Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce X W Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush
Nat Med 2012 ; 18(2):291-5
PMID: Object id #221422286308 [PubMed - as supplied by publisher]

Penetrance of Parkinson disease in glucocerebrosidase gene mutation carriers.
M Anheim, A Elbaz, S Lesage, A Durr, C Condroyer, F Viallet, P Pollak, B Bonaïti, C Bonaïti-Pellié, A Brice,
Neurology 2012 Feb; 78(6):417-420
PMID: Object id #220322282650 [PubMed - as supplied by publisher]

Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice.
Duo Jin, Shin-Ichi Muramatsu, Nobuaki Shimizu, Shigeru Yokoyama, Hirokazu Hirai, Kiyofumi Yamada, Hong-Xiang Liu, Chiharu Higashida, Minako Hashii, Akihiko Higashida, Masahide Asano, Shoji Ohkuma, Haruhiro Higashida
Neurochem Int 2012 Jan;
PMID: Object id #173022265874 [PubMed - as supplied by publisher]

Phenotypic Variation of Autosomal-Dominant Corticobasal Degeneration.
Hans H Jung, Juliane Bremer, Johannes Streffer, Kanwar Virdee, Maria Grazia Spillantini, R Anthony Crowther, Peter Brugger, Christine Van Broeckhoven, Adriano Aguzzi, Markus Tolnay
Eur Neurol 2012 Jan; 67(3):142-150
PMID: Object id #161622261560 [PubMed - as supplied by publisher]

Treatment Options for Tauopathies.
Tarik Karakaya, Fabian Fußer, David Prvulovic, Harald Hampel
Curr Treat Options Neurol 2012 Feb;
PMID: Object id #263022307450 [PubMed - as supplied by publisher]

Neurology].
J N Chabwine, A R Rossetti, L Hirt, T Kuntzer, M Schluep, P Michel, J F Démonet, R A du Pasquier, F G Vingerhoets
Rev Med Suisse 2012 Jan; 8(323):46-50
PMID: Object id #265322303740 [PubMed - as supplied by publisher]

Iron dysregulation in movement disorders.
Petr Dusek, Joseph Jankovic, Weidong Le
Neurobiol Dis 2012 Jan;
PMID: Object id #178722266337 [PubMed - as supplied by publisher]

A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's Disease model.
Rafique Islam, Lichuan Yang, Megha Sah, Kavitha Kannan, Denise Anamani, Chibi Vijayan, Jenny Kwok, Marie E Cantino, M Flint Beal, Yih-Woei C Fridell
Neurobiol Dis 2012 Jan;
PMID: Object id #177022266335 [PubMed - as supplied by publisher]

CHO cells expressing the human P(5)-ATPase ATP13A2 are more sensitive to the toxic effects of herbicide Paraquat.
Felicitas de Tezanos Pinto, Gerardo Raul Corradi, Diego Pablo de la Hera, Hugo Pedro Adamo
Neurochem Int 2012 Jan; 60(3):243-248
PMID: Object id #170422265822 [PubMed - as supplied by publisher]

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.
Renée Vancraenenbroeck, Evy Lobbestael, Stephen D Weeks, Sergei V Strelkov, Veerle Baekelandt, Jean-Marc Taymans, Marc De Maeyer
Biochim Biophys Acta 2012 Jan; 1824(3):450-460
PMID: Object id #143622251894 [PubMed - as supplied by publisher]

Neurochemical characterization of the striatum and the nucleus accumbens in L-type Ca(v)1.3 channels knockout mice.
Ferry S P Sagala, Daniel Harnack, Evgeny Bobrov, Reinhard Sohr, Christoph Gertler, D James Surmeier, Andreas Kupsch
Neurochem Int 2011 Dec; 60(3):229-232
PMID: Object id #39122202668 [PubMed - as supplied by publisher]

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth.
Fumitaka Kawakami, Takatoshi Yabata, Etsuro Ohta, Tatsunori Maekawa, Naoki Shimada, Minori Suzuki, Hiroko Maruyama, Takafumi Ichikawa, Fumiya Obata
PLoS One 2012 ; 7(1):e30834
PMID: Object id #260722303461 [PubMed - as supplied by publisher]

