2015 May;
PMID: 26011561 [PubMed - as supplied by publisher]

Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population.
Shigeru Yokoyama, Naila Al Mahmuda, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Masakazu Yamagishi, Haruhiro Higashida
Brain Sci 2015; 5(2):188-200
PMID: 26010484 [PubMed - as supplied by publisher]

A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and its Biochemical and Structural Characterization.
Cong Han, Kuan-Chuan Pao, Agne Kazlauskaite, Miratul M K Muqit, Satpal Virdee
Chembiochem 2015 May;
PMID: 26010437 [PubMed - as supplied by publisher]

Comprehensive Assessment of Genetic Sequence Variants in the Antioxidant 'Master Regulator' Nrf2 in Idiopathic Parkinson's Disease.
Michael Todorovic, Jeremy R B Newman, Jianguo Shan, Steven Bentley, Stephen A Wood, Peter A Silburn, George D Mellick
PLoS One 2015; 10(5):e0128030
PMID: 26010367 [PubMed - as supplied by publisher]

A new F-box protein 7 gene mutation causing typical Parkinson's disease.
Ebba Lohmann, Anne-Sophie Coquel, Aurélie Honoré, Hakan Gurvit, Hasmet Hanagasi, Murat Emre, Anne L Leutenegger, Valérie Drouet, Mourad Sahbatou, Gamze Guven, Nihan Erginel-Unaltuna, Jean-Francois Deleuze, Suzanne Lesage, Alexis Brice
Mov Disord 2015 May;
PMID: 26010069 [PubMed - as supplied by publisher]

Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.
Pilar Rivero-Ríos, Patricia Gómez-Suaga, Belén Fernández, Jesús Madero-Pérez, Andrew J Schwab, Allison D Ebert, Sabine Hilfiker
Biochem Soc Trans 2015 Jun; 43(3):390-5
PMID: 26009181 [PubMed - as supplied by publisher]

Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to ?-synuclein in Drosophila.
Bing Wang, Qingqing Liu, Hongyun Shan, Chunlin Xia, Zhaohui Liu
Biochem Cell Biol 2015 Apr; :1-8
PMID: 26008822 [PubMed - as supplied by publisher]

LRRK2 Pathways Leading to Neurodegeneration.
Mark R Cookson
Curr Neurol Neurosci Rep 2015 Jul; 15(7):564
PMID: 26008812 [PubMed - as supplied by publisher]

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.
Susanna Kemppainen, Päivi Lindholm, Emilia Galli, Hanna-Maija Lahtinen, Henna Koivisto, Elina Hämäläinen, Mart Saarma, Heikki Tanila
Behav Brain Res 2015 May; 291:1-11
PMID: 25975173 [PubMed - as supplied by publisher]

Novel candidate blood-based transcriptional biomarkers of machado-joseph disease.
Mafalda Raposo, Conceição Bettencourt, Patrícia Maciel, Fuying Gao, Amanda Ramos, Nadiya Kazachkova, João Vasconcelos, Teresa Kay, Ana João Rodrigues, Bruno Bettencourt, Jácome Bruges-Armas, Daniel Geschwind, Giovanni Coppola, Manuela Lima
Mov Disord 2015 Apr;
PMID: 25914309 [PubMed - as supplied by publisher]

Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge.
Fabiana Miraglia, Laura Betti, Lionella Palego, Gino Giannaccini
Cent Nerv Syst Agents Med Chem 2015 ; 15(2):109-16
PMID: 25896035 [PubMed - as supplied by publisher]

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor.
John M Hatcher, Jinwei Zhang, Hwan Geun Choi, Genta Ito, Dario R Alessi, Nathanael S Gray
ACS Med Chem Lett 2015 May; 6(5):584-9
PMID: 26005538 [PubMed - as supplied by publisher]

The role of poly unsaturated fatty acids and GPR40 receptor in brain.
Muhammad Zahid Khan, Ling He
Neuropharmacology 2015 May;
PMID: 26005184 [PubMed - as supplied by publisher]

American Academy of Neurology, Washington, 18-25 April 2015].
I Sibon, B de Toffol, J-P Azulay, F Sellal, C Thomas-Antérion, J-M Léger, C Pierrot-Deseilligny
Rev Neurol (Paris) 2015 May;
PMID: 26005122 [PubMed - as supplied by publisher]

Dynamic Network Communication as a Unifying Neural Basis for Cognition, Development, Aging, and Disease.
Bradley Voytek, Robert T Knight
Biol Psychiatry 2015 Jun; 77(12):1089-1097
PMID: 26005114 [PubMed - as supplied by publisher]

Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila.
Jae Ho Cho, Jeong Hyang Park, Chang Geon Chung, Hyun-Jung Shim, Keun Hye Jeon, Seong-Woon Yu, Sung Bae Lee
Biochem Biophys Res Commun 2015 May;
PMID: 25979357 [PubMed - as supplied by publisher]

Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export.
Andrea Legati, Donatella Giovannini, Gaël Nicolas, Uriel López-Sánchez, Beatriz Quintáns, João R M Oliveira, Renee L Sears, Eliana Marisa Ramos, Elizabeth Spiteri, María-Jesús Sobrido, Ángel Carracedo, Cristina Castro-Fernández, Stéphanie Cubizolle, Brent L Fogel, Cyril Goizet, Joanna C Jen, Suppachok Kirdlarp, Anthony E Lang, Zosia Miedzybrodzka, Witoon Mitarnun, Martin Paucar, Henry Paulson, Jérémie Pariente, Anne-Claire Richard, Naomi S Salins, Sheila A Simpson, Pasquale Striano, Per Svenningsson, François Tison, Vivek K Unni, Olivier Vanakker, Marja W Wessels, Suppachok Wetchaphanphesat, Michele Yang, Francois Boller, Dominique Campion, Didier Hannequin, Marc Sitbon, Daniel H Geschwind, Jean-Luc Battini, Giovanni Coppola
Nat Genet 2015 May;
PMID: 25938945 [PubMed - as supplied by publisher]

The human cytomegalovirus non-coding Beta2.7 RNA as a novel therapeutic for Parkinson's disease - translational research with no translation.
Emma Poole, Wei Li Kuan, Roger Barker, John Sinclair
Virus Res 2015 May;
PMID: 26003955 [PubMed - as supplied by publisher]

Challenges in essential tremor genetics.
L N Clark, E D Louis
Rev Neurol (Paris) 2015 May;
PMID: 26003805 [PubMed - as supplied by publisher]

?-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca(2+) influx upon NMDA stimulation.
Yudong Chen, Weiwei Yang, Xin Li, Xuran Li, Hui Yang, Zhiqing Xu, Shun Yu
Neuroscience 2015 May;
PMID: 26003734 [PubMed - as supplied by publisher]

Transcriptional regulation of the ?-synuclein gene in human brain tissue.
Steffen Brenner, Christophe Wersinger, Thomas Gasser
Neurosci Lett 2015 May;
PMID: 26002080 [PubMed - as supplied by publisher]

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome.
Roberto Simone, Pietro Fratta, Stephen Neidle, Gary N Parkinson, Adrian M Isaacs
FEBS Lett 2015 May;
PMID: 25979174 [PubMed - as supplied by publisher]

The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity.
Débora E Rinaldi, Gerardo R Corradi, Lucía Martínez Cuesta, Hugo P Adamo, Felicitas de Tezanos Pinto
Biochim Biophys Acta 2015 Apr; 1848(8):1646-1655
PMID: 25912790 [PubMed - as supplied by publisher]

Association of TLR9 polymorphisms with sporadic Parkinson's disease in Chinese Han population.
Konghua Zhu, Jijun Teng, Jing Zhao, Hongxin Liu, Anmu Xie
Int J Neurosci 2015 May; :1-16
PMID: 26000920 [PubMed - as supplied by publisher]

Association between sex, systemic iron variation and probability of Parkinson's Disease.
S Mariani, M Ventriglia, I Simonelli, S Bucossi, M Siotto, S Donno, F Vernieri, R Squitti
Int J Neurosci 2015 May; :1-20
PMID: 26000822 [PubMed - as supplied by publisher]

A meta-analysis on relationship of MAO-B intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD.
Yanli Zhang, Xiangyu Piao, Jianli Wu, Yan Li, Qian Liang
Int J Neurosci 2015 May; :1-22
PMID: 26000819 [PubMed - as supplied by publisher]

Mutations in the Glucocerebrosidase Gene Are Common in Patients with Parkinson's Disease from Eastern Canada.
Fabin Han, David A Grimes, Fang Li, Ting Wang, Zhe Yu, Na Song, Shichao Wu, Lemuel Racacho, Dennis E Bulman
Int J Neurosci 2015 May; :1-19
PMID: 26000814 [PubMed - as supplied by publisher]

Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications.
Julieta De Toro, Leticia Herschlik, Claudia Waldner, Claudia Mongini
Front Immunol 2015 ; 6:203
PMID: 25999947 [PubMed - as supplied by publisher]

