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Featured Research

What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Glutamate and GABA concentration changes in the globus pallidus internus of Parkinson's patients during performance of implicit and declarative memory tasks: A report of two subjects.
Robert J Buchanan, Klevest Gjini, David Darrow, Georgeta Varga, Jennifer L Robinson, Zoltan Nadasdy
Neurosci Lett 2015 Jan; 589C:73-78
PMID: 25596441 [PubMed - as supplied by publisher]


Rotenone exerts similar stimulatory effects on H2O2 production by isolated brain mitochondria from young-adult and old rats.
Luiz G B Michelini, Tiago R Figueira, Edilene S Siqueira-Santos, Roger F Castilho
Neurosci Lett 2015 Jan; 589C:25-30
PMID: 25596437 [PubMed - as supplied by publisher]


Systemically administered neuregulin-1?1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease.
Candan Depboylu, Thomas W Rösler, Anderson de Andrade, Wolfgang H Oertel, Günter U Höglinger
J Neurochem 2015 Jan;
PMID: 25581060 [PubMed - as supplied by publisher]


Cystamine induces AIF-mediated apoptosis through glutathione depletion.
Sung-Yup Cho, Jin-Haeng Lee, Mi-Kyeong Ju, Eui Man Jeong, Hyo-Jun Kim, Jisun Lim, Seungun Lee, Nam-Hyuk Cho, Hyun Ho Park, Kihang Choi, Ju-Hong Jeon, In-Gyu Kim
Biochim Biophys Acta 2014 Dec; 1853(3):619-631
PMID: 25549939 [PubMed - as supplied by publisher]


Recent advances in autophagy-based neuroprotection.
Khaled Radad, Rudolf Moldzio, Mubarak Al-Shraim, Barbara Kranner, Christopher Krewenka, Wolf-Dieter Rausch
Expert Rev Neurother 2015 Feb; 15(2):195-205
PMID: 25614954 [PubMed - as supplied by publisher]


Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ADHD research.
Erin M Miller, Jorge E Quintero, Francois Pomerleau, Peter Huettl, Greg A Gerhardt, Paul E A Glaser
J Neurosci Methods 2015 Jan;
PMID: 25614383 [PubMed - as supplied by publisher]


Amyloid ? oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.
Kirsten L Viola, William L Klein
Acta Neuropathol 2015 Feb; 129(2):183-206
PMID: 25604547 [PubMed - as supplied by publisher]


Protective effect of rhGLP-1 (7-36) on brain ischemia/reperfusion damage in diabetic rats.
Libo Zhao, Jia Xu, Qian Wang, Zhonglian Qian, Wanyu Feng, Xiaoxing Yin, Yi Fang
Brain Res 2015 Jan;
PMID: 25601009 [PubMed - as supplied by publisher]


Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.
James M Gruschus, Zhiping Jiang, Thai Leong Yap, Stephanie A Hill, Alexander Grishaev, Grzegorz Piszczek, Ellen Sidransky, Jennifer C Lee
Biochem Biophys Res Commun 2015 Jan;
PMID: 25600808 [PubMed - as supplied by publisher]


Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats.
J Jimenez-Martin, L B Lezcano, M E G Fraguela, M-L Díaz-Hung, T S Sánchez, J L Almenares, L F Turner
Neuroscience 2015 Jan;
PMID: 25596320 [PubMed - as supplied by publisher]


Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson's disease.
S Mitra, N Chakrabarti, S S Dutta, S Ray, P Bhattacharya, P Sinha, A Bhattacharyya
Neuroscience 2015 Jan;
PMID: 25592425 [PubMed - as supplied by publisher]


Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.
Joanna Ruszkiewicz, Jan Albrecht
Neurochem Int 2015 Jan;
PMID: 25576182 [PubMed - as supplied by publisher]