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses.
Mark S Moehle, Philip J Webber, Tonia Tse, Nour Sukar, David G Standaert, Tara M Desilva, Rita M Cowell, Andrew B West
J Neurosci 2012 Feb; 32(5):1602-11
PMID: Object id #254022302802 [PubMed - as supplied by publisher]

Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma.
Reika Iwakawa, Hirokazu Okayama, Takashi Kohno, Aiko Sato-Otsubo, Seishi Ogawa, Jun Yokota
Genes Chromosomes Cancer 2012 Feb;
PMID: Object id #235422302706 [PubMed - as supplied by publisher]

Activation of the Unfolded Protein Response Is an Early Event in Alzheimer's and Parkinson's Disease.
Jeroen J M Hoozemans, Elise S van Haastert, Diana A T Nijholt, Annemieke J M Rozemuller, Wiep Scheper
Neurodegener Dis 2012 Feb;
PMID: Object id #237822302012 [PubMed - as supplied by publisher]

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.
I Pimenta de Castro, A C Costa, D Lam, R Tufi, V Fedele, N Moisoi, D Dinsdale, E Deas, S H Y Loh, L M Martins
Cell Death Differ 2012 Feb;
PMID: Object id #239022301916 [PubMed - as supplied by publisher]

Assaying the Kinase Activity of LRRK2 in vitro.
Patrick A Lewis
J Vis Exp 2012 ; (59)
PMID: Object id #243422301813 [PubMed - as supplied by publisher]

Stress, Allostatic Load, Catecholamines, and Other Neurotransmitters in Neurodegenerative Diseases.
David S Goldstein
Cell Mol Neurobiol 2012 Feb;
PMID: Object id #243622297542 [PubMed - as supplied by publisher]

Nurr1 regulates Top IIbeta and functions in axon genesis of mesencephalic dopaminergic neurons.
Xin Heng, Gang Jin, Xin Zhang, Dehua Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le
Mol Neurodegener 2012 Feb; 7(1):4
PMID: Object id #247822296971 [PubMed - as supplied by publisher]

Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
Erik Cederfjäll, Gurdal Sahin, Deniz Kirik, Tomas Björklund
Mol Ther 2012 Jan;
PMID: Object id #250622294150 [PubMed - as supplied by publisher]

Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways.
Jonathan Wills, Joel Credle, Adam W Oaks, Valeriy Duka, Jae-Hoon Lee, Jessica Jones, Anita Sidhu
PLoS One 2012 ; 7(1):e30745
PMID: Object id #232922292029 [PubMed - as supplied by publisher]

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.
Christian Wider, Owen A Ross, Kenya Nishioka, Michael G Heckman, Carles Vilariño-Güell, Barbara Jasinska-Myga, Nilufer Erketin-Taner, Rosa Rademakers, Neill R Graff-Radford, Deborah C Mash, Spiridon Papapetropoulos, Ranjan Duara, Hirotake Uchikado, Zbigniew K Wszolek, Matthew J Farrer, Dennis W Dickson
J Neurol Neurosurg Psychiatry 2012 Jan;
PMID: Object id #230322291217 [PubMed - as supplied by publisher]

Hypoxia regulation of ATP13A2 (PARK9) gene transcription.
Qian Xu, Hongling Guo, Xiaojie Zhang, Beisha Tang, Fang Cai, Weihui Zhou, Weihong Song
J Neurochem 2012 Jan;
PMID: Object id #226522288903 [PubMed - as supplied by publisher]

Drosophila Models of Proteinopathies: the Little Fly that Coulds.
Diego E Rincon-Limas, Kurt Jensen, Pedro Fernandez-Funez
Curr Pharm Des 2012 Jan;
PMID: Object id #224022288402 [PubMed - as supplied by publisher]

Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity.
S Lopez, L Jouve, N Turle-Lorenzo, L Kerkerian-Legoff, P Salin, M Amalric
Neurobiol Dis 2012 Jan;
PMID: Object id #138622245662 [PubMed - as supplied by publisher]

Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells.
Equar Taka, Elizabeth Mazzio, Karam F A Soliman, R Renee Reams
Neurotoxicology 2012 Jan;
PMID: Object id #214722281203 [PubMed - as supplied by publisher]

