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Sheng-Han Kuo, M.D.

“The PDF Côté Award [in Clinical Genetics] helped me to start my research.”

Sheng-Han Kuo, M.D.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

Impulse Control Disorder

Vision/Visual hallucination



Orthostatic Hypotension


Imaging Studies

Clinical Studies



Treating Parkinson’s

Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

Deep Brain Stimulation

Physical, Occupational and Speech Therapy



Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

Hospice/End of Life/Palliative Care

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Neuroprotective effects of lixisenatide and liraglutide in the MPTP mouse model of Parkinson's disease.
WeiZhen Liu, Jaishree Jalewa, Mohit Sharma, Guanglai Li, Lin Li, Christian Hölscher
Neuroscience 2015 Jun;
PMID: 26141845 [PubMed - as supplied by publisher]

Common pathophysiology affecting diabetic retinopathy and Parkinson's disease.
Tian Tian, Zhaoming Li, Hong Lu
Med Hypotheses 2015 Jun;
PMID: 26141638 [PubMed - as supplied by publisher]

Comparison of the structure, function and autophagic maintenance of mitochondria in nigrostriatal and tuberoinfundibular dopamine neurons.
Hae-Young Hawong, Joseph R Patterson, Brittany M Winner, John L Goudreau, Keith J Lookingland
Brain Res 2015 Jun;
PMID: 26141374 [PubMed - as supplied by publisher]

Overexpression of PGC-1? Influences Mitochondrial Signal Transduction of Dopaminergic Neurons.
Qinyong Ye, Wanling Huang, Dongzhu Li, Erwang Si, Juhua Wang, Yingqing Wang, Chun Chen, Xiaochun Chen
Mol Neurobiol 2015 Jul;
PMID: 26141122 [PubMed - as supplied by publisher]

?-Synuclein interactions with phospholipid model membranes: Key roles for electrostatic interactions and lipid-bilayer structure.
Katja Pirc, Nata?a Poklar Ulrih
Biochim Biophys Acta 2015 Jun;
PMID: 26119565 [PubMed - as supplied by publisher]

Low levels of astroglial markers in Parkinson's disease: relationship to ?-synuclein accumulation.
Junchao Tong, Lee-Cyn Ang, Belinda Williams, Yoshiaki Furukawa, Paul Fitzmaurice, Mark Guttman, Isabelle Boileau, Oleh Hornykiewicz, Stephen J Kish
Neurobiol Dis 2015 Jun; 82:243-253
PMID: 26102022 [PubMed - as supplied by publisher]

Intrastriatal injection of pre-formed mouse ?-synuclein fibrils into rats triggers ?-synuclein pathology and bilateral nigrostriatal degeneration.
Katrina L Paumier, Kelvin C Luk, Fredric P Manfredsson, Nicholas M Kanaan, Jack W Lipton, Timothy J Collier, Kathy Steece-Collier, Christopher J Kemp, Stephanie Celano, Emily Schulz, Ivette M Sandoval, Sheila Fleming, Elliott Dirr, Nicole K Polinski, John Q Trojanowski, Virginia M Lee, Caryl E Sortwell
Neurobiol Dis 2015 Jun; 82:185-199
PMID: 26093169 [PubMed - as supplied by publisher]

When DLB, PD, and PSP masquerade as MSA: An autopsy study of 134 patients.
Shunsuke Koga, Naoya Aoki, Ryan J Uitti, Jay A van Gerpen, William P Cheshire, Keith A Josephs, Zbigniew K Wszolek, J William Langston, Dennis W Dickson
Neurology 2015 Jul;
PMID: 26138942 [PubMed - as supplied by publisher]

Can clock drawing differentiate Alzheimer's disease from other dementias?
Lynnette Pei Lin Tan, Nathan Herrmann, Brian J Mainland, Kenneth Shulman
Int Psychogeriatr 2015 Jul; :1-12
PMID: 26138809 [PubMed - as supplied by publisher]

Fibril growth and seeding capacity play key roles in ?-synuclein-mediated apoptotic cell death.
A-L Mahul-Mellier, F Vercruysse, B Maco, N Ait-Bouziad, M De Roo, D Muller, H A Lashuel
Cell Death Differ 2015 Jul;
PMID: 26138444 [PubMed - as supplied by publisher]