CSF Neurofilament Light Chain but not FLT3 Ligand Discriminates Parkinsonian Disorders.
Megan K Herbert, Marjolein B Aerts, Marijke Beenes, Niklas Norgren, Rianne A J Esselink, Bastiaan R Bloem, H Bea Kuiperij, Marcel M Verbeek
Front Neurol 2015 ; 6:91
PMID: 25999911 [PubMed - as supplied by publisher]

How Mitochondrial Dynamism Orchestrates Mitophagy.
Orian S Shirihai, Moshi Song, Gerald W Dorn
Circ Res 2015 May; 116(11):1835-1849
PMID: 25999423 [PubMed - as supplied by publisher]

Target gene capture sequencing in chinese population of sporadic Parkinson disease.
Zhiming Li, Qing Lin, Wenqing Huang, Chi-Meng Tzeng
Medicine (Baltimore) 2015 May; 94(20):e836
PMID: 25997059 [PubMed - as supplied by publisher]

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Brice Laurens, Radu Constantinescu, Roy Freeman, Alexander Gerhard, Kurt Jellinger, Alexander Jeromin, Florian Krismer, Brit Mollenhauer, Michael G Schlossmacher, Leslie M Shaw, Marcel M Verbeek, Gregor K Wenning, Kristian Winge, Jing Zhang, Wassilios G Meissner
Neurobiol Dis 2015 May;
PMID: 25982836 [PubMed - as supplied by publisher]

Generation and characterization of novel conformation-specific monoclonal antibodies for ?-synuclein pathology.
Nishant N Vaikath, Nour K Majbour, Katerina E Paleologou, Mustafa T Ardah, Esther van Dam, Wilma D J van de Berg, Shelley L Forrest, Laura Parkkinen, Wei-Ping Gai, Nobutaka Hattori, Masashi Takanashi, Seung-Jae Lee, David M A Mann, Yuzuru Imai, Glenda M Halliday, Jia-Yi Li, Omar M A El-Agnaf
Neurobiol Dis 2015 Apr; 79:81-99
PMID: 25937088 [PubMed - as supplied by publisher]

Role of ?- and ?-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.
Akio Sekigawa, Yoshiki Takamatsu, Kazunari Sekiyama, Makoto Hashimoto
Biomolecules 2015; 5(2):1000-1011
PMID: 25996784 [PubMed - as supplied by publisher]

Selenium, selenoproteins and neurodegenerative diseases.
Bárbara Rita Cardoso, Blaine R Roberts, Ashley I Bush, Dominic J Hare
Metallomics 2015 May;
PMID: 25996565 [PubMed - as supplied by publisher]

The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Thomas M Durcan, Edward A Fon
Genes Dev 2015 May; 29(10):989-999
PMID: 25995186 [PubMed - as supplied by publisher]

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.
Nicholas M Kanaan, Timothy J Collier, Allyson Cole-Strauss, Tessa Grabinski, Zachary R Mattingly, Mary E Winn, Kathy Steece-Collier, Caryl E Sortwell, Fredric P Manfredsson, Jack W Lipton
PLoS One 2015 ; 10(5):e0127768
PMID: 25992874 [PubMed - as supplied by publisher]

Quantitative interaction proteomics of neurodegenerative disease proteins.
Fabian Hosp, Hannes Vossfeldt, Matthias Heinig, Djordje Vasiljevic, Anup Arumughan, Emanuel Wyler, , Markus Landthaler, Norbert Hubner, Erich E Wanker, Lars Lannfelt, Martin Ingelsson, Maciej Lalowski, Aaron Voigt, Matthias Selbach
Cell Rep 2015 May; 11(7):1134-46
PMID: 25959826 [PubMed - as supplied by publisher]

Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.
Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu, Yun-Cheng Wu
J Neurochem 2015 May;
PMID: 25991017 [PubMed - as supplied by publisher]

Withaferin A regulates LRRK2 levels by interfering with the Hsp90-Cdc37 chaperone complex.
Malathi Narayan, Juan Zhang, Kaitlyn Braswell, Chelsea Gibson, Ashley Zitnyar, Daniel C Lee, Sheeba Varghese-Gupta, Umesh K Jinwal
Curr Aging Sci 2015 May;
PMID: 25989799 [PubMed - as supplied by publisher]

Impact of Parkinson's disease risk loci on age at onset.
Christina M Lill, Johnni Hansen, Jørgen H Olsen, Harald Binder, Beate Ritz, Lars Bertram
Mov Disord 2015 May; 30(6):847-50
PMID: 25914293 [PubMed - as supplied by publisher]

