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Involvement of activation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by ?-iso-cubebenol.
Sun Young Park, Do Yeon Kim, Jong-Koo Kang, Geuntae Park, Young-Whan Choi
Neurotoxicology 2014 Jul; 44C:160-168
PMID: 24997245 [PubMed - as supplied by publisher]
Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
Yusuke Toyoda, Cihan Erkut, Francisco Pan-Montojo, Sebastian Boland, Martin P Stewart, Daniel J Müller, Wolfgang Wurst, Anthony A Hyman, Teymuras V Kurzchalia
Biol Open 2014 Jul;
PMID: 25063200 [PubMed - as supplied by publisher]
Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.
Da-Wei Li, Zhuqin Gu, Chaodong Wang, Jinghong Ma, Bei-Sha Tang, Sheng-Di Chen, Piu Chan
J Neural Transm 2014 Jul;
PMID: 25062988 [PubMed - as supplied by publisher]
The Co-Occurrence of Alzheimer's Disease and Huntington's Disease: A Neuropathological Study of 15 Elderly Huntington's Disease Subjects.
Marie Y Davis, C Dirk Keene, Suman Jayadev, Thomas Bird
J Huntingtons Dis 2014 Jan; 3(2):209-17
PMID: 25062863 [PubMed - as supplied by publisher]
Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.
Kuldip D Dave, Shehan De Silva, Niketa P Sheth, Sylvie Ramboz, Melissa J Beck, Changyu Quang, Robert C Switzer, Syed O Ahmad, Susan M Sunkin, Dan Walker, Xiaoxia Cui, Daniel A Fisher, Aaron M McCoy, Kevin Gamber, Xiaodong Ding, Matthew S Goldberg, Stanley A Benkovic, Meredith Haupt, Marco A S Baptista, Brian K Fiske, Todd B Sherer, Mark A Frasier
Neurobiol Dis 2014 Jun; 70C:190-203
PMID: 24969022 [PubMed - as supplied by publisher]
Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network.
Mustafa Sertba?, Kutlu Ulgen, Tunahan Cak?r
FEBS Open Bio 2014 ; 4:542-53
PMID: 25061554 [PubMed - as supplied by publisher]
Genetics and genomics of Parkinson's disease.
Michelle K Lin, Matthew J Farrer
Genome Med 2014 ; 6(6):48
PMID: 25061481 [PubMed - as supplied by publisher]
Glial cell line-derived neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier.
Yu-Shiang Peng, Po-Liang Lai, Sydney Peng, His-Chin Wu, Siang Yu, Tsan-Yun Tseng, Li-Fang Wang, I-Ming Chu
Int J Nanomedicine 2014 ; 9:3163-74
PMID: 25061293 [PubMed - as supplied by publisher]
Genetic Susceptibility Model of Parkinson's Disease Resulting from Exposure of DJ-1 Deficient Mice to MPTP: Evaluation of Neuroprotection by Ubisol-Q10.
Krithika Muthukumaran, Jessica Smith, Harshil Jasra, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Daniel Lopatin, Siyaram Pandey
J Parkinsons Dis 2014 Jul;
PMID: 25061060 [PubMed - as supplied by publisher]
Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.
Lixue Chuan, Jie Gao, Yuying Lei, Raoxiang Wang, Lechun Lu, Xianyu Zhang
Neurol Sci 2014 Jul;
PMID: 25060648 [PubMed - as supplied by publisher]
Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain.
Mahalakshmi Subramaniam, Beatrice Kern, Simone Vogel, Verena Klose, Gaby Schneider, Jochen Roeper
Eur J Neurosci 2014 Jul;
PMID: 25059097 [PubMed - as supplied by publisher]
DJ-1 interactions with ?-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.
L Zondler, L Miller-Fleming, M Repici, S Gonçalves, S Tenreiro, R Rosado-Ramos, C Betzer, K R Straatman, P H Jensen, F Giorgini, T F Outeiro
Cell Death Dis 2014 ; 5:e1350
PMID: 25058424 [PubMed - as supplied by publisher]
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Sokhna M S Yakhine-Diop, José M Bravo-San Pedro, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Mario Rodríguez-Arribas, Vicente Climent, Ana Aiastui, Adolfo López de Munain, José M Fuentes, Rosa A González-Polo
Toxicology 2014 Jul; 324C:1-9
PMID: 25017139 [PubMed - as supplied by publisher]
Huntington's Disease - A Brief Historical Perspective.
J Huntingtons Dis 2012 Jan; 1(1):3-4
PMID: 25056613 [PubMed - as supplied by publisher]
Prevalence of amyotrophic lateral sclerosis - United States, 2010-2011.
