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Featured Research

What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.

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Genetics and PD

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene-environment interactions.
Michaela E Johnson, Larisa Bobrovskaya
Neurotoxicology 2014 Dec; 46C:101-116
PMID: 25514659 [PubMed - as supplied by publisher]


An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.
XiaoQin Yuan, YongPing Chen, Bei Cao, Bi Zhao, QianQian Wei, XiaoYan Guo, Yuan Yang, LiXing Yuan, HuiFang Shang
Parkinsonism Relat Disord 2015 Feb; 21(2):147-149
PMID: 25511328 [PubMed - as supplied by publisher]


Amyloid ? oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Kirsten L Viola, William L Klein
Acta Neuropathol 2015 Feb; 129(2):183-206
PMID: 25604547 [PubMed - as supplied by publisher]


Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.
James M Gruschus, Zhiping Jiang, Thai Leong Yap, Stephanie A Hill, Alexander Grishaev, Grzegorz Piszczek, Ellen Sidransky, Jennifer C Lee
Biochem Biophys Res Commun 2015 Jan;
PMID: 25600808 [PubMed - as supplied by publisher]


The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.
Feng Gao, Dong Chen, Jianmin Si, Qingsong Hu, Zhenghong Qin, Ming Fang, Guanghui Wang
Hum Mol Genet 2015 Jan;
PMID: 25612572 [PubMed - as supplied by publisher]


The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease.
Alicia M Pickrell, Richard J Youle
Neuron 2015 Jan; 85(2):257-273
PMID: 25611507 [PubMed - as supplied by publisher]


A53T Human ?-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration.
Linan Chen, Zhiguo Xie, Susie Turkson, Xiaoxi Zhuang
J Neurosci 2015 Jan; 35(3):890-905
PMID: 25609609 [PubMed - as supplied by publisher]


Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Jing Yan, Ahmad Almilaji, Evi Schmid, Bernat Elvira, Derya R Shimshek, Herman van der Putten, Carsten A Wagner, Ekaterina Shumilina, Florian Lang
FASEB J 2015 Jan;
PMID: 25609428 [PubMed - as supplied by publisher]


PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.
Ghazaleh Ashrafi, Thomas L Schwarz
Autophagy 2015 Jan; :0
PMID: 25607607 [PubMed - as supplied by publisher]


The reduction of vascular disease risk mutations contributes to longevity in the Chinese population.
Yong-Han He, Xiang Lu, Ming-Xin Bi, Li-Qin Yang, Liang-You Xu, Qing-Peng Kong
Meta Gene 2014 Dec; 2:761-8
PMID: 25606459 [PubMed - as supplied by publisher]


An early endosome regulator, Rab5b, is an LRRK2 kinase substrate.
Hye Jin Yun, Hyejung Kim, Inhwa Ga, Hakjin Oh, Dong Hwan Ho, Jiyoung Kim, Hyemyung Seo, Ilhong Son, Wongi Seol
J Biochem 2015 Jan;
PMID: 25605758 [PubMed - as supplied by publisher]


Rare variants in ?-Amyloid precursor protein (APP) and Parkinson's disease.
Eva C Schulte, Akio Fukumori, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann
Eur J Hum Genet 2015 Jan;
PMID: 25604855 [PubMed - as supplied by publisher]


Head injury, potential interaction with genes, and risk for Parkinson's disease.
Jianjun Gao, Rui Liu, Edward Zhao, Xuemei Huang, Michael A Nalls, Andrew B Singleton, Honglei Chen
Parkinsonism Relat Disord 2015 Jan;
PMID: 25603768 [PubMed - as supplied by publisher]


CHIP is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Amy Marie Palubinsky, Jeannette Nicole Stankowski, Alixandra Cozette Kale, Simona G Codreanu, Robert J Singer, Daniel C Liebler, Gregg D Stanwood, BethAnn Marie McLaughlin
Antioxid Redox Signal 2015 Jan;
PMID: 25602369 [PubMed - as supplied by publisher]


Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]


Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2014 Dec;
PMID: 25599874 [PubMed - as supplied by publisher]


Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle.
S Pablo Sardi, Seng H Cheng, Lamya S Shihabuddin
Prog Neurobiol 2015 Jan;
PMID: 25573151 [PubMed - as supplied by publisher]


Canonical Wnt Signaling Regulates Atrioventricular Junction Programming and Electrophysiological Properties.
Benjamin S Gillers, Aditi Chiplunkar, Haytham Aly, Tomas Valenta, Konrad Basler, Vincent M Christoffels, Igor R Efimov, Bastiaan J Boukens, Stacey Rentschler
Circ Res 2014 Nov;
PMID: 25599332 [PubMed - as supplied by publisher]


The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.
Gerwyn Morris, Michael Berk, Piotr Galecki, Ken Walder, Michael Maes
Mol Neurobiol 2015 Jan;
PMID: 25598355 [PubMed - as supplied by publisher]


Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.
Yu Tang, Weidong Le
Mol Neurobiol 2015 Jan;
PMID: 25598354 [PubMed - as supplied by publisher]


Purine metabolism gene deregulation in Parkinson's disease.
Paula Garcia-Esparcia, Karina Hernández-Ortega, Belén Ansoleaga, Margarita Carmona, Isidre Ferrer
Neuropathol Appl Neurobiol 2015 Jan;
PMID: 25597950 [PubMed - as supplied by publisher]


Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells.
Tadaatsu Imaizumi, Nina Sakashita, Yasuaki Mushiga, Hidemi Yoshida, Ryo Hayakari, Fei Xing, Liang Wang, Tomoh Matsumiya, Kunikazu Tanji, Yuki Chiba, Ken Furudate, Shogo Kawaguchi, Manabu Murakami, Hiroshi Tanaka
Neurosci Res 2015 Jan;
PMID: 25591911 [PubMed - as supplied by publisher]


The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: Possible significance in the transgenic model mouse of Parkinson's disease.
T Miyajima, E Ohta, H Kawada, T Maekawa, F Obata
Neurosci Lett 2015 Jan; 588C:142-146
PMID: 25562633 [PubMed - as supplied by publisher]


Possible involvement of iron-induced oxidative insults in neurodegeneration.
Takeshi Asano, Masato Koike, Shin-Ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai
Neurosci Lett 2014 Dec; 588C:29-35
PMID: 25549542 [PubMed - as supplied by publisher]


Therapeutic strategies in Parkinson's disease: what we have learned from animal models.
Jorge S Valadas, Melissa Vos, Patrik Verstreken
Ann N Y Acad Sci 2014 Dec;
PMID: 25515068 [PubMed - as supplied by publisher]


CSF tau and tau/A?42 predict cognitive decline in Parkinson's disease.
Changqin Liu, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, , Jing Zhang
Parkinsonism Relat Disord 2015 Jan;
PMID: 25596881 [PubMed - as supplied by publisher]


Overexpression of blood microRNAs 103a, 30b, and 29a in l-dopa-treated patients with PD.
Alice Serafin, Luisa Foco, Stefano Zanigni, Hagen Blankenburg, Anne Picard, Alessandra Zanon, Giulia Giannini, Irene Pichler, Maurizio F Facheris, Pietro Cortelli, Peter P Pramstaller, Andrew A Hicks, Francisco S Domingues, Christine Schwienbacher
Neurology 2015 Jan;
PMID: 25596505 [PubMed - as supplied by publisher]


COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese.
Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu
Mov Disord 2015 Jan;
PMID: 25594503 [PubMed - as supplied by publisher]


Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
Erik Cederfjäll, Lauren Broom, Deniz Kirik
Mol Ther 2015 Jan;
PMID: 25592335 [PubMed - as supplied by publisher]


Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns.
Kenneth K B Tan, Jason Y Tann, Sharvari R Sathe, Seok Hong Goh, Dongliang Ma, Eyleen L K Goh, Evelyn K F Yim
Biomaterials 2015 Mar; 43:32-43
PMID: 25591959 [PubMed - as supplied by publisher]


Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-? hydroxysteroid dehydrogenase type 10.
G Bertolin, M Jacoupy, S Traver, R Ferrando-Miguel, T Saint Georges, K Grenier, H Ardila-Osorio, M-P Muriel, H Takahashi, A J Lees, C Gautier, D Guedin, F Coge, E A Fon, A Brice, O Corti
Cell Death Differ 2015 Jan;
PMID: 25591737 [PubMed - as supplied by publisher]


A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes.
N K Magdalinou, R W Paterson, J M Schott, N C Fox, C Mummery, K Blennow, K Bhatia, H R Morris, P Giunti, T T Warner, R de Silva, A J Lees, H Zetterberg
J Neurol Neurosurg Psychiatry 2015 Jan;
PMID: 25589779 [PubMed - as supplied by publisher]


Role of ?-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease.
Heather E Allen Reish, David G Standaert
J Parkinsons Dis 2015 Jan;
PMID: 25588354 [PubMed - as supplied by publisher]


STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
Pradeep K Kurup, Jian Xu, Rita Alexandra Videira, Chimezie Ononenyi, Graça Baltazar, Paul J Lombroso, Angus C Nairn
Proc Natl Acad Sci U S A 2015 Jan;
PMID: 25583483 [PubMed - as supplied by publisher]


Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Anne Vital, Sebastien Lepreux, Claude Vital
J Peripher Nerv Syst 2015 Jan;
PMID: 25582874 [PubMed - as supplied by publisher]


Comprehensive Analysis of the Mouse Brain Proteome Sampled in Mass Spectrometry Imaging.
Bram Heijs, Ricardo J Carreira, Else A Tolner, Arnoud H de Ru, Arn M J M van den Maagdenberg, Peter A van Veelen, Liam A McDonnell
Anal Chem 2015 Jan;
PMID: 25535922 [PubMed - as supplied by publisher]


Alpha-synuclein biology in Lewy body diseases.
Woojin Scott Kim, Katarina Kågedal, Glenda M Halliday
Alzheimers Res Ther 2014 ; 6(5):73
PMID: 25580161 [PubMed - as supplied by publisher]


Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis.
Yongdui Chen, Siqi Li, Liling Su, Jinghao Sheng, Wen Lv, Guangdi Chen, Zhengping Xu
J Neurol 2015 Jan;
PMID: 25578179 [PubMed - as supplied by publisher]


Association between MAPT haplotype and memory function in patients with Parkinson's disease and healthy aging individuals.
Sophie E Winder-Rhodes, Adam Hampshire, James B Rowe, Jonathan E Peelle, Trevor W Robbins, Adrian M Owen, Roger A Barker
Neurobiol Aging 2014 Dec;
PMID: 25577413 [PubMed - as supplied by publisher]


A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia.
Jun-Ichi Satoh, Naohiro Asahina, Shouta Kitano, Yoshihiro Kino
Gene Regul Syst Bio 2014 ; 8:127-39
PMID: 25574134 [PubMed - as supplied by publisher]


Discovery of functional non-coding conserved regions in the ?-synuclein gene locus.
Lori Sterling, Michael Walter, Dennis Ting, Birgitt Schüle
F1000Res 2014 ; 3:259
PMID: 25566351 [PubMed - as supplied by publisher]


Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on ?-Synuclein.
Nripesh Dhungel, Simona Eleuteri, Ling-Bo Li, Nicholas J Kramer, Justin W Chartron, Brian Spencer, Kori Kosberg, Jerel Adam Fields, Klodjan Stafa, Anthony Adame, Hilal Lashuel, Judith Frydman, Kang Shen, Eliezer Masliah, Aaron D Gitler
Neuron 2015 Jan; 85(1):76-87
PMID: 25533483 [PubMed - as supplied by publisher]