The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms.
Jin-Sung Park, Nicholas F Blair, Carolyn M Sue
Mov Disord 2015 May; 30(6):770-9
PMID: 25900096 [PubMed - as supplied by publisher]

Cytosolic PTEN-INDUCED PUTATIVE KINASE 1 is Stabilized By NF-?B Pathway and Promotes Non-Selective Mitophagy.
Grace G Y Lim, Doreen S K Chua, Adeline H Basil, Hui-Ying Chan, Chou Chai, Thiruma Arumugam, Kah-Leong Lim
J Biol Chem 2015 May;
PMID: 25987559 [PubMed - as supplied by publisher]

Association between bone marrow stromal cell antigen 1 gene polymorphisms and the susceptibility to Parkinson's disease: a meta-analysis.
Shan Wang, Yu-Feng Xu, Xiao-Yan Ding, Zhi-Rong Liu, Yao Ding, Bo Jin, Shuang Wang, Mei-Ping Ding
Neurosci Lett 2015 May;
PMID: 25986899 [PubMed - as supplied by publisher]

6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells.
Tomasz Maciej St?pkowski, Iwona Wasyk, Agnieszka Grzelak, Marcin Kruszewski
Cell Mol Neurobiol 2015 May;
PMID: 25986246 [PubMed - as supplied by publisher]

Mechanisms of Alpha-Synuclein Action on Neurotransmission: Cell-Autonomous and Non-Cell Autonomous Role.
Marco Emanuele, Evelina Chieregatti
Biomolecules 2015; 5(2):865-892
PMID: 25985082 [PubMed - as supplied by publisher]

Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis.
Sujung Yeo, Keon Sang An, Yeon-Mi Hong, Yeong-Gon Choi, Bruce Rosen, Sung-Hoon Kim, Sabina Lim
Genet Mol Biol 2015 Mar; 38(1):115-27
PMID: 25983633 [PubMed - as supplied by publisher]

Splicing: is there an alternative contribution to Parkinson's disease?
Valentina La Cognata, Velia D'Agata, Francesca Cavalcanti, Sebastiano Cavallaro
Neurogenetics 2015 May;
PMID: 25980689 [PubMed - as supplied by publisher]

Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease.
Irene R Taravini, Celia Larramendy, Gimena Gomez, Mariano D Saborido, Floor Spaans, Cristóbal Fresno, Germán A González, Elmer Fernández, Mario Gustavo Murer, Oscar S Gershanik
Neuropharmacology 2015 May;
PMID: 25963416 [PubMed - as supplied by publisher]

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.
Christina M Lill, Aina Rengmark, Lasse Pihlstrøm, Isabella Fogh, Aleksey Shatunov, Patrick M Sleiman, Li-San Wang, Tian Liu, Christina F Lassen, Esther Meissner, Panos Alexopoulos, Andrea Calvo, Adriano Chio, Nil Dizdar, Frank Faltraco, Lars Forsgren, Julia Kirchheiner, Alexander Kurz, Jan P Larsen, Maria Liebsch, Jan Linder, Karen E Morrison, Hans Nissbrandt, Markus Otto, Jens Pahnke, Amanda Partch, Gabriella Restagno, Dan Rujescu, Cathrin Schnack, Christopher E Shaw, Pamela J Shaw, Hayrettin Tumani, Ole-Bjørn Tysnes, Otto Valladares, Vincenzo Silani, Leonard H van den Berg, Wouter van Rheenen, Jan H Veldink, Ulman Lindenberger, Elisabeth Steinhagen-Thiessen, , Stefan Teipel, Robert Perneczky, Hakon Hakonarson, Harald Hampel, Christine A F von Arnim, Jørgen H Olsen, Vivianna M Van Deerlin, Ammar Al-Chalabi, Mathias Toft, Beate Ritz, Lars Bertram
Alzheimers Dement 2015 Apr;
PMID: 25936935 [PubMed - as supplied by publisher]

TDP-43 Pathology Progression Along the Olfactory Pathway as a Possible Substrate for Olfactory Impairment in Amyotrophic Lateral Sclerosis.
Takahiro Takeda, Mutsumi Iijima, Toshiki Uchihara, Takashi Ohashi, Danielle Seilhean, Charles Duyckaerts, Shinichiro Uchiyama
J Neuropathol Exp Neurol 2015 Jun; 74(6):547-56
PMID: 25933387 [PubMed - as supplied by publisher]

