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Featured Research

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Scientists are making inroads because thousands of people with Parkinson’s and their family members have donated their brains to science, including to PDF-supported programs at Columbia University Medical Center and Rush University Medical Center.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

Analysis of the robustness of network-based disease-gene prioritization methods reveals redundancy in the human interactome and functional diversity of disease-genes.
Emre Guney, Baldo Oliva
PLoS One 2014 ; 9(4):e94686
PMID: 24733074 [PubMed - as supplied by publisher]


Unaltered Striatal Dopamine Release Levels in Young Parkin Knockout, Pink1 Knockout, DJ-1 Knockout and LRRK2 R1441G Transgenic Mice.
Gonzalo Sanchez, Rafael K Varaschin, Hansruedi Büeler, Paul C Marcogliese, David S Park, Louis-Eric Trudeau
PLoS One 2014 ; 9(4):e94826
PMID: 24733019 [PubMed - as supplied by publisher]


CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking.
Anat Bar-Shira, Mali Gana-Weisz, Ziv Gan-Or, Eytan Giladi, Nir Giladi, Avi Orr-Urtreger
Neurobiol Aging 2014 Mar;
PMID: 24731518 [PubMed - as supplied by publisher]


Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients.
Yang Song, Hui Ding, Jingfang Yang, Qingling Lin, Jinhua Xue, Yanli Zhang, Piu Chan, Yanning Cai
Neurosci Lett 2014 Apr;
PMID: 24721670 [PubMed - as supplied by publisher]


Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease patients with parkin mutations.
Celia van der Merwe, Ben Loos, Chrisna Swart, Craig Kinnear, Franclo Henning, Lize van der Merwe, Komala Pillay, Nolan Muller, Dan Zaharie, Lize Engelbrecht, Jonathan Carr, Soraya Bardien
Biochem Biophys Res Commun 2014 Apr;
PMID: 24721425 [PubMed - as supplied by publisher]


Zebrafish as a model for investigating developmental lead (Pb) neurotoxicity as a risk factor in adult neurodegenerative disease: A mini-review.
Jinyoung Lee, Jennifer L Freeman
Neurotoxicology 2014 Mar;
PMID: 24698670 [PubMed - as supplied by publisher]


Skin nerve ?-synuclein deposits: A biomarker for idiopathic Parkinson disease.
Vincenzo Donadio, Alex Incensi, Valentina Leta, Maria Pia Giannoccaro, Cesa Scaglione, Paolo Martinelli, Sabina Capellari, Patrizia Avoni, Agostino Baruzzi, Rocco Liguori
Neurology 2014 Apr; 82(15):1362-9
PMID: 24634456 [PubMed - as supplied by publisher]


Association analysis of STK39, MCCC1/LAMP3 and sporadic PD in the Chinese Han population.
Ya-Qin Wang, Bei-Sha Tang, Ri-Li Yu, Kai Li, Zhen-Hua Liu, Qian Xu, Qi-Ying Sun, Xin-Xiang Yan, Ji-Feng Guo
Neurosci Lett 2014 Apr; 566:206-9
PMID: 24631562 [PubMed - as supplied by publisher]


No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese.
Xiao Li, Wen Zhang, Chen Zhang, Wei Gong, Jinsong Tang, Zhenghui Yi, Dong Wang, Weihong Lu, Yiru Fang, Xiaogang Chen, Yong-Gang Yao
Neurosci Lett 2014 Apr; 566:210-5
PMID: 24631561 [PubMed - as supplied by publisher]


Low prevalence of most frequent pathogenic variants of six PARK genes in sporadic Parkinson's disease.
S García, L B López-Hernández, J A Suarez-Cuenca, M Solano-Rojas, M P Gallegos-Arreola, O Gama-Moreno, P Valdez-Anguiano, P Canto, L Dávila-Maldonado, C F Cuevas-García, R M Coral-Vázquez
Folia Neuropathol 2014 ; 52(1):22-9
PMID: 24729340 [PubMed - as supplied by publisher]


Silencing of Hsp70 Intensifies 6-OHDA-Induced Apoptosis and Hsp90 Upregulation in PC12 Cells.
Behrang Alani, Rasoul Salehi, Payam Sadeghi, Fariba Khodagholi, Hadi Digaleh, Siamak Jabbarzadeh-Tabrizi, Mohammad Zare, Hassan Korbekandi
J Mol Neurosci 2014 Apr;
PMID: 24729093 [PubMed - as supplied by publisher]