Application of next-generation sequencing technologies in Neurology.
Teng Jiang, Meng-Shan Tan, Lan Tan, Jin-Tai Yu
Ann Transl Med 2014 Dec; 2(12):125
PMID: 25568878 [PubMed - as supplied by publisher]


Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.
Fanny Charbonnier-Beaupel, Marion Malerbi, Cristina Alcacer, Khadija Tahiri, Wassila Carpentier, Chuansong Wang, Matthew During, Desheng Xu, Paul F Worley, Jean-Antoine Girault, Denis Hervé, Jean-Christophe Corvol
J Neurosci 2015 Jan; 35(1):96-111
PMID: 25568106 [PubMed - as supplied by publisher]


Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data.
Kathrin Reetz, Imis Dogan, Ana S Costa, Manuel Dafotakis, Kathrin Fedosov, Paola Giunti, Michael H Parkinson, Mary G Sweeney, Caterina Mariotti, Marta Panzeri, Lorenzo Nanetti, Javier Arpa, Irene Sanz-Gallego, Alexandra Durr, Perrine Charles, Sylvia Boesch, Wolfgang Nachbauer, Thomas Klopstock, Ivan Karin, Chantal Depondt, Jennifer Müller Vom Hagen, Ludger Schöls, Ilaria A Giordano, Thomas Klockgether, Katrin Bürk, Massimo Pandolfo, Jörg B Schulz
Lancet Neurol 2015 Jan;
PMID: 25566998 [PubMed - as supplied by publisher]


Parkinson's disease: animal models and dopaminergic cell vulnerability.
Javier Blesa, Serge Przedborski
Front Neuroanat 2014 ; 8:155
PMID: 25565980 [PubMed - as supplied by publisher]


PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane.
Stephan Gehrke, Zhihao Wu, Michael Klinkenberg, Yaping Sun, Georg Auburger, Su Guo, Bingwei Lu
Cell Metab 2015 Jan; 21(1):95-108
PMID: 25565208 [PubMed - as supplied by publisher]


Association of MTHFR C677T with total homocysteine plasma levels and susceptibility to Parkinson's disease: a meta-analysis.
Ying Zhu, Rui-Xia Zhu, Zhi-Yi He, Xu Liu, He-Nan Liu
Neurol Sci 2015 Jan;
PMID: 25564416 [PubMed - as supplied by publisher]


Fluorescence quenched substrates for live cell imaging of human glucocerebrosidase activity.
Anuj K Yadav, David Shen, Xiaoyang Shan, Xu He, Allison R Kermode, David J Vocadlo
J Am Chem Soc 2015 Jan;
PMID: 25562638 [PubMed - as supplied by publisher]


Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.
Abhimanyu Krishna, Maria Biryukov, Christophe Trefois, Paul Ma Antony, Rene Hussong, Jake Lin, Merja Heinäniemi, Gustavo Glusman, Sandra Köglsberger, Olga Boyd, Bart Hj van den Berg, Dennis Linke, David Huang, Kai Wang, Leroy Hood, Andreas Tholey, Reinhard Schneider, David J Galas, Rudi Balling, Patrick May
BMC Genomics 2014 ; 15:1154
PMID: 25528190 [PubMed - as supplied by publisher]


Beyond Mitophagy: Cytosolic PINK1 as a messenger of mitochondrial health.
Erin K Steer, Michelle K Dail, Charleen T Chu
Antioxid Redox Signal 2015 Jan;
PMID: 25557302 [PubMed - as supplied by publisher]


PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation.
Boram Min, Young-Chang Kwon, Kwang-Min Choe, Kwang Chul Chung
J Neurosci Res 2014 Dec;
PMID: 25557247 [PubMed - as supplied by publisher]