Identification of novel variants in LRRK2 gene in patients with Parkinson's disease in Serbian population.
Milena Z Jankovi?, Nikola D Kresojevi?, Valerija S Dobri?i?, Vladana V Markovi?, Igor N Petrovi?, Ivana V Novakovi?, Vladimir S Kosti?
J Neurol Sci 2015 Jun; 353(1-2):59-62
PMID: 25899316 [PubMed - as supplied by publisher]

Association Analysis of COQ2 Variant in Dementia and Essential Tremor.
Yin Xia Chao, Ebonne Yu Lin Ng, Huihua Li, Kandiah Nagaendran, Yuen Yih, Mei Sian Chong, Kumar M Prakash, Louis Tan, Wing Lok Au, Yi Zhao, Zhi Dong Zhou, Murni Tio, Ratnagopal Pavanni, Eng King Tan
Parkinsons Dis 2015 ; 2015:926280
PMID: 25977831 [PubMed - as supplied by publisher]

The Role of ?-Synuclein and LRRK2 in Tau Phosphorylation.
Fumitaka Kawakami, Takafumi Ichikawa
Parkinsons Dis 2015 ; 2015:734746
PMID: 25977830 [PubMed - as supplied by publisher]

Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson's disease.
Margherita Maioli, Salvatore Rinaldi, Rossana Migheli, Gianfranco Pigliaru, Gaia Rocchitta, Sara Santaniello, Valentina Basoli, Alessandro Castagna, Vania Fontani, Carlo Ventura, Pier Andrea Serra
Sci Rep 2015 ; 5:10439
PMID: 25976344 [PubMed - as supplied by publisher]

Subtraction suppressive hybridisation analysis of differentially expressed genes associated with puberty in the goat hypothalamus.
G L Cao, T Feng, M X Chu, R Di, Y L Zhang, D W Huang, Q Y Liu, W P Hu, X Y Wang
Reprod Fertil Dev 2015 May;
PMID: 25976271 [PubMed - as supplied by publisher]

Amyloid-? and ?-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease.
Ane Løvli Stav, Dag Aarsland, Krisztina Kunszt Johansen, Erik Hessen, Eirik Auning, Tormod Fladby
Parkinsonism Relat Disord 2015 May;
PMID: 25971633 [PubMed - as supplied by publisher]

Adverse reactions to antipsychotics in Parkinson disease: an analysis of the spanish pharmacovigilance database.
Unax Lertxundi, Arantxazu Isla Ruiz, María Ángeles Solinís Aspiazu, Saioa Domingo-Echaburu, Montserrat García, Carmelo Aguirre, Juan Carlos García-Moncó
Clin Neuropharmacol 2015 May-Jun; 38(3):69-84
PMID: 25970275 [PubMed - as supplied by publisher]

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.
Anthony A Estrada, Zachary K Sweeney
J Med Chem 2015 May;
PMID: 25915084 [PubMed - as supplied by publisher]

Structural Characterization of LRRK2 Inhibitors.
Bernd K Gilsbach, Ana C Messias, Genta Ito, Michael Sattler, Dario R Alessi, Alfred Wittinghofer, Arjan Kortholt
J Med Chem 2015 May; 58(9):3751-6
PMID: 25897865 [PubMed - as supplied by publisher]

Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy.
Ying Tang, Jiankang Liu, Jiangang Long
J Diabetes Investig 2015 May; 6(3):250-5
PMID: 25969707 [PubMed - as supplied by publisher]

Familial hemiplegic migraine type 1 associated with parkinsonism: a case report.
Marie Bruun, Lena Elisabeth Hjermind, Carsten Thomsen, Else Danielsen, Lise Lykke Thomsen, Lars Hageman Pinborg, Nastaran Khabbazbavani, Joergen Erik Nielsen
Case Rep Neurol 2015 Jan-Apr; 7(1):84-9
PMID: 25969684 [PubMed - as supplied by publisher]

Association between PARK16 gene polymorphisms and susceptibility of Parkinson's disease in a Chinese population.
H Xia, Q Luo, X X Li, X L Yang
Genet Mol Res 2015 ; 14(2):2978-85
PMID: 25966061 [PubMed - as supplied by publisher]

Normalization of Overexpressed ?-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference.
Masaki Takahashi, Mari Suzuki, Masashi Fukuoka, Nobuhiro Fujikake, Shoko Watanabe, Miho Murata, Keiji Wada, Yoshitaka Nagai, Hirohiko Hohjoh
Mol Ther Nucleic Acids 2015 ; 4:e241
PMID: 25965551 [PubMed - as supplied by publisher]