Paul Mehta, Vinicius Antao, Wendy Kaye, Marchelle Sanchez, David Williamson, Leah Bryan, Oleg Muravov, Kevin Horton,
MMWR Surveill Summ 2014 Jul; 63 Suppl 7:1-14
PMID: 25054277 [PubMed - as supplied by publisher]
Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
John E Casida, Breanna Ford, Yunden Jinsmaa, Patti Sullivan, Adele Cooney, David S Goldstein
Chem Res Toxicol 2014 Jul;
PMID: 25045800 [PubMed - as supplied by publisher]
Food deprivation and nicotine correct akinesia and freezing in Na(+) -leak current channel (NALCN)-deficient strains of Caenorhabditis elegans.
K Bonnett, R Zweig, E J Aamodt, D S Dwyer
Genes Brain Behav 2014 Jul;
PMID: 24995777 [PubMed - as supplied by publisher]
Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
Dongjun Dai, Peipei Lin, Yunliang Wang, Xingyu Zhou, Jianmin Tao, Danjie Jiang, Hanlin Zhou, Ping Ru, Guanghui Pan, Jinfeng Li, Yuzheng Zhang, Honglei Yin, Shiwei Duan
Biomed Rep 2014 Sep; 2(5):713-718
PMID: 25054016 [PubMed - as supplied by publisher]
A calcineurin and NFAT-dependent pathway is involved in ?-synuclein-induced degeneration of midbrain dopaminergic neurons.
Jing Luo, Lixin Sun, Xian Lin, Guoxiang Liu, Jia Yu, Loukia Parisiadou, Chengsong Xie, Jinhui Ding, Huaibin Cai
Hum Mol Genet 2014 Jul;
PMID: 25051958 [PubMed - as supplied by publisher]
Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats.
Vez Repunte-Canonigo, Celine Lefebvre, Olivier George, Tomoya Kawamura, Marisela Morales, George F Koob, Andrea Califano, Eliezer Masliah, Pietro Paolo Sanna
Mol Neurodegener 2014 ; 9(1):26
PMID: 24980976 [PubMed - as supplied by publisher]
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.
Ian J McGough, Florian Steinberg, Da Jia, Peter A Barbuti, Kirsty J McMillan, Kate J Heesom, Alan L Whone, Maeve A Caldwell, Daniel D Billadeau, Michael K Rosen, Peter J Cullen
Curr Biol 2014 Jul; 24(14):1670-6
PMID: 24980502 [PubMed - as supplied by publisher]
Effect of 17?-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats.
Cinzia Nasuti, Manuel Carloni, Donatella Fedeli, Antonio Di Stefano, Lisa Marinelli, Laura Serafina Cerasa, Clara Meda, Adriana Maggi, Rosita Gabbianelli
Chemosphere 2014 Oct; 112:496-502
PMID: 25048945 [PubMed - as supplied by publisher]
Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain.
Elaine R Peskind, Ge Li, Jane B Shofer, Steven P Millard, James B Leverenz, Chang-En Yu, Murray A Raskind, Joseph F Quinn, Douglas R Galasko, Thomas J Montine
JAMA Neurol 2014 Jul;
PMID: 25048271 [PubMed - as supplied by publisher]
A cell culture model for monitoring ?-synuclein cell-to-cell transfer.
Juan F Reyes, Tomas T Olsson, Jennifer T Lamberts, Michael J Devine, Tilo Kunath, Patrik Brundin
Neurobiol Dis 2014 Jul;
PMID: 25046995 [PubMed - as supplied by publisher]
The Small Heat Shock Protein HspB8: Role in Nervous System Physiology and Pathology.
Mattia Vicario, Stephen D Skaper, Alessandro Negro
CNS Neurol Disord Drug Targets 2014 ; 13(5):885-95
PMID: 25012617 [PubMed - as supplied by publisher]
Association between vitamin D receptor gene polymorphisms and susceptibility to Parkinson's disease: A meta-analysis.
Zi-Teng Zhang, Yi-Chuan He, Xiu-Juan Ma, Dian-You Li, Guo-Cai Lu
Neurosci Lett 2014 Jun; 578C:122-127
PMID: 24993298 [PubMed - as supplied by publisher]
Identification of p.Gln858* in ATP13A2 in two EOPD patients and presentation of their clinical features.
Maryam Malakouti-Nejad, Gholam-Ali Shahidi, Mohammad Rohani, Seyed Mehdi Shojaee, Mehrdad Hashemi, Brandy Klotzle, Jian-Bing Fan, Elahe Elahi
Neurosci Lett 2014 Aug; 577:106-11
PMID: 24949580 [PubMed - as supplied by publisher]
Analysis of Dosage Mutation in PARK2 among Korean Patients with Early-Onset or Familial Parkinson's Disease.
Min Kyung Chu, Won Chan Kim, Jung Mi Choi, Jeong-Hoon Hong, Suk Yun Kang, Hyeo-Il Ma, Yun Joong Kim
J Clin Neurol 2014 Jul; 10(3):244-8
PMID: 25045378 [PubMed - as supplied by publisher]
Genetic deletion of the GATA1-regulated protein ?-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.
