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Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus].
Yang Chen, Ying-Hui Lü, Zhao-Fa Li
Yao Xue Xue Bao 2014 May; 49(5):576-81
PMID: 25151724 [PubMed - as supplied by publisher]


Parkinson's disease and mitochondrial gene variations: A review.
Sasan Andalib, Manouchehr Seyedi Vafaee, Albert Gjedde
J Neurol Sci 2014 Aug;
PMID: 25151610 [PubMed - as supplied by publisher]


Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2-Nrf2 signaling pathway.
Xiao-Li Wang, Gui-Hua Xing, Bo Hong, Xiao-Ming Li, Yu Zou, Xiao-Jie Zhang, Miao-Xian Dong
Life Sci 2014 Aug;
PMID: 25132361 [PubMed - as supplied by publisher]


S-nitrosylating protein disulphide isomerase mediates ?-synuclein aggregation caused by methamphetamine exposure in PC12 cells.
Xiao-Fang Wu, Ai-Feng Wang, Ling Chen, En-Ping Huang, Wei-Bing Xie, Chao Liu, Wei-Ye Huang, Chuan-Xiang Chen, Ping-Ming Qiu, Hui-Jun Wang
Toxicol Lett 2014 Jul; 230(1):19-27
PMID: 25090657 [PubMed - as supplied by publisher]


Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Mike A Nalls, Nathan Pankratz, Christina M Lill, Chuong B Do, Dena G Hernandez, Mohamad Saad, Anita L DeStefano, Eleanna Kara, Jose Bras, Manu Sharma, Claudia Schulte, Margaux F Keller, Sampath Arepalli, Christopher Letson, Connor Edsall, Hreinn Stefansson, Xinmin Liu, Hannah Pliner, Joseph H Lee, Rong Cheng, , , , , , , , , , , , , M Arfan Ikram, John P A Ioannidis, Georgios M Hadjigeorgiou, Joshua C Bis, Maria Martinez, Joel S Perlmutter, Alison Goate, Karen Marder, Brian Fiske, Margaret Sutherland, Georgia Xiromerisiou, Richard H Myers, Lorraine N Clark, Kari Stefansson, John A Hardy, Peter Heutink, Honglei Chen, Nicholas W Wood, Henry Houlden, Haydeh Payami, Alexis Brice, William K Scott, Thomas Gasser, Lars Bertram, Nicholas Eriksson, Tatiana Foroud, Andrew B Singleton
Nat Genet 2014 Jul;
PMID: 25064009 [PubMed - as supplied by publisher]


Novel DYT11 gene mutation in patients without dopaminergic deficit (SWEDD) screened for dystonia.
Roberto Cilia, Chiara Reale, Anna Castagna, Alessia Nasca, Marco Muzi-Falconi, Chiara Barzaghi, Alberto Marzegan, Magda Granata, Giorgio Marotta, Giorgio Sacilotto, Davide Vallauri, Gianni Pezzoli, Stefano Goldwurm, Barbara Garavaglia
Neurology 2014 Aug;
PMID: 25150291 [PubMed - as supplied by publisher]


Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.
Jerome A Roth
Neurotoxicology 2014 Aug;
PMID: 25149416 [PubMed - as supplied by publisher]


Mitochondrial acetylation and genetic models of Parkinson's disease.
Georg Auburger, Suzana Gispert, Marina Jendrach
Prog Mol Biol Transl Sci 2014 ; 127:155-82
PMID: 25149217 [PubMed - as supplied by publisher]


Air Pollution and Children: Neural and Tight Junction Antibodies and Combustion Metals, the Role of Barrier Breakdown and Brain Immunity in Neurodegeneration.
Lilian Calderón-Garcidueńas, Aristo Vojdani, Eleonore Blaurock-Busch, Yvette Busch, Albrecht Friedle, Maricela Franco-Lira, Partha Sarathi-Mukherjee, Su-Bin Park, Ricardo Torres-Jardón, Amedeo D'Angiulli
J Alzheimers Dis 2014 Aug;
PMID: 25147109 [PubMed - as supplied by publisher]


