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DNAJ mutations are rare in Chinese Parkinson's disease patients and controls.
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Neurobiol Aging 2013 Oct;
Authors: Jia Nee Foo, Herty Liany, Louis C Tan, Wing-Lok Au, Kumar-M Prakash, Jianjun Liu, Eng-King Tan
Human Genetics, Genome Institute of Singapore, A*STAR, 138672 Singapore.
Mutations in DNAJC13, DNAJC6 and DNAJC5 have been implicated in Parkinson's disease (PD). To determine if rare coding variants in these genes play a role in PD risk in the Chinese population, we sequenced all coding exons of the three genes in 99 early-onset PD cases and 99 controls, and genotyped 8 missense variants in another 711 PD cases and 539 controls. Besides two common missense variants that did not show association with PD, the remaining missense variants were extremely rare (<0.5%), found in healthy population controls and did not show enrichment in PD cases. Our results suggest that missense mutations in DNAJC13, DNAJC5 and DNAJC6 do not play a major role in PD in the Chinese population.
PMID: 24126164 [PubMed - as supplied by publisher]