Raffaele Renella, Julia S Schlehe, Dennis J Selkoe, David A Williams, Matthew J LaVoie
Am J Hematol 2014 Jul;
PMID: 25043722 [PubMed - as supplied by publisher]
Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.
Juan A Navarro, Sabina Heßner, Sarat C Yenisetti, Florian Bayersdorfer, Li Zhang, Aaron Voigt, Stephan Schneuwly, Jose A Botella
J Neurochem 2014 Jul;
PMID: 25040725 [PubMed - as supplied by publisher]
An association analysis of the rs1572931 polymorphism of the RAB7L1 gene in Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy in China.
X-Y Guo, Y-P Chen, W Song, B Zhao, B Cao, Q-Q Wei, R-W Ou, Y Yang, L-X Yuan, H-F Shang
Eur J Neurol 2014 Jul;
PMID: 25040112 [PubMed - as supplied by publisher]
Genetic, Structural, and Molecular Insights into the Function of Ras of Complex Proteins Domains.
Laura Civiero, Sybille Dihanich, Patrick A Lewis, Elisa Greggio
Chem Biol 2014 Jul; 21(7):809-818
PMID: 24981771 [PubMed - as supplied by publisher]
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
Lauran Reyniers, Maria Grazia Del Giudice, Laura Civiero, Elisa Belluzzi, Evy Lobbestael, Alexandra Beilina, Giorgio Arrigoni, Rita Derua, Etienne Waelkens, Yan Li, Claudia Crosio, Ciro Iaccarino, Mark R Cookson, Veerle Baekelandt, Elisa Greggio, Jean-Marc Taymans
J Neurochem 2014 Jun;
PMID: 24947832 [PubMed - as supplied by publisher]
Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.
Marusela Oliveras-Salvá, Francesca Macchi, Valérie Coessens, Angélique Deleersnijder, Melanie Gérard, Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt
Neurobiol Aging 2014 Jun;
PMID: 25037286 [PubMed - as supplied by publisher]
Parkinson's disease biomarker: a patent evaluation of WO2013153386.
Werner J Geldenhuys, Samir M Abdelmagid, Patrick J Gallegos, Fayez F Safadi
Expert Opin Ther Pat 2014 Aug; 24(8):947-51
PMID: 24962176 [PubMed - as supplied by publisher]
Network modulation following sham surgery in Parkinson's disease.
Ji Hyun Ko, Andrew Feigin, Paul J Mattis, Chris C Tang, Yilong Ma, Vijay Dhawan, Matthew J During, Michael G Kaplitt, David Eidelberg
J Clin Invest 2014 Jul;
PMID: 25036712 [PubMed - as supplied by publisher]
Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population.
Hongying Hao, Ming Shao, Jing An, Chushuang Chen, Xiuli Feng, Shu Xie, Zhuqin Gu, Piu Chan,
Parkinsonism Relat Disord 2014 Jul;
PMID: 25034874 [PubMed - as supplied by publisher]
Tetranectin Knockout Mice Develop Features of Parkinson Disease.
Er-Song Wang, Xiao-Ping Zhang, Hui-Bin Yao, Gan Wang, Shi-Wen Chen, Wen-Wei Gao, Hai-Jun Yao, Yi-Rui Sun, Cai-Hua Xi, Yao-Dong Ji
Cell Physiol Biochem 2014 Jul; 34(2):277-287
PMID: 25033953 [PubMed - as supplied by publisher]
FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease.
Chiung-Mei Chen, I-Cheng Chen, Yi-Cheng Huang, Hsueh-Fen Juan, Ying-Lin Chen, Yi-Chun Chen, Chih-Hsin Lin, Li-Ching Lee, Chi-Mei Lee, Guey-Jen Lee-Chen, Yun-Ju Lai, Yih-Ru Wu
PLoS One 2014 ; 9(7):e101392
PMID: 25029497 [PubMed - as supplied by publisher]
The association between the LRRK2 G2385R variant and the risk of Parkinson's disease: a meta-analysis based on 23 case-control studies.
Cheng-Long Xie, Jia-Lin Pan, Wen-Wen Wang, Yu Zhang, Su-Fang Zhang, Jing Gan, Zhen-Guo Liu
Neurol Sci 2014 Jul;
PMID: 25027012 [PubMed - as supplied by publisher]
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Tianxia Li, Dejun Yang, Shijun Zhong, Joseph M Thomas, Fengtian Xue, Jingnan Liu, Lingbo Kong, Pamela Voulalas, Hazem E Hassan, Jae-Sung Park, Alexander D MacKerell, Wanli W Smith
Hum Mol Genet 2014 Jul;
PMID: 24993787 [PubMed - as supplied by publisher]
Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells.