The Novel Parkinson's Disease Linked Mutation G51D Attenuates In Vitro Aggregation and Membrane Binding of ?-Synuclein, and Enhances its Secretion and Nuclear Localization in Cells.
Mohamed-Bilal Fares, Nadine A Bouziad, Igor Dikiy, Martial K Mbefo, Ana Jovi?i?, Aoife Kiely, Janice L Holton, Seung-Jae Lee, Aaron D Gitler, David Eliezer, Hilal A Lashuel
Hum Mol Genet 2014 Apr;
PMID: 24728187 [PubMed - as supplied by publisher]


Oligonucleotide-Based Therapy for Neurodegenerative Diseases.
Iddo Magen, Eran Hornstein
Brain Res 2014 Apr;
PMID: 24727531 [PubMed - as supplied by publisher]


Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson's Disease.
Ian Martin, Jungwoo Wren Kim, Byoung Dae Lee, Ho Chul Kang, Jin-Chong Xu, Hao Jia, Jeannette Stankowski, Min-Sik Kim, Jun Zhong, Manoj Kumar, Shaida A Andrabi, Yulan Xiong, Dennis W Dickson, Zbigniew K Wszolek, Akhilesh Pandey, Ted M Dawson, Valina L Dawson
Cell 2014 Apr; 157(2):472-85
PMID: 24725412 [PubMed - as supplied by publisher]


Multiplying Messages LRRK beneath Parkinson Disease.
William T Dauer, Ming Guo
Cell 2014 Apr; 157(2):291-3
PMID: 24725399 [PubMed - as supplied by publisher]


CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
María Florencia Ogara, Laura M Belluscio, Verónica de la Fuente, Bruno G Berardino, Silvina V Sonzogni, Laura Byk, Mariela Marazita, Eduardo T Cánepa
Biochim Biophys Acta 2014 Apr;
PMID: 24703879 [PubMed - as supplied by publisher]


Association of seven functional polymorphisms of one-carbon metabolic pathway with total plasma homocysteine levels and susceptibility to Parkinson's disease among South Indians.
Nadella Kumudini, Addepally Uma, Shaik Mohammad Naushad, Rukmini Mridula, Rupam Borgohain, Vijay Kumar Kutala
Neurosci Lett 2014 Mar; 568C:1-5
PMID: 24686188 [PubMed - as supplied by publisher]


Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
Andrew B West, Rita M Cowell, João P L Daher, Mark S Moehle, Kelly M Hinkle, Heather L Melrose, David G Standaert, Laura A Volpicelli-Daley
J Comp Neurol 2014 Mar;
PMID: 24633735 [PubMed - as supplied by publisher]


PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.
Tsz Hang Wong, Wang Zheng Chiu, Guido J Breedveld, Ka Wan Li, Annemieke J M H Verkerk, David Hondius, Renate K Hukema, Harro Seelaar, Petra Frick, Lies-Anne Severijnen, Gert-Jan Lammers, Joyce H G Lebbink, Sjoerd G van Duinen, Wouter Kamphorst, Annemieke J Rozemuller, , E Bert Bakker, , Manuela Neumann, Rob Willemsen, Vincenzo Bonifati, August B Smit, John van Swieten
Brain 2014 Apr;
PMID: 24722252 [PubMed - as supplied by publisher]


Extracellular ?-Synuclein Leads to Microtubule Destabilization via GSK-3?-Dependent Tau Phosphorylation in PC12 Cells.
Magdalena G?ssowska, Grzegorz A Czapski, Beata Paj?k, Magdalena Cie?lik, Anna M Lenkiewicz, Agata Adamczyk
PLoS One 2014 ; 9(4):e94259
PMID: 24722055 [PubMed - as supplied by publisher]


Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae.
Chien-Wei Feng, Zhi-Hong Wen, Shi-Ying Huang, Han-Chun Hung, Chun-Hong Chen, San-Nan Yang, Nan-Fu Chen, Hui-Min Wang, Chung-Der Hsiao, Wu-Fu Chen
Zebrafish 2014 Apr;
PMID: 24720843 [PubMed - as supplied by publisher]


Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.
Koji Kasanuki, Eizo Iseki, Daizo Kondo, Hiroshige Fujishiro, Michiko Minegishi, Kiyoshi Sato, Omi Katsuse, Hiroaki Hino, Kenji Kosaka, Heii Arai
Neurosci Lett 2014 Apr;
PMID: 24704327 [PubMed - as supplied by publisher]


Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
Indranil Basak, Ramavati Pal, Ketan S Patil, Aisling Dunne, Hsin-Pin Ho, Sungsu Lee, Diluka Peiris, Jodi Maple-Grødem, Mark Odell, Emmanuel J Chang, Jan Petter Larsen, Simon G Møller
J Biol Chem 2014 Apr;
PMID: 24719325 [PubMed - as supplied by publisher]


Abnormal visual gain control in a Parkinson's Disease model.
Farinaz Afsari, Kenneth V Christensen, Garrick Paul Smith, Morten Hentzer, Olivia M Nippe, Christopher J H Elliott, Alex R Wade
Hum Mol Genet 2014 Apr;
PMID: 24718285 [PubMed - as supplied by publisher]


Alpha-synuclein in Parkinson's disease].
Anna Oczkowska, Wojciech Kozubski, Jolanta Dorszewska
Przegl Lek 2014 ; 71(1):26-32
PMID: 24712265 [PubMed - as supplied by publisher]


Impaired motor coordination in Pitx3 overexpression mice.
Hongwon Kim, Xiaoyuan Quan, Yeju Seong, Jongpil Kim
Biochem Biophys Res Commun 2014 Mar;
PMID: 24680684 [PubMed - as supplied by publisher]


Effective variant detection by targeted deep sequencing of DNA pools: an example from Parkinson's disease.
Lasse Pihlstrøm, Aina Rengmark, Kari Anne Bjørnarå, Mathias Toft
Ann Hum Genet 2014 May; 78(3):243-52
PMID: 24660942 [PubMed - as supplied by publisher]


Increased lipid droplet accumulation associated with a peripheral sensory neuropathy.
Lee L Marshall, Scott E Stimpson, Ryan Hyland, Jens R Coorssen, Simon J Myers
J Chem Biol 2014 Apr; 7(2):67-76
PMID: 24711860 [PubMed - as supplied by publisher]


Transient neuroprotection by SRY up-regulation in dopamine cells following injury in males.
Daniel P Czech, Joohyung Lee, Jeanne Correia, Hannah Loke, Eva Möller, Vincent R Harley
Endocrinology 2014 Apr; :en20132158
PMID: 24708242 [PubMed - as supplied by publisher]


iPS cell technologies: significance and applications to CNS regeneration and disease.
Hideyuki Okano, Shinya Yamanaka
Mol Brain 2014 ; 7(1):22
PMID: 24685317 [PubMed - as supplied by publisher]


Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase.
Leonor Miller-Fleming, Pedro Antas, Teresa Faria Pais, Joshua L Smalley, Flaviano Giorgini, Tiago Fleming Outeiro
Proc Natl Acad Sci U S A 2014 Apr;
PMID: 24706893 [PubMed - as supplied by publisher]


Meta analysis of the association of rs7702187 SNP in SEMA5A gene with risk of Parkinson's disease.
X Yu, F Wang, J-P Zhang
Eur Rev Med Pharmacol Sci 2014 Mar; 18(6):900-4
PMID: 24706317 [PubMed - as supplied by publisher]


EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population.
Kenya Nishioka, Manabu Funayama, Carles Vilariño-Güell, Kotaro Ogaki, Yuanzhe Li, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, Jennifer M Kachergus, Stephanie A Cobb, Hirohide Takahashi, Yoshikuni Mizuno, Matthew J Farrer, Owen A Ross, Nobutaka Hattori
Parkinsonism Relat Disord 2014 Mar;
PMID: 24704100 [PubMed - as supplied by publisher]


Genetic mutations in early-onset Parkinson's disease Mexican patients: Molecular testing implications.
Nancy Monroy-Jaramillo, Jorge Luis Guerrero-Camacho, Mayela Rodríguez-Violante, Marie-Catherine Boll-Woehrlen, Petra Yescas-Gómez, María Elisa Alonso-Vilatela, Marisol López-López
Am J Med Genet B Neuropsychiatr Genet 2014 Apr; 165(3):235-44
PMID: 24677602 [PubMed - as supplied by publisher]


Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells.
D Ouazia, L-C Levros, E Rassart, R R Desrosiers
Neuroscience 2014 Mar; 267C:263-276
PMID: 24631677 [PubMed - as supplied by publisher]


Treating Parkinson's disease in the 21st century: Can stem cell transplantation compete?
Philip C Buttery, Roger A Barker
J Comp Neurol 2014 Mar;
PMID: 24610597 [PubMed - as supplied by publisher]


Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort.
Shu-Jun Feng, Kun Nie, Rong Gan, Jing Huang, You-Wen Zhang, Li-Min Wang, Jie-Hao Zhao, Hong-Mei Tang, Liang Gao, Rui-Ming Zhu, Zhen-Peng Duan, Yu-Hu Zhang, Li-Juan Wang
Neurobiol Aging 2014 Jul; 35(7):1780.e11-2
PMID: 24602511 [PubMed - as supplied by publisher]


Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia.
Myriam Heiman, Adrian Heilbut, Veronica Francardo, Ruth Kulicke, Robert J Fenster, Eric D Kolaczyk, Jill P Mesirov, Dalton J Surmeier, M Angela Cenci, Paul Greengard
Proc Natl Acad Sci U S A 2014 Mar; 111(12):4578-83
PMID: 24599591 [PubMed - as supplied by publisher]


Parkinson disease: Gene therapy for Parkinson disease-a hope, or a dream?
C Warren Olanow
Nat Rev Neurol 2014 Apr; 10(4):186-7
PMID: 24662536 [PubMed - as supplied by publisher]


Does ?-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?
Katerina Markopoulou, Joanna M Biernacka, Sebastian M Armasu, Kari J Anderson, J Eric Ahlskog, Bruce A Chase, Sun Ju Chung, Julie M Cunningham, Matthew Farrer, Roberta Frigerio, Demetrius M Maraganore
Parkinsonism Relat Disord 2014 Mar;
PMID: 24656894 [PubMed - as supplied by publisher]


Preconditioning as a Potential Strategy for the Prevention of Parkinson's Disease.
Mojtaba Golpich, Behrouz Rahmani, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond, Abolhassan Ahmadiani
Mol Neurobiol 2014 Apr;
PMID: 24696268 [PubMed - as supplied by publisher]


The Parkinson's disease-linked LRRK2 mutation I2020T stabilizes an active state conformation leading to increased kinase activity.
Soumya Ray, Samantha Bender, Stephanie Kang, Regina Lin, Marcie A Glicksman, Min Liu
J Biol Chem 2014 Apr;
PMID: 24695735 [PubMed - as supplied by publisher]


Pharmacological studies on neurodegenerative diseases focusing on refolding and degradation of unfolded proteins in the endoplasmic reticulum.
Yasuyuki Nomura
Yakugaku Zasshi 2014 ; 134(4):537-43
PMID: 24694815 [PubMed - as supplied by publisher]


Exosomes as mediators of neuroinflammation.
Archana Gupta, Lynn Pulliam
J Neuroinflammation 2014 Apr; 11(1):68
PMID: 24694258 [PubMed - as supplied by publisher]


Genomic and pharmacogenomic biomarkers of Parkinson's disease.
Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Elena Garcia-Martin, Jose A G Agundez
Curr Drug Metab 2014 Feb; 15(2):129-81
PMID: 24694231 [PubMed - as supplied by publisher]


Pathogenesis of Parkinson's disease through LRRK2 mutation].
Etsuro Ohta, Fumiya Obata
Seikagaku 2014 Feb; 86(1):92-7
PMID: 24693706 [PubMed - as supplied by publisher]


The Copper Metabolism MURR1 Domain Protein 1 (COMMD1) Modulates the Aggregation of Misfolded Protein Species in a Client-Specific Manner.
Willianne I M Vonk, Vaishali Kakkar, Paulina Bartuzi, Dick Jaarsma, Ruud Berger, Marten H Hofker, Leo W J Klomp, Cisca Wijmenga, Harm H Kampinga, Bart van de Sluis
PLoS One 2014 ; 9(4):e92408
PMID: 24691167 [PubMed - as supplied by publisher]


Ultrasonographic (TCS) and clinical findings in overlapping phenotype of essential tremor and Parkinson's disease (ET-PD).
Kristina Lau?kait?, Daiva Rastenyt?, Danguol? Surkien?, Birut? Vaidelyt?, Gabriel? Dambrauskait?, Andrius Sakalauskas, Antanas Vaitkus, Rymant? Gleiznien?
BMC Neurol 2014 ; 14(1):54
PMID: 24655437 [PubMed - as supplied by publisher]


Gypenosides might have neuroprotective and immunomodulatory effects on optic neuritis.
Kaijun Li, Yi Du, Qian Fan, Cheng-Ye Tang, Jian-Feng He
Med Hypotheses 2014 May; 82(5):636-8
PMID: 24629564 [PubMed - as supplied by publisher]