Fatty Acid Composition of the Anterior Cingulate Cortex Indicates a High Susceptibility to Lipid Peroxidation in Parkinson's Disease.
Sarah K Abbott, Andrew M Jenner, Adena S Spiro, Marijka Batterham, Glenda M Halliday, Brett Garner
J Parkinsons Dis 2015 Jan;
PMID: 25613350 [PubMed - as supplied by publisher]


The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway.
Feng Gao, Dong Chen, Jianmin Si, Qingsong Hu, Zhenghong Qin, Ming Fang, Guanghui Wang
Hum Mol Genet 2015 Jan;
PMID: 25612572 [PubMed - as supplied by publisher]


The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease.
Alicia M Pickrell, Richard J Youle
Neuron 2015 Jan; 85(2):257-273
PMID: 25611507 [PubMed - as supplied by publisher]


Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease.
Xiao-Gang Gong, Hong-Mei Sun, Yi Zhang, Shu-Jing Zhang, Yu-Shan Gao, Jing Feng, Jing-Hong Hu, Cong Gai, Zhen-Yu Guo, Hong Xu, Ling Ma
Evid Based Complement Alternat Med 2014 ; 2014:729195
PMID: 25610480 [PubMed - as supplied by publisher]


Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD.
Philipp Mahlknecht, Alex Iranzo, Birgit Högl, Birgit Frauscher, Christoph Müller, Joan Santamaría, Eduardo Tolosa, Monica Serradell, Thomas Mitterling, Viola Gschliesser, Georg Goebel, Florian Brugger, Christoph Scherfler, Werner Poewe, Klaus Seppi, ,
Neurology 2015 Jan;
PMID: 25609758 [PubMed - as supplied by publisher]


A53T Human ?-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration.
Linan Chen, Zhiguo Xie, Susie Turkson, Xiaoxi Zhuang
J Neurosci 2015 Jan; 35(3):890-905
PMID: 25609609 [PubMed - as supplied by publisher]


The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson's Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia.
Xiqun Chen, Pauline Wales, Luisa Quinti, Fuxing Zuo, Sébastien Moniot, Fanny Herisson, Nazifa Abdul Rauf, Hua Wang, Richard B Silverman, Cenk Ayata, Michelle M Maxwell, Clemens Steegborn, Michael A Schwarzschild, Tiago F Outeiro, Aleksey G Kazantsev
PLoS One 2015 ; 10(1):e0116919
PMID: 25608039 [PubMed - as supplied by publisher]


Early Parkinson's disease symptoms in ?-synuclein transgenic monkeys.
Yuyu Niu, Xiangyu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Weili Yang, Yu Kang, Wei Si, Hong Wang, Shang-Hsun Yang, Shihua Li, Weizhi Ji, Xiao-Jiang Li
Hum Mol Genet 2014 Dec;
PMID: 25552648 [PubMed - as supplied by publisher]


Extent of Inhibition of ?-Synuclein Aggregation in Vitro by SUMOylation Is Conjugation Site- and SUMO Isoform-Selective.
Tharindumala Abeywardana, Matthew R Pratt
Biochemistry 2015 Jan;
PMID: 25607946 [PubMed - as supplied by publisher]


PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.
Ghazaleh Ashrafi, Thomas L Schwarz
Autophagy 2015 Jan; :0
PMID: 25607607 [PubMed - as supplied by publisher]


Head injury, potential interaction with genes, and risk for Parkinson's disease.
Jianjun Gao, Rui Liu, Edward Zhao, Xuemei Huang, Michael A Nalls, Andrew B Singleton, Honglei Chen
Parkinsonism Relat Disord 2015 Jan;
PMID: 25603768 [PubMed - as supplied by publisher]


Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.
Anna Kubesova, Hana Tejkalova, Kamila Syslova, Petr Kacer, Jana Vondrousova, Filip Tyls, Michaela Fujakova, Tomas Palenicek, Jiri Horacek
PLoS One 2015 ; 10(1):e0115439
PMID: 25602957 [PubMed - as supplied by publisher]