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.
Aurelija Jucaite, Per Svenningsson, Juha O Rinne, Zsolt Cselényi, Katarina Varnäs, Peter Johnström, Nahid Amini, Anna Kirjavainen, Semi Helin, Margaret Minkwitz, Alan R Kugler, Joel A Posener, Samantha Budd, Christer Halldin, Andrea Varrone, Lars Farde
Brain 2015 Jul;
PMID: 26137956 [PubMed - as supplied by publisher]

?-Synuclein and Lewy pathology in Parkinson's disease.
Lorraine V Kalia, Suneil K Kalia
Curr Opin Neurol 2015 Aug; 28(4):375-81
PMID: 26110807 [PubMed - as supplied by publisher]

Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics.
Hao Liu, Ping Mao, Jia Wang, Tuo Wang, Chang-Hou Xie
Cell Physiol Biochem 2015 ; 36(3):966-79
PMID: 26087780 [PubMed - as supplied by publisher]

shRNA targeting ?-synuclein prevents neurodegeneration in a Parkinson's disease model.
Alevtina D Zharikov, Jason R Cannon, Victor Tapias, Qing Bai, Max P Horowitz, Vipul Shah, Amina El Ayadi, Teresa G Hastings, J Timothy Greenamyre, Edward A Burton
J Clin Invest 2015 Jul; 125(7):2721-35
PMID: 26075822 [PubMed - as supplied by publisher]

Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases.
A Rieckmann, S N Gomperts, K A Johnson, J H Growdon, K R A Van Dijk
Neuroimage Clin 2015; 8:554-559
PMID: 26137443 [PubMed - as supplied by publisher]

Effect of lysosomal and ubiquitin-proteasome system dysfunction on the abnormal aggregation of ?-synuclein in PC12 cells.
Runqing Wang, Jie Zhao, Jiewen Zhang, Wei Liu, Meiying Zhao, Jiangtao Li, Juan Lv, Yanan Li
Exp Ther Med 2015 Jun; 9(6):2088-2094
PMID: 26136940 [PubMed - as supplied by publisher]

Neuroprotective effects of ?-melanocyte-stimulating hormone against the neurotoxicity of 1-methyl-4-phenylpyridinium.
Tao Peng, Jingtao Wang, Jingjing Lu, Hong Lu, Junfang Teng, Yanjie Jia
IUBMB Life 2015 Jul;
PMID: 26136377 [PubMed - as supplied by publisher]

Targeting ?-synuclein as a therapeutic strategy for Parkinson's disease.
Nada B Lawand, Nayef E Saadé, Omar M El-Agnaf, Bared Safieh-Garabedian
Expert Opin Ther Targets 2015 Jul; :1-10
PMID: 26135549 [PubMed - as supplied by publisher]

Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate Model.
LinLin Tian, Yuanxuan Xia, Hubert P Flores, Meghan C Campbell, Stephen M Moerlein, Joel S Perlmutter
PLoS One 2015; 10(7):e0132064
PMID: 26135399 [PubMed - as supplied by publisher]

Multiple sclerosis and Parkinson's disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature.
Anastasia Bougea, Elisabeth Kapaki, George P Paraskevas, Kostas Kilidireas, Elisabeth Andreadou
Neurol Sci 2015 Jul;
PMID: 26134747 [PubMed - as supplied by publisher]

The phosphorylation of ?-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease.
Yan Xu, Yulin Deng, Hong Qing
J Neurochem 2015 Jul;
PMID: 26134497 [PubMed - as supplied by publisher]

A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Tine Holemans, Danny Mollerup Sřrensen, Sarah van Veen, Shaun Martin, Diane Hermans, Gerdi Christine Kemmer, Chris Van den Haute, Veerle Baekelandt, Thomas Günther Pomorski, Patrizia Agostinis, Frank Wuytack, Michael Palmgren, Jan Eggermont, Peter Vangheluwe
Proc Natl Acad Sci U S A 2015 Jul;
PMID: 26134396 [PubMed - as supplied by publisher]

Cerebrospinal fluid tau and amyloid-?1-42 in patients with dementia.
Tobias Skillbäck, Bahman Y Farahmand, Christoffer Rosén, Niklas Mattsson, Katarina Nägga, Lena Kilander, Dorota Religa, Anders Wimo, Bengt Winblad, Jonathan M Schott, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg
Brain 2015 Jun;
PMID: 26133663 [PubMed - as supplied by publisher]

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats.
Xiaorong Pan, Chunxia Chen, Jianping Huang, Haiming Wei, Qiuping Fan
Neurosci Lett 2015 Jun; 600:220-225
PMID: 26101828 [PubMed - as supplied by publisher]

Current knowledge and pharmacological profile of berberine: An update.
Anil Kumar, Ekavali, Kanwaljit Chopra, Madhurima Mukherjee, Raghavender Pottabathini, Dinesh K Dhull
Eur J Pharmacol 2015 Jun; 761:288-297
PMID: 26092760 [PubMed - as supplied by publisher]

The Significance of Experiences of Nature for People with Parkinson's Disease, with Special Focus on Freezing of Gait-The Necessity for a Biophilic Environment. A Multi-Method Single Subject Study.
Johan Ottosson, Lillian Lavesson, Stefan Pinzke, Patrik Grahn
Int J Environ Res Public Health 2015; 12(7):7274-7299
PMID: 26132480 [PubMed - as supplied by publisher]

fMRI Validation of fNIRS Measurements During a Naturalistic Task.
J Adam Noah, Yumie Ono, Yasunori Nomoto, Sotaro Shimada, Atsumichi Tachibana, Xian Zhang, Shaw Bronner, Joy Hirsch
J Vis Exp 2015; (100)
PMID: 26132365 [PubMed - as supplied by publisher]

Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease.
Kun-Ling Tsai, Yuan-Yang Cheng, Hsin-Bang Leu, Yi-Yen Lee, Tzeng-Ji Chen, Ding-Hao Liu, Chung-Lan Kao
Neurobiol Aging 2015 Jun;
PMID: 26130063 [PubMed - as supplied by publisher]

Cu(II) Promotes Amyloid Pore Formation.
Hangyu Zhang, Jean-Christophe Rochet, Lia A Stanciu
Biochem Biophys Res Commun 2015 Jun;
PMID: 26129772 [PubMed - as supplied by publisher]

Changes in secondary structure of ?-synuclein during oligomerization induced by reactive aldehydes.
Yixiao Cai, Christofer Lendel, Lars Österlund, Alex Kasrayan, Lars Lannfelt, Martin Ingelsson, Fredrik Nikolajeff, Mikael Karlsson, Joakim Bergström
Biochem Biophys Res Commun 2015 Jun;
PMID: 26129771 [PubMed - as supplied by publisher]

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease.
A Miyashita, H Hatsuta, M Kikuchi, A Nakaya, Y Saito, T Tsukie, N Hara, S Ogishima, N Kitamura, K Akazawa, A Kakita, H Takahashi, S Murayama, Y Ihara, T Ikeuchi, R Kuwano,
Transl Psychiatry 2014 ; 4:e396
PMID: 26126179 [PubMed - as supplied by publisher]

Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: The Normative Aging Study.
Rachel Grashow, David Sparrow, Howard Hu, Marc G Weisskopf
Neurotoxicology 2015 Jun;
PMID: 26121922 [PubMed - as supplied by publisher]

No evidence for substrate accumulation in Parkinson brains with GBA mutations.
Matthew E Gegg, Lindsay Sweet, Bing H Wang, Lamya S Shihabuddin, Sergio Pablo Sardi, Anthony H V Schapira
Mov Disord 2015 Jun;
PMID: 26096906 [PubMed - as supplied by publisher]

Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia.
Simone Bido, Nicola Solari, Marzia Indrigo, Angela D'Antoni, Riccardo Brambilla, Michele Morari, Stefania Fasano
Ann Clin Transl Neurol 2015 Jun; 2(6):662-78
PMID: 26125041 [PubMed - as supplied by publisher]

Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo.
Kyoung Hoon Jeong, Un Ju Jung, Sang Ryong Kim
Evid Based Complement Alternat Med 2015 ; 2015:354326
PMID: 26124853 [PubMed - as supplied by publisher]

Modulation of the neuronal network activity by P2X receptors and their involvement in neurological disorders.
F Sáez-Orellana, P A Godoy, T Silva-Grecchi, K M Barra, J Fuentealba
Pharmacol Res 2015 Jun;
PMID: 26122853 [PubMed - as supplied by publisher]