Julio Cesar Aguila, Alexandra Blak, Joris van Arensbergen, Amaia Sousa, Nerea Vázquez, Ariane Aduriz, Mayela Gayosso, Maria Paz Lopez Mato, Rakel Lopez de Maturana, Eva Hedlund, Kai Sonntag, Rosario Sanchez Pernaute
Stem Cells Transl Med 2014 Jul;
PMID: 25024431 [PubMed - as supplied by publisher]
HSPA1A-independent suppression of PARK2 C289G protein aggregation by human small heat shock proteins.
Melania Minoia, Corien Grit, Harm H Kampinga
Mol Cell Biol 2014 Jul;
PMID: 25022755 [PubMed - as supplied by publisher]
Advances in pediatric celiac disease.
Tran H Tran
Curr Opin Pediatr 2014 Jul;
PMID: 25022217 [PubMed - as supplied by publisher]
Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals.
Tam Duong, Jaetaek Kim, H Earl Ruley, Daewoong Jo
PLoS One 2014 ; 9(7):e102517
PMID: 25019626 [PubMed - as supplied by publisher]
Genomic analysis of the causative agents of coccidiosis in domestic chickens.
Adam James Reid, Damer Peter Blake, Hifzur Rahman Ansari, Karen Billington, Hilary P Browne, Josephine M Bryant, Matthew Dunn, Stacy S Hung, Fumiya Kawahara, Diego Miranda-Saavedra, Tareq Malas, Tobias Mourier, Hardeep Naghra, Mridul Nair, Thomas Dan Otto, Neil David Rawlings, Pierre Rivailler, Alejandro Sanchez-Flores, Mandy Sanders, Chandra Subramaniam, Yea-Ling Tay, Yong Woo, Xikun Wu, Bart Barrell, Paul H Dear, Christian Doerig, Arthur Gruber, Alasdair C Ivens, John Parkinson, Marie-Adèle Rajandream, Martin William Shirley, Kiew-Lan Wan, Matthew Berriman, Fiona M Tomley, Arnab Pain
Genome Res 2014 Jul;
PMID: 25015382 [PubMed - as supplied by publisher]
0239? Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders0239? Inducible nitric oxide synthase gene methylation and parkinsonism in manganese-exposed welders.
Susan Nielsen, Harvey Checkoway, Susan Criswell, Federico Farin, Brad Racette
Occup Environ Med 2014 Jun; 71 Suppl 1:A32
PMID: 25018322 [PubMed - as supplied by publisher]
1-O-Tigloyl-1-O-deacetylnimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-?B and JNK Activation in Microglia Cells.
Li Tao, Fali Zhang, Lili Hao, Jing Wu, Jia Jia, Jiang-Yun Liu, Long Tai Zheng, Xuechu Zhen
J Pharmacol Sci 2014 Jul;
PMID: 25018136 [PubMed - as supplied by publisher]
Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism.
Sha-Sha Chen, Chun Yang, Fei Hao, Chen Li, Tao Lu, Li-Ru Zhao, Wei-Ming Duan
Exp Neurol 2014 Jul;
PMID: 24997241 [PubMed - as supplied by publisher]
Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.
Nicolas Dzamko, Jinxia Zhou, Yue Huang, Glenda M Halliday
Front Mol Neurosci 2014 ; 7:57
PMID: 25009465 [PubMed - as supplied by publisher]
LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status.
April Reynolds, Elizabeth A Doggett, Steve M Riddle, Connie S Lebakken, R Jeremy Nichols
Front Mol Neurosci 2014 ; 7:54
PMID: 25009464 [PubMed - as supplied by publisher]
Synucleins regulate the kinetics of synaptic vesicle endocytosis.
Karina J Vargas, Sachin Makani, Taylor Davis, Christopher H Westphal, Pablo E Castillo, Sreeganga S Chandra
J Neurosci 2014 Jul; 34(28):9364-76
PMID: 25009269 [PubMed - as supplied by publisher]
PPAR? and PGC-1? as Therapeutic Targets in Parkinson's.
Juan Carlos Corona, Michael R Duchen
Neurochem Res 2014 Jul;
PMID: 25007880 [PubMed - as supplied by publisher]
Do CSF levels of t-Tau, p-Tau and ?1-42 amyloid correlate with dopaminergic system impairment in patients with a clinical diagnosis of Parkinson disease? A (123)I-FP-CIT study in the early stages of the disease.
Agostino Chiaravalloti, Alessandro Stefani, Alessandro Fiorentini, Annamaria Lacanfora, Paolo Stanzione, Orazio Schillaci
Eur J Nucl Med Mol Imaging 2014 Jul;
PMID: 25007849 [PubMed - as supplied by publisher]
Woman With X-Linked Recessive Dystonia-Parkinsonism: Clue to the Epidemiology of Parkinsonism in Filipino Women?