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin.
Michael Lazarou, Seok Min Jin, Lesley A Kane, Richard J Youle
Dev Cell 2012 Jan;
PMID: Object id #212822280891 [PubMed - as supplied by publisher]

Role of axonal transport in ALS.
Fumiaki Tanaka, Kensuke Ikenaka, Gen Sobue
Rinsho Shinkeigaku 2011 Nov; 51(11):1189-91
PMID: Object id #209122277530 [PubMed - as supplied by publisher]

"Pathophysiology and clinical presentation of Parkinson's disease-up to date" pathomechanisms of Parkinson's disease.
Takafumi Hasegawa
Rinsho Shinkeigaku 2011 Nov; 51(11):1165-7
PMID: Object id #207122277521 [PubMed - as supplied by publisher]

Selective degradation of expanded polyglutamine proteins by their specific recognition with QBP1.
Yoshitaka Nagai, Nobuyuki Nukina
Rinsho Shinkeigaku 2011 Nov; 51(11):1108-10
PMID: Object id #205422277499 [PubMed - as supplied by publisher]

Seed, aggregation and propagation of abnormal proteins could explain neurodegeneration?
Shigeo Murayama
Rinsho Shinkeigaku 2011 Nov; 51(11):1097-9
PMID: Object id #203422277493 [PubMed - as supplied by publisher]

Genetics of sporadic disease: insights from high-throughput sequencing -Parkinson disease-.
Jun Mitsui
Rinsho Shinkeigaku 2011 Nov; 51(11):973-4
PMID: Object id #202022277445 [PubMed - as supplied by publisher]

"Atypical" method for understanding dementia. How can studying epigenetics contribute?
Atsushi Iwata
Rinsho Shinkeigaku 2011 Nov; 51(11):928-9
PMID: Object id #199522277421 [PubMed - as supplied by publisher]

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.
Eisuke Itakura, Chieko Kishi-Itakura, Ikuko Koyama-Honda, Noboru Mizushima
J Cell Sci 2012 Jan;
PMID: Object id #195422275429 [PubMed - as supplied by publisher]

Head injury, alpha-synuclein Rep1, and Parkinson's disease.
Samuel M Goldman, Freya Kamel, G Webster Ross, Sarah A Jewell, Grace S Bhudhikanok, David Umbach, Connie Marras, Robert A Hauser, Joseph Jankovic, Stewart A Factor, Susan Bressman, Kelly E Lyons, Cheryl Meng, Monica Korell, Diana F Roucoux, Jane A Hoppin, Dale P Sandler, J William Langston, Caroline M Tanner
Ann Neurol 2012 Jan; 71(1):40-8
PMID: Object id #195222275250 [PubMed - as supplied by publisher]

Towards a systems level view of the ECM and related proteins: A framework for the systematic definition and analysis of biological systems.
Graham L Cromar, Xuejian Xiong, Emilie Chautard, Sylvie Ricard-Blum, John Parkinson
Proteins 2012 Jan;
PMID: Object id #189722275077 [PubMed - as supplied by publisher]

Advances in the Treatment of Neurodegenerative Disorders Employing Nanoparticles.
Carlos Spuch, Ortolano Saida, Carmen Navarro
Recent Pat Drug Deliv Formul 2012 Jan;
PMID: Object id #188622272933 [PubMed - as supplied by publisher]

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.
Ji Won Um, Kyung Ah Han, Eunju Im, Yohan Oh, Kyule Lee, Kwang Chul Chung
J Neurosci Res 2012 Jan;
PMID: Object id #186522271254 [PubMed - as supplied by publisher]

Towards unveiling the genetics of neurodegenerative diseases.
Christina M Lill, Lars Bertram
Semin Neurol 2011 Nov; 31(5):531-41
PMID: Object id #183922266890 [PubMed - as supplied by publisher]

Genetics of Parkinson's disease.
Kishore R Kumar, Ana Djarmati-Westenberger, Anne Grünewald
Semin Neurol 2011 Nov; 31(5):433-40
PMID: Object id #179622266881 [PubMed - as supplied by publisher]