Disturbed mitochondrial dynamics and neurodegenerative disorders.
Florence Burté, Valerio Carelli, Patrick F Chinnery, Patrick Yu-Wai-Man
Nat Rev Neurol 2015 Jan; 11(1):11-24
PMID: 25486875 [PubMed - as supplied by publisher]


The link between the SNCA gene and parkinsonism.
Wei Xu, Lan Tan, Jin-Tai Yu
Neurobiol Aging 2014 Dec;
PMID: 25554495 [PubMed - as supplied by publisher]


Epigenetic mechanisms in Parkinson's disease.
Ya Feng, Joseph Jankovic, Yun-Cheng Wu
J Neurol Sci 2014 Dec;
PMID: 25553963 [PubMed - as supplied by publisher]


Functions and characteristics of PINK1 and Parkin in cancer.
Satoru Matsuda, Atsuko Nakanishi, Akari Minami, Yoko Wada, Yasuko Kitagishi
Front Biosci (Landmark Ed) 2015 ; 20:491-501
PMID: 25553463 [PubMed - as supplied by publisher]


Lipid rafts involvement in the pathogenesis of Parkinson's disease.
Shin-Ichiro Kubo, Taku Hatano, Nobutaka Hattori
Front Biosci (Landmark Ed) 2015 ; 20:263-79
PMID: 25553450 [PubMed - as supplied by publisher]


Exploring determinants of progression in Parkinson's disease. Is there a difference among Jewish ethnic groups?
Y Orlev, G Yahalom, O S Cohen, S Elincx-Benizri, E Kozlova, R Inzelberg, U Goldbourt, S Hassin-Baer
Parkinsonism Relat Disord 2014 Oct;
PMID: 25550275 [PubMed - as supplied by publisher]


Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M Griggs, Laura Zavala-Flores, Elsa M Reyes-Reyes, Javier Seravalli, Lia A Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franco
Neurobiol Dis 2014 Dec;
PMID: 25497688 [PubMed - as supplied by publisher]


ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter ?-Synuclein Metabolism in SH-SY5Y Cells.
Eun-Jin Bae, Cheolsoon Lee, He-Jin Lee, Seokjoong Kim, Seung-Jae Lee
Exp Neurobiol 2014 Dec; 23(4):365-71
PMID: 25548536 [PubMed - as supplied by publisher]


Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes.
Ji-Young Han, Ji-Soo Kim, Jin H Son
Exp Neurobiol 2014 Dec; 23(4):345-51
PMID: 25548534 [PubMed - as supplied by publisher]


ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.
Tomás Lopes da Fonseca, Tiago Fleming Outeiro
Exp Neurobiol 2014 Dec; 23(4):314-23
PMID: 25548531 [PubMed - as supplied by publisher]


Alpha-synuclein function and dysfunction on cellular membranes.
David Snead, David Eliezer
Exp Neurobiol 2014 Dec; 23(4):292-313
PMID: 25548530 [PubMed - as supplied by publisher]


Hypothesis: somatic mosaicism and Parkinson disease.
Han-Joon Kim, Beom S Jeon
Exp Neurobiol 2014 Dec; 23(4):271-6
PMID: 25548528 [PubMed - as supplied by publisher]


Ultrasound-based motion analysis demonstrates bilateral arm hypokinesia during gait in heterozygous PINK1 mutation carriers.
Lucas Nürnberger, Christine Klein, Simon Baudrexel, Julia Roggendorf, Marcel Hildner, Shu Chen, Jun-Suk Kang, Rüdiger Hilker, Johann Hagenah
Mov Disord 2014 Dec;
PMID: 25545816 [PubMed - as supplied by publisher]


Parkinson's disease correlates with promoter methylation in the ?-synuclein gene.
Lasse Pihlstrøm, Victoria Berge, Aina Rengmark, Mathias Toft
Mov Disord 2014 Dec;
PMID: 25545759 [PubMed - as supplied by publisher]