Molecular Determinants of ?-Synuclein Mutants' Oligomerization and Membrane Interactions.
Igor F Tsigelny, Yuriy Sharikov, Valentina L Kouznetsova, Jerry P Greenberg, Wolf Wrasidlo, Cassia Overk, Tania Gonzalez, Margarita Trejo, Brian Spencer, Kori Kosberg, Eliezer Masliah
ACS Chem Neurosci 2015 Jan;
PMID: 25561023 [PubMed - as supplied by publisher]


Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Keigo Hikishima, Kiyoshi Ando, Ryutaro Yano, Kenji Kawai, Yuji Komaki, Takashi Inoue, Toshio Itoh, Masayuki Yamada, Suketaka Momoshima, Hirotaka J Okano, Hideyuki Okano
Radiology 2015 Jan; :140601
PMID: 25602507 [PubMed - as supplied by publisher]


CHIP is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.
Amy Marie Palubinsky, Jeannette Nicole Stankowski, Alixandra Cozette Kale, Simona G Codreanu, Robert J Singer, Daniel C Liebler, Gregg D Stanwood, BethAnn Marie McLaughlin
Antioxid Redox Signal 2015 Jan;
PMID: 25602369 [PubMed - as supplied by publisher]


Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]


Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2014 Dec;
PMID: 25599874 [PubMed - as supplied by publisher]


Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle.
S Pablo Sardi, Seng H Cheng, Lamya S Shihabuddin
Prog Neurobiol 2015 Jan;
PMID: 25573151 [PubMed - as supplied by publisher]


Attenuation of the Early Events of ?-Synuclein Aggregation: A Fluorescence Correlation Spectroscopy and Laser Scanning Microscopy Study in the Presence of Surface-Coated Fe3O4 Nanoparticles.
Nidhi Joshi, Sujit Basak, Sangeeta Kundu, Goutam De, Anindita Mukhopadhyay, Krishnananda Chattopadhyay
Langmuir 2015 Jan;
PMID: 25561279 [PubMed - as supplied by publisher]


Saliva ?-Synuclein and A High Extinction Coefficient Protein: A Novel Approach in Assessment Biomarkers of Parkinson's Disease.
Marwan S M Al-Nimer, Sabah F Mshatat, Hajer I Abdulla
N Am J Med Sci 2014 Dec; 6(12):633-7
PMID: 25599051 [PubMed - as supplied by publisher]


The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases.
Gerwyn Morris, Michael Berk, Piotr Galecki, Ken Walder, Michael Maes
Mol Neurobiol 2015 Jan;
PMID: 25598355 [PubMed - as supplied by publisher]


Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.
Yu Tang, Weidong Le
Mol Neurobiol 2015 Jan;
PMID: 25598354 [PubMed - as supplied by publisher]


Purine metabolism gene deregulation in Parkinson's disease.
Paula Garcia-Esparcia, Karina Hernández-Ortega, Belén Ansoleaga, Margarita Carmona, Isidre Ferrer
Neuropathol Appl Neurobiol 2015 Jan;
PMID: 25597950 [PubMed - as supplied by publisher]


Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice.
Yuki Kambe, Atsuro Miyata
Neurosci Lett 2015 Jan; 588C:166-171
PMID: 25576703 [PubMed - as supplied by publisher]


Small heat shock proteins: Role in cellular functions and pathology.
Raman Bakthisaran, Ramakrishna Tangirala, Ch Mohan Rao
Biochim Biophys Acta 2014 Dec; 1854(4):291-319
PMID: 25556000 [PubMed - as supplied by publisher]


Possible involvement of iron-induced oxidative insults in neurodegeneration.
Takeshi Asano, Masato Koike, Shin-Ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai
Neurosci Lett 2014 Dec; 588C:29-35
PMID: 25549542 [PubMed - as supplied by publisher]