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.
Lisa Glasl, Karina Kloos, Florian Giesert, Anne Roethig, Barbara Di Benedetto, Ralf Kühn, Jingzhong Zhang, Ulrich Hafen, Julia Zerle, Andreas Hofmann, Martin Hrabé de Angelis, Konstanze F Winklhofer, Sabine M Hölter, Daniela M Vogt Weisenhorn, Wolfgang Wurst
Exp Neurol 2012 Jan;
PMID: Object id #167222265660 [PubMed - as supplied by publisher]

MicroRNAs in Parkinson's disease.
M Maral Mouradian
Neurobiol Dis 2012 Jan;
PMID: Object id #135722245218 [PubMed - as supplied by publisher]

Use of viral vectors to create animal models for Parkinson's disease.
Karin Löw, Patrick Aebischer
Neurobiol Dis 2011 Dec;
PMID: Object id #95022227451 [PubMed - as supplied by publisher]

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration.
Jeyapriya R Sundaram, Elizabeth S Chan, Charlene P Poore, Tej K Pareek, Wei Fun Cheong, Guanghou Shui, Ning Tang, Chian-Ming Low, Markus R Wenk, Sashi Kesavapany
J Neurosci 2012 Jan; 32(3):1020-34
PMID: Object id #164222262900 [PubMed - as supplied by publisher]

Update on Genetics of Parkinsonism.
Shinsuke Fujioka, Zbigniew K Wszolek
Neurodegener Dis 2012 Jan;
PMID: Object id #158422261420 [PubMed - as supplied by publisher]

High content screening in neurodegenerative diseases.
Shushant Jain, Ronald E van Kesteren, Peter Heutink
J Vis Exp 2012 ; (59)
PMID: Object id #156522257990 [PubMed - as supplied by publisher]

Tef polymorphism is associated with sleep disturbances in patients with Parkinson's disease.
Ping Hua, Weiguo Liu, Yanyan Zhao, Haixia Ding, Li Wang, Hong Xiao
Sleep Med 2012 Jan;
PMID: Object id #153522257907 [PubMed - as supplied by publisher]

The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.
Edward C Lauterbach, Leonardo F Fontenelle, Antonio L Teixeira
Parkinsons Dis 2012 ; 2012:753548
PMID: Object id #150722254151 [PubMed - as supplied by publisher]

Critical aspects of clinical trial design for novel cell and gene therapies.
Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie
Parkinsons Dis 2011 ; 2011:804041
PMID: Object id #147322254150 [PubMed - as supplied by publisher]

LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?
Patrick A Lewis, Claudia Manzoni
Sci Signal 2012 ; 5(207):pe2
PMID: Object id #145322253261 [PubMed - as supplied by publisher]

Sleep-Disordered Breathing in Neurodegenerative Diseases.
Carles Gaig, Alex Iranzo
Curr Neurol Neurosci Rep 2012 Jan;
PMID: Object id #140622249490 [PubMed - as supplied by publisher]

A DNA resequencing array for genes involved in Parkinson's disease.
E J Wilkins, J P Rubio, K E Kotschet, T F Cowie, W C Boon, M O'Hely, R Burfoot, W Wang, C M Sue, T P Speed, J Stankovitch, M K Horne
Parkinsonism Relat Disord 2012 Jan;
PMID: Object id #133522243833 [PubMed - as supplied by publisher]

The role of mitochondrial dynamics in neurodegeneration].
Wen-Wei Li, Min Zhu, Chuan-Zhen Lv
Sheng Li Ke Xue Jin Zhan 2011 Oct; 42(5):347-52
PMID: Object id #128622242401 [PubMed - as supplied by publisher]

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease.
Zhi Yao, Sonia Gandhi, Victoria S Burchell, Helene Plun-Favreau, Nicholas W Wood, Andrey Y Abramov
J Cell Sci 2011 Dec; 124(Pt 24):4194-202
PMID: Object id #89822223879 [PubMed - as supplied by publisher]