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.
Rojeen Shahni, Catherine M Cale, Glenn Anderson, Laura D Osellame, Sophie Hambleton, Thomas S Jacques, Yehani Wedatilake, Jan-Willem Taanman, Emma Chan, Waseem Qasim, Vincent Plagnol, Annapurna Chalasani, Michael R Duchen, Kimberly C Gilmour, Shamima Rahman
Brain 2015 Jun;
PMID: 26122121 [PubMed - as supplied by publisher]

Synthetic Proteins and Peptides for the Direct Interrogation of ?-Synuclein Posttranslational Modifications.
Matthew R Pratt, Tharindumala Abeywardana, Nicholas P Marotta
Biomolecules 2015 ; 5(3):1210-27
PMID: 26120904 [PubMed - as supplied by publisher]

An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling.
Robin S B Williams, Clive Bate
Neuropharmacology 2015 Jun;
PMID: 26116815 [PubMed - as supplied by publisher]

Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway.
X S Zhang, S Ha, X L Wang, Y L Shi, S S Duan, Z A Li
Neuroscience 2015 Jun;
PMID: 26116522 [PubMed - as supplied by publisher]

Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection.
Liting Hang, John Thundyil, Kah-Leong Lim
Ann N Y Acad Sci 2015 Jun;
PMID: 26121488 [PubMed - as supplied by publisher]

Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.
Zahra Kiasalari, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Cell Mol Neurobiol 2015 Jun;
PMID: 26119304 [PubMed - as supplied by publisher]

Contact between the ?1 and ?2 Segments of ?-Synuclein that Inhibits Amyloid Formation.
Hamed Shaykhalishahi, Aziz Gauhar, Michael M Wördehoff, Clara S R Grüning, Antonia N Klein, Oliver Bannach, Matthias Stoldt, Dieter Willbold, Torleif Härd, Wolfgang Hoyer
Angew Chem Int Ed Engl 2015 Jun;
PMID: 26119103 [PubMed - as supplied by publisher]

Nrf2-ARE signals mediated the anti-oxidative action of electro-acupuncture in an MPTP mouse model of Parkinson's disease.
E Lv, Jiahui Deng, Yan Yu, Yalong Wang, Xiaoli Gong, Jun Jia, Xiaomin Wang
Free Radic Res 2015 Jun; :1-30
PMID: 26118717 [PubMed - as supplied by publisher]

Inhibition of amyloid-? plaque formation by ?-synuclein.
Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Müller, Marco Prinz, Harald Steiner, Bradley T Hyman, Christian Haass, Melanie Meyer-Luehmann
Nat Med 2015 Jun;
PMID: 26099047 [PubMed - as supplied by publisher]

Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate.
Maude Beaudoin-Gobert, Justine Epinat, Elise Météreau, Sandra Duperrier, Sara Neumane, Bénédicte Ballanger, Franck Lavenne, François Liger, Christian Tourvielle, Frédéric Bonnefoi, Nicolas Costes, Didier Le Bars, Emmanuel Broussolle, Stéphane Thobois, Léon Tremblay, Véronique Sgambato-Faure
Brain 2015 Jun;
PMID: 26117365 [PubMed - as supplied by publisher]

Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model.
Mi Jin Kim, Meeyoung Park, Dae Won Kim, Min Jea Shin, Ora Son, Hyo Sang Jo, Hyeon Ji Yeo, Su Bin Cho, Jung Hwan Park, Chi Hern Lee, Duk-Soo Kim, Oh-Shin Kwon, Joon Kim, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi
Biomaterials 2015 Jun; 64:45-56
PMID: 26117230 [PubMed - as supplied by publisher]

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
Agne Kazlauskaite, R Julio Martínez-Torres, Scott Wilkie, Atul Kumar, Julien Peltier, Alba Gonzalez, Clare Johnson, Jinwei Zhang, Anthony G Hope, Mark Peggie, Matthias Trost, Daan Mf van Aalten, Dario R Alessi, Alan R Prescott, Axel Knebel, Helen Walden, Miratul Mk Muqit
EMBO Rep 2015 Jun;
PMID: 26116755 [PubMed - as supplied by publisher]

?-Synuclein in Parkinson's disease: getting to the core of the matter.
Robert A Hauser
Lancet Neurol 2015 Jun;
PMID: 26116313 [PubMed - as supplied by publisher]

Targeted Overexpression of ?-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse.
Lian-Kun Song, Kai-Li Ma, Yu-He Yuan, Zheng Mu, Xiu-Yun Song, Fei Niu, Ning Han, Nai-Hong Chen
PLoS One 2015 ; 10(6):e0131281
PMID: 26114655 [PubMed - as supplied by publisher]

Ginsenoside Rd Protects SH-SY5Y Cells against 1-Methyl-4-phenylpyridinium Induced Injury.
Yang Liu, Ren-Yu Zhang, Jun Zhao, Zheng Dong, Dong-Yun Feng, Rui Wu, Ming Shi, Gang Zhao
Int J Mol Sci 2015 ; 16(7):14395-408
PMID: 26114390 [PubMed - as supplied by publisher]

Mitochondrial Dysfunction in Parkinson's Disease.
Hyo Eun Moon, Sun Ha Paek
Exp Neurobiol 2015 Jun; 24(2):103-16
PMID: 26113789 [PubMed - as supplied by publisher]

The initial stage of reversal learning is impaired in mice hemizygous for the vesicular glutamate transporter VGluT1.
Björn Granseth, Fredrik K Andersson, Sarah H Lindström
Genes Brain Behav 2015 Jun;
PMID: 26113146 [PubMed - as supplied by publisher]

Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients.
Rosa Lippolis, Rosa Anna Siciliano, Consiglia Pacelli, Anna Ferretta, Maria Fiorella Mazzeo, Salvatore Scacco, Francesco Papa, Antonio Gaballo, Claudia Dell'Aquila, Michele De Mari, Sergio Papa, Tiziana Cocco
Biochim Biophys Acta 2015 Jun;
PMID: 26096686 [PubMed - as supplied by publisher]

Younger age at onset of sporadic Parkinson's disease among subjects occupationally exposed to metals and pesticides.
Marcia H Ratner, David H Farb, Josef Ozer, Robert G Feldman, Raymon Durso
Interdiscip Toxicol 2014 Sep; 7(3):123-33
PMID: 26109889 [PubMed - as supplied by publisher]

Structural and functional imaging study in dementia with Lewy bodies and Parkinson's disease dementia.
Barbara Borroni, Enrico Premi, Anna Formenti, Rosanna Turrone, Antonella Alberici, Elisabetta Cottini, Cristina Rizzetti, Roberto Gasparotti, Alessandro Padovani
Parkinsonism Relat Disord 2015 Jun;
PMID: 26109553 [PubMed - as supplied by publisher]

Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice.
Supriti Samantaray, Varduhi H Knaryan, Donald C Shields, April A Cox, Azizul Haque, Naren L Banik
Mol Neurobiol 2015 Jun;
PMID: 26108182 [PubMed - as supplied by publisher]

Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy.
Marina Theodorou, Benedict Rauser, Jingzhong Zhang, Nilima Prakash, Wolfgang Wurst, Joel A Schick
Hum Gene Ther Methods 2015 Jun;
PMID: 26107288 [PubMed - as supplied by publisher]

Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease.
Naomi P Visanji, Iman Kamali Sarvestani, Meaghan C Creed, Zahra Shams Shoaei, José N Nobrega, Clement Hamani, Lili-Naz Hazrati
Front Cell Neurosci 2015 ; 9:221
PMID: 26106299 [PubMed - as supplied by publisher]

Optogenetic probing of mitochondrial damage responses.
Wei Yuan Yang
Ann N Y Acad Sci 2015 Jun;
PMID: 26104771 [PubMed - as supplied by publisher]

Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease.
Carmen Noelker, Lixia Lu, Matthias Höllerhage, Franca Vulinovic, Annekathrin Sturn, René Roscher, Günter U Höglinger, Etienne C Hirsch, Wolfgang H Oertel, Daniel Alvarez-Fischer, Hartmann Andreas
J Neurol Sci 2015 Jun;
PMID: 26104567 [PubMed - as supplied by publisher]

Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy.
Cathrin Meissner, Holger Lorenz, Beate Hehn, Marius K Lemberg
Autophagy 2015 Jun; :0
PMID: 26101826 [PubMed - as supplied by publisher]

Splicing variants of porcine synphilin-1.
Knud Larsen, Lone Bruhn Madsen, Leila Farajzadeh, Christian Bendixen
Meta Gene 2015 Sep; 5:32-42
PMID: 26101749 [PubMed - as supplied by publisher]

Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature.
S A Schneider, M Boettner, A Alexoudi, D Zorenkov, G Deuschl, T Wedel
Eur J Neurol 2015 Jun;
PMID: 26100920 [PubMed - as supplied by publisher]

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.
Anne-Sophie Van Rompuy, Marusela Oliveras-Salvá, Anke Van der Perren, Olga Corti, Chris Van den Haute, Veerle Baekelandt
Mol Neurodegener 2015 ; 10(1):23
PMID: 26099628 [PubMed - as supplied by publisher]

Association of the COQ2 V393A Variant with Parkinson's Disease: A Case-Control Study and Meta-Analysis.
Xinglong Yang, Jing Xi, Quanzhen Zhao, Hua Jia, Ran An, Zhuolin Liu, Yanming Xu
PLoS One 2015 ; 10(6):e0130970
PMID: 26098829 [PubMed - as supplied by publisher]

Oculo-visual changes and clinical considerations affecting older patients with dementia.
Richard Armstrong, Hélčne Kergoat
Ophthalmic Physiol Opt 2015 Jul; 35(4):352-76
PMID: 26094831 [PubMed - as supplied by publisher]

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases.
Cristina Carvalho, Sónia C Correia, Susana Cardoso, Ana I Plácido, Emanuel Candeias, Ana I Duarte, Paula I Moreira
Expert Rev Neurother 2015 Jun; :1-18
PMID: 26092668 [PubMed - as supplied by publisher]

Current treatment and future prospects of dopa-induced dyskinesias.
S Mazzucchi, D Frosini, U Bonuccelli, R Ceravolo
Drugs Today (Barc) 2015 May; 51(5):315-29
PMID: 26097904 [PubMed - as supplied by publisher]

The roles of redox enzymes in Parkinson's disease: Focus on glutaredoxin.
William M Johnson, Amy L Wilson-Delfosse, Shu G Chen, John J Mieyal
Ther Targets Neurol Dis 2015; 2(2)
PMID: 26097894 [PubMed - as supplied by publisher]

Localization of nuclear receptor subfamily 4, group A, member 3 (NR4A3) in Lewy body disease and multiple system atrophy.
Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Fumiaki Mori, Masahiko Tomiyama, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Jun Utsumi, Hidenao Sasaki, Koichi Wakabayashi
Neuropathology 2015 Jun;
PMID: 26096603 [PubMed - as supplied by publisher]

Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study.
Tanya Simuni, Chelsea Caspell-Garcia, Christopher Coffey, Lama M Chahine, Shirley Lasch, Wolfgang H Oertel, Geert Mayer, Birgit Högl, Ron Postuma, Aleksandar Videnovic, Amy Willis Amara, Ken Marek,
Mov Disord 2015 Jun;
PMID: 26095202 [PubMed - as supplied by publisher]

2, 2'- and 4, 4'- cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP.
Chamila C Kadigamuwa, Viet Q Le, Kandatege Wimalasena
J Neurochem 2015 Jun;
PMID: 26094622 [PubMed - as supplied by publisher]

Chronic pharmacological glucocerebrosidase inhibition induces ?-synuclein aggregation, microglial and complement activation and synaptic protein changes in mice.
Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Anne-Renee Graham, Eilish Brown, Jesse R McLean, Melissa A Hayes, Jonathan Beagan, Sarah C Izen, Eduardo Perez-Torres, Penelope J Hallett, Ole Isacson
Antioxid Redox Signal 2015 Jun;
PMID: 26094487 [PubMed - as supplied by publisher]

l-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or l-Dopa history.
Lufei Shan, Oscar Diaz, Yajun Zhang, Bruce Ladenheim, Jean-Lud Cadet, Yung-Hsiao Chiang, Lars Olson, Barry J Hoffer, Cristina M Bäckman
Brain Res 2015 Jun;
PMID: 26086365 [PubMed - as supplied by publisher]

Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study.
Niels Kruse, Staffan Persson, Daniel Alcolea, Justyna M C Bahl, Ines Baldeiras, Elisabetta Capello, Davide Chiasserini, Luisella Bocchio Chiavetto, Andreja Emersic, Sebastiaan Engelborghs, Erden Eren, Tormod Fladby, Giovanni Frisoni, María-Salud García-Ayllón, Sermin Genc, Olymbia Gkatzima, Niels H H Heegaard, André M Janeiro, Branislav Ková?ech, H Bea Kuiperij, Maria J Leităo, Alberto Lleó, Madalena Martins, Mafalda Matos, Hanne M Mollergard, Flavio Nobili, Annika Öhrfelt, Lucilla Parnetti, Catarina Resende de Oliveira, Uros Rot, Javier Sáez-Valero, Hanne Struyfs, Julia T Tanassi, Peggy Taylor, Magda Tsolaki, Eugeen Vanmechelen, Marcel M Verbeek, Norbert Zilka, Kaj Blennow, Henrik Zetterberg, Brit Mollenhauer
Neurobiol Aging 2015 May;
PMID: 26093515 [PubMed - as supplied by publisher]