Aloysius Domingo, Lillian V Lee, Norbert Brüggemann, Karen Freimann, Frank J Kaiser, Roland D G Jamora, Raymond L Rosales, Christine Klein, Ana Westenberger
JAMA Neurol 2014 Jul;
PMID: 25004170 [PubMed - as supplied by publisher]
A 6.4 Mb Duplication of the ?-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism: Phenotype-Genotype Correlations.
Eleanna Kara, Aoife P Kiely, Christos Proukakis, Nicola Giffin, Seth Love, Jason Hehir, Khadija Rantell, Amelie Pandraud, Dena G Hernandez, Elizabeth Nacheva, Alan M Pittman, Mike A Nalls, Andrew B Singleton, Tamas Revesz, Kailash P Bhatia, Niall Quinn, John Hardy, Janice L Holton, Henry Houlden
JAMA Neurol 2014 Jul;
PMID: 25003242 [PubMed - as supplied by publisher]
Chromosome 22q11.2 deletion may contain a locus for recessive early-onset Parkinson's disease.
Kotaro Ogaki, Owen A Ross
Parkinsonism Relat Disord 2014 Jun;
PMID: 25001314 [PubMed - as supplied by publisher]
Behavioral Deficits and Striatal DA Signaling in LRRK2 p.G2019S Transgenic Rats: A Multimodal Investigation Including PET Neuroimaging.
Matthew D Walker, Mattia Volta, Stefano Cataldi, Katherine Dinelle, Dayne Beccano-Kelly, Lise Munsie, Rick Kornelsen, Chenoa Mah, Patrick Chou, Kimberly Co, Jaskaran Khinda, Marta Mroczek, Sabrina Bergeron, Katrina Yu, Li Ping Cao, Natalja Funk, Thomas Ott, Dagmar Galter, Olaf Riess, Saskia Biskup, Austen J Milnerwood, A Jon Stoessl, Matthew J Farrer, Vesna Sossi
J Parkinsons Dis 2014 Jul;
PMID: 25000966 [PubMed - as supplied by publisher]
Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklund
PLoS One 2014 ; 9(7):e100869
PMID: 24999658 [PubMed - as supplied by publisher]
Parkinsonian syndrome in familial frontotemporal dementia.
Joanna Siuda, Shinsuke Fujioka, Zbigniew K Wszolek
Parkinsonism Relat Disord 2014 Jun;
PMID: 24998994 [PubMed - as supplied by publisher]
Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population.
Teeratorn Pulkes, Chutima Papsing, Ammarin Thakkinstian, Sunsanee Pongpakdee, Kongkiat Kulkantrakorn, Suchat Hanchaiphiboolkul, Somsak Tiamkao, Pairoj Boonkongchuen
Parkinsonism Relat Disord 2014 Jun;
PMID: 24997548 [PubMed - as supplied by publisher]
Role of genomics in translational research for Parkinson's disease.
Kazunari Sekiyama, Yoshiki Takamatsu, Masaaki Waragai, Makoto Hashimoto
Biochem Biophys Res Commun 2014 Jun;
PMID: 24950403 [PubMed - as supplied by publisher]
Expression analysis of genes of ubiquitin-proteasome protein degradation system in MPTP-induced mice models of early stages of Parkinson's disease.
E V Filatova, M I Shadrina, A Kh Alieva, A A Kolacheva, P A Slominsky, M V Ugrumov
Dokl Biochem Biophys 2014 May; 456(1):116-8
PMID: 24993970 [PubMed - as supplied by publisher]
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
Niccolò E Mencacci, Ioannis U Isaias, Martin M Reich, Christos Ganos, Vincent Plagnol, James M Polke, Jose Bras, Joshua Hersheson, Maria Stamelou, Alan M Pittman, Alastair J Noyce, Kin Y Mok, Thomas Opladen, Erdmute Kunstmann, Sybille Hodecker, Alexander Münchau, Jens Volkmann, Samuel Samnick, Katie Sidle, Tina Nanji, Mary G Sweeney, Henry Houlden, Amit Batla, Anna L Zecchinelli, Gianni Pezzoli, Giorgio Marotta, Andrew Lees, Paulo Alegria, Paul Krack, Florence Cormier-Dequaire, Suzanne Lesage, Alexis Brice, Peter Heutink, Thomas Gasser, Steven J Lubbe, Huw R Morris, Pille Taba, Sulev Koks, Elisa Majounie, J Raphael Gibbs, Andrew Singleton, John Hardy, Stephan Klebe, Kailash P Bhatia, Nicholas W Wood,
Brain 2014 Jul;
PMID: 24993959 [PubMed - as supplied by publisher]
Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.