The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants.
Sven Vilain, Giovanni Esposito, Dominik Haddad, Onno Schaap, Mariya P Dobreva, Melissa Vos, Stefanie Van Meensel, Vanessa A Morais, Bart De Strooper, Patrik Verstreken
PLoS Genet 2012 Jan; 8(1):e1002456
PMID: Object id #127922242018 [PubMed - as supplied by publisher]

parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress.
Amanda Vincent, Laura Briggs, Griff F J Chatwin, Elizabeth Emery, Rose Tomlins, Matt Oswald, C Adam Middleton, Gareth J O Evans, Sean T Sweeney, Christopher J H Elliott
Hum Mol Genet 2012 Jan;
PMID: Object id #68322215442 [PubMed - as supplied by publisher]

PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's disease.
Chin-Song Lu, Szu-Chia Lai, Ruey-Meei Wu, Yi-Hsin Weng, Chia-Ling Huang, Rou-Shayn Chen, Hsiu-Chen Chang, Yah-Huei Wu-Chou, Tu-Hsueh Yeh
Am J Med Genet B Neuropsychiatr Genet 2012 Mar; 159B(2):183-91
PMID: Object id #67322213678 [PubMed - as supplied by publisher]

Microtubule affinity regulating kinase 2 (MARK2) turns PTEN-induced kinase 1 (PINK1) on at T313, a mutation site in Parkinson's disease: Effects on mitochondrial transport.
Dorthe Matenia, Cindy Hempp, Thomas Timm, Annika Eikhof, Eva-Maria Mandelkow
J Biol Chem 2012 Jan;
PMID: Object id #125022238344 [PubMed - as supplied by publisher]

Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1.
Oliver Kaut, Ina Schmitt, Ullrich Wüllner
Neurogenetics 2012 Jan;
PMID: Object id #122322238121 [PubMed - as supplied by publisher]

L-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor.
Amandine Berthet, Erwan Bezard, Gregory Porras, Stefania Fasano, Pedro Barroso-Chinea, Benjamin Dehay, Audrey Martinez, Marie-Laure Thiolat, Marika Nosten-Bertrand, Bruno Giros, Jérôme Baufreton, Qin Li, Bertrand Bloch, Marie-Laure Martin-Negrier
J Neurosci 2012 Jan; 32(2):681-91
PMID: Object id #119922238104 [PubMed - as supplied by publisher]

Reduced Content of ?-Synuclein in Peripheral Blood Leukocytes of Patients with LRRK2-Associated Parkinson's Disease.
S N Pchelina, A K Emelyanov, A F Yakimovskii, D W Miller, I G Shabalina, A S Drozdova, A L Schwarzman
Bull Exp Biol Med 2011 Apr; 150(6):679-81
PMID: Object id #116822235415 [PubMed - as supplied by publisher]

Genetic bases and phenotypes of autosomal recessive Parkinson disease in a Turkish population.
E Lohmann, B Dursun, S Lesage, H A Hanagasi, G Sevinc, A Honore, B Bilgic, H Gürvit, O Dogu, H Kaleagas?, G Babacan, J Yazici, N Erginel-Unaltuna, A Brice, M Emre
Eur J Neurol 2012 Jan;
PMID: Object id #113622233331 [PubMed - as supplied by publisher]

A prolyl oligopeptidase inhibitor, KYP-2047, reduces ?-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.
T T Myöhänen, M J Hannula, R Van Elzen, M Gerard, P Van Der Veken, J A García-Horsman, V Baekelandt, P T Männistö, A M Lambeir
Br J Pharmacol 2012 Jan;
PMID: Object id #108322233220 [PubMed - as supplied by publisher]

Glutathione S-transferase Omega 1 Activity is Sufficient to Suppress Neurodegeneration in a Drosophila Model of Parkinson's Disease.
Kiyoung Kim, Song-Hee Kim, Jaekwang Kim, Heuijong Kim, Jeongbin Yim
J Biol Chem 2012 Jan;
PMID: Object id #73022219196 [PubMed - as supplied by publisher]

Phosphorylation of ?-synuclein at Ser129 reduces neuronal dysfunction by lowering its membrane-binding property in Caenorhabditis elegans.
Tomoki Kuwahara, Reina Tonegawa, Genta Ito, Shohei Mitani, Takeshi Iwatsubo
J Biol Chem 2012 Jan;
PMID: Object id #108222232559 [PubMed - as supplied by publisher]

