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Tracking Parkinson's (the proband study)-interim report from the first 1000 cases.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Donald Grosset, Naveed Malek, Nin Bajaj, Roger Barker, David Burn, Yoav Ben-Shlomo, Tom Foltynie, Huw Morris, Nigel Williams, Nicholas Wood
Southern General Hospital, Glasgow; University College London; Queen's Medical Centre, Nottingham; Cambridge Centre for Brain Repair; Clinical Ageing Research Unit, University of Newcastle; University of Bristol; University Hospital of Wales, Cardiff; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff.
Although several Mendelian genes causing Parkinson's disease are known, these are relevant to only a small proportion of total cases.(1) The significant variation in disease expression (presence, pattern and severity of motor and non-motor features, and progression rates), however, is likely to be influenced by genetic variation (single nucleotide polymorphisms) at several loci.
PMID: 24108936 [PubMed - as supplied by publisher]