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Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Mutant of leucine-rich repeat kinase 2 is not associated with non-motor symptoms in Chinese Parkinson's disease patients.
Maolin Hao, Ning Pan, Qinghua Zhang, Xiaohong Wang
Int J Clin Exp Med 2014 ; 7(8):2253-7
PMID: 25232417 [PubMed - as supplied by publisher]


D-beta-hydroxybutyrate extends lifespan in C. elegans.
Clare Edwards, John Canfield, Neil Copes, Muhammad Rehan, David Lipps, Patrick C Bradshaw
Aging (Albany NY) 2014 Aug; 6(8):621-44
PMID: 25127866 [PubMed - as supplied by publisher]


Computational Study of Human Tyrosine Hydroxylase Mutants to Uphold [4-(Propan-2-yl) Phenyl]Carbamic Acid as a Potential Inhibitor.
M S Nawaz, Z Parveen, L Wang, S Rashid, M Q Fatmi, M A Kamal
CNS Neurol Disord Drug Targets 2014 Sep;
PMID: 25230230 [PubMed - as supplied by publisher]


The Impact of Dementia Development Concurrent with Parkinson's Disease: A New Perspective.
A Russell, A Drozdova, W Wang, M Thomas
CNS Neurol Disord Drug Targets 2014 Sep;
PMID: 25230219 [PubMed - as supplied by publisher]


Unique Functional and Structural Properties of the LRRK2 ATP-Binding Pocket.
Zhiyong Liu, Robert A Galemmo, Kyle B Fraser, Mark S Moehle, Saurabh Sen, Laura A Volpicelli-Daley, Lawrence J DeLucas, Larry J Ross, Jacob Valiyaveettil, Omar Moukha-Chafiq, Ashish K Pathak, Sam Ananthan, Hollis Kezar, E Lucile White, Vandana Gupta, Joseph A Maddry, Mark J Suto, Andrew B West
J Biol Chem 2014 Sep;
PMID: 25228699 [PubMed - as supplied by publisher]


Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study.
Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Leslie A Scarffe, Valina L Dawson, Owen A Ross, Wolfdieter Springer, Ted M Dawson, Zbigniew K Wszolek
Parkinsonism Relat Disord 2014 Sep;
PMID: 25226871 [PubMed - as supplied by publisher]


Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Elpida Tsika, Meghna Kannan, Caroline Shi-Yan Foo, Dustin Dikeman, Liliane Glauser, Sandra Gellhaar, Dagmar Galter, Graham W Knott, Ted M Dawson, Valina L Dawson, Darren J Moore
Neurobiol Dis 2014 Aug; 71C:345-358
PMID: 25174890 [PubMed - as supplied by publisher]


Pharmacogenetics of drug response in Parkinson's disease.
Eleonora D?olji?, Ivana Novakovi?, Maja Krajinovic, Ivan Grbatini?, Vladimir Kosti?
Int J Neurosci 2014 Sep; :1-33
PMID: 25226559 [PubMed - as supplied by publisher]


Cholesterol in brain disease: sometimes determinant and frequently implicated.
Mauricio G Martín, Frank Pfrieger, Carlos G Dotti
EMBO Rep 2014 Sep;
PMID: 25223281 [PubMed - as supplied by publisher]


Construction of bicistronic lentiviral vectors for tracking the expression of CDNF in transduced cells.
Anllely Fernández, Sheyla Guzmán, Yocelin Cruz, Pedro Zamorano
Plasmid 2014 Sep;
PMID: 25217797 [PubMed - as supplied by publisher]


Protective role of olesoxime against wild type alpha-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells.
C Gouarné, J Tracz, M Giraudon Paoli, V Deluca, M Seimandi, G Tardif, M Xilouri, L Stefanis, T Bordet, R M Pruss
Br J Pharmacol 2014 Sep;
PMID: 25220617 [PubMed - as supplied by publisher]


Mutations in Niemann Pick type C gene are risk factor for Alzheimer's disease.
Nikola Kresojevi?, Valerija Dobri?i?, Marina Svetel, Vladimir Kosti?
Med Hypotheses 2014 Sep;
PMID: 25220527 [PubMed - as supplied by publisher]


Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.
Stefan Göring, Jean-Marc Taymans, Veerle Baekelandt, Boris Schmidt
Bioorg Med Chem Lett 2014 Aug;
PMID: 25219901 [PubMed - as supplied by publisher]


Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies.
Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay
Curr Neurol Neurosci Rep 2014 Nov; 14(11):495
PMID: 25218483 [PubMed - as supplied by publisher]


The role of transcriptional control in multiple system atrophy.
Jieqiong Chen, James D Mills, Glenda M Halliday, Michael Janitz
Neurobiol Aging 2014 Aug;
PMID: 25218777 [PubMed - as supplied by publisher]


Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits.
Asa Hatami, Marie-Francoise Chesselet
Curr Top Behav Neurosci 2014 Sep;
PMID: 25218491 [PubMed - as supplied by publisher]


Short Mitochondrial ARF Triggers Parkin/PINK1-Dependent Mitophagy.
Karl Grenier, Maria Kontogiannea, Edward A Fon
J Biol Chem 2014 Sep;
PMID: 25217637 [PubMed - as supplied by publisher]


USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Thomas M Durcan, Matthew Y Tang, Joëlle R Pérusse, Eman A Dashti, Miguel A Aguileta, Gian-Luca McLelland, Priti Gros, Thomas A Shaler, Denis Faubert, Benoit Coulombe, Edward A Fon
EMBO J 2014 Sep;
PMID: 25216678 [PubMed - as supplied by publisher]


Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches.
Cristina Sampaio, Beth Borowsky, Ralf Reilmann
Mov Disord 2014 Sep; 29(11):1419-28
PMID: 25216371 [PubMed - as supplied by publisher]


A familial form of parkinsonism, dementia, and motor neuron disease: A longitudinal study.
Shinsuke Fujioka, Bradley F Boeve, Joseph E Parisi, Pawel Tacik, Naoya Aoki, Audrey J Strongosky, Matt Baker, Monica Sanchez-Contreras, Owen A Ross, Rosa Rademakers, Vesna Sossi, Dennis W Dickson, A Jon Stoessl, Zbigniew K Wszolek
Parkinsonism Relat Disord 2014 Aug;
PMID: 25175602 [PubMed - as supplied by publisher]


Huntingtin-lowering strategies in Huntington's disease: Antisense oligonucleotides, small RNAs, and gene editing.
Neil Aronin, Marian DiFiglia
Mov Disord 2014 Sep; 29(11):1455-61
PMID: 25164989 [PubMed - as supplied by publisher]


A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Marlène Cassar, Abdul-Raouf Issa, Thomas Riemensperger, Céline Petitgas, Thomas Rival, Hélène Coulom, Magali Iché-Torres, Kyung-An Han, Serge Birman
Hum Mol Genet 2014 Aug;
PMID: 25158689 [PubMed - as supplied by publisher]


Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease.
David S Howland, Ignacio Munoz-Sanjuan
Mov Disord 2014 Sep; 29(11):1397-403
PMID: 25155258 [PubMed - as supplied by publisher]


Targets for future clinical trials in Huntington's disease: What's in the pipeline?
Edward J Wild, Sarah J Tabrizi
Mov Disord 2014 Sep; 29(11):1434-45
PMID: 25155142 [PubMed - as supplied by publisher]


Genetic modifiers of Huntington's disease.
James F Gusella, Marcy E MacDonald, Jong-Min Lee
Mov Disord 2014 Sep; 29(11):1359-65
PMID: 25154728 [PubMed - as supplied by publisher]


Onset of Huntington's disease: Can it be purely cognitive?
Jane S Paulsen, Jeffrey D Long
Mov Disord 2014 Sep; 29(11):1342-50
PMID: 25142616 [PubMed - as supplied by publisher]


Identification of a common founder couple for 40 South African Afrikaner families with Parkinson's disease.
Gerhard Geldenhuys, Brigitte Glanzmann, Debbie Lombard, Sihaam Boolay, Jonathan Carr, Soraya Bardien
S Afr Med J 2014 Jun; 104(6):413-9
PMID: 25214250 [PubMed - as supplied by publisher]


Dopamine transporter SLC6A3 genotype affects cortico-striatal activity of set-shifts in Parkinson's disease.
Claudine Habak, Anne Noreau, Atsuko Nagano-Saito, Beatriz Mejía-Constaín, Clotilde Degroot, Antonio P Strafella, Sylvain Chouinard, Anne-Louise Lafontaine, Guy A Rouleau, Oury Monchi
Brain 2014 Sep;
PMID: 25212851 [PubMed - as supplied by publisher]


Correlation between decreased CSF ?-synuclein and A?1-42 in Parkinson disease.
Chandana Buddhala, Meghan C Campbell, Joel S Perlmutter, Paul T Kotzbauer
Neurobiol Aging 2014 Aug;
PMID: 25212463 [PubMed - as supplied by publisher]


DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress.
Mohammad Parsanejad, Noam Bourquard, Dianbo Qu, Yi Zhang, En Huang, Maxime W C Rousseaux, Hossein Aleyasin, Isabella Irrcher, Steve Callaghan, Dominique C Vaillant, Raymond H Kim, Ruth S Slack, Tak W Mak, Srinivasa T Reddy, Daniel Figeys, David S Park
PLoS One 2014 ; 9(9):e106601
PMID: 25210784 [PubMed - as supplied by publisher]


Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.
Jerome A Roth
Neurotoxicology 2014 Aug; 44C:314-325
PMID: 25149416 [PubMed - as supplied by publisher]


Deciphering the Function and Regulation of microRNAs in Alzheimer's Disease and Parkinson's Disease.
Lifeng Qiu, Wei Zhang, Eng King Tan, Li Zeng
ACS Chem Neurosci 2014 Sep;
PMID: 25210999 [PubMed - as supplied by publisher]


Dual Small-Molecule Targeting of SMAD Signaling Stimulates Human Induced Pluripotent Stem Cells toward Neural Lineages.
Methichit Wattanapanitch, Nuttha Klincumhom, Porntip Potirat, Rattaya Amornpisutt, Chanchao Lorthongpanich, Yaowalak U-Pratya, Chuti Laowtammathron, Pakpoom Kheolamai, Niphon Poungvarin, Surapol Issaragrisil
PLoS One 2014 ; 9(9):e106952
PMID: 25207966 [PubMed - as supplied by publisher]


From yeast to patient neurons and back again: A powerful new discovery platform.
Daniel F Tardiff, Vikram Khurana, Chee Yeun Chung, Susan Lindquist
Mov Disord 2014 Sep; 29(10):1231-40
PMID: 25131316 [PubMed - as supplied by publisher]


Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease.
Long Teng, Fang Hong, Chenguang Zhang, Jiancheng He, Haiying Wang
Neural Regen Res 2014 Feb; 9(4):407-12
PMID: 25206828 [PubMed - as supplied by publisher]


The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.
Ting Zou, Xiangqi Tang, Zhiling Huang, Niangui Xu, Zhiping Hu
Neural Regen Res 2014 Feb; 9(4):402-6
PMID: 25206827 [PubMed - as supplied by publisher]


Construction of human Fab library and screening of a single-domain antibody of amyloid-beta 42 oligomers.
Zuanning Yuan, Minge Du, Yiwen Chen, Fei Dou
Neural Regen Res 2013 Nov; 8(33):3107-15
PMID: 25206631 [PubMed - as supplied by publisher]


Autophagy and neurodegenerative disorders.
Evangelia Kesidou, Roza Lagoudaki, Olga Touloumi, Kyriaki-Nefeli Poulatsidou, Constantina Simeonidou
Neural Regen Res 2013 Aug; 8(24):2275-83
PMID: 25206537 [PubMed - as supplied by publisher]


Systemic administration of valproic acid stimulates overexpression of microtubule-associated protein 2 in the spinal cord injury model to promote neurite outgrowth.
Alireza Abdanipour, Hermann J Schluesener, Taki Tiraihi, Ali Noori-Zadeh
Neurol Res 2014 Sep; :1743132814Y0000000438
PMID: 25203772 [PubMed - as supplied by publisher]


Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu, Huaibin Cai
EMBO J 2014 Sep;
PMID: 25201882 [PubMed - as supplied by publisher]


Costeff syndrome: clinical features and natural history.
Gilad Yahalom, Yair Anikster, Ruth Huna-Baron, Chen Hoffmann, Lubov Blumkin, Dorit Lev, Rakefet Tsabari, Zeev Nitsan, Sheera F Lerman, Bruria Ben-Zeev, Ben Pode-Shakked, Shira Sofer, Avraham Schweiger, Tally Lerman-Sagie, Sharon Hassin-Baer
J Neurol 2014 Sep;
PMID: 25201222 [PubMed - as supplied by publisher]


Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging.
Ananda S Prasad
J Trace Elem Med Biol 2014 Aug;
PMID: 25200490 [PubMed - as supplied by publisher]


COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population.
Chin-Hsien Lin, Hang-I Lin, Meng-Ling Chen, Ruey-Meei Wu
Neurobiol Aging 2014 Aug;
PMID: 25200193 [PubMed - as supplied by publisher]


Screening for characteristic genes in osteoarthritis induced by destabilization of the medial meniscus utilizing bioinformatics approach.
X Yang, J Zhao, Y He, X Huangfu
J Musculoskelet Neuronal Interact 2014 Sep; 14(3):343-8
PMID: 25198230 [PubMed - as supplied by publisher]


Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules.
Alice Grison, Silvia Zucchelli, Alice Urzì, Ilaria Zamparo, Dejan Lazarevic, Giovanni Pascarella, Paola Roncaglia, Alejandro Giorgetti, Paula Garcia-Esparcia, Christina Vlachouli, Roberto Simone, Francesca Persichetti, Alistair Rr Forrest, Yoshihide Hayashizaki, Paolo Carloni, Isidro Ferrer, Claudia Lodovichi, Charles Plessy, , Piero Carninci, Stefano Gustincich
BMC Genomics 2014 ; 15:729
PMID: 25164183 [PubMed - as supplied by publisher]


Mutations in the ATP13A2 Gene and Parkinsonism: A Preliminary Review.
Xinglong Yang, Yanming Xu
Biomed Res Int 2014 ; 2014:371256
PMID: 25197640 [PubMed - as supplied by publisher]


Fiber-modified adenovirus for central nervous system Parkinson's disease gene therapy.
Travis B Lewis, Joel N Glasgow, Ashley S Harms, David G Standaert, David T Curiel
Viruses 2014 Aug; 6(8):3293-310
PMID: 25196484 [PubMed - as supplied by publisher]


A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ?FosB Expression.
Michael Feyder, Erik Södersten, Emanuela Santini, Vincent Vialou, Quincey LaPlant, Emily L Watts, Giada Spigolon, Klaus Hansen, Jocelyne Caboche, Eric J Nestler, Gilberto Fisone
Biol Psychiatry 2014 Jul;
PMID: 25193242 [PubMed - as supplied by publisher]


Corrigendum: Advances in non-dopaminergic pharmacological treatments of Parkinson's disease.
Sandy Stayte, Bryce Vissel
Front Neurosci 2014 ; 8:254
PMID: 25191219 [PubMed - as supplied by publisher]


Linkage analysis and whole-exome sequencing exclude extra mutations responsible for the parkinsonian phenotype of spinocerebellar ataxia-2.
Chaodong Wang, Yanming Xu, Xiuli Feng, Jinghong Ma, Shu Xie, Yanli Zhang, Bei-Sha Tang, Piu Chan
Neurobiol Aging 2014 Aug;
PMID: 25189117 [PubMed - as supplied by publisher]


Non-SMC condensin I complex, subunit D2 gene polymorphisms are associated with Parkinson's disease: a Han Chinese study.
Ping Zhang, Ling Liu, Jinsha Huang, Liang Shao, Hongcai Wang, Nian Xiong, Tao Wang
Genome 2014 May; 57(5):253-7
PMID: 25166511 [PubMed - as supplied by publisher]


TREM2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in postmortem temporal cortices.
Lih-Fen Lue, Christopher T Schmitz, Geidy Sorrano, Lucia I Sue, Thomas G Beach, Douglas G Walker
Brain Pathol 2014 Sep;
PMID: 25186950 [PubMed - as supplied by publisher]


The Cardiovascular Actions of DOPA Mediated by the Gene Product of ocular albinism 1.
Yoshio Goshima, Fumio Nakamura, Daiki Masukawa, Sandy Chen, Motokazu Koga
J Pharmacol Sci 2014 Sep;
PMID: 25185585 [PubMed - as supplied by publisher]


Identifying and prioritizing disease-related genes based on the network topological features.
Zhan-Chao Li, Yan-Hua Lai, Li-Li Chen, Yun Xie, Zong Dai, Xiao-Yong Zou
Biochim Biophys Acta 2014 Aug;
PMID: 25183318 [PubMed - as supplied by publisher]


I716F A?PP Mutation Associates with the Deposition of Oligomeric Pyroglutamate Amyloid-? and ?-Synucleinopathy with Lewy Bodies.
Evelyn Sieczkowski, Ivan Milenkovic, Vivek Venkataramani, Regina Giera, Thomas Ströbel, Romana Höftberger, Pawe? P Liberski, Eduard Auff, Oliver Wirths, Thomas A Bayer, Gabor G Kovacs
J Alzheimers Dis 2014 Sep;
PMID: 25182745 [PubMed - as supplied by publisher]


Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD).
Anna De Rosa, Claudia Carducci, Carla Carducci, Silvio Peluso, Maria Lieto, Andrea Mazzella, Francesco Saccà, Vincenzo Brescia Morra, Sabina Pappatà, Vincenzo Leuzzi, Giuseppe De Michele
J Neurol 2014 Sep;
PMID: 25182701 [PubMed - as supplied by publisher]


Genetic diagnosis of two dopa-responsive dystonia families by exome sequencing.
Zhan-Fang Sun, Yu-Han Zhang, Ji-Feng Guo, Qi-Ying Sun, Jun-Pu Mei, Han-Lin Zhou, Li-Ping Guan, Jin-Yong Tian, Zheng-Mao Hu, Jia-da Li, Kun Xia, Xin-Xiang Yan, Bei-Sha Tang
PLoS One 2014 ; 9(9):e106388
PMID: 25181484 [PubMed - as supplied by publisher]


Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming.
Yiping Fan, Guillaume Marcy, Eddy S M Lee, Steve Rozen, Citra N Z Mattar, Simon N Waddington, Eyleen L K Goh, Mahesh Choolani, Jerry K Y Chan
PLoS One 2014 ; 9(9):e105985
PMID: 25181041 [PubMed - as supplied by publisher]


APOE, MAPT, and SNCA Genes and Cognitive Performance in Parkinson Disease.
Ignacio F Mata, James B Leverenz, Daniel Weintraub, John Q Trojanowski, Howard I Hurtig, Vivianna M Van Deerlin, Beate Ritz, Rebecca Rausch, Shannon L Rhodes, Stewart A Factor, Cathy Wood-Siverio, Joseph F Quinn, Kathryn A Chung, Amie L Peterson, Alberto J Espay, Fredy J Revilla, Johnna Devoto, Shu-Ching Hu, Brenna A Cholerton, Jia Y Wan, Thomas J Montine, Karen L Edwards, Cyrus P Zabetian
JAMA Neurol 2014 Sep;
PMID: 25178429 [PubMed - as supplied by publisher]


Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells.
Brigham J Hartley, Stewart A Fabb, Ben A L Finnin, John M Haynes, Colin W Pouton
J Vis Exp 2014 ; (90)
PMID: 25177806 [PubMed - as supplied by publisher]


Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin.
Ghazaleh Ashrafi, Julia S Schlehe, Matthew J LaVoie, Thomas L Schwarz
J Cell Biol 2014 Sep; 206(5):655-70
PMID: 25154397 [PubMed - as supplied by publisher]


Lysosomes and ?-synuclein form a dangerous duet leading to neuronal cell death.
Mathieu Bourdenx, Erwan Bezard, Benjamin Dehay
Front Neuroanat 2014 ; 8:83
PMID: 25177278 [PubMed - as supplied by publisher]


Identifying rare and common disease associated variants in genomic data using Parkinson¿s disease as a model.
Ying-Chao Lin, Ai-Ru Hsieh, Ching-Lin Hsiao, Shang-Jung Wu, Hui-Min Wang, Ie-Bin Lian, Cathy Fann
J Biomed Sci 2014 Aug; 21(1):88
PMID: 25175702 [PubMed - as supplied by publisher]


Mutation analysis of patients with neurodegenerative disorders using NeuroX array.
Mahdi Ghani, Anthony E Lang, Lorne Zinman, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi, Andrea Tedde, Maria Carmela Tartaglia, Ezequiel I Surace, Christine Sato, Danielle Moreno, Zhengrui Xi, Rachel Hung, Mike A Nalls, Andrew Singleton, Peter St George-Hyslop, Ekaterina Rogaeva
Neurobiol Aging 2014 Aug;
PMID: 25174650 [PubMed - as supplied by publisher]


Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
Jang-Won Lee, Victor Tapias, Roberto Di Maio, J Timothy Greenamyre, Jason R Cannon
Neurobiol Aging 2014 Jul;
PMID: 25174649 [PubMed - as supplied by publisher]


Zebrafish as a systems toxicology model for developmental neurotoxicity testing.
Yuhei Nishimura, Soichiro Murakami, Yoshifumi Ashikawa, Shota Sasagawa, Noriko Umemoto, Yasuhito Shimada, Toshio Tanaka
Congenit Anom (Kyoto) 2014 Sep;
PMID: 25174267 [PubMed - as supplied by publisher]


Improvement of Neurological Dysfunctions in Aphakia Mice, a Model of Parkinson's Disease, after Transplantation of ES Cell-Derived Dopaminergic Neuronal Precursors.
Sangmi Chung, Jisook Moon, Kwang-Soo Kim
Methods Mol Biol 2014 ; 1213:285-91
PMID: 25173391 [PubMed - as supplied by publisher]


Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression.
XinJian Liu, Qian Huang, Fang Li, Chuan-Yuan Li
Sci China Life Sci 2014 Sep; 57(9):867-75
PMID: 25129808 [PubMed - as supplied by publisher]


Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease.
Hindol Rakshit, Nitin Rathi, Debjani Roy
PLoS One 2014 ; 9(8):e103047
PMID: 25170921 [PubMed - as supplied by publisher]


Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.
Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Birgit Schüle, Jeff Alexander, William Wallace, Glenda M Halliday, J William Langston, Scott Braxton, Ted Yednock, Thomas Shaler, Jennifer A Johnston
PLoS One 2014 ; 9(8):e102909
PMID: 25170892 [PubMed - as supplied by publisher]


Vitamin D receptor gene polymorphisms and the risk of Parkinson's disease.
Chunlei Li, Huiping Qi, Shuqin Wei, Le Wang, Xiaoxue Fan, Shurong Duan, Sheng Bi
Neurol Sci 2014 Aug;
PMID: 25169913 [PubMed - as supplied by publisher]


Association of rs62063857 Variant of the Saitohin Gene with Parkinson's Disease.
Ezgi Sonmez, Mavi Deniz Ozel, Eylul Ece Islek, Ali Sazci, Halil Atilla Idrisoglu
Cell Mol Neurobiol 2014 Aug;
PMID: 25168738 [PubMed - as supplied by publisher]


Cognitive impairment in carriers of glucocerebrosidase gene mutation in Parkinson disease patients.
Michalina Malec-Litwinowicz, Monika Rudzi?ska, Micha? Szubiga, Micha? Michalski, Tomasz Tomaszewski, Andrzej Szczudlik
Neurol Neurochir Pol 2014 ; 48(4):258-61
PMID: 25168325 [PubMed - as supplied by publisher]


Phenotypic variability of PINK1 expression: 12 Years' clinical follow-up of two Italian families.
Lucia Ricciardi, Simona Petrucci, Arianna Guidubaldi, Tamara Ialongo, Laura Serra, Alessandro Ferraris, Barbara Spanò, Marco Bozzali, Enza Maria Valente, Anna Rita Bentivoglio
Mov Disord 2014 Aug;
PMID: 25164310 [PubMed - as supplied by publisher]


Gene Therapy for the Nervous System: Challenges and New Strategies.
Casey A Maguire, Servio H Ramirez, Steven F Merkel, Miguel Sena-Esteves, Xandra O Breakefield
Neurotherapeutics 2014 Aug;
PMID: 25159276 [PubMed - as supplied by publisher]


Cadherin-8 expression, synaptic localization and molecular control of neuronal form in prefrontal cortico-striatal circuits.
Lauren G Friedman, Fréderike W Riemslagh, Josefa M Sullivan, Roxana Mesias, Frances M Williams, George W Huntley, Deanna L Benson
J Comp Neurol 2014 Aug;
PMID: 25158904 [PubMed - as supplied by publisher]


Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
M Ingallinesi, L Le Bouil, N Faucon Biguet, A Do Thi, C Mannoury la Cour, M J Millan, P Ravassard, J Mallet, R Meloni
Mol Psychiatry 2014 Aug;
PMID: 25155879 [PubMed - as supplied by publisher]


Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus].
Yang Chen, Ying-Hui Lü, Zhao-Fa Li
Yao Xue Xue Bao 2014 May; 49(5):576-81
PMID: 25151724 [PubMed - as supplied by publisher]


Parkinson's disease and mitochondrial gene variations: A review.
Sasan Andalib, Manouchehr Seyedi Vafaee, Albert Gjedde
J Neurol Sci 2014 Aug;
PMID: 25151610 [PubMed - as supplied by publisher]


Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2-Nrf2 signaling pathway.
Xiao-Li Wang, Gui-Hua Xing, Bo Hong, Xiao-Ming Li, Yu Zou, Xiao-Jie Zhang, Miao-Xian Dong
Life Sci 2014 Aug;
PMID: 25132361 [PubMed - as supplied by publisher]


Novel DYT11 gene mutation in patients without dopaminergic deficit (SWEDD) screened for dystonia.
Roberto Cilia, Chiara Reale, Anna Castagna, Alessia Nasca, Marco Muzi-Falconi, Chiara Barzaghi, Alberto Marzegan, Magda Granata, Giorgio Marotta, Giorgio Sacilotto, Davide Vallauri, Gianni Pezzoli, Stefano Goldwurm, Barbara Garavaglia
Neurology 2014 Aug;
PMID: 25150291 [PubMed - as supplied by publisher]


Mitochondrial acetylation and genetic models of Parkinson's disease.
Georg Auburger, Suzana Gispert, Marina Jendrach
Prog Mol Biol Transl Sci 2014 ; 127:155-82
PMID: 25149217 [PubMed - as supplied by publisher]


Air Pollution and Children: Neural and Tight Junction Antibodies and Combustion Metals, the Role of Barrier Breakdown and Brain Immunity in Neurodegeneration.
Lilian Calderón-Garcidueñas, Aristo Vojdani, Eleonore Blaurock-Busch, Yvette Busch, Albrecht Friedle, Maricela Franco-Lira, Partha Sarathi-Mukherjee, Su-Bin Park, Ricardo Torres-Jardón, Amedeo D'Angiulli
J Alzheimers Dis 2014 Aug;
PMID: 25147109 [PubMed - as supplied by publisher]


RIT2, a susceptibility gene for Parkinson's disease in Iranian population.
Babak Emamalizadeh, Abolfazl Movafagh, Mojdeh Akbari, Somayyeh Kazeminasab, Atena Fazeli, Marzieh Motallebi, Gholam-Ali Shahidi, Peyman Petramfar, Reza Mirfakhraie, Hossein Darvish
Neurobiol Aging 2014 Jul;
PMID: 25146456 [PubMed - as supplied by publisher]


UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease.
Kai Wu, Jia Liu, Na Zhuang, Tao Wang
FASEB J 2014 Aug;
PMID: 25145627 [PubMed - as supplied by publisher]


Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.
Michaela Matthes, Martin Preusse, Jingzhong Zhang, Julia Schechter, Daniela Mayer, Bernd Lentes, Fabian Theis, Nilima Prakash, Wolfgang Wurst, Dietrich Trümbach
Database (Oxford) 2014 ; 2014
PMID: 25145340 [PubMed - as supplied by publisher]


DYT16 revisited: Exome sequencing identifies PRKRA mutations in a European dystonia family.
Michael Zech, Florian Castrop, Barbara Schormair, Angela Jochim, Thomas Wieland, Nadine Gross, Peter Lichtner, Annette Peters, Christian Gieger, Thomas Meitinger, Tim M Strom, Konrad Oexle, Bernhard Haslinger, Juliane Winkelmann
Mov Disord 2014 Aug;
PMID: 25142429 [PubMed - as supplied by publisher]


Lardy brains make Parkinson's disease mice worse.
Mark R Cookson
J Neurochem 2014 Aug;
PMID: 25142063 [PubMed - as supplied by publisher]


Parkinson's disease pharmacogenomics: new findings and perspectives.
Artur F Schumacher-Schuh, Carlos Rm Rieder, Mara H Hutz
Pharmacogenomics 2014 Jun; 15(9):1253-71
PMID: 25141900 [PubMed - as supplied by publisher]


Alternative Splicing Generates Different Parkin Protein Isoforms: Evidences in Human, Rat, and Mouse Brain.
Soraya Scuderi, Valentina La Cognata, Filippo Drago, Sebastiano Cavallaro, Velia D'Agata
Biomed Res Int 2014 ; 2014:690796
PMID: 25136611 [PubMed - as supplied by publisher]


Genetic factors and manganese-induced neurotoxicity.
Pan Chen, Nancy Parmalee, Michael Aschner
Front Genet 2014 ; 5:265
PMID: 25136353 [PubMed - as supplied by publisher]


Cardiac Sympathetic Denervation in 6-OHDA-Treated Nonhuman Primates.
Valerie Joers, Kristine Dilley, Shahrose Rahman, Corinne Jones, Jeanette Shultz, Heather Simmons, Marina E Emborg
PLoS One 2014 ; 9(8):e104850
PMID: 25133405 [PubMed - as supplied by publisher]


Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions.
Michael H Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C Hermida, Ruana Tiseo, Linda L Sackett-Lundeen, Erhard L Haus
Sleep Med Rev 2014 Jul;
PMID: 25129839 [PubMed - as supplied by publisher]


SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.
Xiao Yan Guo, Yong Ping Chen, Wei Song, Bi Zhao, Bei Cao, Qian Qian Wei, Ru Wei Ou, Yuan Yang, Li Xing Yuan, Hui-Fang Shang
Neurobiol Aging 2014 Jul;
PMID: 25129240 [PubMed - as supplied by publisher]


Quercetin Glycosides Induced Neuroprotection by Changes in the Gene Expression in a Cellular Model of Parkinson's Disease.
Kasthuri Bai Magalingam, Ammu Radhakrishnan, Premdass Ramdas, Nagaraja Haleagrahara
J Mol Neurosci 2014 Aug;
PMID: 25129099 [PubMed - as supplied by publisher]


Interest in Genetic Testing in Ashkenazi Jewish Parkinson's Disease Patients and Their Unaffected Relatives.
Manisha Gupte, Roy N Alcalay, Helen Mejia-Santana, Deborah Raymond, Rachel Saunders-Pullman, Ernest Roos, Martha Orbe-Reily, Ming-X Tang, Anat Mirelman, Laurie Ozelius, Avi Orr-Urtreger, Lorraine Clark, Nir Giladi, Susan Bressman, Karen Marder
J Genet Couns 2014 Aug;
PMID: 25127731 [PubMed - as supplied by publisher]


Cognitive dysfunction in Parkinson's disease related to the R1441G mutation in LRRK2.
A Estanga, M C Rodriguez-Oroz, J Ruiz-Martinez, M Barandiaran, A Gorostidi, A Bergareche, E Mondragon, A Lopez de Munain, J F Marti-Masso
Parkinsonism Relat Disord 2014 Jul;
PMID: 25127457 [PubMed - as supplied by publisher]


Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders.
Ronald W Irwin, Christine M Solinsky, Roberta Diaz Brinton
Front Cell Neurosci 2014 ; 8:203
PMID: 25126056 [PubMed - as supplied by publisher]


GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
S Bellani, A Mescola, G Ronzitti, H Tsushima, S Tilve, C Canale, F Valtorta, E Chieregatti
Cell Death Differ 2014 Aug;
PMID: 25124556 [PubMed - as supplied by publisher]


Addition of exogenous ?-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous ?-synuclein to Lewy body and Lewy neurite-like aggregates.
Laura A Volpicelli-Daley, Kelvin C Luk, Virginia M-Y Lee
Nat Protoc 2014 Sep; 9(9):2135-46
PMID: 25122523 [PubMed - as supplied by publisher]