Association of Sequence Alterations in the Putative Promoter of RAB7L1 With a Reduced Parkinson Disease Risk.
Ziv Gan-Or, Anat Bar-Shira, Dvir Dahary, Anat Mirelman, Merav Kedmi, Tanya Gurevich, Nir Giladi, Avi Orr-Urtreger
Arch Neurol 2012 Jan; 69(1):105-10
PMID: Object id #105322232350 [PubMed - as supplied by publisher]

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway.
Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen
Mol Neurodegener 2012 Jan; 7(1):2
PMID: Object id #101822230652 [PubMed - as supplied by publisher]

TARGETING MITOCHONDRIA FOR NEUROPROTECTION IN PARKINSON'S DISEASE.
Anthony H V Schapira
Antioxid Redox Signal 2012 Jan;
PMID: Object id #99222229791 [PubMed - as supplied by publisher]

LRRK2 Regulates Mitochondrial Dynamics and Function through Direct Interaction with DLP1.
Xinglong Wang, Michael H Yan, Hisashi Fujioka, Jun Liu, Amy Wilson-Delfosse, Shu G Chen, George Perry, Gemma Casadesus, Xiongwei Zhu
Hum Mol Genet 2012 Jan;
PMID: Object id #95722228096 [PubMed - as supplied by publisher]

DNA Repair Genes in Parkinson's Disease.
Mehmet Gencer, Selcuk Dasdemir, Bedia Cakmakoglu, Yilmaz Cetinkaya, Figen Varlibas, Hulya Tireli, Cem Ismail Kucukali, Elif Ozkok, Makbule Aydin
Genet Test Mol Biomarkers 2012 Jan;
PMID: Object id #93322224629 [PubMed - as supplied by publisher]

Promoter methylation analysis of seven clock genes in Parkinson's disease.
Qingling Lin, Hui Ding, Zheng Zheng, Zhuqin Gu, Jinghong Ma, Ling Chen, Piu Chan, Yanning Cai
Neurosci Lett 2012 Jan; 507(2):147-50
PMID: Object id #15222193177 [PubMed - as supplied by publisher]

Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease.
Helen Michelakakis, Georgia Xiromerisiou, Efthimios Dardiotis, Maria Bozi, Demetrios Vassilatis, Persa-Maria Kountra, Gianna Patramani, Marina Moraitou, Dimitra Papadimitriou, Eleftherios Stamboulis, Leonidas Stefanis, Elias Zintzaras, Georgios M Hadjigeorgiou
Mov Disord 2012 Jan;
PMID: Object id #87622223122 [PubMed - as supplied by publisher]

Novel muscarinic receptor mutant mouse models.
Jürgen Wess
Handb Exp Pharmacol 2012 ; 208:95-117
PMID: Object id #82722222697 [PubMed - as supplied by publisher]

Tau acts as an independent genetic risk factor in pathologically proven PD.
Gavin Charlesworth, Sonia Gandhi, Jose M Bras, Roger A Barker, David J Burn, Patrick F Chinnery, Stephen M Gentleman, Rita Guerreiro, John Hardy, Janice L Holton, Andrew Lees, Karen Morrison, Una-Marie Sheerin, Nigel Williams, Huw Morris, Tamas Revesz, Nicholas W Wood
Neurobiol Aging 2012 Jan;
PMID: Object id #82322221882 [PubMed - as supplied by publisher]

Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways.
Lilach Soreq, Yoram Ben-Shaul, Zvi Israel, Hagai Bergman, Hermona Soreq
Neurobiol Dis 2011 Dec;
PMID: Object id #31222198569 [PubMed - as supplied by publisher]

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy.
Aaron M Gusdon, Jianhui Zhu, Bennett Van Houten, Charleen T Chu
Neurobiol Dis 2011 Dec;
PMID: Object id #28622198378 [PubMed - as supplied by publisher]

ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice.
Xin Liu, Michael Dobbie, Rob Tunningley, Belinda Whittle, Yafei Zhang, Lars M Ittner, Jürgen Götz
J Biomed Biotechnol 2011 ; 2011:130947
PMID: Object id #77522219655 [PubMed - as supplied by publisher]

Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to L: -dopa in a Parkinson's animal model.
Alba Minelli, C Conte, I Cacciatore, C Cornacchia, F Pinnen
Amino Acids 2012 Jan;
PMID: Object id #69222218995 [PubMed - as supplied by publisher]

Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner.
Chang Deng, Ran Tao, Shun-Zhi Yu, Hua Jin
Mol Med Report 2012 Mar; 5(3):847-51
PMID: Object id #34022200816 [PubMed - as supplied by publisher]

25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.
Masahiko Suzuki, Masayuki Yoshioka, Masaya Hashimoto, Maiko Murakami, Keiichi Kawasaki, Miki Noya, Daisuke Takahashi, Mitsuyoshi Urashima
Mov Disord 2011 Dec;
PMID: Object id #64322213340 [PubMed - as supplied by publisher]

PINK1 Overexpression Protects Against C2-ceramide-Induced CAD Cell Death Through the PI3K/AKT Pathway.
Ruth Mélida Sánchez-Mora, Humberto Arboleda, Gonzalo Arboleda
J Mol Neurosci 2012 Jan;
PMID: Object id #61522212487 [PubMed - as supplied by publisher]

Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.
Meaghan Morris, Akihiko Koyama, Eliezer Masliah, Lennart Mucke
PLoS One 2011 ; 6(12):e29257
PMID: Object id #54022206005 [PubMed - as supplied by publisher]

Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.
Ellen Gerhardt, Simone Gräber, Eva M Szego, Nicoleta Moisoi, L Miguel Martins, Tiago F Outeiro, Pawel Kermer
PLoS One 2011 ; 6(12):e28855
PMID: Object id #56322205977 [PubMed - as supplied by publisher]

New brain-specific beta-synuclein isoforms show expression ratio changes in Lewy body diseases.
Katrin Beyer, Ana M Munoz-Marmol, Carolina Sanz, Ruth Marginet-Flinch, Isidro Ferrer, Aurelio Ariza
Neurogenetics 2011 Dec;
PMID: Object id #50622205345 [PubMed - as supplied by publisher]

Targeting Skp1, an Ubiquitin E3 Ligase Component Found Decreased in Sporadic Parkinson's Disease.
Silvia A Mandel, Tali Fishman-Jacob, Moussa B H Youdim
Neurodegener Dis 2011 Dec;
PMID: Object id #50222205206 [PubMed - as supplied by publisher]

Neurorescue Effect of Rosmarinic Acid on 6-Hydroxydopamine-Lesioned Nigral Dopamine Neurons in Rat Model of Parkinson's Disease.
Jieyu Wang, Huamin Xu, Hong Jiang, Xixun Du, Peng Sun, Junxia Xie
J Mol Neurosci 2011 Dec;
PMID: Object id #48922205146 [PubMed - as supplied by publisher]

Parkin: Much More than a Simple Ubiquitin Ligase.
C Alves da Costa, F Checler
Neurodegener Dis 2011 Dec;
PMID: Object id #44722204976 [PubMed - as supplied by publisher]

Regulation of Physiologic Actions of LRRK2: Focus on Autophagy.
Andrew Ferree, Maria Guillily, Hu Li, Katelyn Smith, Aki Takashima, Rachel Squillace, Manfred Weigele, James J Collins, Benjamin Wolozin
Neurodegener Dis 2011 Dec;
PMID: Object id #42422204929 [PubMed - as supplied by publisher]

Therapeutic effect of near infrared (NIR) light on Parkinson's disease models.
Brendan J Quirk, Kristina D Desmet, Michele Henry, Ellen Buchmann, Margaret Wong-Riley, Janis T Eells, Harry T Whelan
Front Biosci (Elite Ed) 2012 ; 4:818-23
PMID: Object id #36722201916 [PubMed - as supplied by publisher]

The Transcription Factor NURR1 Exerts Concentration-Dependent Effects on Target Genes Mediating Distinct Biological Processes.
Magen M Johnson, Sharon K Michelhaugh, Mohamad Bouhamdan, Carl J Schmidt, Michael J Bannon
Front Neurosci 2011 ; 5:135
PMID: Object id #29222194714 [PubMed - as supplied by publisher]