LRRK2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Giovanni Piccoli, Franco Onofri, Maria Daniela Cirnaru, Christoph J O Kaiser, Pravinkumar Jagtap, Andreas Kastenmüller, Francesca Pischedda, Antonella Marte, Felix von Zweydorf, Andreas Vogt, Florian Giesert, Lifeng Pan, Flavia Antonucci, Christina Kiel, Mingjie Zhang, Sevil Weinkauf, Michael Sattler, Carlo Sala, Michela Matteoli, Marius Ueffing, Christian Johannes Gloeckner
Mol Cell Biol 2014 Mar;
PMID: 24687852 [PubMed - as supplied by publisher]


Sleep and Circadian Rhythm Regulation in Early Parkinson Disease.
David P Breen, Romina Vuono, Upekshani Nawarathna, Kate Fisher, John M Shneerson, Akhilesh B Reddy, Roger A Barker
JAMA Neurol 2014 Mar;
PMID: 24687146 [PubMed - as supplied by publisher]


Tissue Transglutaminase in Alzheimer's Disease: Involvement in Pathogenesis and its Potential as a Therapeutic Target.
Micha M M Wilhelmus, Mieke de Jager, Erik N T P Bakker, Benjamin Drukarch
J Alzheimers Dis 2014 Mar;
PMID: 24685636 [PubMed - as supplied by publisher]


Serotonin transporter polymorphic region 5-HTTLPR modulates risk for Parkinson's disease.
Xiong Zhang, Xing Cheng, Yan-Bing Hu, Jun-Mei Lai, Hui You, Pei-Long Hu, Ming Zou, Jian-Hong Zhu
Neurobiol Aging 2014 Mar;
PMID: 24684793 [PubMed - as supplied by publisher]


Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease.
Barbara Shannon, Alexandra Soto-Ortolaza, Sruti Rayaprolu, Heather D Cannon, Catherine Labbé, Bruno A Benitez, Jiyoon Choi, Timothy Lynch, Magdalena Boczarska-Jedynak, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Jay A Van Gerpen, Ryan J Uitti, Wolfdieter Springer, Carlos Cruchaga, Zbigniew K Wszolek, Owen A Ross
Neurobiol Aging 2014 Mar;
PMID: 24684791 [PubMed - as supplied by publisher]


TMEM106B expression is reduced in Alzheimer's disease brains.
Jun-Ichi Satoh, Yoshihiro Kino, Natsuki Kawana, Yoji Yamamoto, Tsuyoshi Ishida, Yuko Saito, Kunimasa Arima
Alzheimers Res Ther 2014 Mar; 6(2):17
PMID: 24684749 [PubMed - as supplied by publisher]


Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.
Jason Schapansky, Jonathan D Nardozzi, Fredrik Felizia, Matthew J Lavoie
Hum Mol Genet 2014 Mar;
PMID: 24682598 [PubMed - as supplied by publisher]


Association of glycogen synthase kinase?3? with Parkinson's disease (Review).
Da-Wei Li, Zhi-Qiang Liu, Wei Chen, Min Yao, Guang-Ren Li
Mol Med Rep 2014 Mar;
PMID: 24681994 [PubMed - as supplied by publisher]


The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes.
C H O'Flanagan, V A Morais, W Wurst, B De Strooper, C O'Neill
Oncogene 2014 Mar; 0
PMID: 24681957 [PubMed - as supplied by publisher]


Tat-Fused Recombinant Human SAG Prevents Dopaminergic Neurodegeneration in a MPTP-Induced Parkinson's Disease Model.
Eun Jeong Sohn, Min Jea Shin, Dae Won Kim, Eun Hee Ahn, Hyo Sang Jo, Duk-Soo Kim, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Choi
Mol Cells 2014 Mar; 37(3):226-33
PMID: 24625574 [PubMed - as supplied by publisher]


A Novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy.
Eiichi Araki, Yoshio Tsuboi, Justus Daechsel, Austen Milnerwood, Carles Vilarino-Guell, Naoki Fujii, Takayasu Mishima, Takayuki Oka, Hideo Hara, Jiro Fukae, Matthew J Farrer
Mov Disord 2014 Feb;
PMID: 24676999 [PubMed - as supplied by publisher]


Low-Power Inversion Recovery MRI Preserves Brain Tissue Contrast for Patients with Parkinson Disease with Deep Brain Stimulators.
S N Sarkar, E Papavassiliou, R Rojas, D L Teich, D B Hackney, R A Bhadelia, J Stormann, R L Alterman
AJNR Am J Neuroradiol 2014 Mar;
PMID: 24676004 [PubMed - as supplied by publisher]


Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis.
Tiziana Alberio, Heather Bondi, Flavia Colombo, Isabella Alloggio, Luisa Pieroni, Andrea Urbani, Mauro Fasano
Mol Biosyst 2014 Mar;
PMID: 24675778 [PubMed - as supplied by publisher]


LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?
Isabella Russo, Luigi Bubacco, Elisa Greggio
J Neuroinflammation 2014 ; 11:52
PMID: 24655756 [PubMed - as supplied by publisher]


Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson's disease mouse model.
Ah-Reum Doo, Seung-Nam Kim, Dae-Hyun Hahm, Hye Hyun Yoo, Ji-Yeun Park, Hyejung Lee, Songhee Jeon, Jongpil Kim, Seong-Uk Park, Hi-Joon Park
BMC Complement Altern Med 2014 ; 14:107
PMID: 24650244 [PubMed - as supplied by publisher]


K27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
Nicol Birsa, Rosalind Norkett, Tobias Wauer, Tycho E T Mevissen, Hsiu-Chuan Wu, Thomas Foltynie, Kailash Bhatia, Warren D Hirst, David Komander, Helene Plun-Favreau, Josef T Kittler
J Biol Chem 2014 Mar;
PMID: 24671417 [PubMed - as supplied by publisher]


Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics.
Hemi Dimant, Liya Zhu, Laura N Kibuuka, Zhanyun Fan, Bradley T Hyman, Pamela J McLean
PLoS One 2014 ; 9(3):e92098
PMID: 24664141 [PubMed - as supplied by publisher]


Variant R244H in Na(+)/Mg(2+) exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg(2+) efflux function.
Chih-Hsin Lin, Yih-Ru Wu, Wan-Ling Chen, Hao-Chun Wang, Chi-Mei Lee, Guey-Jen Lee-Chen, Chiung-Mei Chen
Parkinsonism Relat Disord 2014 Mar;
PMID: 24661466 [PubMed - as supplied by publisher]


Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine65.
Agne Kazlauskaite, Chandana Kondapalli, Robert Gourlay, David G Campbell, Maria Stella Ritorto, Kay Hofmann, Dario R Alessi, Axel Knebel, Matthias Trost, Miratul M K Muqit
Biochem J 2014 Mar;
PMID: 24660806 [PubMed - as supplied by publisher]


Isolated limb dystonia as presenting feature of Parkin disease.
Antonio E Elia, Francesca Del Sorbo, Luigi M Romito, Chiara Barzaghi, Barbara Garavaglia, Alberto Albanese
J Neurol Neurosurg Psychiatry 2014 Mar;
PMID: 24659796 [PubMed - as supplied by publisher]


?-Synuclein is Prone to Interaction with the GC-Box-Like Sequence In Vitro.
Kai-Li Ma, Lian-Kun Song, Yu-He Yuan, Ying Zhang, Jin-Ling Yang, Ping Zhu, Nai-Hong Chen
Cell Mol Neurobiol 2014 Mar;
PMID: 24659023 [PubMed - as supplied by publisher]


The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis.
Ying Liu, Zhiyun Wang, Benshu Zhang
Ann Saudi Med 2014 Jan-Feb; 34(1):12-7
PMID: 24658549 [PubMed - as supplied by publisher]


Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders.
Elisabetta Maffioletti, Daniela Tardito, Massimo Gennarelli, Luisella Bocchio-Chiavetto
Front Cell Neurosci 2014 ; 8:75
PMID: 24653674 [PubMed - as supplied by publisher]


Genetic variants in diseases of the extrapyramidal system.
Anna Oczkowska, Wojciech Kozubski, Margarita Lianeri, Jolanta Dorszewska
Curr Genomics 2014 Feb; 15(1):18-27
PMID: 24653660 [PubMed - as supplied by publisher]


Association studies of sporadic Parkinson's disease in the genomic era.
Catherine Labbé, Owen A Ross
Curr Genomics 2014 Feb; 15(1):2-10
PMID: 24653658 [PubMed - as supplied by publisher]


Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
Mareike Caesar, Sandra Felk, Susanne Zach, Gunnar Brønstad, Jan O Aasly, Thomas Gasser, Frank Gillardon
Glia 2014 Mar;
PMID: 24652679 [PubMed - as supplied by publisher]


Polymorphisms of DRD2 and DRD3 genes and Parkinson's disease: A meta-analysis.
Dongjun Dai, Yunliang Wang, Lingyan Wang, Jinfeng Li, Qingqing Ma, Jianmin Tao, Xingyu Zhou, Hanlin Zhou, Yi Jiang, Guanghui Pan, Limin Xu, Ping Ru, Danfeng Lin, Jun Pan, Leiting Xu, Meng Ye, Shiwei Duan
Biomed Rep 2014 Mar; 2(2):275-281
PMID: 24649110 [PubMed - as supplied by publisher]


Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease.
Teresa Botta-Orfila, Xavier Morató, Yaroslau Compta, Juan José Lozano, Neus Falgàs, Francesc Valldeoriola, Claustre Pont-Sunyer, Dolores Vilas, Lourdes Mengual, Manel Fernández, José Luis Molinuevo, Anna Antonell, Maria José Martí, Rubén Fernández-Santiago, Mario Ezquerra
J Neurosci Res 2014 Mar;
PMID: 24648008 [PubMed - as supplied by publisher]


Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.
Agne Kazlauskaite, Van Kelly, Clare Johnson, Carla Baillie, C James Hastie, Mark Peggie, Thomas Macartney, Helen I Woodroof, Dario R Alessi, Patrick G A Pedrioli, Miratul M K Muqit
Open Biol 2014 ; 4(3):130213
PMID: 24647965 [PubMed - as supplied by publisher]


Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer's Disease and Parkinson's Disease.
Hong Shang, Guiyou Liu, Yongshuai Jiang, Jin Fu, Benping Zhang, Rongrong Song, Weizhi Wang
Mol Neurobiol 2014 Mar;
PMID: 24647822 [PubMed - as supplied by publisher]


Dicarbonyl proteome and genome damage in metabolic and vascular disease.
Naila Rabbani, Paul J Thornalley
Biochem Soc Trans 2014 Apr; 42(2):425-32
PMID: 24646255 [PubMed - as supplied by publisher]


Therapeutic Application of Intrabodies Against Age-Related Neurodegenerative Disorders.
Alessio Cardinale, Daniela Merlo, Paolo Giunchedi, Silvia Biocca
Curr Pharm Des 2014 Mar;
PMID: 24641233 [PubMed - as supplied by publisher]


Clinical and genetic analysis of Taiwanese patients with hereditary spastic paraplegia type 5.
M-Y Lan, T-H Yeh, Y-Y Chang, H-C Kuo, H S Sun, S-C Lai, C-S Lu
Eur J Neurol 2014 Mar;
PMID: 24641183 [PubMed - as supplied by publisher]


Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes ?-Synuclein externalization via exosomes.
Stephanie M Y Kong, Brian K K Chan, Jin-Sung Park, Kathryn J Hill, Jade B Aitken, Louise Cottle, Hovik Farghaian, Adam R Cole, Peter A Lay, Carolyn M Sue, Antony A Cooper
Hum Mol Genet 2014 Mar;
PMID: 24603074 [PubMed - as supplied by publisher]


Rifampicin Protects PC12 Cells from Rotenone-Induced Cytotoxicity by Activating GRP78 via PERK-eIF2?-ATF4 Pathway.
Xiuna Jing, Qiaoyun Shi, Wei Bi, Zhifen Zeng, Yanran Liang, Xia Wu, Songhua Xiao, Jun Liu, Lianhong Yang, Enxiang Tao
PLoS One 2014 ; 9(3):e92110
PMID: 24638036 [PubMed - as supplied by publisher]


Transgenic expression of human glial cell line-derived neurotrophic factor (hGDNF) from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease.
Ngoc Bao Lu-Nguyen, Martin Broadstock, Maximilian G Schliesser, Cynthia Bartholomae, Christof von Kalle, Manfred Schmidt, Rafael J Yáñez-Muñoz
Hum Gene Ther 2014 Mar;
PMID: 24635742 [PubMed - as supplied by publisher]


Sequence Variants in SLC6A3, DRD2, and BDNF Genes and Time to Levodopa-Induced Dyskinesias in Parkinson's Disease.
Natalie Kaplan, Aya Vituri, Amos D Korczyn, Oren S Cohen, Rivka Inzelberg, Gilad Yahalom, Evgenia Kozlova, Roni Milgrom, Yael Laitman, Eitan Friedman, Saharon Rosset, Sharon Hassin-Baer
J Mol Neurosci 2014 Mar;
PMID: 24633632 [PubMed - as supplied by publisher]


Transcriptomic analysis of the effects of a fish oil enriched diet on murine brains.
Rasha Hammamieh, Nabarun Chakraborty, Aarti Gautam, Stacy-Ann Miller, Seid Muhie, James Meyerhoff, Marti Jett
PLoS One 2014 ; 9(3):e90425
PMID: 24632812 [PubMed - as supplied by publisher]