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson's disease.
Guillaume Grolez, Caroline Moreau, Bernard Sablonnière, Guillaume Garçon, Jean-Christophe Devedjian, Sayah Meguig, Patrick Gelé, Christine Delmaire, Regis Bordet, Luc Defebvre, Ioav Z Cabantchik, David Devos
BMC Neurol 2015 ; 15:74
PMID: 25943368 [PubMed - as supplied by publisher]

Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study.
Li Gao, Chao Li, Ran-Yao Yang, Wen-Wen Lian, Jian-Song Fang, Xiao-Cong Pang, Xue-Mei Qin, Ai-Lin Liu, Guan-Hua Du
Pharmacol Biochem Behav 2015 Jun; 133:155-63
PMID: 25895692 [PubMed - as supplied by publisher]

Folic Acid Supplementation Ameliorates Oxidative Stress, Metabolic Functions and Developmental Anomalies in a Novel Fly Model of Parkinson's Disease.
Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, Saripella Srikrishna
Neurochem Res 2015 May;
PMID: 25963948 [PubMed - as supplied by publisher]

Dyrk1A Phosphorylates Parkin at Ser-131 and Negatively Regulates its Ubiquitin E3 Ligase Activity.
Eunju Im, Kwang Chul Chung
J Neurochem 2015 May;
PMID: 25963095 [PubMed - as supplied by publisher]

Plasma Oligomeric Alpha-Synuclein Is Associated With Glucocerebrosidase Activity in Gaucher Disease.
Evgenii Nuzhnyi, Anton Emelyanov, Tatyana Boukina, Tatiana Usenko, Andrey Yakimovskii, Ekaterina Zakharova, Sofya Pchelina
Mov Disord 2015 May;
PMID: 25962734 [PubMed - as supplied by publisher]

LRRK2 mutations in Parkinson disease; a sex effect or lack thereof? A meta-analysis.
Ziv Gan-Or, Claire S Leblond, Victoria Mallett, Avi Orr-Urtreger, Patrick A Dion, Guy A Rouleau
Parkinsonism Relat Disord 2015 May;
PMID: 25962553 [PubMed - as supplied by publisher]

SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.
Yue Huang, Gang Wang, Dominic Rowe, Ying Wang, John B J Kwok, Qin Xiao, Frank Mastaglia, Jun Liu, Sheng-Di Chen, Glenda Halliday
Biomed Res Int 2015 ; 2015:135674
PMID: 25960998 [PubMed - as supplied by publisher]

Neurophysiology of Drosophila models of Parkinson's disease.
Ryan J H West, Rebecca Furmston, Charles A C Williams, Christopher J H Elliott
Parkinsons Dis 2015 ; 2015:381281
PMID: 25960916 [PubMed - as supplied by publisher]

Autonomic involvement in Parkinsonian carriers of PARK2 gene mutations.
Beatriz Tijero, Iñigo Gabilondo, Elena Lezcano, Nuria Teran-Villagrá, Verónica Llorens, Javier Ruiz-Martinez, Jose Felix Marti-Masso, M Carmona, Maria Rosario Luquin, Koldo Berganzo, Ivan Fernandez, Manuel Fernandez, Juan José Zarranz, Juan Carlos Gómez-Esteban
Parkinsonism Relat Disord 2015 Apr;
PMID: 25960264 [PubMed - as supplied by publisher]

Cellular processes associated with LRRK2 function and dysfunction.
Rebecca Wallings, Claudia Manzoni, Rina Bandopadhyay
FEBS J 2015 Apr;
PMID: 25899482 [PubMed - as supplied by publisher]

Presenting symptoms of GBA-related Parkinson's disease.
Nikola Kresojevi?, Milena Jankovi?, Igor Petrovi?, Kishore R Kumar, Nata?a Draga?evi?, Valerija Dobri?i?, Ivana Novakovi?, Marina Svetel, Christine Klein, Tatjana Pekmezovi?, Vladimir S Kosti?
Parkinsonism Relat Disord 2015 May;
PMID: 25957717 [PubMed - as supplied by publisher]

Association of LRRK2 and GBA mutations in a Brazilian family with Parkinson's disease.
Mariana Spitz, João Santos Pereira, Denise Hack Nicareta, Gabriella de Medeiros Abreu, Elenice Ferreira Bastos, Taís Leite Seixas, Márcia Mattos Gonçalves Pimentel
Parkinsonism Relat Disord 2015 May;
PMID: 25952961 [PubMed - as supplied by publisher]

Disclosure of research results in genetic studies of Parkinson's disease caused by LRRK2 mutations.
Claustre Pont-Sunyer, Susan Bressman, Deborah Raymond, Amanda Glickman, Eduardo Tolosa, Rachel Saunders-Pullman
Mov Disord 2015 May;
PMID: 25952684 [PubMed - as supplied by publisher]

