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Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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LC-MS-based Urinary Metabolite Signatures in Idiopathic Parkinson's Disease.
Hemi Luan, Liang-Feng Liu, Nan Meng, Zhi Tang, Ka-Kit Chua, Lei-Lei Chen, Ju-Xian Song, Vincent Ct Mok, Li-Xia Xie, Min Li, Zongwei Cai
J Proteome Res 2014 Oct;
PMID: 25271123 [PubMed - as supplied by publisher]


Induction of pi form of glutathione S-transferase by carnosic acid is mediated through PI3K/Akt/NF-?B pathway and protects against neurotoxicity.
Chia-Yun Lin, Jing-Hsien Chen, Ru-Huei Fu, Chia-Wen Tsai
Chem Res Toxicol 2014 Sep;
PMID: 25271104 [PubMed - as supplied by publisher]


Clinical workout for the early detection of cognitive decline and dementia.
M Tsolaki
Eur J Clin Nutr 2014 Oct;
PMID: 25271010 [PubMed - as supplied by publisher]


Cypermethrin alters the status of oxidative stress in the peripheral blood: relevance to Parkinsonism.
Pratibha Tripathi, Ashish Singh, Sonal Agrawal, Om Prakash, Mahendra Pratap Singh
J Physiol Biochem 2014 Oct;
PMID: 25270427 [PubMed - as supplied by publisher]


(1)H NMR-based metabolomics study on a goldfish model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Zhaoguang Lu, Junsong Wang, Minghui Li, Qingwang Liu, Dandan Wei, Minghua Yang, Lingyi Kong
Chem Biol Interact 2014 Sep; 223C:18-26
PMID: 25242684 [PubMed - as supplied by publisher]


Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers.
Lana Dokleja, Mirva J Hannula, Timo T Myöhänen
Neurosci Lett 2014 Sep; 583C:37-42
PMID: 25240592 [PubMed - as supplied by publisher]


Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration.
Zhuo Luan, Keith Reddig, Hong-Sheng Li
Exp Neurol 2014 Sep; 261C:791-801
PMID: 25205229 [PubMed - as supplied by publisher]


Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
Ming-Kai Pan, Chun-Hwei Tai, Wen-Chuan Liu, Ju-Chun Pei, Wen-Sung Lai, Chung-Chin Kuo
J Clin Invest 2014 Oct; 124(10):4629-4641
PMID: 25202982 [PubMed - as supplied by publisher]


Effects of the Parkinsonian toxin MPP(+) on electrophysiological properties of nigral dopaminergic neurons.
Andrew G Yee, Sun-Min Lee, Morag R Hunter, Michelle Glass, Peter S Freestone, Janusz Lipski
Neurotoxicology 2014 Sep; 45C:1-11
PMID: 25193392 [PubMed - as supplied by publisher]


The newly Discovered Parkinson's Disease Associated Finnish Mutation (A53E) Attenuates ?-Synuclein Aggregation and Membrane Binding.
Dhiman Ghosh, Shruti Sahay, Priyatosh Ranjan, Shimul Salot, Ganesh M Mohite, Pradeep K Singh, Saumya Dwivedi, Edmund Carvalho, Rinti Banerjee, Ashutosh Kumar, Samir K Maji
Biochemistry 2014 Sep;
PMID: 25268550 [PubMed - as supplied by publisher]


Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
A Ledonne, A Nobili, E C Latagliata, V Cavallucci, E Guatteo, S Puglisi-Allegra, M D'Amelio, N B Mercuri
Mol Psychiatry 2014 Sep;
PMID: 25266126 [PubMed - as supplied by publisher]


Neurotoxin-Induced Pathway Perturbation in Human Neuroblastoma SH-EP Cells.
Jin Hwan Do
Mol Cells 2014 Sep; 37(9):672-84
PMID: 25234470 [PubMed - as supplied by publisher]


Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu, Huaibin Cai
EMBO J 2014 Sep;
PMID: 25201882 [PubMed - as supplied by publisher]


Increased plasma oligomeric alpha-synuclein in patients with lysosomal storage diseases.
S N Pchelina, E P Nuzhnyi, A K Emelyanov, T M Boukina, T S Usenko, M A Nikolaev, G N Salogub, A F Yakimovskii, E Yu Zakharova
Neurosci Lett 2014 Sep;
PMID: 25265039 [PubMed - as supplied by publisher]


A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Brian P Dranka, Alison Gifford, Donna McAllister, Jacek Zielonka, Joy Joseph, Crystal L O'Hara, Cheryl L Stucky, Anumantha G Kanthasamy, Balaraman Kalyanaraman
Neurosci Lett 2014 Sep;
PMID: 25263790 [PubMed - as supplied by publisher]


Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song Lu
Exp Neurol 2014 Sep;
PMID: 25263579 [PubMed - as supplied by publisher]


Mechanism of the beneficial effect of melatonin in experimental Parkinson's disease.
Fatos Belgin Yildirim, Ozlem Ozsoy, Gamze Tanriover, Yasemin Kaya, Eren Ogut, Burcu Gemici, Sayra Dilmac, Ayse Ozkan, Aysel Agar, Mutay Aslan
Neurochem Int 2014 Sep;
PMID: 25263280 [PubMed - as supplied by publisher]


Parkinson's disease and age: The obvious but largely unexplored link.
Rashed Abdullah, Indranil Basak, Ketan Patil, Guido Alves, Jan Petter Larsen, Simon Geir Møller
Exp Gerontol 2014 Sep;
PMID: 25261764 [PubMed - as supplied by publisher]


Puerarin protects dopaminergic neurons in Parkinson's disease models.
X Zhang, J Xiong, S Liu, L Wang, J Huang, L Liu, J Yang, G Zhang, K Guo, Z Zhang, P Wu, D Wang, Z Lin, N Xiong, T Wang
Neuroscience 2014 Sep; 280C:88-98
PMID: 25218963 [PubMed - as supplied by publisher]


Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade.
Ana Carolina D Noseda, Lais S Rodrigues, Adriano D S Targa, Mariana F Aurich, Maria A B F Vital, Cláudio Da Cunha, Marcelo M S Lima
Behav Brain Res 2014 Sep; 275C:136-145
PMID: 25218873 [PubMed - as supplied by publisher]


Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?
Gurdeep Marwarha, Othman Ghribi
Exp Gerontol 2014 Sep;
PMID: 25261765 [PubMed - as supplied by publisher]


Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL.
Xiao-Yun Liu, Maria E Gonzalez-Toledo, Austin Fagan, Yanying Liu, Wei-Ming Duan, Siyuan Zhang, Bin Li, Chun-Shu Piao, Li-Ru Zhao
Neurobiol Dis 2014 Sep;
PMID: 25251607 [PubMed - as supplied by publisher]


In vivo mitochondrial inhibition alters corticostriatal synaptic function and the modulatory effects of neurotrophins.
E Mendoza, J A Miranda-Barrientos, R A Vázquez-Roque, E Morales-Herrera, A Ruelas, G De la Rosa, G Flores, E Hernández-Echeagaray
Neuroscience 2014 Sep;
PMID: 25241069 [PubMed - as supplied by publisher]


Minocycline inhibits ICAD degradation and the NF-?B activation induced by 6-OHDA in PC12 cells.
Bao-Ping Jiang, Liang Le, Li-Jia Xu, Pei-Gen Xiao
Brain Res 2014 Sep;
PMID: 25195972 [PubMed - as supplied by publisher]


Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP.
Joon Ho Moon, Ji Ho Kim, Hyung-Jun Im, Dong Soo Lee, Eun Jung Park, Kilyoung Song, Hyun Ju Oh, Su Bin Hyun, Sang Chul Kang, Hyunil Kim, Hyo Eun Moon, Hyung Woo Park, Hong Jae Lee, Eun Ji Kim, Seokjoong Kim, Byeong Chun Lee, Sun Ha Paek
Exp Neurobiol 2014 Sep; 23(3):258-65
PMID: 25258574 [PubMed - as supplied by publisher]


Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: Evidence from a meta-analysis.
Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaji
Mov Disord 2014 Sep;
PMID: 25258345 [PubMed - as supplied by publisher]


Interactions between Calcium and Alpha-Synuclein in Neurodegeneration.
Alex Rcom-H'cheo-Gauthier, Jacob Goodwin, Dean L Pountney
Biomolecules 2014 ; 4(3):795-811
PMID: 25256602 [PubMed - as supplied by publisher]


Air pollution and your brain: what do you need to know right now.
Lilian Calderón-Garcidueñas, Ana Calderón-Garcidueñas, Ricardo Torres-Jardón, José Avila-Ramírez, Randy J Kulesza, Amedeo D Angiulli
Prim Health Care Res Dev 2014 Sep; :1-17
PMID: 25256239 [PubMed - as supplied by publisher]


Visual signs and symptoms of multiple system atrophy.
Richard A Armstrong
Clin Exp Optom 2014 Sep;
PMID: 25256122 [PubMed - as supplied by publisher]


Protein/Lipid Coaggregates are Formed During ?-Synuclein-Induced Disruption of Lipid Bilayers.
Andreas van Maarschalkerweerd, Valeria Vetri, Annette Eva Langkilde, Vito Foderà, Bente Vestergaard
Biomacromolecules 2014 Sep;
PMID: 25210839 [PubMed - as supplied by publisher]


Besides fibrillization: putative role of the peptide fragment 71-82 on the structural and assembly behavior of ?-synuclein.
Laurie Bédard, Thierry Lefèvre, Emilie Morin-Michaud, Michèle Auger
Biochemistry 2014 Sep;
PMID: 25255476 [PubMed - as supplied by publisher]


Stimulation of ? Opioid Receptor and Blockade of Nociceptin/Orphanin FQ Receptor Synergistically Attenuate Parkinsonism.
Omar S Mabrouk, Riccardo Viaro, Mattia Volta, Ada Ledonne, Nicola Mercuri, Michele Morari
J Neurosci 2014 Sep; 34(39):12953-62
PMID: 25253844 [PubMed - as supplied by publisher]


Neuroprotective effect of Buddleja cordata methanolic extract in the 1-methyl-4-phenylpyridinium Parkinson's disease rat model.
Gabriela Pérez-Barrón, José Guillermo Avila-Acevedo, Ana María García-Bores, Sergio Montes, Sara García-Jiménez, Ismael León-Rivera, Moisés Rubio-Osornio, Antonio Monroy-Noyola
J Nat Med 2014 Sep;
PMID: 25253176 [PubMed - as supplied by publisher]


ß-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network.
Bérangère Deleglise, Sebastien Magnifico, Eric Duplus, Pauline Vaur, Vanessa Soubeyre, Morgane Belle, Maeva Vignes, Jean-Louis Viovy, Etienne Jacotot, Jean-Michel Peyrin, Bernard Brugg
Acta Neuropathol Commun 2014 Sep; 2(1):145
PMID: 25253021 [PubMed - as supplied by publisher]


Does anxiety cause freezing of gait in Parkinson's disease?
Kaylena A Ehgoetz Martens, Colin G Ellard, Quincy J Almeida
PLoS One 2014 ; 9(9):e106561
PMID: 25250691 [PubMed - as supplied by publisher]


LRRK2 Pathobiology in Parkinson's Disease.
Ian Martin, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson
J Neurochem 2014 Sep;
PMID: 25251388 [PubMed - as supplied by publisher]