Differential aggregation properties of alpha-synuclein isoforms.
May Bungeroth, Silke Appenzeller, Annika Regulin, Wolfgang Völker, Inken Lorenzen, Joachim Grötzinger, Manuela Pendziwiat, Gregor Kuhlenbäumer
Neurobiol Aging 2014 Feb;
PMID: 24629672 [PubMed - as supplied by publisher]


Astrocytic JWA Expression is Essential to Dopaminergic Neuron Survival in the Pathogenesis of Parkinson's Disease.
Shu-Han Miao, Hong-Bin Sun, Yang Ye, Jing-Jing Yang, Yao-Wei Shi, Ming Lu, Gang Hu, Jian-Wei Zhou
CNS Neurosci Ther 2014 Mar;
PMID: 24628733 [PubMed - as supplied by publisher]


Genetic Predisposition to Parkinson's Disease and Cancer.
Li Zhiming, Qing Lin, Ma Qilin, Lu Congxia, Chi-Meng Tzeng
Curr Cancer Drug Targets 2014 Mar;
PMID: 24628274 [PubMed - as supplied by publisher]


MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese.
Q Liao, N N Li, X Y Mao, X L Chang, D M Zhao, J H Zhang, W J Yu, E K Tan, R Peng
Acta Neurol Scand 2014 Mar;
PMID: 24628244 [PubMed - as supplied by publisher]


Unusual Case of Levodopa-Responsive Camptocormia in a Patient With Negative Dopamine Transporter Scan and Normal DYT 5 Gene.
Srivadee Oravivattanakul, Hesham Abboud, Hubert Fernandez, Ilia Itin
Clin Neuropharmacol 2014 Mar-Apr; 37(2):63-4
PMID: 24614670 [PubMed - as supplied by publisher]


Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental l-DOPA-induced dyskinesia.
Yong Wang, Qiao Jun Zhang, Hui Sheng Wang, Tao Wang, Jian Liu
Synapse 2014 Mar;
PMID: 24599755 [PubMed - as supplied by publisher]


Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins.
Xiaoyan Qin, Chaoya Zheng, John R Yates Iii, Lujian Liao
Mol Biosyst 2014 Mar;
PMID: 24626860 [PubMed - as supplied by publisher]


Parkinson: the latest results of gene therapy].
Jean-Yves Nau
Rev Med Suisse 2014 Jan; 10(414):202-3
PMID: 24624739 [PubMed - as supplied by publisher]


High-frequency stimulation of the subthalamic nucleus counteracts cortical expression of major histocompatibility complex genes in a rat model of Parkinson's disease.
Benjamin Grieb, Gerhard Engler, Andrew Sharott, Constantin von Nicolai, Thomas Streichert, Ismini Papageorgiou, Alexander Schulte, Manfred Westphal, Katrin Lamszus, Andreas K Engel, Christian K E Moll, Wolfgang Hamel
PLoS One 2014 ; 9(3):e91663
PMID: 24621597 [PubMed - as supplied by publisher]


Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson's disease.
Johannes Cm Schlachetzki, Franz Marxreiter, Martin Regensburger, Anna Kulinich, Beate Winner, Jürgen Winkler
Restor Neurol Neurosci 2014 Mar;
PMID: 24604006 [PubMed - as supplied by publisher]


Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway.
Giuseppina Amadoro, Veronica Corsetti, Fulvio Florenzano, Anna Atlante, Antonella Bobba, Vanessa Nicolin, Stefania L Nori, Pietro Calissano
Front Aging Neurosci 2014 ; 6:18
PMID: 24600391 [PubMed - as supplied by publisher]


The Perplexing Paradox of Paraquat: The Case for Host-Based Susceptibility and Postulated Neurodegenerative Effects.
Byron C Jones, Xuemei Huang, Richard B Mailman, Lu Lu, Robert W Williams
J Biochem Mol Toxicol 2014 Mar;
PMID: 24599642 [PubMed - as supplied by publisher]


A Reliable Indirect Cell-Labelling Protocol for Optical Imaging allows Ex Vivo Visualisation of Mesenchymal Stem Cells after Transplantation.
Valentina Diana, Ilaria Vittoria Libani, Marie-Therese Armentero, Fabio Blandini, Giovanni Lucignani, Vincenzo Silani, Lidia Cova, Luisa Ottobrini
Arch Ital Biol 2013 Sep; 151(3):114-25
PMID: 24599629 [PubMed - as supplied by publisher]