A 7.5-Mb duplication at chromosome 11q21-11q22.3 is associated with a novel spastic ataxia syndrome.
Janel O Johnson, Giovanni Stevanin, Joyce van de Leemput, Dena G Hernandez, Sampath Arepalli, Sylvie Forlani, Reza Zonozi, J Raphael Gibbs, Alexis Brice, Alexandra Durr, Andrew B Singleton
Mov Disord 2014 Dec;
PMID: 25545641 [PubMed - as supplied by publisher]


A De Novo ADCY5 mutation causes early-onset autosomal dominant chorea and dystonia.
Raphael Carapito, Nicodème Paul, Meiggie Untrau, Marion Le Gentil, Louise Ott, Ghada Alsaleh, Pierre Jochem, Mirjana Radosavljevic, Cédric Le Caignec, Albert David, Philippe Damier, Bertrand Isidor, Seiamak Bahram
Mov Disord 2014 Dec;
PMID: 25545163 [PubMed - as supplied by publisher]


Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers.
Rick C Helmich, Avner Thaler, Bart F L van Nuenen, Tanya Gurevich, Anat Mirelman, Karen S Marder, Susan Bressman, Avi Orr-Urtreger, Nir Giladi, Bastiaan R Bloem, Ivan Toni,
Neurology 2014 Dec;
PMID: 25540317 [PubMed - as supplied by publisher]


The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases.
Sahar Al-Mahdawi, Sara Anjomani Virmouni, Mark A Pook
Front Neurosci 2014 ; 8:397
PMID: 25538551 [PubMed - as supplied by publisher]


Correction: high-frequency stimulation of the subthalamic nucleus counteracts cortical expression of major histocompatibility complex genes in a rat model of Parkinson's disease.
PLoS One 2014 ; 9(12):e116365
PMID: 25536402 [PubMed - as supplied by publisher]


Glucocerebrosidase Gene Mutations Associated with Parkinson's Disease: A Meta-Analysis in a Chinese population.
Jia Chen, Wei Li, Tao Zhang, Yan-Jiang Wang, Xiao-Jiang Jiang, Zhi-Qiang Xu
PLoS One 2014 ; 9(12):e115747
PMID: 25535748 [PubMed - as supplied by publisher]


Vitamin C Facilitates Dopamine Neuron Differentiation in Fetal Midbrain Through Tet1- aND Jmjd3-Dependent Epigenetic Control Manner.
Xi-Biao He, Mirang Kim, Seon-Young Kim, Sang-Hoon Yi, Yong-Hee Rhee, Taeho Kim, Eun-Hye Lee, Chang-Hwan Park, Shilpy Dixit, Fiona E Harrison, Sang-Hun Lee
Stem Cells 2014 Dec;
PMID: 25535150 [PubMed - as supplied by publisher]


Silencing of PINK1 Inhibits Insulin-Like Growth Factor-1-Mediated Receptor Activation and Neuronal Survival.
María J Contreras-Zárate, Andrea Niño, Liliana Rojas, Humberto Arboleda, Gonzalo Arboleda
J Mol Neurosci 2014 Dec;
PMID: 25534921 [PubMed - as supplied by publisher]


The RIT2 and STX1B polymorphisms are associated with Parkinson's disease.
Jian-Yong Wang, Mei-Ying Gong, Yang-Lie Ye, Jin-Min Ye, Guo-Liang Lin, Qing-Qing Zhuang, Xiong Zhang, Jian-Hong Zhu
Parkinsonism Relat Disord 2014 Dec;
PMID: 25534083 [PubMed - as supplied by publisher]


Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease?
Nino Spataro, Francesc Calafell, Laura Cervera-Carles, Ferran Casals, Javier Pagonabarraga, Berta Pascual-Sedano, Antònia Campolongo, Jaime Kulisevsky, Alberto Lleó, Arcadi Navarro, Jordi Clarimón, Elena Bosch
Hum Mol Genet 2014 Dec;
PMID: 25504046 [PubMed - as supplied by publisher]


Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.
Pan Chen, Margaret R DeWitt, Julia Bornhorst, Felix A Soares, Somshuvra Mukhopadhyay, Aaron B Bowman, Michael Aschner
Metallomics 2014 Dec;
PMID: 25531510 [PubMed - as supplied by publisher]


PINK1 Catalytic Activity is Regulated by Phosphorylation on Serines 228 and 402.
Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais
J Biol Chem 2014 Dec;
PMID: 25527497 [PubMed - as supplied by publisher]


Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra.
Beatriz Raposo Corradini, Priscila Iamashita, Edilaine Tampellini, José Marcelo Farfel, Lea Tenenholz Grinberg, Carlos Alberto Moreira-Filho
Biomed Res Int 2014 ; 2014:543673
PMID: 25525598 [PubMed - as supplied by publisher]


Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's Disease.
Janelle Drouin-Ouellet, Isabelle St-Amour, Martine Saint-Pierre, Jérôme Lamontagne-Proulx, Jasna Kriz, Roger A Barker, Francesca Cicchetti
Int J Neuropsychopharmacol 2014 Dec;
PMID: 25522431 [PubMed - as supplied by publisher]


Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
Nathan C Rowland, Philip A Starr, Paul S Larson, Jill L Ostrem, William J Marks, Daniel A Lim
Mov Disord 2014 Dec;
PMID: 25521796 [PubMed - as supplied by publisher]


Detection of protein aggregates in brain and cerebrospinal fluid derived from multiple sclerosis patients.
Monique Antoinette David, Mourad Tayebi
Front Neurol 2014 ; 5:251
PMID: 25520699 [PubMed - as supplied by publisher]


Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.
Feng Zhang, Dan Xu, Ling Yuan, Yiming Sun, Zhiheng Xu
Nat Commun 2014 ; 5:5815
PMID: 25519973 [PubMed - as supplied by publisher]


Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease.
Zhe Yu, Ting Wang, Jun Xu, Wei Wang, Guifang Wang, Chao Chen, Lili Zheng, Li Pan, Dianrong Gong, Xueli Li, Huaiqian Qu, Fang Li, Bin Zhang, Weidong Le, Fabin Han
J Hum Genet 2014 Dec;
PMID: 25518742 [PubMed - as supplied by publisher]


PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.
Michel Belyk, Shelly Jo Kraft, Steven Brown
J Hum Genet 2014 Dec;
PMID: 25518740 [PubMed - as supplied by publisher]


Correction: cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals.
PLoS One 2014 ; 9(12):e116242
PMID: 25517621 [PubMed - as supplied by publisher]


Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats.
Cheng-Long Xie, Wen-Wen Wang, Su-Fang Zhang, Ming-Lu Yuan, Jun-Yi Che, Jing Gan, Lu Song, Wei-En Yuan, Zhen-Guo Liu
Sci Rep 2014 ; 4:7506
PMID: 25511986 [PubMed - as supplied by publisher]


Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.
Rasajna Nadella, Merja H Voutilainen, Mart Saarma, Juan A Gonzalez-Barrios, Bertha A Leon-Chavez, Judith M Dueñas Jiménez, Sergio H Dueñas Jiménez, Lourdes Escobedo, Daniel Martinez-Fong
J Neuroinflammation 2014 Dec; 11(1):209
PMID: 25511018 [PubMed - as supplied by publisher]


Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing ?-synuclein.
Iddo Magen, Regina Ostritsky, Franziska Richter, Chunni Zhu, Sheila M Fleming, Vincent Lemesre, Alistair J Stewart, Bruce H Morimoto, Illana Gozes, Marie-Françoise Chesselet
Pharmacol Res Perspect 2014 Oct; 2(5):e00065
PMID: 25505609 [PubMed - as supplied by publisher]


Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra.
Panojot Bifsha, Jianqi Yang, Rory A Fisher, Jacques Drouin
PLoS Genet 2014 Dec; 10(12):e1004863
PMID: 25501001 [PubMed - as supplied by publisher]


Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Ruth Chia, Sara Haddock, Alexandra Beilina, Iakov N Rudenko, Adamantios Mamais, Alice Kaganovich, Yan Li, Ravindran Kumaran, Michael A Nalls, Mark R Cookson
Nat Commun 2014 ; 5:5827
PMID: 25500533 [PubMed - as supplied by publisher]


Evolution of Prodromal Clinical Markers of Parkinson Disease in a GBA Mutation-Positive Cohort.
Michelle Beavan, Alisdair McNeill, Christos Proukakis, Derralynn A Hughes, Atul Mehta, Anthony H V Schapira
JAMA Neurol 2014 Dec;
PMID: 25506732 [PubMed - as supplied by publisher]


LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism.
Amaia M Arranz, Lore Delbroek, Kristof Van Kolen, Marco R Guimarães, Wim Mandemakers, Guy Daneels, Samer Matta, Sara Calafate, Hamdy Shaban, Pieter Baatsen, Pieter-Jan De Bock, Kris Gevaert, Pieter Vanden Berghe, Patrik Verstreken, Bart De Strooper, Diederik Moechars
J Cell Sci 2014 Dec;
PMID: 25501810 [PubMed - as supplied by publisher]


Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson¿s disease ¿ a multicenter study.
Malin von Otter, Petra Bergström, Aldo Quattrone, Elvira De Marco, Grazia Annesi, Peter Söderkvist, Stephanie Wettinger, Marek Drozdzik, Monika Bialecka, Hans Nissbrandt, Christine Klein, Michael Nilsson, Ola Hammarsten, Staffan Nilsson, Henrik Zetterberg
BMC Med Genet 2014 Dec; 15(1):131
PMID: 25496089 [PubMed - as supplied by publisher]


Association between two ?-2-macroglobulin gene polymorphisms and Parkinson's disease: a meta-analysis.
Guo Xingzhi, Tang Peng, Li Xiaoqing, Chong Li, Zhang Xin, Li Rui
Int J Neurosci 2014 Dec; :1-19
PMID: 25495992 [PubMed - as supplied by publisher]


How E3 activity of Parkin is enhanced by damaged mitochondria].
Fumika Koyano, Noriyuki Matsuda
Seikagaku 2014 Oct; 86(5):676-82
PMID: 25509337 [PubMed - as supplied by publisher]


Differential Co-Expression between ?-Synuclein and IFN-? Signaling Genes across Development and in Parkinson's Disease.
Noa Liscovitch, Leon French
PLoS One 2014 ; 9(12):e115029
PMID: 25493648 [PubMed - as supplied by publisher]


Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?
Rachel Saunders-Pullman, Anat Mirelman, Cuiling Wang, Roy N Alcalay, Marta San Luciano, Robert Ortega, Deborah Raymond, Helen Mejia-Santana, Laurie Ozelius, Lorraine Clark, Avi Orr-Utreger, Karen Marder, Nir Giladi, Susan B Bressman
Ann Clin Transl Neurol 2014 Sep; 1(9):670-8
PMID: 25493281 [PubMed - as supplied by publisher]


Motor phenotype of LRRK2-associated Parkinson's disease: A tunisian longitudinal study.
Fatma Nabli, Samia Ben Sassi, Rim Amouri, John E Duda, Matthew J Farrer, Fayçal Hentati
Mov Disord 2014 Dec;
PMID: 25487881 [PubMed - as supplied by publisher]


Autophagy functions on EMT in gastrulation of avian embryo.
Wen-Hui Lu, Guang Wang, Yan Li, Shuai Li, Xiao-Yu Song, Xiao-Yu Wang, Manli Chuai, Kenneth Ka Ho Lee, Liu Cao, Xuesong Yang
Cell Cycle 2014 Sep; 13(17):2752-64
PMID: 25486362 [PubMed - as supplied by publisher]