RIT2, a susceptibility gene for Parkinson's disease in Iranian population.
Babak Emamalizadeh, Abolfazl Movafagh, Mojdeh Akbari, Somayyeh Kazeminasab, Atena Fazeli, Marzieh Motallebi, Gholam-Ali Shahidi, Peyman Petramfar, Reza Mirfakhraie, Hossein Darvish
Neurobiol Aging 2014 Jul;
PMID: 25146456 [PubMed - as supplied by publisher]


UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease.
Kai Wu, Jia Liu, Na Zhuang, Tao Wang
FASEB J 2014 Aug;
PMID: 25145627 [PubMed - as supplied by publisher]


Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.
Michaela Matthes, Martin Preusse, Jingzhong Zhang, Julia Schechter, Daniela Mayer, Bernd Lentes, Fabian Theis, Nilima Prakash, Wolfgang Wurst, Dietrich Trümbach
Database (Oxford) 2014 ; 2014
PMID: 25145340 [PubMed - as supplied by publisher]


Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.
Taku Amo, Shinji Saiki, Tadashi Sawayama, Shigeto Sato, Nobutaka Hattori
Neurosci Lett 2014 Aug; 580C:37-40
PMID: 25092611 [PubMed - as supplied by publisher]


Onset of Huntington's disease: Can it be purely cognitive?
Jane S Paulsen, Jeffrey D Long
Mov Disord 2014 Aug;
PMID: 25142616 [PubMed - as supplied by publisher]


DYT16 revisited: Exome sequencing identifies PRKRA mutations in a European dystonia family.
Michael Zech, Florian Castrop, Barbara Schormair, Angela Jochim, Thomas Wieland, Nadine Gross, Peter Lichtner, Annette Peters, Christian Gieger, Thomas Meitinger, Tim M Strom, Konrad Oexle, Bernhard Haslinger, Juliane Winkelmann
Mov Disord 2014 Aug;
PMID: 25142429 [PubMed - as supplied by publisher]


Lardy brains make Parkinson's disease mice worse.
Mark R Cookson
J Neurochem 2014 Aug;
PMID: 25142063 [PubMed - as supplied by publisher]


Parkinson's disease pharmacogenomics: new findings and perspectives.
Artur F Schumacher-Schuh, Carlos Rm Rieder, Mara H Hutz
Pharmacogenomics 2014 Jun; 15(9):1253-71
PMID: 25141900 [PubMed - as supplied by publisher]


Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain.
Soraya Scuderi, Valentina La Cognata, Filippo Drago, Sebastiano Cavallaro, Velia D'Agata
Biomed Res Int 2014 ; 2014:690796
PMID: 25136611 [PubMed - as supplied by publisher]


Genetic factors and manganese-induced neurotoxicity.
Pan Chen, Nancy Parmalee, Michael Aschner
Front Genet 2014 ; 5:265
PMID: 25136353 [PubMed - as supplied by publisher]


Cardiac Sympathetic Denervation in 6-OHDA-Treated Nonhuman Primates.
Valerie Joers, Kristine Dilley, Shahrose Rahman, Corinne Jones, Jeanette Shultz, Heather Simmons, Marina E Emborg
PLoS One 2014 ; 9(8):e104850
PMID: 25133405 [PubMed - as supplied by publisher]


Human FGF1 promoter is active in ependymal cells and dopaminergic neurons in the brains of F1B-GFP transgenic mice.
Mei-Shu Chen, Hua-Kuo Lin, Hsun Chiu, Don-Ching Lee, Yu-Fen Chung, Ing-Ming Chiu
Dev Neurobiol 2014 Aug;
PMID: 25104610 [PubMed - as supplied by publisher]


From yeast to patient neurons and back again: A powerful new discovery platform.
Daniel F Tardiff, Vikram Khurana, Chee Yeun Chung, Susan Lindquist
Mov Disord 2014 Aug;
PMID: 25131316 [PubMed - as supplied by publisher]


Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions.
Michael H Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C Hermida, Ruana Tiseo, Linda L Sackett-Lundeen, Erhard L Haus
Sleep Med Rev 2014 Jul;
PMID: 25129839 [PubMed - as supplied by publisher]


Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression.
XinJian Liu, Qian Huang, Fang Li, Chuan-Yuan Li
Sci China Life Sci 2014 Aug;
PMID: 25129808 [PubMed - as supplied by publisher]


SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.
Xiao Yan Guo, Yong Ping Chen, Wei Song, Bi Zhao, Bei Cao, Qian Qian Wei, Ru Wei Ou, Yuan Yang, Li Xing Yuan, Hui-Fang Shang
Neurobiol Aging 2014 Jul;
PMID: 25129240 [PubMed - as supplied by publisher]


Quercetin Glycosides Induced Neuroprotection by Changes in the Gene Expression in a Cellular Model of Parkinson's Disease.
Kasthuri Bai Magalingam, Ammu Radhakrishnan, Premdass Ramdas, Nagaraja Haleagrahara
J Mol Neurosci 2014 Aug;
PMID: 25129099 [PubMed - as supplied by publisher]


D-beta-hydroxybutyrate extends lifespan in C. elegans.
Clare Edwards, John Canfield, Neil Copes, Muhammad Rehan, David Lipps, Patrick C Bradshaw
Aging (Albany NY) 2014 Aug;
PMID: 25127866 [PubMed - as supplied by publisher]


Interest in Genetic Testing in Ashkenazi Jewish Parkinson's Disease Patients and Their Unaffected Relatives.
Manisha Gupte, Roy N Alcalay, Helen Mejia-Santana, Deborah Raymond, Rachel Saunders-Pullman, Ernest Roos, Martha Orbe-Reily, Ming-X Tang, Anat Mirelman, Laurie Ozelius, Avi Orr-Urtreger, Lorraine Clark, Nir Giladi, Susan Bressman, Karen Marder
J Genet Couns 2014 Aug;
PMID: 25127731 [PubMed - as supplied by publisher]


Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
Yusuke Toyoda, Cihan Erkut, Francisco Pan-Montojo, Sebastian Boland, Martin P Stewart, Daniel J Müller, Wolfgang Wurst, Anthony A Hyman, Teymuras V Kurzchalia
Biol Open 2014 ; 3(8):777-84
PMID: 25063200 [PubMed - as supplied by publisher]


A cell culture model for monitoring ?-synuclein cell-to-cell transfer.
Juan F Reyes, Tomas T Olsson, Jennifer T Lamberts, Michael J Devine, Tilo Kunath, Patrik Brundin
Neurobiol Dis 2014 Jul;
PMID: 25046995 [PubMed - as supplied by publisher]


Cognitive dysfunction in Parkinson's disease related to the R1441G mutation in LRRK2.
A Estanga, M C Rodriguez-Oroz, J Ruiz-Martinez, M Barandiaran, A Gorostidi, A Bergareche, E Mondragon, A Lopez de Munain, J F Marti-Masso
Parkinsonism Relat Disord 2014 Jul;
PMID: 25127457 [PubMed - as supplied by publisher]


Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders.
Ronald W Irwin, Christine M Solinsky, Roberta Diaz Brinton
Front Cell Neurosci 2014 ; 8:203
PMID: 25126056 [PubMed - as supplied by publisher]


GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
S Bellani, A Mescola, G Ronzitti, H Tsushima, S Tilve, C Canale, F Valtorta, E Chieregatti
Cell Death Differ 2014 Aug;
PMID: 25124556 [PubMed - as supplied by publisher]


Addition of exogenous ?-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous ?-synuclein to Lewy body and Lewy neurite-like aggregates.
Laura A Volpicelli-Daley, Kelvin C Luk, Virginia M-Y Lee
Nat Protoc 2014 Sep; 9(9):2135-46
PMID: 25122523 [PubMed - as supplied by publisher]


Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.
Jean-Marc Taymans, Veerle Baekelandt, Kirsten Harvey
Front Mol Neurosci 2014 ; 7:71
PMID: 25120428 [PubMed - as supplied by publisher]


Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.
Pascal F Durrenberger, Francesca S Fernando, Samira N Kashefi, Tim P Bonnert, Danielle Seilhean, Brahim Nait-Oumesmar, Andrea Schmitt, Peter J Gebicke-Haerter, Peter Falkai, Edna Grünblatt, Miklos Palkovits, Thomas Arzberger, Hans Kretzschmar, David T Dexter, Richard Reynolds
J Neural Transm 2014 Aug;
PMID: 25119539 [PubMed - as supplied by publisher]


The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.
S Saez-Atienzar, L Bonet-Ponce, J R Blesa, F J Romero, M P Murphy, J Jordan, M F Galindo
Cell Death Dis 2014 ; 5:e1368
PMID: 25118928 [PubMed - as supplied by publisher]