Changes in Neuronal Dopamine Homeostasis Following 1-Methyl-4-Phenylpyridinium (MPP+) Exposure.
Se Joon Choi, Anne Panhelainen, Yvonne Schmitz, Kristin E Larsen, Ellen Kanter, Min Wu, David Sulzer, Eugene V Mosharov
J Biol Chem 2015 Jan;
PMID: 25596531 [PubMed - as supplied by publisher]


Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mTOR-independent autophagy.
Yukiko Sasazawa, Natsumi Sato, Kazuo Umezawa, Siro Simizu
J Biol Chem 2015 Jan;
PMID: 25596530 [PubMed - as supplied by publisher]


Lysosomal-associated membrane protein 2 Isoforms Are Differentially Affected in Early Parkinson's Disease.
Karen E Murphy, Amanda M Gysbers, Sarah K Abbott, Adena S Spiro, Akiko Furuta, Antony Cooper, Brett Garner, Tomohiro Kabuta, Glenda M Halliday
Mov Disord 2015 Jan;
PMID: 25594542 [PubMed - as supplied by publisher]


COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese.
Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu
Mov Disord 2015 Jan;
PMID: 25594503 [PubMed - as supplied by publisher]


Flavonoid-Based Therapies in the Early Management of Neurodegenerative Diseases.
Isha Solanki, Priyanka Parihar, Mohammad Lukman Mansuri, Mordhwaj S Parihar
Adv Nutr 2015 Jan; 6(1):64-72
PMID: 25593144 [PubMed - as supplied by publisher]


Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease.
Kazuki Ide, Hiroshi Yamada, Keizo Umegaki, Katsuki Mizuno, Nobuko Kawakami, Yuka Hagiwara, Mizuki Matsumoto, Hidefumi Yoshida, Kang Kim, Emi Shiosaki, Tsunehiro Yokochi, Kiyoshi Harada
Nutrition 2015 Feb; 31(2):406-8
PMID: 25592020 [PubMed - as supplied by publisher]


Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease.
Joel Henrique Ellwanger, Patrícia Molz, Danieli Rosane Dallemole, Ariana Pereira Dos Santos, Talise Ellwanger Müller, Lucas Cappelletti, Manoela Gonçalves da Silva, Silvia Isabel Rech Franke, Daniel Prá, João Antonio Pêgas Henriques
Nutrition 2015 Feb; 31(2):359-65
PMID: 25592015 [PubMed - as supplied by publisher]


Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-? hydroxysteroid dehydrogenase type 10.
G Bertolin, M Jacoupy, S Traver, R Ferrando-Miguel, T Saint Georges, K Grenier, H Ardila-Osorio, M-P Muriel, H Takahashi, A J Lees, C Gautier, D Guedin, F Coge, E A Fon, A Brice, O Corti
Cell Death Differ 2015 Jan;
PMID: 25591737 [PubMed - as supplied by publisher]


Neuronal cell cycle: The neuron itself and its circumstances.
José M Frade, María C Ovejero-Benito
Cell Cycle 2015 Jan; :0
PMID: 25590687 [PubMed - as supplied by publisher]


A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes.
N K Magdalinou, R W Paterson, J M Schott, N C Fox, C Mummery, K Blennow, K Bhatia, H R Morris, P Giunti, T T Warner, R de Silva, A J Lees, H Zetterberg
J Neurol Neurosurg Psychiatry 2015 Jan;
PMID: 25589779 [PubMed - as supplied by publisher]


Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration.
Robert P Friedland
J Alzheimers Dis 2015 Jan;
PMID: 25589730 [PubMed - as supplied by publisher]


Colonic mucosal ?-synuclein lacks specificity as a biomarker for Parkinson disease.
Naomi P Visanji, Connie Marras, Drew S Kern, Amaal Al Dakheel, Andrew Gao, Louis W C Liu, Anthony E Lang, Lili-Naz Hazrati
Neurology 2015 Jan;
PMID: 25589666 [PubMed - as supplied by publisher]


Autophagy Inhibition by Caffeine Increases Toxicity of Methamphetamine in SH-SY5Y Neuroblastoma Cell Line.
Rujiraporn Pitaksalee, Yupin Sanvarinda, Theerin Sinchai, Pantip Sanvarinda, Anusorn Thampithak, Nattinee Jantaratnotai, Surawat Jariyawat, Patoomratana Tuchinda, Piyarat Govitrapong, Pimtip Sanvarinda
Neurotox Res 2015 Jan;
PMID: 25588864 [PubMed - as supplied by publisher]


Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease.
Iddo Magen, Eileen Ruth Torres, Diana Dinh, Andrew Chung, Eliezer Masliah, Marie-Françoise Chesselet
J Parkinsons Dis 2015 Jan;
PMID: 25588356 [PubMed - as supplied by publisher]


Role of ?-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease.
Heather E Allen Reish, David G Standaert
J Parkinsons Dis 2015 Jan;
PMID: 25588354 [PubMed - as supplied by publisher]


Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism.
Nikenza Viceconte, Miguel A Burguillos, Antonio J Herrera, Rocío M De Pablos, Bertrand Joseph, José L Venero
J Neuroinflammation 2015 Jan; 12(1):5
PMID: 25586882 [PubMed - as supplied by publisher]


Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson's disease.
Michele Morari, Martina Fantin
Analyst 2015 Jan;
PMID: 25584655 [PubMed - as supplied by publisher]


STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.
Pradeep K Kurup, Jian Xu, Rita Alexandra Videira, Chimezie Ononenyi, Graça Baltazar, Paul J Lombroso, Angus C Nairn
Proc Natl Acad Sci U S A 2015 Jan;
PMID: 25583483 [PubMed - as supplied by publisher]


Fibril Breaking Accelerates ?-Synuclein Fibrillization.
Volodymyr V Shvadchak, Mireille M A E Claessens, Vinod Subramaniam
J Phys Chem B 2015 Jan;
PMID: 25582977 [PubMed - as supplied by publisher]


Recent advances in biomarkers for Parkinson's disease focusing on biochemicals, omics and neuroimaging.
Rutong Ren, Yi Sun, Xin Zhao, Xiaoping Pu
Clin Chem Lab Med 2015 Jan;
PMID: 25581757 [PubMed - as supplied by publisher]


Lipid peroxidation is essential for ?-synuclein-induced cell death.
Plamena R Angelova, Mathew H Horrocks, David Klenerman, Sonia Gandhi, Andrey Y Abramov, Mikhail S Shchepinov
J Neurochem 2015 Jan;
PMID: 25580849 [PubMed - as supplied by publisher]


Alpha-synuclein biology in Lewy body diseases.
Woojin Scott Kim, Katarina Kågedal, Glenda M Halliday
Alzheimers Res Ther 2014 ; 6(5):73
PMID: 25580161 [PubMed - as supplied by publisher]


Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression.
Ling-Hsuan Wu, Chingju Lin, Hsiao-Yun Lin, Yu-Shu Liu, Caren Yu-Ju Wu, Cheng-Fang Tsai, Pei-Chun Chang, Wei-Lan Yeh, Dah-Yuu Lu
Mol Neurobiol 2015 Jan;
PMID: 25579382 [PubMed - as supplied by publisher]


S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function.
Weiwei Wu, Oi Wan Wan, Kenny K K Chung
Apoptosis 2015 Jan;
PMID: 25578648 [PubMed - as supplied by publisher]


Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Jing Xiong, Xiaowei Zhang, Jinsha Huang, Chunnuan Chen, Zhenzhen Chen, Ling Liu, Guoxin Zhang, Jiaolong Yang, Zhentao Zhang, Zhaohui Zhang, Zhicheng Lin, Nian Xiong, Tao Wang
Mol Neurobiol 2015 Jan;
PMID: 25575680 [PubMed - as supplied by publisher]


Cucurbitacin e has neuroprotective properties and autophagic modulating activities on dopaminergic neurons.
Anne-Marie Arel-Dubeau, Fanny Longpré, Julie Bournival, Cindy Tremblay, Julie Demers-Lamarche, Pavlina Haskova, Everaldo Attard, Marc Germain, Maria-Grazia Martinoli
Oxid Med Cell Longev 2014 ; 2014:425496
PMID: 25574337 [PubMed - as supplied by publisher]


Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone.
Zhong-Kui Xiong, Juan Lang, Gang Xu, Hai-Yu Li, Yun Zhang, Lei Wang, Yao Su, Ai-Jing Sun
Exp Ther Med 2015 Feb; 9(2):553-558
PMID: 25574233 [PubMed - as supplied by publisher]


Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion?induced neurotoxicity in PC12 cells.
Weihai Liu, Songzhi Kong, Qingfeng Xie, Jiyan Su, Wenjie Li, Huizhen Guo, Shanshan Li, Xuexuan Feng, Ziren Su, Yang Xu, Xiaoping Lai
Int J Mol Med 2014 Dec;
PMID: 25573459 [PubMed - as supplied by publisher]


Discovery of functional non-coding conserved regions in the ?-synuclein gene locus.
Lori Sterling, Michael Walter, Dennis Ting, Birgitt Schüle
F1000Res 2014 ; 3:259
PMID: 25566351 [PubMed - as supplied by publisher]


Parkinson's disease assessment based on gait analysis using an innovative RGB-D camera system.
Ana Patricia Rocha, Hugo Choupina, Jose Maria Fernandes, Maria Jose Rosas, Rui Vaz, Joao Paulo Silva Cunha
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3126-9
PMID: 25570653 [PubMed - as supplied by publisher]


Linking the VPS35 and EIF4G1 Pathways in Parkinson's Disease.
Owen A Ross, Casey Cook, Leonard Petrucelli
Neuron 2015 Jan; 85(1):1-3
PMID: 25569341 [PubMed - as supplied by publisher]


Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.
Fanny Charbonnier-Beaupel, Marion Malerbi, Cristina Alcacer, Khadija Tahiri, Wassila Carpentier, Chuansong Wang, Matthew During, Desheng Xu, Paul F Worley, Jean-Antoine Girault, Denis Hervé, Jean-Christophe Corvol
J Neurosci 2015 Jan; 35(1):96-111
PMID: 25568106 [PubMed - as supplied by publisher]


Protein Phosphatase 2A is Involved in the Tyrosine Hydroxylase Phosphorylation Regulated by ?-Synuclein.
Gao Hua, Lan Xiaolei, Yang Weiwei, Wang Hao, Zhu Yuangang, Liu Dongmei, Zhang Yazhuo, Yang Hui
Neurochem Res 2015 Jan;
PMID: 25567480 [PubMed - as supplied by publisher]


Alpha-synuclein spreading in Parkinson's disease.
Ariadna Recasens, Benjamin Dehay
Front Neuroanat 2014 ; 8:159
PMID: 25565982 [PubMed - as supplied by publisher]


Parkinson's disease: animal models and dopaminergic cell vulnerability.
Javier Blesa, Serge Przedborski
Front Neuroanat 2014 ; 8:155
PMID: 25565980 [PubMed - as supplied by publisher]


Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update.
Lars Brichta, Paul Greengard
Front Neuroanat 2014 ; 8:152
PMID: 25565977 [PubMed - as supplied by publisher]


PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane.
Stephan Gehrke, Zhihao Wu, Michael Klinkenberg, Yaping Sun, Georg Auburger, Su Guo, Bingwei Lu
Cell Metab 2015 Jan; 21(1):95-108
PMID: 25565208 [PubMed - as supplied by publisher]


Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases.
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Patrick Boissin, Edilio Borroni, Bernd Büttelmann, Simona Ceccarelli, Nicole Clemann, Beatrice David, Christoph Funk, Wolfgang Guba, Anthony Harrison, Thomas Hartung, Michael Honer, Jörg Huwyler, Martin Kuratli, Urs Niederhauser, Axel Pähler, Jens-Uwe Peters, Ann Petersen, Eric Prinssen, Antonio Ricci, Daniel Rueher, Marianne Rueher, Manfred Schneider, Paul Spurr, Theodor Stoll, Daniel Tännler, Jürgen Wichmann, Richard H Porter, Joseph G Wettstein, Lothar Lindemann
J Med Chem 2015 Jan;
PMID: 25565255 [PubMed - as supplied by publisher]


An overview on the correlation of neurological disorders with cardiovascular disease.
C K Firoz, Nasimudeen R Jabir, Mohd Shahnawaz Khan, Maged Mahmoud, Shazi Shakil, Ghazi A Damanhouri, Syed Kashif Zaidi, Shams Tabrez, Mohammad A Kamal
Saudi J Biol Sci 2015 Jan; 22(1):19-23
PMID: 25561878 [PubMed - as supplied by publisher]


Catechol-O-Methyltransferase Inhibitors in Parkinson's Disease.
Thomas Müller
Drugs 2015 Jan;
PMID: 25559423 [PubMed - as supplied by publisher]


Beyond Mitophagy: Cytosolic PINK1 as a messenger of mitochondrial health.
Erin K Steer, Michelle K Dail, Charleen T Chu
Antioxid Redox Signal 2015 Jan;
PMID: 25557302 [PubMed - as supplied by publisher]


PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation.
Boram Min, Young-Chang Kwon, Kwang-Min Choe, Kwang Chul Chung
J Neurosci Res 2014 Dec;
PMID: 25557247 [PubMed - as supplied by publisher]


?-Synuclein forms non-selective cation channels and stimulates ATP-sensitive potassium channels in hippocampal neurons.
Sergej L Mironov
J Physiol 2015 Jan; 593(1):145-59
PMID: 25556793 [PubMed - as supplied by publisher]


Prolyl Oligopeptidase Enhances ?-synuclein Dimerization via Direct Protein-Protein Interaction.
Mari H Savolainen, Xu Yan, Timo T Myöhänen, Henri J Huttunen
J Biol Chem 2015 Jan;
PMID: 25555914 [PubMed - as supplied by publisher]


SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity.
Lei Liu, Carina Peritore, Jessica Ginsberg, Merve Kayhan, Gizem Donmez
Neurochem Res 2015 Jan;
PMID: 25555707 [PubMed - as supplied by publisher]


The link between the SNCA gene and parkinsonism.
Wei Xu, Lan Tan, Jin-Tai Yu
Neurobiol Aging 2014 Dec;
PMID: 25554495 [PubMed - as supplied by publisher]


Epigenetic mechanisms in Parkinson's disease.
Ya Feng, Joseph Jankovic, Yun-Cheng Wu
J Neurol Sci 2014 Dec;
PMID: 25553963 [PubMed - as supplied by publisher]


Functions and characteristics of PINK1 and Parkin in cancer.
Satoru Matsuda, Atsuko Nakanishi, Akari Minami, Yoko Wada, Yasuko Kitagishi
Front Biosci (Landmark Ed) 2015 ; 20:491-501
PMID: 25553463 [PubMed - as supplied by publisher]


Lipid rafts involvement in the pathogenesis of Parkinson's disease.
Shin-Ichiro Kubo, Taku Hatano, Nobutaka Hattori
Front Biosci (Landmark Ed) 2015 ; 20:263-79
PMID: 25553450 [PubMed - as supplied by publisher]


RBC acetyl cholinesterase: A poor man's early diagnostic biomarker for familial alzheimer's and Parkinson's disease dementia.
Himmatrao Saluba Bawaskar, Parag Himmatrao Bawaskar, Pramodini Himmatrao Bawaskar
J Neurosci Rural Pract 2015 Jan; 6(1):33-8
PMID: 25552849 [PubMed - as supplied by publisher]