R A Charan, B N Johnson, S Zaganelli, J D Nardozzi, M J LaVoie
Cell Death Dis 2014 ; 5:e1313
PMID: 24991765 [PubMed - as supplied by publisher]
Titer and product affect the distribution of gene expression after intraputaminal convection-enhanced delivery.
Marina E Emborg, Samuel A Hurley, Valerie Joers, Do P M Tromp, Christine R Swanson, Sachiko Ohshima-Hosoyama, Viktorya Bondarenko, Kyle Cummisford, Marc Sonnemans, Stephan Hermening, Bas Blits, Andrew L Alexander
Stereotact Funct Neurosurg 2014 ; 92(3):182-94
PMID: 24943657 [PubMed - as supplied by publisher]
SREBF1 links lipogenesis to mitophagy and sporadic Parkinson disease.
Rachael M Ivatt, Alexander J Whitworth
Autophagy 2014 Jun; 10(8)
PMID: 24991824 [PubMed - as supplied by publisher]
A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases.
William B Pratt, Yoshihiro Morishima, Jason E Gestwicki, Andrew P Lieberman, Yoichi Osawa
Exp Biol Med (Maywood) 2014 Jul;
PMID: 24990484 [PubMed - as supplied by publisher]
Defective Autophagy in Parkinson's Disease: Lessons from Genetics.
H Zhang, C Duan, H Yang
Mol Neurobiol 2014 Jul;
PMID: 24990317 [PubMed - as supplied by publisher]
Update on SPECT and PET in parkinsonism - part 2: biomarker imaging of cognitive impairment in Lewy-body diseases.
Philipp T Meyer, Lars Frings, Sabine Hellwig
Curr Opin Neurol 2014 Aug; 27(4):398-404
PMID: 24978635 [PubMed - as supplied by publisher]
The role of alpha-synuclein in Parkinson's disease].
Ildiko Miklya, Noemi Pencz, Florencia Hafenscher, Patricia Goltl
Neuropsychopharmacol Hung 2014 Jun; 16(2):77-84
PMID: 24978050 [PubMed - as supplied by publisher]
The role of parkin in Parkinson's disease].
Ildiko Miklya, Patricia Goltl, Florencia Hafenscher, Noemi Pencz
Neuropsychopharmacol Hung 2014 Jun; 16(2):67-76
PMID: 24978049 [PubMed - as supplied by publisher]
Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases.
Lin Tan, Jin-Tai Yu, Lan Tan
Mol Neurobiol 2014 Jun;
PMID: 24973986 [PubMed - as supplied by publisher]
Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease.
Taku Hatano, Manabu Funayama, Shin-Ichiro Kubo, Ignacio F Mata, Yutaka Oji, Akio Mori, Cyrus P Zabetian, Sarah M Waldherr, Hiroyo Yoshino, Genko Oyama, Yasushi Shimo, Ken-Ichi Fujimoto, Hirokazu Oshima, Yasuto Kunii, Hirooki Yabe, Yoshikuni Mizuno, Nobutaka Hattori
Neurobiol Aging 2014 Jun;
PMID: 24973808 [PubMed - as supplied by publisher]
The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model.
Diana Fernández-Suárez, Marta Celorrio, José Ignacio Riezu-Boj, Ana Ugarte, Rodrigo Pacheco, Hugo González, Julen Oyarzabal, Cecilia J Hillard, Rafael Franco, María S Aymerich
Neurobiol Aging 2014 May;
PMID: 24973119 [PubMed - as supplied by publisher]
Association between 5-HTTLPR polymorphism and Parkinson's disease: a meta analysis.
Lianbo Gao, Honghua Gao
Mol Biol Rep 2014 Jun;
PMID: 24972569 [PubMed - as supplied by publisher]
The role of dopamine in huntington's disease.
Carlos Cepeda, Kerry P S Murphy, Martin Parent, Michael S Levine
Prog Brain Res 2014 ; 211:235-54
PMID: 24968783 [PubMed - as supplied by publisher]
The neurogenetics of atypical parkinsonian disorders.
Brent L Fogel, Mary C Clark, Daniel H Geschwind
Semin Neurol 2014 Apr; 34(2):217-24
PMID: 24963681 [PubMed - as supplied by publisher]
Progressive supranuclear palsy.
Lawrence I Golbe
Semin Neurol 2014 Apr; 34(2):151-9
PMID: 24963674 [PubMed - as supplied by publisher]
Suppression of miR-155 Expression in IFN-?-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression.
Jong-Hyeon Kim, Ilo Jou, Eun-Hye Joe
Exp Neurobiol 2014 Jun; 23(2):148-54
PMID: 24963279 [PubMed - as supplied by publisher]
High-throughput Functional Screening using a Homemade Dual-glow Luciferase Assay.
Jessica M Baker, Frederick M Boyce
J Vis Exp 2014 ; (88)
PMID: 24962249 [PubMed - as supplied by publisher]
Bioinformatics analysis raises candidate genes in blood for early screening of Parkinson's disease.
Yi Zhang, Li Yao, Wei Liu, Wei Li, Chan Tian, Zhao Yang Wang, Di Liu
Biomed Environ Sci 2014 Jun; 27(6):462-5
PMID: 24961856 [PubMed - as supplied by publisher]
Tissue- and cell-specific mitochondrial defect in parkin-deficient mice.
Maria Damiano, Clément A Gautier, Anne-Laure Bulteau, Rosa Ferrando-Miguel, Caroline Gouarne, Marc Giraudon Paoli, Rebecca Pruss, Françoise Auchère, Caroline L'Hermitte-Stead, Frédéric Bouillaud, Alexis Brice, Olga Corti, Anne Lombès
PLoS One 2014 ; 9(6):e99898
PMID: 24959870 [PubMed - as supplied by publisher]
Nrf2 Signaling Contributes to the Neuroprotective Effects of Urate against 6-OHDA Toxicity.
Ning Zhang, Hai-Yang Shu, Tingting Huang, Qi-Lin Zhang, Da Li, Guan-Qun Zhang, Xiao-Yan Peng, Chun-Feng Liu, Wei-Feng Luo, Li-Fang Hu
PLoS One 2014 ; 9(6):e100286
PMID: 24959672 [PubMed - as supplied by publisher]
N-Terminal Truncated UCH-L1 Prevents Parkinson's Disease Associated Damage.
Hee-Jung Kim, Hyun Jung Kim, Jae-Eun Jeong, Jeong Yeob Baek, Jaeho Jeong, Sun Kim, Young-Mee Kim, Youhwa Kim, Jin Han Nam, Sue Hee Huh, Jawon Seo, Byung Kwan Jin, Kong-Joo Lee
PLoS One 2014 ; 9(6):e99654
PMID: 24959670 [PubMed - as supplied by publisher]
Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy.
Annamaria Vallelunga, Marco Ragusa, Stefania Di Mauro, Tommaso Iannitti, Manuela Pilleri, Roberta Biundo, Luca Weis, Cinzia Di Pietro, Angela De Iuliis, Alessandra Nicoletti, Mario Zappia, Michele Purrello, Angelo Antonini
Front Cell Neurosci 2014 ; 8:156
PMID: 24959119 [PubMed - as supplied by publisher]
Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications.
Iakov N Rudenko, Mark R Cookson
Neurotherapeutics 2014 Jun;
PMID: 24957201 [PubMed - as supplied by publisher]
Large-Scale East-Asian eQTL Mapping Reveals Novel Candidate Genes for LD Mapping and the Genomic Landscape of Transcriptional Effects of Sequence Variants.
Maiko Narahara, Koichiro Higasa, Seiji Nakamura, Yasuharu Tabara, Takahisa Kawaguchi, Miho Ishii, Kenichi Matsubara, Fumihiko Matsuda, Ryo Yamada
PLoS One 2014 ; 9(6):e100924
PMID: 24956270 [PubMed - as supplied by publisher]
Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene.
Valentina La Cognata, Rosario Iemmolo, Velia D'Agata, Soraya Scuderi, Filippo Drago, Mario Zappia, Sebastiano Cavallaro
Curr Genomics 2014 Jun; 15(3):203-16
PMID: 24955028 [PubMed - as supplied by publisher]
Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer's and Parkinson's diseases.
E V Stelmashook, N K Isaev, E E Genrikhs, G A Amelkina, L G Khaspekov, V G Skrebitsky, S N Illarioshkin
Biochemistry (Mosc) 2014 May; 79(5):391-6
PMID: 24954589 [PubMed - as supplied by publisher]
A single pathway targets several health challenges of the elderly.
Ben A Bahr
Rejuvenation Res 2014 Jun;
PMID: 24953230 [PubMed - as supplied by publisher]
The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease.
Ilona Joniec-Maciejak, Agnieszka Ciesielska, Adriana Wawer, Anna Sznejder-Pacho?ek, Joanna Schwenkgrub, Agnieszka Cudna, Piotr Hadaczek, Kristof S Bankiewicz, Anna Cz?onkowska, Andrzej Cz?onkowski
Pharmacol Rep 2014 Aug; 66(4):660-9
PMID: 24948069 [PubMed - as supplied by publisher]
Role of vitamin D in the physiopathology of neurodegenerative diseases].
Pascal Millet, Véréna Landel, Isabelle Virard, Maria Morello, François Féron
Biol Aujourdhui 2014 ; 208(1):77-88
PMID: 24948021 [PubMed - as supplied by publisher]
The F-box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE).
Jengmin Kang, Kwang Chul Chung
Cell Mol Life Sci 2014 Jun;
PMID: 24947323 [PubMed - as supplied by publisher]
Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.
Saurabh Khasnavis, Kalipada Pahan
J Neuroimmune Pharmacol 2014 Jun;
PMID: 24946862 [PubMed - as supplied by publisher]
Phosphorylated ubiquitin: a new shade of PINK1 in Parkin activation.
Véronique Sauvé, Kalle Gehring
Cell Res 2014 Jun;
PMID: 24946738 [PubMed - as supplied by publisher]
T313M polymorphism of the PINK1 gene in Parkinson's disease.
Qin Luo, Xinling Yang, Yani Yao, Hongjuan Li, Yuling Wang
Exp Ther Med 2014 Jul; 8(1):286-290
PMID: 24944636 [PubMed - as supplied by publisher]
Frontotemporal dementia and its subtypes: a genome-wide association study.
Raffaele Ferrari, Dena G Hernandez, Michael A Nalls, Jonathan D Rohrer, Adaikalavan Ramasamy, John B J Kwok, Carol Dobson-Stone, William S Brooks, Peter R Schofield, Glenda M Halliday, John R Hodges, Olivier Piguet, Lauren Bartley, Elizabeth Thompson, Eric Haan, Isabel Hernández, Agustín Ruiz, Mercè Boada, Barbara Borroni, Alessandro Padovani, Carlos Cruchaga, Nigel J Cairns, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Gianluigi Forloni, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Elio Scarpini, Jordi Clarimón, Alberto Lleó, Rafael Blesa, Maria Landqvist Waldö, Karin Nilsson, Christer Nilsson, Ian R A Mackenzie, Ging-Yuek R Hsiung, David M A Mann, Jordan Grafman, Christopher M Morris, Johannes Attems, Timothy D Griffiths, Ian G McKeith, Alan J Thomas, P Pietrini, Edward D Huey, Eric M Wassermann, Atik Baborie, Evelyn Jaros, Michael C Tierney, Pau Pastor, Cristina Razquin, Sara Ortega-Cubero, Elena Alonso, Robert Perneczky, Janine Diehl-Schmid, Panagiotis Alexopoulos, Alexander Kurz, Innocenzo Rainero, Elisa Rubino, Lorenzo Pinessi, Ekaterina Rogaeva, Peter St George-Hyslop, Giacomina Rossi, Fabrizio Tagliavini, Giorgio Giaccone, James B Rowe, Johannes C M Schlachetzki, James Uphill, John Collinge, Simon Mead, Adrian Danek, Vivianna M Van Deerlin, Murray Grossman, John Q Trojanowski, Julie van der Zee, William Deschamps, Tim Van Langenhove, Marc Cruts, Christine Van Broeckhoven, Stefano F Cappa, Isabelle Le Ber, Didier Hannequin, Véronique Golfier, Martine Vercelletto, Alexis Brice, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Irene Piaceri, Jørgen E Nielsen, Lena E Hjermind, Matthias Riemenschneider, Manuel Mayhaus, Bernd Ibach, Gilles Gasparoni, Sabrina Pichler, Wei Gu, Martin N Rossor, Nick C Fox, Jason D Warren, Maria Grazia Spillantini, Huw R Morris, Patrizia Rizzu, Peter Heutink, Julie S Snowden, Sara Rollinson, Anna Richardson, Alexander Gerhard, Amalia C Bruni, Raffaele Maletta, Francesca Frangipane, Chiara Cupidi, Livia Bernardi, Maria Anfossi, Maura Gallo, Maria Elena Conidi, Nicoletta Smirne, Rosa Rademakers, Matt Baker, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, David Knopman, Keith A Josephs, Bradley F Boeve, Joseph E Parisi, William W Seeley, Bruce L Miller, Anna M Karydas, Howard Rosen, John C van Swieten, Elise G P Dopper, Harro Seelaar, Yolande A L Pijnenburg, Philip Scheltens, Giancarlo Logroscino, Rosa Capozzo, Valeria Novelli, Annibale A Puca, Massimo Franceschi, Alfredo Postiglione, Graziella Milan, Paolo Sorrentino, Mark Kristiansen, Huei-Hsin Chiang, Caroline Graff, Florence Pasquier, Adeline Rollin, Vincent Deramecourt, Florence Lebert, Dimitrios Kapogiannis, Luigi Ferrucci, Stuart Pickering-Brown, Andrew B Singleton, John Hardy, Parastoo Momeni
Lancet Neurol 2014 Jul; 13(7):686-99
PMID: 24943344 [PubMed - as supplied by publisher]
Arsenite Stress Downregulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2) Promoting Self-Association and Cellular Redistribution.
Adamantios Mamais, Ruth Chia, Alexandra Beilina, David N Hauser, Christine Hall, Patrick A Lewis, Mark R Cookson, Rina Bandopadhyay
J Biol Chem 2014 Jun;
PMID: 24942733 [PubMed - as supplied by publisher]