The Effect of Lentivirus-Mediated PSPN Genetic Engineering Bone Marrow Mesenchymal Stem Cells on Parkinson's Disease Rat Model.
Xiaofeng Yin, Huamin Xu, Yunxia Jiang, Wenshuai Deng, Zeyu Wu, Hengwei Xiang, Peng Sun, Junxia Xie
PLoS One 2014 ; 9(8):e105118
PMID: 25118697 [PubMed - as supplied by publisher]


Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson's disease by bioinformatics.
Shuqin Cui, Hanwen Sun, Xiangling Gu, E Lv, Yancong Zhang, Pingxuan Dong, Chunhua Fu, Chao Zhu
Neurol Sci 2014 Aug;
PMID: 25116258 [PubMed - as supplied by publisher]


Tetranectin knockout mice develop features of Parkinson disease.
Er-Song Wang, Xiao-Ping Zhang, Hui-Bin Yao, Gan Wang, Shi-Wen Chen, Wen-Wei Gao, Hai-Jun Yao, Yi-Rui Sun, Cai-Hua Xi, Yao-Dong Ji
Cell Physiol Biochem 2014 ; 34(2):277-87
PMID: 25033953 [PubMed - as supplied by publisher]


Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Paul Galatsis, Jaclyn L Henderson, Bethany L Kormos, Seungil Han, Ravi G Kurumbail, Travis T Wager, Patrick R Verhoest, G Stephen Noell, Yi Chen, Elie Needle, Zdenek Berger, Stefanus J Steyn, Christopher Houle, Warren D Hirst
Bioorg Med Chem Lett 2014 Jul;
PMID: 25113930 [PubMed - as supplied by publisher]


Walking Deficits and Centrophobism in an Alpha-Synuclein Fly Model of Parkinson's Disease.
Alex Y Chen, Paul Wilburn, Xue Hao, Tim Tully
Genes Brain Behav 2014 Aug;
PMID: 25113870 [PubMed - as supplied by publisher]


Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence.
Jane A Driver
Biogerontology 2014 Aug;
PMID: 25113739 [PubMed - as supplied by publisher]


LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.
Patricia Gómez-Suaga, Pilar Rivero-Ríos, Elena Fdez, Marian Blanca Ramírez, Isidro Ferrer, Ana Aiastui, Adolfo López De Munain, Sabine Hilfiker
Hum Mol Genet 2014 Jul;
PMID: 25080504 [PubMed - as supplied by publisher]


Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease.
Ajay Gupta, Baptiste Lacoste, Paul J Pistel, Donald K Ingram, Edith Hamel, Moulay A Alaoui-Jamali, Walter A Szarek, Jason Z Vlahakis, Su Jie, Wei Song, Hyman M Schipper
J Neurochem 2014 Aug;
PMID: 25111043 [PubMed - as supplied by publisher]


Zebrafish as a systems toxicology model for developmental neurotoxicity testing.
Yuhei Nishimura, Soichiro Murakami, Yoshifumi Ashikawa, Shota Sasagawa, Noriko Umemoto, Yasuhito Shimada, Toshio Tanaka
Congenit Anom (Kyoto) 2014 Aug;
PMID: 25109898 [PubMed - as supplied by publisher]


The Applications of Pharmacogenomics to Neurological Disorders.
C Gilman, C McSweeney, Y Mao
Curr Mol Med 2014 Aug;
PMID: 25109797 [PubMed - as supplied by publisher]


Upregulation of human PINK1 gene expression by NFżB signalling.
Xiaoling Duan, Jade Tong, Qin Xu, Yili Wu, Fang Cai, Tingyu Li, Weihong Song
Mol Brain 2014 Aug; 7(1):57
PMID: 25108683 [PubMed - as supplied by publisher]


Catechol-O-methyltransferase Val158Met polymorphism: Modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease.
Hui Wu, Fangyi Dong, Ying Wang, Qin Xiao, Qiong Yang, Jing Zhao, Thomas J Quinn, Sheng-di Chen, Jun Liu
Parkinsonism Relat Disord 2014 Jul;
PMID: 25108642 [PubMed - as supplied by publisher]