Trunk muscle exercises as a means of improving postural stability in people with Parkinson's disease: a protocol for a randomised controlled trial.
Ryan P Hubble, Geraldine A Naughton, Peter A Silburn, Michael H Cole
BMJ Open 2014 ; 4(12):e006095
PMID: 25552609 [PubMed - as supplied by publisher]


Resveratrol at Anti-angiogenesis/Anticancer Concentrations Suppresses Protein Kinase G Signaling and Decreases IAPs Expression in HUVECs.
Janica C Wong, Ronald R Fiscus
Anticancer Res 2015 Jan; 35(1):273-81
PMID: 25550561 [PubMed - as supplied by publisher]


ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter ?-Synuclein Metabolism in SH-SY5Y Cells.
Eun-Jin Bae, Cheolsoon Lee, He-Jin Lee, Seokjoong Kim, Seung-Jae Lee
Exp Neurobiol 2014 Dec; 23(4):365-71
PMID: 25548536 [PubMed - as supplied by publisher]


What is the Clinical Significance of Cerebrospinal Fluid Biomarkers in Parkinson's disease? Is the Significance Diagnostic or Prognostic?
Dana Kim, Jin Hui Paik, Dong-Woon Shin, Hak-Su Kim, Chang-Shin Park, Ju-Hee Kang
Exp Neurobiol 2014 Dec; 23(4):352-64
PMID: 25548535 [PubMed - as supplied by publisher]


Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes.
Ji-Young Han, Ji-Soo Kim, Jin H Son
Exp Neurobiol 2014 Dec; 23(4):345-51
PMID: 25548534 [PubMed - as supplied by publisher]


Exploring myelin dysfunction in multiple system atrophy.
Joanna H Wong, Glenda M Halliday, Woojin Scott Kim
Exp Neurobiol 2014 Dec; 23(4):337-44
PMID: 25548533 [PubMed - as supplied by publisher]


Protein Transmission, Seeding and Degradation: Key Steps for ?-Synuclein Prion-Like Propagation.
Abid Oueslati, Methodios Ximerakis, Kostas Vekrellis
Exp Neurobiol 2014 Dec; 23(4):324-36
PMID: 25548532 [PubMed - as supplied by publisher]


ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy.
Tomás Lopes da Fonseca, Tiago Fleming Outeiro
Exp Neurobiol 2014 Dec; 23(4):314-23
PMID: 25548531 [PubMed - as supplied by publisher]


Alpha-synuclein function and dysfunction on cellular membranes.
David Snead, David Eliezer
Exp Neurobiol 2014 Dec; 23(4):292-313
PMID: 25548530 [PubMed - as supplied by publisher]


TRANSGLUTAMINASE 2 IS INVOLVED IN HOMOCYSTEINE-INDUCED ACTIVATION OF HUMAN THP-1 MONOCYTES.
Curro Monica, Gangemi Chiara, Gugliandolo Agnese, Risitano Roberto, Ferlazzo Nadia, Ientile Ricardo, Caccamo Daniela
Free Radic Res 2014 Dec; :1-31
PMID: 25547897 [PubMed - as supplied by publisher]


The ICF as a framework to collect and interpret data on the extent and variety of disability in neurological conditions.
A Raggi, M Leonardi, V Covelli, D Sattin, C Scaratti, S Schiavolin, M Willems, P Meucci
NeuroRehabilitation 2014 Dec;
PMID: 25547761 [PubMed - as supplied by publisher]


Protective Effects of Lycium barbarum Polysaccharide on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway.
Kai Gao, Meiyou Liu, Jinyi Cao, Minna Yao, Yunyang Lu, Jiankang Li, Xiaohe Zhu, Zhifu Yang, Aidong Wen
Molecules 2014 ; 20(1):293-308
PMID: 25547727 [PubMed - as supplied by publisher]