Alpha-synuclein as a Pathological Link between Chronic Traumatic Brain Injury and Parkinson's disease.
Sandra A Acosta, Naoki Tajiri, Ike de la Pena, Marina Bastawrous, Paul R Sanberg, Yuji Kaneko, Cesar V Borlongan
J Cell Physiol 2014 Sep;
PMID: 25251017 [PubMed - as supplied by publisher]


Glucocerebrosidase mutations in primary parkinsonism.
Rosanna Asselta, Valeria Rimoldi, Chiara Siri, Roberto Cilia, Ilaria Guella, Silvana Tesei, Giulia Soldà, Gianni Pezzoli, Stefano Duga, Stefano Goldwurm
Parkinsonism Relat Disord 2014 Sep;
PMID: 25249066 [PubMed - as supplied by publisher]


A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype.
Michael Veitinger, Rudolf Oehler, Ellen Umlauf, Roland Baumgartner, Georg Schmidt, Christopher Gerner, Rita Babeluk, Johannes Attems, Goran Mitulovic, Eduard Rappold, John Lamont, Maria Zellner
Acta Neuropathol 2014 Sep;
PMID: 25248508 [PubMed - as supplied by publisher]


High Stability and Cooperative Unfolding of ?-Synuclein Oligomers.
Wojciech Paslawski, Maria Andreasen, Søren Bang Nielsen, Nikolai Lorenzen, Karen Thomsen, Jørn Døvling Kaspersen, Jan Skov Pedersen, Daniel E Otzen
Biochemistry 2014 Sep;
PMID: 25216651 [PubMed - as supplied by publisher]


Phosphatidylethanolamine deficiency disrupts ?-synuclein homeostasis in yeast and worm models of Parkinson disease.
Shaoxiao Wang, Siyuan Zhang, Liang-Chun Liou, Qun Ren, Zhaojie Zhang, Guy A Caldwell, Kim A Caldwell, Stephan N Witt
Proc Natl Acad Sci U S A 2014 Sep; 111(38):E3976-85
PMID: 25201965 [PubMed - as supplied by publisher]


Antibodies and protein misfolding: From structural research tools to therapeutic strategies.
Erwin De Genst, Anne Messer, Christopher M Dobson
Biochim Biophys Acta 2014 Sep;
PMID: 25194824 [PubMed - as supplied by publisher]


The toxic effect of manganese on the acetylcholinesterase activity in rat brains.
Vahid Yousefi Babadi, Leila Sadeghi, Kobra Shirani, Ali Akbar Malekirad, Mohammad Rezaei
J Toxicol 2014 ; 2014:946372
PMID: 25246936 [PubMed - as supplied by publisher]


Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions.
Hideki Okamoto, Masaomi Iyo, Keigo Ueda, Cheolsun Han, Yoshiro Hirasaki, Takao Namiki
Neuropsychiatr Dis Treat 2014 ; 10:1727-42
PMID: 25246794 [PubMed - as supplied by publisher]


?-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation.
Jacqueline Burré, Manu Sharma, Thomas C Südhof
Proc Natl Acad Sci U S A 2014 Sep;
PMID: 25246573 [PubMed - as supplied by publisher]


Detection of a novel neurotoxic metabolite of Parkinson's disease-related neurotoxin, 1-benzyl-1,2,3,4- tetrahydroisoquinoline.
Yaichiro Kotake, Yoko Sekiya, Katsuhiro Okuda, Shigeru Ohta
J Toxicol Sci 2014 ; 39(5):749-54
PMID: 25242405 [PubMed - as supplied by publisher]


Neurodegeneration through oxidative stress: Monitoring hydrogen peroxide induced apoptosis in primary cells from the subventricular zone of BALB/c mice using field-effect transistors.
D Koppenhöfer, F Kettenbaum, A Susloparova, J K Y Law, X T Vu, T Schwab, K H Schäfer, S Ingebrandt
Biosens Bioelectron 2014 Sep;
PMID: 25241122 [PubMed - as supplied by publisher]


WebBioBank: A new platform for integrating clinical forms and shared neurosignal analyses to support multi-centre studies in Parkinson's Disease.
Elena Rossi, Manuela Rosa, Lorenzo Rossi, Alberto Priori, Sara Marceglia
J Biomed Inform 2014 Sep;
PMID: 25205596 [PubMed - as supplied by publisher]


Increased neurotrophic factor levels in ventral mesencephalic cultures do not explain the protective effect of osteopontin and the synthetic 15-mer RGD domain against MPP+ toxicity.
Lauren Broom, Peter Jenner, Sarah Rose
Exp Neurol 2014 Sep;
PMID: 25218309 [PubMed - as supplied by publisher]


MicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA.
Doo Chul Choi, Yoon-Jee Chae, Savan Kabaria, Amrita Datta Chaudhuri, Mohit Raja Jain, Hong Li, M Maral Mouradian, Eunsung Junn
J Neurosci 2014 Sep; 34(38):12725-37
PMID: 25232110 [PubMed - as supplied by publisher]


Interplay between sumoylation and phosphorylation for protection against alpha-synuclein inclusions.
Hedieh Shahpasandzadeh, Blagovesta Popova, Alexandra Kleinknecht, Paul E Fraser, Tiago F Outeiro, Gerhard H Braus
J Biol Chem 2014 Sep;
PMID: 25231978 [PubMed - as supplied by publisher]


Regulatory Cascade of Neuronal Loss and Glucose Metabolism.
M Hassan, S A Sehgal, S Rashid
CNS Neurol Disord Drug Targets 2014 Sep;
PMID: 25230224 [PubMed - as supplied by publisher]


Ignored Avenues in Alpha-Synuclein Associated Proteopathy.
R K Chowhan, S Mittal, T A Dar, M A Kamal, L R Singh
CNS Neurol Disord Drug Targets 2014 Sep;
PMID: 25230221 [PubMed - as supplied by publisher]


Effect of monocrotophos, an organophosphorus insecticide, on the striatal dopaminergic system in a mouse model of Parkinson's disease.
Shaheen Jafri Ali, Padmanabhan Sharda Rajini
Toxicol Ind Health 2014 Sep;
PMID: 25227224 [PubMed - as supplied by publisher]


Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study.
Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Leslie A Scarffe, Valina L Dawson, Owen A Ross, Wolfdieter Springer, Ted M Dawson, Zbigniew K Wszolek
Parkinsonism Relat Disord 2014 Sep;
PMID: 25226871 [PubMed - as supplied by publisher]


Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder.
Wei Lu, Senthilkumar S Karuppagounder, Danielle A Springer, Michele D Allen, Lixin Zheng, Brittany Chao, Yan Zhang, Valina L Dawson, Ted M Dawson, Michael Lenardo
Nat Commun 2014 ; 5:4930
PMID: 25222142 [PubMed - as supplied by publisher]


Protective role of olesoxime against wild type alpha-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells.
C Gouarné, J Tracz, M Giraudon Paoli, V Deluca, M Seimandi, G Tardif, M Xilouri, L Stefanis, T Bordet, R M Pruss
Br J Pharmacol 2014 Sep;
PMID: 25220617 [PubMed - as supplied by publisher]


Apoptosis signal-regulating kinase 1 modulates the phenotype of ?-synuclein transgenic mice.
Kang-Woo Lee, Jong-Min Woo, Joo-Young Im, Eun S Park, Liqiang He, Hidenori Ichijo, Eunsung Junn, M Maral Mouradian
Neurobiol Aging 2014 Jul;
PMID: 25219466 [PubMed - as supplied by publisher]


Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies.
Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay
Curr Neurol Neurosci Rep 2014 Nov; 14(11):495
PMID: 25218483 [PubMed - as supplied by publisher]


Pharmacokinetic/pharmacodynamic evaluation of rasagiline mesylate for Parkinson's disease.
Thomas Müller
Expert Opin Drug Metab Toxicol 2014 Oct; 10(10):1423-32
PMID: 25196265 [PubMed - as supplied by publisher]


The role of transcriptional control in multiple system atrophy.
Jieqiong Chen, James D Mills, Glenda M Halliday, Michael Janitz
Neurobiol Aging 2014 Aug;
PMID: 25218777 [PubMed - as supplied by publisher]


Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions.
Marco C Miotto, Andrés Binolfi, Markus Zweckstetter, Christian Griesinger, Claudio O Fernández
J Inorg Biochem 2014 Sep;
PMID: 25218565 [PubMed - as supplied by publisher]


The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Daniel Santos, A Raquel Esteves, Diana F Silva, Cristina Januário, Sandra M Cardoso
Mol Neurobiol 2014 Sep;
PMID: 25218511 [PubMed - as supplied by publisher]


Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits.
Asa Hatami, Marie-Francoise Chesselet
Curr Top Behav Neurosci 2014 Sep;
PMID: 25218491 [PubMed - as supplied by publisher]


Short Mitochondrial ARF Triggers Parkin/PINK1-Dependent Mitophagy.
Karl Grenier, Maria Kontogiannea, Edward A Fon
J Biol Chem 2014 Sep;
PMID: 25217637 [PubMed - as supplied by publisher]


USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Thomas M Durcan, Matthew Y Tang, Joëlle R Pérusse, Eman A Dashti, Miguel A Aguileta, Gian-Luca McLelland, Priti Gros, Thomas A Shaler, Denis Faubert, Benoit Coulombe, Edward A Fon
EMBO J 2014 Sep;
PMID: 25216678 [PubMed - as supplied by publisher]


Down-regulating ?-synuclein for treating synucleopathies.
Mathieu Bourdenx, Benjamin Dehay, Erwan Bezard
Mov Disord 2014 Sep;
PMID: 25214445 [PubMed - as supplied by publisher]


Correlation between decreased CSF ?-synuclein and A?1-42 in Parkinson disease.
Chandana Buddhala, Meghan C Campbell, Joel S Perlmutter, Paul T Kotzbauer
Neurobiol Aging 2014 Aug;
PMID: 25212463 [PubMed - as supplied by publisher]


Chronic L-Dopa Decreases Serotonin Neurons in a Sub-region of the Dorsal Raphe Nucleus.
Branden J Stansley, Bryan K Yamamoto
J Pharmacol Exp Ther 2014 Sep;
PMID: 25212217 [PubMed - as supplied by publisher]


DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress.
Mohammad Parsanejad, Noam Bourquard, Dianbo Qu, Yi Zhang, En Huang, Maxime W C Rousseaux, Hossein Aleyasin, Isabella Irrcher, Steve Callaghan, Dominique C Vaillant, Raymond H Kim, Ruth S Slack, Tak W Mak, Srinivasa T Reddy, Daniel Figeys, David S Park
PLoS One 2014 ; 9(9):e106601
PMID: 25210784 [PubMed - as supplied by publisher]


Cross Dimerization of Amyloid-? and ?Synuclein Proteins in Aqueous Environment: A Molecular Dynamics Simulations Study.
Jaya C Jose, Prathit Chatterjee, Neelanjana Sengupta
PLoS One 2014 ; 9(9):e106883
PMID: 25210774 [PubMed - as supplied by publisher]


Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice.
Yan Liu, Yu-He Yuan, Jian-Dong Sun, Jing Li, Zhi-Peng Li, Nai-Hong Chen
F1000Res 2014 ; 3:68
PMID: 25210616 [PubMed - as supplied by publisher]


New ¿- and ¿-synuclein immunopathological lesions in human brain.
Irina Surgucheva, Kathy L Newell, Jeffrey Burns, Andrei Surguchov
Acta Neuropathol Commun 2014 Sep; 2(1):132
PMID: 25209836 [PubMed - as supplied by publisher]


Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an ?-Helical Conformation.
Marta Robotta, Hanne R Gerding, Antonia Vogel, Karin Hauser, Stefan Schildknecht, Christiaan Karreman, Marcel Leist, Vinod Subramaniam, Malte Drescher
Chembiochem 2014 Sep;
PMID: 25209675 [PubMed - as supplied by publisher]


Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase.
Qingshan Wang, Chun-Hsien Chu, Li Qian, Shih-Heng Chen, Belinda Wilson, Esteban Oyarzabal, Lulu Jiang, Syed Ali, Bonnie Robinson, Hyoung-Chun Kim, Jau-Shyong Hong
J Neurosci 2014 Sep; 34(37):12490-503
PMID: 25209287 [PubMed - as supplied by publisher]


Brain Injection of ?-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker.
Amanda N Sacino, Mieu Brooks, Alex B McKinney, Michael A Thomas, Gerry Shaw, Todd E Golde, Benoit I Giasson
J Neurosci 2014 Sep; 34(37):12368-78
PMID: 25209277 [PubMed - as supplied by publisher]


Heat shock proteins in neurodegenerative disorders and aging.
Rehana K Leak
J Cell Commun Signal 2014 Sep;
PMID: 25208934 [PubMed - as supplied by publisher]


Structural and functional imaging in parkinsonian syndromes.
Stephen M Broski, Christopher H Hunt, Geoffrey B Johnson, Robert F Morreale, Val J Lowe, Patrick J Peller
Radiographics 2014 Sep-Oct; 34(5):1273-92
PMID: 25208280 [PubMed - as supplied by publisher]


Targeted Suppression of Chaperone-Mediated Autophagy by miR-320a Promotes ?-Synuclein Aggregation.
Guobin Li, Haiying Yang, Dezhang Zhu, Hui Huang, Guoyuan Liu, Peng Lun
Int J Mol Sci 2014 ; 15(9):15845-57
PMID: 25207598 [PubMed - as supplied by publisher]


Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons.
Yunchun Tai, Ling Chen, Enping Huang, Chao Liu, Xingyi Yang, Pingming Qiu, Huijun Wang
Neural Regen Res 2014 May; 9(9):951-8
PMID: 25206917 [PubMed - as supplied by publisher]


Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression.
Chunyan Guo, Xin Chen, Pei Xiong
Neural Regen Res 2014 Mar; 9(6):630-6
PMID: 25206866 [PubMed - as supplied by publisher]


The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.
Ting Zou, Xiangqi Tang, Zhiling Huang, Niangui Xu, Zhiping Hu
Neural Regen Res 2014 Feb; 9(4):402-6
PMID: 25206827 [PubMed - as supplied by publisher]


Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice.
Zihua Liu, Yuhong Jing, Jie Yin, Jiying Mu, Tingting Yao, Liping Gao
Neural Regen Res 2013 Dec; 8(35):3275-83
PMID: 25206649 [PubMed - as supplied by publisher]


Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway.
Ji-Young Kim, Beom Seok Jeon, Han-Joon Kim, Tae-Beom Ahn
Neural Regen Res 2013 Dec; 8(35):3269-74
PMID: 25206648 [PubMed - as supplied by publisher]


Construction of human Fab library and screening of a single-domain antibody of amyloid-beta 42 oligomers.
Zuanning Yuan, Minge Du, Yiwen Chen, Fei Dou
Neural Regen Res 2013 Nov; 8(33):3107-15
PMID: 25206631 [PubMed - as supplied by publisher]


How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?
Shaogang Lin, Shuifen Ye, Jinmu Huang, Yun Tian, Yihui Xu, Mengqi Wu, Jingxia Wang, Songying Wu, Jing Cai
Neural Regen Res 2013 Oct; 8(30):2820-6
PMID: 25206603 [PubMed - as supplied by publisher]


Autophagy and neurodegenerative disorders.
Evangelia Kesidou, Roza Lagoudaki, Olga Touloumi, Kyriaki-Nefeli Poulatsidou, Constantina Simeonidou
Neural Regen Res 2013 Aug; 8(24):2275-83
PMID: 25206537 [PubMed - as supplied by publisher]


Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.
Xingrong Ma, Zhikun Sun, Yanru Liu, Yanjie Jia, Boai Zhang, Jiewen Zhang
Neural Regen Res 2013 Aug; 8(22):2050-9
PMID: 25206513 [PubMed - as supplied by publisher]


Cerebrospinal fluid Alpha-synuclein as A Biomarker for Parkinson's disease Diagnosis: A Systematic review and Meta-analysis.
Liang Gao, Hongmei Tang, Kun Nie, Limin Wang, Jiehao Zhao, Rong Gan, Jing Huang, Ruiming Zhu, Shujun Feng, Zhenpeng Duan, Yuhu Zhang, Lijuan Wang
Int J Neurosci 2014 Sep; :1-26
PMID: 25202803 [PubMed - as supplied by publisher]


Testosterone as the missing link between pesticides, Alzheimer disease, and Parkinson disease-reply.
Jason R Richardson
JAMA Neurol 2014 Sep; 71(9):1190
PMID: 25200543 [PubMed - as supplied by publisher]


Testosterone as the missing link between pesticides, Alzheimer disease, and Parkinson disease.
Ralph Martins, Malcolm Carruthers
JAMA Neurol 2014 Sep; 71(9):1189-90
PMID: 25200541 [PubMed - as supplied by publisher]


Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging.
Ananda S Prasad
J Trace Elem Med Biol 2014 Aug;
PMID: 25200490 [PubMed - as supplied by publisher]


Mutations in the ATP13A2 Gene and Parkinsonism: A Preliminary Review.
Xinglong Yang, Yanming Xu
Biomed Res Int 2014 ; 2014:371256
PMID: 25197640 [PubMed - as supplied by publisher]


Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia.
Karlijn J Doorn, Benjamin Drukarch, Anne-Marie van Dam, Paul J Lucassen
Neural Plast 2014 ; 2014:959154
PMID: 25197578 [PubMed - as supplied by publisher]


Fractalkine Over Expression Suppresses ?-Synuclein mediated Neurodegeneration.
Kevin R Nash, Peter Moran, Dylan Finneran, Charles Hudson, Jesse Robinson, Dave Morgan, Paula C Bickford
Mol Ther 2014 Sep;
PMID: 25195598 [PubMed - as supplied by publisher]


PRDX6 Exacerbates Dopaminergic Neurodegeneration in a MPTP Mouse Model of Parkinson's Disease.
Hyung-Mun Yun, Dong Young Choi, Ki Wan Oh, Jin Tae Hong
Mol Neurobiol 2014 Sep;
PMID: 25193021 [PubMed - as supplied by publisher]


Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury.
Kai Kysenius, Cecilia A Brunello, Henri J Huttunen
PLoS One 2014 ; 9(9):e107129
PMID: 25192195 [PubMed - as supplied by publisher]


Rectifying rectifier channels in Huntington disease.
Juliane Proft, Norbert Weiss
Commun Integr Biol 2014 ; 7:e29410
PMID: 25191533 [PubMed - as supplied by publisher]


The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light.
Joanna F Collingwood, Mark R Davidson
Front Pharmacol 2014 ; 5:191
PMID: 25191270 [PubMed - as supplied by publisher]


TREM2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in postmortem temporal cortices.
Lih-Fen Lue, Christopher T Schmitz, Geidy Sorrano, Lucia I Sue, Thomas G Beach, Douglas G Walker
Brain Pathol 2014 Sep;
PMID: 25186950 [PubMed - as supplied by publisher]