A new pathway for mitochondrial quality control: mitochondrial-derived vesicles.
Ayumu Sugiura, Gian-Luca McLelland, Edward A Fon, Heidi M McBride
EMBO J 2014 Aug;
PMID: 25107473 [PubMed - as supplied by publisher]


Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Francesco Longo, Isabella Russo, Derya R Shimshek, Elisa Greggio, Michele Morari
Neurobiol Dis 2014 Aug;
PMID: 25107341 [PubMed - as supplied by publisher]


The Paths to Neurodegeneration in Genetic Parkinson's Disease.
O E Abdel-Salam
CNS Neurol Disord Drug Targets 2014 Aug;
PMID: 25106632 [PubMed - as supplied by publisher]


Animal Models for Parkinson's Disease.
Dilip Ashok Patil, Vishal Ashok Patil, Sanjay Baburao Bari, Sanjay J Surana, Pravin Onkar Patil
CNS Neurol Disord Drug Targets 2014 Aug;
PMID: 25106631 [PubMed - as supplied by publisher]


BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson's Disease.
Pawel Kermer, Anja Köhn, Marlena Schnieder, Paul Lingor, Mathias Bähr, Jan Liman, Christoph Peter Dohm
J Mol Neurosci 2014 Aug;
PMID: 25106480 [PubMed - as supplied by publisher]


Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.
David R Whitfield, Julie Vallortigara, Amani Alghamdi, David Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Stephen Newhouse, Clive Ballard, Alan J Thomas, John T O'Brien, Dag Aarsland, Paul T Francis
Neurobiol Aging 2014 Jun;
PMID: 25104558 [PubMed - as supplied by publisher]


Regional Multiple Pathology Scores are Associated with Cognitive Decline in Lewy Body Dementias.
David R Howlett, David Whitfield, Mary Johnson, Johannes Attems, John T O'Brien, Dag Aarsland, Mitchell Kp Lai, Jasinda H Lee, Christopher Chen, Clive Ballard, Tibor Hortobágyi, Paul T Francis
Brain Pathol 2014 Aug;
PMID: 25103200 [PubMed - as supplied by publisher]


Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease.
Michal Mielcarek, Linda Inuabasi, Marie K Bondulich, Thomas Muller, Georgina F Osborne, Sophie A Franklin, Donna L Smith, Andreas Neueder, Jim Rosinski, Ivan Rattray, Andrea Protti, Gillian P Bates
PLoS Genet 2014 Aug; 10(8):e1004550
PMID: 25101683 [PubMed - as supplied by publisher]


Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.
J Romaní-Aumedes, M Canal, N Martín-Flores, X Sun, V Pérez-Fernández, S Wewering, R Fernández-Santiago, M Ezquerra, C Pont-Sunyer, A Lafuente, J Alberch, H Luebbert, E Tolosa, O A Levy, L A Greene, C Malagelada
Cell Death Dis 2014 ; 5:e1364
PMID: 25101677 [PubMed - as supplied by publisher]


Gene-Gene and Gene-Environment Interaction on the Risk of Parkinson's Disease.
Neeraj Kumar Singh, B D Banerjee, Kiran Bala, Mitra Basu, Neelam Chhillar
Curr Aging Sci 2014 Aug;
PMID: 25101650 [PubMed - as supplied by publisher]


Genetic Convergence of Parkinson's Disease and Lysosomal Storage Disorders.
Hao Deng, Xiaofei Xiu, Joseph Jankovic
Mol Neurobiol 2014 Aug;
PMID: 25099932 [PubMed - as supplied by publisher]


Biological metals and metal-targeting compounds in major neurodegenerative diseases.
Kevin J Barnham, Ashley I Bush
Chem Soc Rev 2014 Aug;
PMID: 25099276 [PubMed - as supplied by publisher]


Pesticides and Parkinson's disease: is it in your genes?
Lisa M Barnhill, Jeff M Bronstein
Neurodegener Dis Manag 2014 Jun; 4(3):197-200
PMID: 25095814 [PubMed - as supplied by publisher]


Pathological alpha-synuclein propagates through neural networks.
Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Maki Kubo, Aki Shimozawa, Haruhiko Akiyama, Masato Hasegawa
Acta Neuropathol Commun 2014 Aug; 2(1):88
PMID: 25095794 [PubMed - as supplied by publisher]


Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants.
Roy N Alcalay, Jan Aasly, Daniela Berg, Susan Bressman, Alexis Brice, Kathrin Brockmann, Piu Chan, Lorraine Clark, Florence Cormier, Jean-Christophe Corvol, Alexandra Durr, Maurizio Facheris, Matthew Farrer, Tatiana M Foroud, Thomas Gasser, Nir Giladi, Cheryl Halter, Anthony Lang, J William Langston, Connie Marras, Jose-Felix Marti-Masso, Javier Ruiz Martinez, Helen Mejia-Santana, Anat Mirelman, Claustre Pont-Sunyer, Avi Orr-Urtreger, Deborah Raymond, Rachel Saunders-Pullman, Birgitt Schüle, Caroline Tanner, Eduardo Tolosa, Alison Urkowitz, Dolores Vilas, Adina Wise, Karen Marder
Genet Med 2014 Aug; 16(8):644-5
PMID: 25093570 [PubMed - as supplied by publisher]


Genetic analysis of SNCA coding mutation in Chinese Han patients with Parkinson disease.
Sheng Deng, Xiong Deng, Lamei Yuan, Zhi Song, Zhijian Yang, Wei Xiong, Hao Deng
Acta Neurol Belg 2014 Aug;
PMID: 25092551 [PubMed - as supplied by publisher]


Null genotype of GSTT1 contributes to increased Parkinson's disease risk in Caucasians: evidence from a meta-analysis.
Dan Wang, Jun-Xia Zhai, Li-Mei Zhang, Dian-Wu Liu
Mol Biol Rep 2014 Aug;
PMID: 25086621 [PubMed - as supplied by publisher]


Network modulation following sham surgery in Parkinson's disease.
Ji Hyun Ko, Andrew Feigin, Paul J Mattis, Chris C Tang, Yilong Ma, Vijay Dhawan, Matthew J During, Michael G Kaplitt, David Eidelberg
J Clin Invest 2014 Aug; 124(8):3656-66
PMID: 25036712 [PubMed - as supplied by publisher]


Mitochondrial Oxidative Phosphorylation Transcriptome Alterations in Human Amyotrophic Lateral Sclerosis Spinal Cord and Blood.
Amy C Ladd, Paula M Keeney, Maria M Govind, James P Bennett
Neuromolecular Med 2014 Aug;
PMID: 25081190 [PubMed - as supplied by publisher]


Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.
Juan A Navarro, Sabina Heßner, Sarat C Yenisetti, Florian Bayersdorfer, Li Zhang, Aaron Voigt, Stephan Schneuwly, Jose A Botella
J Neurochem 2014 Jul;
PMID: 25040725 [PubMed - as supplied by publisher]


Blood Genome-Wide Transcriptional Profiles Reflect Broad Molecular Impairments and Strong Blood-Brain Links in Alzheimer's Disease.
Bartholomew J Naughton, F Jason Duncan, Darren A Murrey, Aaron S Meadows, David E Newsom, Nicoleta Stoicea, Peter White, Douglas W Scharre, Douglas M Mccarty, Haiyan Fu
J Alzheimers Dis 2014 Jul;
PMID: 25079797 [PubMed - as supplied by publisher]


Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Beatriz Alvarez-Castelao, Ana Gorostidi, Javier Ruíz-Martínez, Adolfo López de Munain, José G Castańo
Front Aging Neurosci 2014 ; 6:169
PMID: 25076905 [PubMed - as supplied by publisher]


Function and expression differences between ergot and non-ergot dopamine D2 agonists on heart valve interstitial cells.
Fumiki Oana, Hiroshi Onozuka, Akihiro Tsuchioka, Takayuki Suzuki, Nobuyuki Tanaka, Kouichi Kaidoh, Yuji Hoyano, Masahiro Hiratochi, Shinji Kikuchi, Yasuo Takehana, Nobuo Shibata
J Heart Valve Dis 2014 Mar; 23(2):246-52
PMID: 25076559 [PubMed - as supplied by publisher]


Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?
Michael Beekes, Achim Thomzig, Walter J Schulz-Schaeffer, Reinhard Burger
Acta Neuropathol 2014 Jul;
PMID: 25073522 [PubMed - as supplied by publisher]


