What can we learn by studying genetics and Parkinson's? PDF-funded researchers Drs. Mata and Zabetian share their progress six years after launching the first large-scale survey of PD genetics in Latin America.
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Causes and Pathology
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Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an (11)C altropane positron emission tomography study.
Marta Marquie, Joseph J Locascio, Dorene M Rentz, J Alex Becker, Trey Hedden, Keith A Johnson, John H Growdon, Stephen N Gomperts
Alzheimers Res Ther 2014 ; 6(5-8):52
PMID: 25429309 [PubMed - as supplied by publisher]
RTCB-1 Mediates Neuroprotection via XBP-1 mRNA Splicing in the Unfolded Protein Response Pathway.
Arpita Ray, Siyuan Zhang, Courtney Rentas, Kim A Caldwell, Guy A Caldwell
J Neurosci 2014 Nov; 34(48):16076-85
PMID: 25429148 [PubMed - as supplied by publisher]
Structural features of membrane-bound glucocerebrosidase and ?-synuclein probed by neutron reflectometry and fluorescence spectroscopy.
Thai Leong Yap, Zhiping Jiang, Frank Heinrich, James M Gruschus, Candace M Pfefferkorn, Marilia Barros, Joseph E Curtis, Ellen Sidransky, Jennifer C Lee
J Biol Chem 2014 Nov;
PMID: 25429104 [PubMed - as supplied by publisher]
Cortical Metabolic and Nigrostriatal Abnormalities Associated With Clinical Stage-Specific Dementia With Lewy Bodies.
Shu-Hua Huang, Chiung-Chih Chang, Chun-Chung Lui, Nai-Ching Chen, Chen-Chang Lee, Pei-Wen Wang, Ching-Fen Jiang
Clin Nucl Med 2014 Nov;
PMID: 25426755 [PubMed - as supplied by publisher]
Phosphatases of ?-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism.
Jean-Marc Taymans, Veerle Baekelandt
Front Genet 2014 ; 5:382
PMID: 25426138 [PubMed - as supplied by publisher]
Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease.
Félix J Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, José A G Agúndez
Front Cell Neurosci 2014 ; 8:369
PMID: 25426023 [PubMed - as supplied by publisher]
Acceleration of ?-Synuclein Aggregation by Exosomes.
Marie Grey, Christopher J Dunning, Ricardo Gaspar, Carl Grey, Patrik Brundin, