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Sheng-Han Kuo, M.D.

“The PDF Côté Award [in Clinical Genetics] helped me to start my research.”

Sheng-Han Kuo, M.D.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

Impulse Control Disorder

Vision/Visual hallucination



Orthostatic Hypotension


Imaging Studies

Clinical Studies



Treating Parkinson’s

Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

Deep Brain Stimulation

Physical, Occupational and Speech Therapy



Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

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Possible Mechanisms Underlying the Therapeutic Effects of Transcranial Magnetic Stimulation.
Alexander V Chervyakov, Andrey Yu Chernyavsky, Dmitry O Sinitsyn, Michael A Piradov
Front Hum Neurosci 2015 ; 9:303
PMID: 26136672 [PubMed - as supplied by publisher]

Imaging pathological tau in atypical parkinsonian disorders.
Sarah Coakeley, Antonio P Strafella
Curr Opin Neurol 2015 Aug; 28(4):447-52
PMID: 26110795 [PubMed - as supplied by publisher]

Dopa-responsive dystonia-clinical and genetic heterogeneity.
Subhashie Wijemanne, Joseph Jankovic
Nat Rev Neurol 2015 Jul; 11(7):414-424
PMID: 26100751 [PubMed - as supplied by publisher]

Restoration of synaptic function in sight for degenerative retinal disease.
Timm Schubert, Bernd Wissinger
J Clin Invest 2015 Jul; 125(7):2572-5
PMID: 26098210 [PubMed - as supplied by publisher]

GIGYF2 mutation in late-onset Parkinson's disease with cognitive impairment.
Javier Ruiz-Martinez, Catharine E Krebs, Vladimir Makarov, Ana Gorostidi, Jose Félix Martí-Massó, Coro Paisán-Ruiz
J Hum Genet 2015 Jul;
PMID: 26134514 [PubMed - as supplied by publisher]

A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Tine Holemans, Danny Mollerup Sørensen, Sarah van Veen, Shaun Martin, Diane Hermans, Gerdi Christine Kemmer, Chris Van den Haute, Veerle Baekelandt, Thomas Günther Pomorski, Patrizia Agostinis, Frank Wuytack, Michael Palmgren, Jan Eggermont, Peter Vangheluwe
Proc Natl Acad Sci U S A 2015 Jul;
PMID: 26134396 [PubMed - as supplied by publisher]

Cerebrospinal fluid tau and amyloid-?1-42 in patients with dementia.
Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg
Brain 2015 Jun;
PMID: 26133663 [PubMed - as supplied by publisher]

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.
Jingzhong Zhang, Sebastian Götz, Daniela M Vogt Weisenhorn, Antonio Simeone, Wolfgang Wurst, Nilima Prakash
Neurobiol Dis 2015 Jun; 82:32-45
PMID: 26049140 [PubMed - as supplied by publisher]

Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease.
Kun-Ling Tsai, Yuan-Yang Cheng, Hsin-Bang Leu, Yi-Yen Lee, Tzeng-Ji Chen, Ding-Hao Liu, Chung-Lan Kao
Neurobiol Aging 2015 Jun;
PMID: 26130063 [PubMed - as supplied by publisher]

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease.
A Miyashita, H Hatsuta, M Kikuchi, A Nakaya, Y Saito, T Tsukie, N Hara, S Ogishima, N Kitamura, K Akazawa, A Kakita, H Takahashi, S Murayama, Y Ihara, T Ikeuchi, R Kuwano,
Transl Psychiatry 2014 ; 4:e396
PMID: 26126179 [PubMed - as supplied by publisher]

Identification of Candidate Adherent-Invasive E. coli Signature Transcripts by Genomic/Transcriptomic Analysis.
Yuanhao Zhang, Leahana Rowehl, Julia M Krumsiek, Erika P Orner, Nurmohammad Shaikh, Phillip I Tarr, Erica Sodergren, George M Weinstock, Edgar C Boedeker, Xuejian Xiong, John Parkinson, Daniel N Frank, Ellen Li, Grace Gathungu
PLoS One 2015 ; 10(6):e0130902
PMID: 26125937 [PubMed - as supplied by publisher]

Potential hippocampal genes and pathways involved in Alzheimer's disease: a bioinformatic analysis.
L Zhang, X Q Guo, J F Chu, X Zhang, Z R Yan, Y Z Li
Genet Mol Res 2015 ; 14(2):7218-32
PMID: 26125932 [PubMed - as supplied by publisher]

Association of CHRNA4 gene rs1044396 and rs1044397 polymorphisms with Parkinson's disease symptoms and smoking.
L M Zhang, X P Zhang, Y Q Chen, W Ye
Genet Mol Res 2015 ; 14(2):5112-22
PMID: 26125703 [PubMed - as supplied by publisher]

Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: The Normative Aging Study.
Rachel Grashow, David Sparrow, Howard Hu, Marc G Weisskopf
Neurotoxicology 2015 Jun;
PMID: 26121922 [PubMed - as supplied by publisher]

Gene-based vaccines and immunotherapeutic strategies against neurodegenerative diseases: Potential utility and limitations.
Jeremy J Kudrna, Kenneth E Ugen
Hum Vaccin Immunother 2015 Jun; :0
PMID: 26125436 [PubMed - as supplied by publisher]

Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia.
Simone Bido, Nicola Solari, Marzia Indrigo, Angela D'Antoni, Riccardo Brambilla, Michele Morari, Stefania Fasano
Ann Clin Transl Neurol 2015 Jun; 2(6):662-78
PMID: 26125041 [PubMed - as supplied by publisher]

Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
Chun-Hyung Kim, Baek-Soo Han, Jisook Moon, Deog-Joong Kim, Joon Shin, Sreekanth Rajan, Quoc Toan Nguyen, Mijin Sohn, Won-Gon Kim, Minjoon Han, Inhye Jeong, Kyoung-Shim Kim, Eun-Hye Lee, Yupeng Tu, Jacqueline L Naffin-Olivos, Chang-Hwan Park, Dagmar Ringe, Ho Sup Yoon, Gregory A Petsko, Kwang-Soo Kim
Proc Natl Acad Sci U S A 2015 Jun;
PMID: 26124091 [PubMed - as supplied by publisher]

Selective Expression of Parkinson's disease-related Leucine-rich Repeat Kinase 2 G2019S Missense Mutation in Midbrain Dopaminergic Neurons Impairs Dopamine Release and Dopaminergic Gene Expression.
Guoxiang Liu, Carmelo Sgobio, Xinglong Gu, Lixin Sun, Xian Lin, Jia Yu, Loukia Parisiadou, Chengsong Xie, Namratha Sastry, Jinhui Ding, Kelly M Lohr, Gary W Miller, Yolanda Mateo, David M Lovinger, Huaibin Cai
Hum Mol Genet 2015 Jun;
PMID: 26123485 [PubMed - as supplied by publisher]

Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Xiaoling Li, Hongmei Liu, Paula L Fischhaber, Tie-Shan Tang
Prog Neurobiol 2015 Jun;
PMID: 26123252 [PubMed - as supplied by publisher]

Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.
Matthew Hamm, Rachel Bailey, Gerry Shaw, Shu-Hui Yen, Jada Lewis, Benoit I Giasson
J Neurosci Res 2015 Jun;
PMID: 26123245 [PubMed - as supplied by publisher]

Gene therapy for neurodegenerative diseases.
Deirdre M O'Connor, Nicholas M Boulis
Trends Mol Med 2015 Jun;
PMID: 26122838 [PubMed - as supplied by publisher]

Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway.
X S Zhang, S Ha, X L Wang, Y L Shi, S S Duan, Z A Li
Neuroscience 2015 Jun;
PMID: 26116522 [PubMed - as supplied by publisher]

Age-related gene expression changes in substantia nigra dopamine neurons of the rat.
Gemma M Parkinson, Christopher V Dayas, Doug W Smith
Mech Ageing Dev 2015 Jun; 149:41-49
PMID: 26065381 [PubMed - as supplied by publisher]

Biological factors underlying sex differences in neurological disorders.
Hannah Loke, Vincent Harley, Joohyung Lee
Int J Biochem Cell Biol 2015 May; 65:139-150
PMID: 26028290 [PubMed - as supplied by publisher]

Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection.
Liting Hang, John Thundyil, Kah-Leong Lim
Ann N Y Acad Sci 2015 Jun;
PMID: 26121488 [PubMed - as supplied by publisher]

Nrf2-ARE signals mediated the anti-oxidative action of electro-acupuncture in an MPTP mouse model of Parkinson's disease.
E Lv, Jiahui Deng, Yan Yu, Yalong Wang, Xiaoli Gong, Jun Jia, Xiaomin Wang
Free Radic Res 2015 Jun; :1-30
PMID: 26118717 [PubMed - as supplied by publisher]

Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations.
Roy N Alcalay, Oren A Levy, Cheryl C Waters, Stanley Fahn, Blair Ford, Sheng-Han Kuo, Pietro Mazzoni, Michael W Pauciulo, William C Nichols, Ziv Gan-Or, Guy A Rouleau, Wendy K Chung, Pavlina Wolf, Petra Oliva, Joan Keutzer, Karen Marder, Xiaokui Zhang
Brain 2015 Jun;
PMID: 26117366 [PubMed - as supplied by publisher]

Genetic determinants of swallowing impairments among community dwelling older population.
Alicja Raginis-Zborowska, Krisztina Mekli, Antony Payton, William Ollier, Shaheen Hamdy, Neil Pendleton
Exp Gerontol 2015 Jun;
PMID: 26116289 [PubMed - as supplied by publisher]

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells.
Giulia Ambrosi, Cristina Ghezzi, Roberta Zangaglia, Giovanna Levandis, Claudio Pacchetti, Fabio Blandini
Neurobiol Dis 2015 Jun;
PMID: 26094596 [PubMed - as supplied by publisher]

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
Agne Kazlauskaite, R Julio Martínez-Torres, Scott Wilkie, Atul Kumar, Julien Peltier, Alba Gonzalez, Clare Johnson, Jinwei Zhang, Anthony G Hope, Mark Peggie, Matthias Trost, Daan Mf van Aalten, Dario R Alessi, Alan R Prescott, Axel Knebel, Helen Walden, Miratul Mk Muqit
EMBO Rep 2015 Jun;
PMID: 26116755 [PubMed - as supplied by publisher]

Role of 5-hydroxymethylcytosine in neurodegeneration.
Shariq I Sherwani, Haseeb A Khan
Gene 2015 Jun;
PMID: 26115768 [PubMed - as supplied by publisher]

Targeted Overexpression of ?-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse.
Lian-Kun Song, Kai-Li Ma, Yu-He Yuan, Zheng Mu, Xiu-Yun Song, Fei Niu, Ning Han, Nai-Hong Chen
PLoS One 2015 ; 10(6):e0131281
PMID: 26114655 [PubMed - as supplied by publisher]

Mitochondrial Dysfunction in Parkinson's Disease.
Hyo Eun Moon, Sun Ha Paek
Exp Neurobiol 2015 Jun; 24(2):103-16
PMID: 26113789 [PubMed - as supplied by publisher]

The initial stage of reversal learning is impaired in mice hemizygous for the vesicular glutamate transporter VGluT1.
Björn Granseth, Fredrik K Andersson, Sarah H Lindström
Genes Brain Behav 2015 Jun;
PMID: 26113146 [PubMed - as supplied by publisher]

ApaI, BsmI, FokI, and TaqI Polymorphisms in the Vitamin D Receptor Gene and Parkinson's Disease.
Meng-Yue Niu, Lei Wang, An-Mu Xie
Chin Med J (Engl) 2015 5th Jul; 128(13):1809-1814
PMID: 26112724 [PubMed - as supplied by publisher]

Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.
Rosa Lippolis, Rosa Anna Siciliano, Consiglia Pacelli, Anna Ferretta, Maria Fiorella Mazzeo, Salvatore Scacco, Francesco Papa, Antonio Gaballo, Claudia Dell'Aquila, Michele De Mari, Sergio Papa, Tiziana Cocco
Biochim Biophys Acta 2015 Jun;
PMID: 26096686 [PubMed - as supplied by publisher]

Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should it be classified together as traumatic encephalopathy?
Patricia M Washington, Sonia Villapol, Mark P Burns
Exp Neurol 2015 Jun;
PMID: 26091850 [PubMed - as supplied by publisher]

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3? signaling pathway.
Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo, Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano
Hum Mol Genet 2015 Jun;
PMID: 26056228 [PubMed - as supplied by publisher]

The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease.
R B Mounsey, H L Martin, M C Nelson, R M Evans, P Teismann
Neuroscience 2015 Aug; 300:576-84
PMID: 26028469 [PubMed - as supplied by publisher]

Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy.
Marina Theodorou, Benedict Rauser, Jingzhong Zhang, Nilima Prakash, Wolfgang Wurst, Joel A Schick
Hum Gene Ther Methods 2015 Jun;
PMID: 26107288 [PubMed - as supplied by publisher]

Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease.
Naomi P Visanji, Iman Kamali Sarvestani, Meaghan C Creed, Zahra Shams Shoaei, José N Nobrega, Clement Hamani, Lili-Naz Hazrati
Front Cell Neurosci 2015 ; 9:221
PMID: 26106299 [PubMed - as supplied by publisher]

Optogenetic probing of mitochondrial damage responses.
Wei Yuan Yang
Ann N Y Acad Sci 2015 Jun;
PMID: 26104771 [PubMed - as supplied by publisher]

Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease.
Carmen Noelker, Lixia Lu, Matthias Höllerhage, Franca Vulinovic, Annekathrin Sturn, René Roscher, Günter U Höglinger, Etienne C Hirsch, Wolfgang H Oertel, Daniel Alvarez-Fischer, Hartmann Andreas
J Neurol Sci 2015 Jun;
PMID: 26104567 [PubMed - as supplied by publisher]

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Cathrin Meissner, Holger Lorenz, Beate Hehn, Marius K Lemberg
Autophagy 2015 Jun; :0
PMID: 26101826 [PubMed - as supplied by publisher]

Splicing variants of porcine synphilin-1.
Knud Larsen, Lone Bruhn Madsen, Leila Farajzadeh, Christian Bendixen
Meta Gene 2015 Sep; 5:32-42
PMID: 26101749 [PubMed - as supplied by publisher]

Pathways to Parkinsonism Redux: Convergent pathobiological mechanisms in genetics of Parkinson's disease.
Ravindran Kumaran, Mark R Cookson
Hum Mol Genet 2015 Jun;
PMID: 26101198 [PubMed - as supplied by publisher]

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.
Anne-Sophie Van Rompuy, Marusela Oliveras-Salvá, Anke Van der Perren, Olga Corti, Chris Van den Haute, Veerle Baekelandt
Mol Neurodegener 2015 ; 10(1):23
PMID: 26099628 [PubMed - as supplied by publisher]

Association of the COQ2 V393A Variant with Parkinson's Disease: A Case-Control Study and Meta-Analysis.
Xinglong Yang, Jing Xi, Quanzhen Zhao, Hua Jia, Ran An, Zhuolin Liu, Yanming Xu
PLoS One 2015 ; 10(6):e0130970
PMID: 26098829 [PubMed - as supplied by publisher]

The roles of redox enzymes in Parkinson's disease: Focus on glutaredoxin.
William M Johnson, Amy L Wilson-Delfosse, Shu G Chen, John J Mieyal
Ther Targets Neurol Dis 2015; 2(2)
PMID: 26097894 [PubMed - as supplied by publisher]

Gaucher disease and comorbidities: B-cell malignancy and parkinsonism.
Timothy M Cox, Barry E Rosenbloom, Roger A Barker
Am J Hematol 2015 Jul; 90 Suppl 1:S25-8
PMID: 26096744 [PubMed - as supplied by publisher]

l-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or l-Dopa history.
Lufei Shan, Oscar Diaz, Yajun Zhang, Bruce Ladenheim, Jean-Lud Cadet, Yung-Hsiao Chiang, Lars Olson, Barry J Hoffer, Cristina M Bäckman
Brain Res 2015 Jun;
PMID: 26086365 [PubMed - as supplied by publisher]

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.
Jean-Marc Taymans, Aurore Nkiliza, Marie-Christine Chartier-Harlin
Trends Mol Med 2015 Jun;
PMID: 26091824 [PubMed - as supplied by publisher]

Heme Oxygenase 1 and 2 Common Genetic Variants and Risk for Essential Tremor.
Pedro Ayuso, José A G Agúndez, Hortensia Alonso-Navarro, Carmen Martínez, Julián Benito-León, Sara Ortega-Cubero, Oswaldo Lorenzo-Betancor, Pau Pastor, Tomás López-Alburquerque, Elena García-Martín, Félix J Jiménez-Jiménez
Medicine (Baltimore) 2015 Jun; 94(24):e968
PMID: 26091465 [PubMed - as supplied by publisher]

Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson's Disease Locus.
Catherine Labbé, Kotaro Ogaki, Oswaldo Lorenzo-Betancor, Minerva M Carrasquillo, Michael G Heckman, Allan McCarthy, Alexandra I Soto-Ortolaza, Ronald L Walton, Timothy Lynch, Joanna Siuda, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Krzysztof Czyzewski, Dennis W Dickson, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross
PLoS One 2015 ; 10(6):e0128586
PMID: 26090850 [PubMed - as supplied by publisher]

The epigenetics of aging and neurodegeneration.
Roy Lardenoije, Artemis Iatrou, Gunter Kenis, Konstantinos Kompotis, Harry W M Steinbusch, Diego Mastroeni, Paul Coleman, Cynthia A Lemere, Patrick R Hof, Daniel L A van den Hove, Bart P F Rutten
Prog Neurobiol 2015 Jun;
PMID: 26072273 [PubMed - as supplied by publisher]

New macrophage models of Gaucher disease offer new tools for drug development.
Daniel K Borger, Ellen Sidransky, Elma Aflaki
Macrophage (Houst) 2015; 2(1):e712
PMID: 26090519 [PubMed - as supplied by publisher]

Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.
Myungjin Kim, Ian Semple, Boyoung Kim, Alexandra Kiers, Samuel Nam, Hwan-Woo Park, Haeli Park, Seung-Hyun Ro, Jeong-Sig Kim, Gábor Juhász, Jun Hee Lee
Autophagy 2015 Jun; :0
PMID: 26086452 [PubMed - as supplied by publisher]

PRKAG2 mutation: An easily missed cardiac specific non-lysosomal glycogenosis.
Varun Aggarwal, Nancy Dobrolet, Steven Fishberger, Jenny Zablah, Parul Jayakar, Zineb Ammous
Ann Pediatr Cardiol 2015 May-Aug; 8(2):153-6
PMID: 26085771 [PubMed - as supplied by publisher]

Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson's disease patients.
Gabriela S Longo, Marcela A S Pinhel, Michele L Gregório, Bruno A P Oliveira, Driele C G Quinhoneiro, Waldir A Tognola, Fábio N Oliveira, Sabrina M Cezario, Caroline L Sado, Marcelo A Nakazone, Maria C J Calastri, Dorotéia R S Souza
Arq Neuropsiquiatr 2015 Jun; 73(6):506-9
PMID: 26083886 [PubMed - as supplied by publisher]

?-Synuclein strains cause distinct synucleinopathies after local and systemic administration.
W Peelaerts, L Bousset, A Van der Perren, A Moskalyuk, R Pulizzi, M Giugliano, C Van den Haute, R Melki, V Baekelandt
Nature 2015 Jun; 522(7556):340-4
PMID: 26061766 [PubMed - as supplied by publisher]

Association of Polymorphism of Neuronal Nitric Oxide Synthase Gene with Risk to Parkinson's Disease.
Satya Prakash Gupta, Ritul Kamal, Sarad Kumar Mishra, Maneesh Kumar Singh, Rakesh Shukla, Mahendra Pratap Singh
Mol Neurobiol 2015 Jun;
PMID: 26081147 [PubMed - as supplied by publisher]

Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model.
Neha Sharma, Bimla Nehru
Mol Neurobiol 2015 Jun;
PMID: 26081143 [PubMed - as supplied by publisher]

LRRK2 Pharmacological Inhibition Abates ?-Synuclein Induced Neurodegeneration.
João P L Daher, Hisham A Abdelmotilib, Xianzhen Hu, Laura A Volpicelli-Daley, Mark S Moehle, Kyle B Faser, Elie Needle, Yi Chen, Stefanus J Steyn, Paul Galatsis, Warren D Hirst, Andrew B West
J Biol Chem 2015 Jun;
PMID: 26078453 [PubMed - as supplied by publisher]

Candidate genes for Parkinson disease: Lessons from pathogenesis.
Priscilla De Rosa, Elettra Sara Marini, Vania Gelmetti, Enza Maria Valente
Clin Chim Acta 2015 Jun;
PMID: 26048192 [PubMed - as supplied by publisher]

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
Olena Korvatska, James B Leverenz, Suman Jayadev, Pamela McMillan, Irina Kurtz, Xindi Guo, Malia Rumbaugh, Mark Matsushita, Santhosh Girirajan, Michael O Dorschner, Kostantin Kiianitsa, Chang-En Yu, Zoran Brkanac, Gwenn A Garden, Wendy H Raskind, Thomas D Bird
JAMA Neurol 2015 Jun;
PMID: 26076170 [PubMed - as supplied by publisher]

Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells.
Begum Alural, Aysegul Ozerdem, Jens Allmer, Kursad Genc, Sermin Genc
Front Cell Neurosci 2015 ; 9:209
PMID: 26074776 [PubMed - as supplied by publisher]

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.
Michael W Weiner, Dallas P Veitch, Paul S Aisen, Laurel A Beckett, Nigel J Cairns, Jesse Cedarbaum, Robert C Green, Danielle Harvey, Clifford R Jack, William Jagust, Johan Luthman, John C Morris, Ronald C Petersen, Andrew J Saykin, Leslie Shaw, Li Shen, Adam Schwarz, Arthur W Toga, John Q Trojanowski,
Alzheimers Dement 2015 Jun; 11(6):e1-e120
PMID: 26073027 [PubMed - as supplied by publisher]

Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population.
Leyla Haghnejad, Babak Emamalizadeh, Javad Jamshidi, Alireza Zare Bidoki, Hamid Ghaedi, Ehsan Ahmadi, Shokoufeh Abdollahi, Neda Shahmohammadibeni, Shaghayegh Taghavi, Atena Fazeli, Marzieh Motallebi, Amir Ehtesham Shafiei Zarneh, Saeed Mohammadihosseinabad, Mohammad Reza Abbaszadegan, Shahram Torkamandi, Masoumeh Amini Gavenaroudi, Negar Pedram, Gholam-Ali Shahidi, Abbas Tafakhori, Hossein Darvish, Abolfazl Movafagh
J Neurol Sci 2015 May;
PMID: 26070653 [PubMed - as supplied by publisher]

Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo.
Hyung-Wook Kim, Won-Seok Choi, Noah Sorscher, Hyung Joon Park, François Tronche, Richard D Palmiter, Zhengui Xia
Neurobiol Aging 2015 May;
PMID: 26070241 [PubMed - as supplied by publisher]

Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses.
Diego Iacono, Maria Geraci-Erck, Hui Peng, Marcie L Rabin, Roger Kurlan
Tremor Other Hyperkinet Mov (N Y) 2015 ; 5
PMID: 26069855 [PubMed - as supplied by publisher]

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Wambui S Wandu, Cuiyan Tan, Osato Ogbeifun, Barbara P Vistica, Guangpu Shi, Samuel J H Hinshaw, Chengsong Xie, Xi Chen, Dennis M Klinman, Huaibin Cai, Igal Gery
PLoS One 2015 ; 10(6):e0128906
PMID: 26067490 [PubMed - as supplied by publisher]

Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach.
Qi Ni, Xianming Su, Jingqi Chen, Weidong Tian
Biomed Res Int 2015 ; 2015:432012
PMID: 26064912 [PubMed - as supplied by publisher]

Neural Progenitor Cells Derived from Human Embryonic Stem Cells as an Origin of Dopaminergic Neurons.
Parinya Noisa, Taneli Raivio, Wei Cui
Stem Cells Int 2015 ; 2015:647437
PMID: 26064138 [PubMed - as supplied by publisher]

Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium.
Karen Marder, Yuanjia Wang, Roy N Alcalay, Helen Mejia-Santana, Ming-Xin Tang, Annie Lee, Deborah Raymond, Anat Mirelman, Rachel Saunders-Pullman, Lorraine Clark, Laurie Ozelius, Avi Orr-Urtreger, Nir Giladi, Susan Bressman,
Neurology 2015 Jun;
PMID: 26062626 [PubMed - as supplied by publisher]

Head injury, ?-synuclein Rep1 and Parkinson's disease: a meta-analytic view of gene-environment interaction.
S M Goldman, D M Umbach, F Kamel, C M Tanner
Eur J Neurol 2015 Jul; 22(7):e75
PMID: 26060929 [PubMed - as supplied by publisher]

Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial.
C Warren Olanow, Raymond T Bartus, Tiffany L Baumann, Stewart Factor, Nicholas Boulis, Mark Stacy, Dennis A Turner, William Marks, Paul Larson, Phillip A Starr, Joseph Jankovic, Richard Simpson, Ray Watts, Barton Guthrie, Kathleen Poston, Jaimie M Henderson, Matthew Stern, Gordon Baltuch, Christopher G Goetz, Christopher Herzog, Jeffrey H Kordower, Ron Alterman, Andres M Lozano, Anthony E Lang
Ann Neurol 2015 Jun;
PMID: 26061140 [PubMed - as supplied by publisher]

Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population.
Yongping Chen, Xueping Chen, Xiaoyan Guo, Wei Song, Bei Cao, Qianqian Wei, Ruwei Ou, Bi Zhao, Hui-Fang Shang
Neurol Sci 2015 Jun;
PMID: 26058955 [PubMed - as supplied by publisher]

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.
Shengli Xu, Piu Chan
Biomolecules 2015 ; 5(2):1122-42
PMID: 26057626 [PubMed - as supplied by publisher]

Glucocerebrosidase Gene Mutation and Preclinical Markers of Parkinson Disease-Reply.
Michelle Beavan, Anthony H V Schapira
JAMA Neurol 2015 Jun; 72(6):724
PMID: 26053444 [PubMed - as supplied by publisher]

Glucocerebrosidase Gene Mutation and Preclinical Markers of Parkinson Disease.
Antonella Macerollo
JAMA Neurol 2015 Jun; 72(6):723-4
PMID: 26053443 [PubMed - as supplied by publisher]

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration.
Jennifer M Deger, Julia E Gerson, Rakez Kayed
Aging Cell 2015 Jun;
PMID: 26053162 [PubMed - as supplied by publisher]

Targeting ?-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.
Benjamin Dehay, Mathieu Bourdenx, Philippe Gorry, Serge Przedborski, Miquel Vila, Stéphane Hunot, Andrew Singleton, C Warren Olanow, Kalpana M Merchant, Erwan Bezard, Gregory A Petsko, Wassilios G Meissner
Lancet Neurol 2015 Jun;
PMID: 26050140 [PubMed - as supplied by publisher]

Epidermal growth factor-dependent activation of the ERK pathway by DJ-1 through its direct binding to c-Raf.
Kazuko Takahashi-Niki, Izumi Kato-Ose, Hiroaki Murata, Hiroshi Maita, Sanae M M Iguchi-Ariga, Hiroyoshi Ariga
J Biol Chem 2015 Jun;
PMID: 26048984 [PubMed - as supplied by publisher]

When is a Proof-of-Concept (POC) not a POC? Pomaglumetad (LY2140023) as a Case Study for Antipsychotic Efficacy.
Gerard J Marek
Curr Pharm Des 2015 Jun;
PMID: 26044978 [PubMed - as supplied by publisher]

The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.
Mathieu Méquinion, Christophe Chauveau, Odile Viltart
Front Endocrinol (Lausanne) 2015 ; 6:68
PMID: 26042085 [PubMed - as supplied by publisher]

Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors.
Kaneyasu Nishimura, Shigeo Murayama, Jun Takahashi
Stem Cells Transl Med 2015 Jun;
PMID: 26041738 [PubMed - as supplied by publisher]

The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.
Ashraf Virmani, Luigi Pinto, Otto Bauermann, Saf Zerelli, Andreas Diedenhofen, Zbigniew K Binienda, Syed F Ali, Feike R van der Leij
Mol Neurobiol 2015 Jun;
PMID: 26041663 [PubMed - as supplied by publisher]

Cerebellar neurochemical alterations in spinocerebellar ataxia type 14 appear to include glutathione deficiency.
Sarah Doss, Jan Leo Rinnenthal, Tanja Schmitz-Hübsch, Alexander U Brandt, Sebastian Papazoglou, Silke Lux, Stephan Maul, Jens Würfel, Matthias Endres, Thomas Klockgether, Martina Minnerop, Friedemann Paul
J Neurol 2015 Jun;
PMID: 26041613 [PubMed - as supplied by publisher]

Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.
Aditya Sen, Sreehari Kalvakuri, Rolf Bodmer, Rachel T Cox
Dis Model Mech 2015 Jun; 8(6):577-89
PMID: 26035866 [PubMed - as supplied by publisher]

Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis.
Wenjun Liu, Hailong Wu, Lili Chen, Yankai Wen, Xiaoni Kong, Wei-Qiang Gao
Cell Res 2015 Jun; 25(6):691-706
PMID: 26021615 [PubMed - as supplied by publisher]

SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells.
Silvia Zucchelli, Francesca Fasolo, Roberta Russo, Laura Cimatti, Laura Patrucco, Hazuki Takahashi, Michael H Jones, Claudio Santoro, Daniele Sblattero, Diego Cotella, Francesca Persichetti, Piero Carninci, Stefano Gustincich
Front Cell Neurosci 2015 ; 9:174
PMID: 26029048 [PubMed - as supplied by publisher]

Common mechanisms of onset of cancer and neurodegenerative diseases.
Hiroyoshi Ariga
Biol Pharm Bull 2015 ; 38(6):795-808
PMID: 26027820 [PubMed - as supplied by publisher]

Mild cognitive impairment: at the crossroad of neurodegeneration and vascular dysfunction.
Saito S, Yamamoto Y, Ihara M
Curr Alzheimer Res 2015 May;
PMID: 26027811 [PubMed - as supplied by publisher]

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.
Nirit Lev, Yael Barhum, Tali Ben-Zur, Israel Aharony, Lena Trifonov, Noa Regev, Eldad Melamed, Arie Gruzman, Daniel Offen
PLoS One 2015 ; 10(5):e0127549
PMID: 26024237 [PubMed - as supplied by publisher]

A current review for biological monitoring of manganese with exposure, susceptibility, and response biomarkers.
Gyuri Kim, Ho-Sun Lee, Joon Seok Bang, Boram Kim, Dahae Ko, Mihi Yang
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2015 Apr; 33(2):229-54
PMID: 26023759 [PubMed - as supplied by publisher]

Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage.
Mi-Sun Lim, Mi-Yoon Chang, Sang-Mi Kim, Sang-Hoon Yi, Haeyoung Suh-Kim, Sung Jun Jung, Min Jung Kim, Jin Hyuk Kim, Yong-Sung Lee, Soo Young Lee, Dong-Wook Kim, Sang-Hun Lee, Chang-Hwan Park
J Biol Chem 2015 May;
PMID: 26023233 [PubMed - as supplied by publisher]

Transgenic LRRK2 (R1441G) rats-a model for Parkinson disease?
Komal T Shaikh, Alvin Yang, Ekaterina Youshin, Susanne Schmid
PeerJ 2015 ; 3:e945
PMID: 26020005 [PubMed - as supplied by publisher]

Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
Weili Yang, Guohao Wang, Chuan-En Wang, Xiangyu Guo, Peng Yin, Jinquan Gao, Zhuchi Tu, Zhengbo Wang, Jing Wu, Xintian Hu, Shihua Li, Xiao-Jiang Li
J Neurosci 2015 May; 35(21):8345-58
PMID: 26019347 [PubMed - as supplied by publisher]

Evaluation of PARKIN gene variants in West Bengal Parkinson's disease patients.
Jaya Sanyal, Arpita Jana, Epsita Ghosh, Tapas K Banerjee, Durga P Chakraborty, Vadlamudi R Rao
J Hum Genet 2015 May;
PMID: 26016408 [PubMed - as supplied by publisher]

LRRK2 Promotes Tau Accumulation, Aggregation and Release.
Patrícia Silva Guerreiro, Ellen Gerhardt, Tomás Lopes da Fonseca, Mathias Bähr, Tiago Fleming Outeiro, Katrin Eckermann
Mol Neurobiol 2015 May;
PMID: 26014385 [PubMed - as supplied by publisher]