Understanding the Influence of Parkinson's Disease on Adolf Hitler's Decision-Making during World War II.
Raghav Gupta, Christopher Kim, Nitin Agarwal, Bryan Lieber, Edward A Monaco
World Neurosurg 2015 Jun;
PMID: 26093359 [PubMed - as supplied by publisher]

Tea Polyphenols in Parkinson's Disease.
Mario Caruana, Neville Vassallo
Adv Exp Med Biol 2015 ; 863:117-37
PMID: 26092629 [PubMed - as supplied by publisher]

Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.
Jean-Marc Taymans, Aurore Nkiliza, Marie-Christine Chartier-Harlin
Trends Mol Med 2015 Jun;
PMID: 26091824 [PubMed - as supplied by publisher]

Parkinson's Disease and Home Healthcare Use and Expenditures among Elderly Medicare Beneficiaries.
Sandipan Bhattacharjee, Aaron Metzger, Cindy Tworek, Wenhui Wei, Xiaoyun Pan, Usha Sambamoorthi
Parkinsons Dis 2015 ; 2015:606810
PMID: 26090265 [PubMed - as supplied by publisher]

(123)I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review.
Eun Joo Chung, Sang Jin Kim
J Mov Disord 2015 May; 8(2):55-66
PMID: 26090077 [PubMed - as supplied by publisher]

Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7.
Xijin Wang, Qiang Guan, Meihua Wang, Liu Yang, Jie Bai, Zhiqiang Yan, Yuhong Zhang, Zhenguo Liu
Drug Des Devel Ther 2015 ; 9:2553-63
PMID: 26089639 [PubMed - as supplied by publisher]

Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease.
Anke A Dijkstra, Angela Ingrassia, Renee X de Menezes, Ronald E van Kesteren, Annemieke J M Rozemuller, Peter Heutink, Wilma D J van de Berg
PLoS One 2015 ; 10(6):e0128651
PMID: 26087293 [PubMed - as supplied by publisher]

Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD.
Kelly R Genskow, Joshua M Bradner, Muhammad M Hossain, Jason R Richardson, W Michael Caudle
Neurotoxicol Teratol 2015 Jun;
PMID: 26073293 [PubMed - as supplied by publisher]

Melatonin:- A potential antioxidant therapeutic agent for mitochondrial dysfunctions and related disorders.
Showkat Ahmad Ganie, Tanveer Dar, Aashiq Bhat, Khalid Dar, Suhail Anees, Akbar Masood, Mohammad Afzal Zargar
Rejuvenation Res 2015 Jun;
PMID: 26087000 [PubMed - as supplied by publisher]

Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis.
Myungjin Kim, Ian Semple, Boyoung Kim, Alexandra Kiers, Samuel Nam, Hwan-Woo Park, Haeli Park, Seung-Hyun Ro, Jeong-Sig Kim, Gábor Juhász, Jun Hee Lee
Autophagy 2015 Jun; :0
PMID: 26086452 [PubMed - as supplied by publisher]

Intraventricular cerebrospinal fluid temperature analysis using MR diffusion-weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects.
Kaoru Sumida, Noriko Sato, Miho Ota, Koji Sakai, Yasumasa Nippashi, Daichi Sone, Kota Yokoyama, Kimiteru Ito, Norihide Maikusa, Etsuko Imabayashi, Hiroshi Matsuda, Kei Yamada, Miho Murata, Akira Kunimatsu, Kuni Ohtomo
Brain Behav 2015 Jun; 5(6):e00340
PMID: 26085965 [PubMed - as supplied by publisher]

Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function.
Lei Wei, Li Ding, Ming-Shu Mo, Ming Lei, Limin Zhang, Kang Chen, Pingyi Xu
Transl Neurodegener 2015 ; 4:11
PMID: 26085927 [PubMed - as supplied by publisher]

Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis.
Chris Stinton, Ian McKeith, John-Paul Taylor, Louise Lafortune, Eneida Mioshi, Elijah Mak, Victoria Cambridge, James Mason, Alan Thomas, John T O'Brien
Am J Psychiatry 2015 Jun; :appiajp201514121582
PMID: 26085043 [PubMed - as supplied by publisher]

Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model.
Yan-Hua Li, Qing He, Jie-Zhong Yu, Chun-Yun Liu, Ling Feng, Zhi Chai, Qing Wang, Hong-Zhen Zhang, Guang-Xian Zhang, Bao-Guo Xiao, Cun-Gen Ma
Metab Brain Dis 2015 Jun;
PMID: 26084861 [PubMed - as supplied by publisher]

Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson's disease patients.
Gabriela S Longo, Marcela A S Pinhel, Michele L Gregório, Bruno A P Oliveira, Driele C G Quinhoneiro, Waldir A Tognola, Fábio N Oliveira, Sabrina M Cezario, Caroline L Sado, Marcelo A Nakazone, Maria C J Calastri, Dorotéia R S Souza
Arq Neuropsiquiatr 2015 Jun; 73(6):506-9
PMID: 26083886 [PubMed - as supplied by publisher]

Association of Polymorphism of Neuronal Nitric Oxide Synthase Gene with Risk to Parkinson's Disease.
Satya Prakash Gupta, Ritul Kamal, Sarad Kumar Mishra, Maneesh Kumar Singh, Rakesh Shukla, Mahendra Pratap Singh
Mol Neurobiol 2015 Jun;
PMID: 26081147 [PubMed - as supplied by publisher]

Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease.
Taku Homma, Yoko Mochizuki, Kazushi Takahashi, Takashi Komori
Neuropathology 2015 Jun;
PMID: 26079638 [PubMed - as supplied by publisher]

Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson's Disease.
Maria Graciela Cersosimo
Gastroenterol Res Pract 2015 ; 2015:476041
PMID: 26078752 [PubMed - as supplied by publisher]

LRRK2 Pharmacological Inhibition Abates ?-Synuclein Induced Neurodegeneration.
Joăo P L Daher, Hisham A Abdelmotilib, Xianzhen Hu, Laura A Volpicelli-Daley, Mark S Moehle, Kyle B Faser, Elie Needle, Yi Chen, Stefanus J Steyn, Paul Galatsis, Warren D Hirst, Andrew B West
J Biol Chem 2015 Jun;
PMID: 26078453 [PubMed - as supplied by publisher]

Olfactory function and neuropsychological profile to differentiate dementia with Lewy bodies from Alzheimer's disease in patients with mild cognitive impairment: A 5-year follow-up study.
Jung Han Yoon, Min Kim, So Young Moon, Seok Woo Yong, Ji Man Hong
J Neurol Sci 2015 Jun;
PMID: 26076880 [PubMed - as supplied by publisher]

Parkinson-causing ?-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.
Ulf Dettmer, Andrew J Newman, Frank Soldner, Eric S Luth, Nora C Kim, Victoria E von Saucken, John B Sanderson, Rudolf Jaenisch, Tim Bartels, Dennis Selkoe
Nat Commun 2015 ; 6:7314
PMID: 26076669 [PubMed - as supplied by publisher]

Dopaminergic Neurons Respond to Iron-Induced Oxidative Stress by Modulating Lipid Acylation and Deacylation Cycles.
Sofía Sánchez Campos, Guadalupe Rodríguez Diez, Gerardo Martín Oresti, Gabriela Alejandra Salvador
PLoS One 2015 ; 10(6):e0130726
PMID: 26076361 [PubMed - as supplied by publisher]

R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
Olena Korvatska, James B Leverenz, Suman Jayadev, Pamela McMillan, Irina Kurtz, Xindi Guo, Malia Rumbaugh, Mark Matsushita, Santhosh Girirajan, Michael O Dorschner, Kostantin Kiianitsa, Chang-En Yu, Zoran Brkanac, Gwenn A Garden, Wendy H Raskind, Thomas D Bird
JAMA Neurol 2015 Jun;
PMID: 26076170 [PubMed - as supplied by publisher]

Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells.
Begum Alural, Aysegul Ozerdem, Jens Allmer, Kursad Genc, Sermin Genc
Front Cell Neurosci 2015 ; 9:209
PMID: 26074776 [PubMed - as supplied by publisher]