The potential of epigenetic therapies in neurodegenerative diseases.
Fabio Coppedč
Front Genet 2014 ; 5:220
PMID: 25071843 [PubMed - as supplied by publisher]


The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?
Francesca Cicchetti, Roger A Barker
Front Pharmacol 2014 ; 5:139
PMID: 25071571 [PubMed - as supplied by publisher]


Interaction of LRRK2 with kinase and GTPase signaling cascades.
Joon Y Boon, Julien Dusonchet, Chelsea Trengrove, Benjamin Wolozin
Front Mol Neurosci 2014 ; 7:64
PMID: 25071441 [PubMed - as supplied by publisher]


A calcineurin- and NFAT-dependent pathway is involved in ?-synuclein-induced degeneration of midbrain dopaminergic neurons.
Jing Luo, Lixin Sun, Xian Lin, Guoxiang Liu, Jia Yu, Loukia Parisiadou, Chengsong Xie, Jinhui Ding, Huaibin Cai
Hum Mol Genet 2014 Jul;
PMID: 25051958 [PubMed - as supplied by publisher]


Functional polymorphisms of the MAO gene with Parkinson disease susceptibility: A meta-analysis.
Yong-Xin Sun, Xiao-Hong Wang, Ai-Hua Xu, Jiu-Han Zhao
J Neurol Sci 2014 Jul;
PMID: 25066260 [PubMed - as supplied by publisher]


Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives.
Jesse V Veenvliet, Marten P Smidt
Cell Mol Life Sci 2014 Jul;
PMID: 25064061 [PubMed - as supplied by publisher]


Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.
Da-Wei Li, Zhuqin Gu, Chaodong Wang, Jinghong Ma, Bei-Sha Tang, Sheng-Di Chen, Piu Chan
J Neural Transm 2014 Jul;
PMID: 25062988 [PubMed - as supplied by publisher]


The co-occurrence of Alzheimer's disease and Huntington's disease: a neuropathological study of 15 elderly Huntington's disease subjects.
Marie Y Davis, C Dirk Keene, Suman Jayadev, Thomas Bird
J Huntingtons Dis 2014 ; 3(2):209-17
PMID: 25062863 [PubMed - as supplied by publisher]


Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network.
Mustafa Sertba?, Kutlu Ulgen, Tunahan Cak?r
FEBS Open Bio 2014 ; 4:542-53
PMID: 25061554 [PubMed - as supplied by publisher]


Genetics and genomics of Parkinson's disease.
Michelle K Lin, Matthew J Farrer
Genome Med 2014 ; 6(6):48
PMID: 25061481 [PubMed - as supplied by publisher]


Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier.
Yu-Shiang Peng, Po-Liang Lai, Sydney Peng, His-Chin Wu, Siang Yu, Tsan-Yun Tseng, Li-Fang Wang, I-Ming Chu
Int J Nanomedicine 2014 ; 9:3163-74
PMID: 25061293 [PubMed - as supplied by publisher]


Genetic Susceptibility Model of Parkinson's Disease Resulting from Exposure of DJ-1 Deficient Mice to MPTP: Evaluation of Neuroprotection by Ubisol-Q10.
Krithika Muthukumaran, Jessica Smith, Harshil Jasra, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Daniel Lopatin, Siyaram Pandey
J Parkinsons Dis 2014 Jul;
PMID: 25061060 [PubMed - as supplied by publisher]


Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.
Lixue Chuan, Jie Gao, Yuying Lei, Raoxiang Wang, Lechun Lu, Xianyu Zhang
Neurol Sci 2014 Jul;
PMID: 25060648 [PubMed - as supplied by publisher]


Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain.
Mahalakshmi Subramaniam, Beatrice Kern, Simone Vogel, Verena Klose, Gaby Schneider, Jochen Roeper
Eur J Neurosci 2014 Jul;
PMID: 25059097 [PubMed - as supplied by publisher]


DJ-1 interactions with ?-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.
L Zondler, L Miller-Fleming, M Repici, S Gonçalves, S Tenreiro, R Rosado-Ramos, C Betzer, K R Straatman, P H Jensen, F Giorgini, T F Outeiro
Cell Death Dis 2014 ; 5:e1350
PMID: 25058424 [PubMed - as supplied by publisher]