MicroRNAs in Human Diseases: From Autoimmune Diseases to Skin, Psychiatric and Neurodegenerative Diseases.
Tai-You Ha
Immune Netw 2011 Oct; 11(5):227-44
PMID: Object id #23322194706 [PubMed - as supplied by publisher]

Bioenergetic Origins of Complexity and Disease.
D C Wallace
Cold Spring Harb Symp Quant Biol 2011 Dec;
PMID: Object id #16122194359 [PubMed - as supplied by publisher]

Clinical and Pathological Characteristics of LRRK2 G2019S Patients with PD.
Markos Poulopoulos, Etty Cortes, Jean-Paul G Vonsattel, Stanley Fahn, Cheryl Waters, Lucien J Cote, Carol Moskowitz, Lawrence S Honig, Lorraine N Clark, Karen S Marder, Roy N Alcalay
J Mol Neurosci 2011 Dec;
PMID: Object id #21922194196 [PubMed - as supplied by publisher]

Olfaction in Parkinson's disease and related disorders.
Richard L Doty
Neurobiol Dis 2011 Dec;
PMID: Object id #12222192366 [PubMed - as supplied by publisher]

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis.
Michael A van Es, Helenius J Schelhaas, Paul W J van Vught, Nicola Ticozzi, Peter M Andersen, Ewout J N Groen, Claudia Schulte, Hylke M Blauw, Max Koppers, Frank P Diekstra, Katsumi Fumoto, Ashley Lyn LeClerc, Pamela Keagle, Bastiaan R Bloem, Hans Scheffer, Bart F L van Nuenen, Marka van Blitterswijk, Wouter van Rheenen, Anne-Marie Wills, Patrick P Lowe, Guo-fu Hu, Wenhao Yu, Hiroko Kishikawa, David Wu, Rebecca D Folkerth, Claudio Mariani, Stefano Goldwurm, Gianni Pezzoli, Philip Van Damme, Robin Lemmens, Caroline Dahlberg, Anna Birve, Rubén Fernández-Santiago, Stefan Waibel, Christine Klein, Markus Weber, Anneke J van der Kooi, Marianne de Visser, Dagmar Verbaan, Jacobus J van Hilten, Peter Heutink, Eric A M Hennekam, Edwin Cuppen, Daniela Berg, Robert H Brown, Vincenzo Silani, Thomas Gasser, Albert C Ludolph, Wim Robberecht, Roel A Ophoff, Jan H Veldink, R Jeroen Pasterkamp, Paul I W de Bakker, John E Landers, Bart P van de Warrenburg, Leonard H van den Berg
Ann Neurol 2011 Dec; 70(6):964-73
PMID: Object id #9322190368 [PubMed - as supplied by publisher]

Molecular pathways in sporadic PD.
Enza Maria Valente, Giuseppe Arena, Liliana Torosantucci, Vania Gelmetti
Parkinsonism Relat Disord 2012 Jan; 18 Suppl 1:S71-3
PMID: Object id #7022166460 [PubMed - as supplied by publisher]

Autosomal dominant Parkinson's disease.
Christina Sundal, Shinsuke Fujioka, Ryan J Uitti, Zbigniew K Wszolek
Parkinsonism Relat Disord 2012 Jan; 18 Suppl 1:S7-10
PMID: Object id #258022166459 [PubMed - as supplied by publisher]

Role of Mendelian genes in "sporadic" Parkinson's disease.
Suzanne Lesage, Alexis Brice
Parkinsonism Relat Disord 2012 Jan; 18 Suppl 1:S66-70
PMID: Object id #256222166458 [PubMed - as supplied by publisher]

Genetic variants in sporadic Parkinson's disease: East vs West.
Tasneem Peeraully, E K Tan
Parkinsonism Relat Disord 2012 Jan; 18 Suppl 1:S63-5
PMID: Object id #269322166457 [PubMed - as supplied by publisher]

Parkinson's disease: molecular risk factors.
Edna Grünblatt
Parkinsonism Relat Disord 2012 Jan; 18 Suppl 1:S45-8
PMID: Object id #271322166452 [PubMed - as supplied by publisher]