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.
Ravindra Boddu, Travis D Hull, Subhashini Bolisetty, Xianzhen Hu, Mark S Moehle, João Paulo Lima Daher, Ahmed Ibrahim Kamal, Reny Joseph, James F George, Anupam Agarwal, Lisa M Curtis, Andrew B West
Hum Mol Genet 2015 Apr;
PMID: 25904107 [PubMed - as supplied by publisher]

Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands.
Silvia Pace, Giandomenico Brogin, Maria Antonietta Stasi, Teresa Riccioni, Franco Borsini, Francesca Capocasa, Francesco Manera, Carlo Tallarico, Pietro Grossi, Federica Vacondio, Michele Bassi, Francesca Bartoccini, Simone Lucarini, Giovanni Piersanti, Giorgio Tarzia, Walter Cabri, Patrizia Minetti
ChemMedChem 2015 May;
PMID: 25951302 [PubMed - as supplied by publisher]

Neuroaxonal dystrophy in PLA2G6 knockout mice.
Hisae Sumi-Akamaru, Goichi Beck, Shinsuke Kato, Hideki Mochizuki
Neuropathology 2015 May;
PMID: 25950622 [PubMed - as supplied by publisher]

Moment based gene set tests.
Jessica L Larson, Art B Owen
BMC Bioinformatics 2015 ; 16:132
PMID: 25928861 [PubMed - as supplied by publisher]

Animal models for prion-like diseases.
Natalia Fernández-Borges, Hasier Eraña, Vanesa Venegas, Saioa R Elezgarai, Chafik Harrathi, Joaquín Castilla
Virus Res 2015 Apr;
PMID: 25907990 [PubMed - as supplied by publisher]

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.
Robert D Leone, Ying-Chun Lo, Jonathan D Powell
Comput Struct Biotechnol J 2015 ; 13:265-72
PMID: 25941561 [PubMed - as supplied by publisher]

LRRK2 Dephosphorylation increases its ubiquitination.
Jing Zhao, Tyler P Molitor, J William Langston, R Jeremy Nichols
Biochem J 2015 May;
PMID: 25939886 [PubMed - as supplied by publisher]

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin.
Fabienne C Fiesel, Thomas R Caulfield, Elisabeth L Moussaud-Lamodière, Kotaro Ogaki1 Daniel F A R Dourado, Samuel C Flores, Owen A Ross, Wolfdieter Springer
Hum Mutat 2015 May;
PMID: 25939424 [PubMed - as supplied by publisher]

DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson's disease patients.
Shahidee Zainal Abidin, Eng Liang Tan, Soon-Choy Chan, Ameerah Jaafar, Alex Xuen Lee, Mohd Hamdi Noor Abd Hamid, Nor Azian Abdul Murad, Nur Fadlina Pakarul Razy, Shahrul Azmin, Azlina Ahmad Annuar, Shen Yang Lim, Pike-See Cheah, King-Hwa Ling, Norlinah Mohamed Ibrahim
BMC Neurol 2015 ; 15:59
PMID: 25896831 [PubMed - as supplied by publisher]

Parkinson's Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder.
Z Gan-Or, S L Girard, A Noreau, C S Leblond, J F Gagnon, I Arnulf, C Mirarchi, Y Dauvilliers, A Desautels, T Mitterling, V Cochen De Cock, B Frauscher, C Monaca, B Hogl, P A Dion, R B Postuma, J Y Montplaisir, G A Rouleau
J Mol Neurosci 2015 May;
PMID: 25929833 [PubMed - as supplied by publisher]

MRI of lumbar trunk muscles in patients with Parkinson's disease and camptocormia.
N G Margraf, A Rohr, O Granert, J Hampel, A Drews, G Deuschl
J Neurol 2015 May;
PMID: 25929656 [PubMed - as supplied by publisher]

A study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations.
Gra?yna T Truszkowska, Zofia T Bili?ska, Joanna Kosi?ska, Justyna ?leszycka, Ma?gorzata Rydzanicz, Ma?gorzata Sobieszcza?ska-Ma?ek, Maria Franaszczyk, Maria Bili?ska, Piotr Stawi?ski, Ewa Michalak, ?ukasz A Ma?ek, Przemys?aw Chmielewski, Bogna Foss-Nieradko, Marcin M Machnicki, Tomasz Stok?osa, Joanna Poni?ska, ?ukasz Szumowski, Jacek Grzybowski, Jerzy Piwo?ski, Wojciech Drygas, Tomasz Zieli?ski, Rafa? P?oski
BMC Med Genet 2015 ; 16(1):21
PMID: 25928149 [PubMed - as supplied by publisher]

Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation.
J Michael Gee, Meredith B Gibbons, Marsa Taheri, Sierra Palumbos, S Craig Morris, Roy M Smeal, Katherine F Flynn, Michael N Economo, Christian G Cizek, Mario R Capecchi, Petr Tvrdik, Karen S Wilcox, John A White
Front Mol Neurosci 2015 ; 8:10
PMID: 25926768 [PubMed - as supplied by publisher]

The G2019S LRRK2 Mutation Increases Myeloid Cell Chemotactic Responses and Enhances LRRK2 Binding to Actin-Regulatory Proteins.
Mark S Moehle, João Paulo Lima Daher, Travis D Hull, Ravindra Boddu, Hisham A Abdelmotilib, James Mobley, George T Kannarkat, Malú G Tansey, Andrew B West
Hum Mol Genet 2015 Apr;
PMID: 25926623 [PubMed - as supplied by publisher]

Gene expression profile analysis of colorectal cancer to investigate potential mechanisms using bioinformatics.
Yubin Kou, Suya Zhang, Xiaoping Chen, Sanyuan Hu
Onco Targets Ther 2015 ; 8:745-52
PMID: 25914544 [PubMed - as supplied by publisher]

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases.
Miguel Chin-Chan, Juliana Navarro-Yepes, Betzabet Quintanilla-Vega
Front Cell Neurosci 2015 ; 9:124
PMID: 25914621 [PubMed - as supplied by publisher]

Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease.
S García, Rm Coral-Vázquez, M P Gallegos-Arreola, L A Montes-Almanza, P Canto, F A García-Martínez, G Chavira-Hernández, C Palma-Flores, L Dávila-Maldonado, C F Cuevas-García, L B López Hernández
Folia Neuropathol 2015 ; 53(1):24-8
PMID: 25909872 [PubMed - as supplied by publisher]

Variants associated with Gaucher disease in multiple system atrophy.
Jun Mitsui, Takashi Matsukawa, Hidenao Sasaki, Ichiro Yabe, Masaaki Matsushima, Alexandra Dürr, Alexis Brice, Hiroshi Takashima, Akio Kikuchi, Masashi Aoki, Hiroyuki Ishiura, Tsutomu Yasuda, Hidetoshi Date, Budrul Ahsan, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yasuo Nakahara, Yoshio Momose, Yuji Takahashi, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Takamichi Hattori, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Tomoyoshi Kondo, Shigeo Murayama, Nobutaka Hattori, Mitsutoshi Yamamoto, Miho Murata, Wataru Satake, Tatsushi Toda, Alessandro Filla, Thomas Klockgether, Ullrich Wüllner, Garth Nicholson, Sid Gilman, Caroline M Tanner, Walter A Kukull, Mathew B Stern, Virginia M-Y Lee, John Q Trojanowski, Eliezer Masliah, Phillip A Low, Paola Sandroni, Laurie J Ozelius, Tatiana Foroud, Shoji Tsuji
Ann Clin Transl Neurol 2015 Apr; 2(4):417-26
PMID: 25909086 [PubMed - as supplied by publisher]

Association of TLR4 gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population.
Jing Zhao, Xun Han, Li Xue, Konghua Zhu, Hongxin Liu, Anmu Xie
Neurol Sci 2015 Apr;
PMID: 25908385 [PubMed - as supplied by publisher]

The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning.
David H Jang, Joshua W Lampe, Lance B Becker
J Med Toxicol 2015 Apr;
PMID: 25907836 [PubMed - as supplied by publisher]

The KM-parkin-DB: A Sub-set MutationView Database Specialized for PARK2 (PARKIN) Variants.
Susumu Mitsuyama, Masafumi Ohtsubo, Shinsei Minoshima, Nobuyoshi Shimizu
Hum Mutat 2015 Apr;
PMID: 25907632 [PubMed - as supplied by publisher]

Are striatal tyrosine hydroxylase interneurons dopaminergic?
Harry S Xenias, Osvaldo Ibáñez-Sandoval, Tibor Koós, James M Tepper
J Neurosci 2015 Apr; 35(16):6584-99
PMID: 25904808 [PubMed - as supplied by publisher]

Parkinson's disease-associated PINK1 G309D mutation increases abnormal phosphorylation of Tau.
Ming Ye, Dai Zhou, Youxin Zhou, Chunming Sun
IUBMB Life 2015 Apr;
PMID: 25899925 [PubMed - as supplied by publisher]