Prevalence of amyotrophic lateral sclerosis - United States, 2010-2011.
Paul Mehta, Vinicius Antao, Wendy Kaye, Marchelle Sanchez, David Williamson, Leah Bryan, Oleg Muravov, Kevin Horton,
MMWR Surveill Summ 2014 Jul; 63 Suppl 7:1-14
PMID: 25054277 [PubMed - as supplied by publisher]


Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
John E Casida, Breanna Ford, Yunden Jinsmaa, Patti Sullivan, Adele Cooney, David S Goldstein
Chem Res Toxicol 2014 Jul;
PMID: 25045800 [PubMed - as supplied by publisher]


Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
Dongjun Dai, Peipei Lin, Yunliang Wang, Xingyu Zhou, Jianmin Tao, Danjie Jiang, Hanlin Zhou, Ping Ru, Guanghui Pan, Jinfeng Li, Yuzheng Zhang, Honglei Yin, Shiwei Duan
Biomed Rep 2014 Sep; 2(5):713-718
PMID: 25054016 [PubMed - as supplied by publisher]


Effect of 17?-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats.
Cinzia Nasuti, Manuel Carloni, Donatella Fedeli, Antonio Di Stefano, Lisa Marinelli, Laura Serafina Cerasa, Clara Meda, Adriana Maggi, Rosita Gabbianelli
Chemosphere 2014 Oct; 112:496-502
PMID: 25048945 [PubMed - as supplied by publisher]


Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain.
Elaine R Peskind, Ge Li, Jane B Shofer, Steven P Millard, James B Leverenz, Chang-En Yu, Murray A Raskind, Joseph F Quinn, Douglas R Galasko, Thomas J Montine
JAMA Neurol 2014 Jul;
PMID: 25048271 [PubMed - as supplied by publisher]


Analysis of Dosage Mutation in PARK2 among Korean Patients with Early-Onset or Familial Parkinson's Disease.
Min Kyung Chu, Won Chan Kim, Jung Mi Choi, Jeong-Hoon Hong, Suk Yun Kang, Hyeo-Il Ma, Yun Joong Kim
J Clin Neurol 2014 Jul; 10(3):244-8
PMID: 25045378 [PubMed - as supplied by publisher]


Genetic deletion of the GATA1-regulated protein ?-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.
Raffaele Renella, Julia S Schlehe, Dennis J Selkoe, David A Williams, Matthew J LaVoie
Am J Hematol 2014 Jul;
PMID: 25043722 [PubMed - as supplied by publisher]


An association analysis of the rs1572931 polymorphism of the RAB7L1 gene in Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy in China.
X-Y Guo, Y-P Chen, W Song, B Zhao, B Cao, Q-Q Wei, R-W Ou, Y Yang, L-X Yuan, H-F Shang
Eur J Neurol 2014 Jul;
PMID: 25040112 [PubMed - as supplied by publisher]


Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.
Marusela Oliveras-Salvá, Francesca Macchi, Valérie Coessens, Angélique Deleersnijder, Melanie Gérard, Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt
Neurobiol Aging 2014 Jun;
PMID: 25037286 [PubMed - as supplied by publisher]


Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population.
Hongying Hao, Ming Shao, Jing An, Chushuang Chen, Xiuli Feng, Shu Xie, Zhuqin Gu, Piu Chan,
Parkinsonism Relat Disord 2014 Jul;
PMID: 25034874 [PubMed - as supplied by publisher]


FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease.
Chiung-Mei Chen, I-Cheng Chen, Yi-Cheng Huang, Hsueh-Fen Juan, Ying-Lin Chen, Yi-Chun Chen, Chih-Hsin Lin, Li-Ching Lee, Chi-Mei Lee, Guey-Jen Lee-Chen, Yun-Ju Lai, Yih-Ru Wu
PLoS One 2014 ; 9(7):e101392
PMID: 25029497 [PubMed - as supplied by publisher]


The association between the LRRK2 G2385R variant and the risk of Parkinson's disease: a meta-analysis based on 23 case-control studies.
Cheng-Long Xie, Jia-Lin Pan, Wen-Wen Wang, Yu Zhang, Su-Fang Zhang, Jing Gan, Zhen-Guo Liu
Neurol Sci 2014 Jul;
PMID: 25027012 [PubMed - as supplied by publisher]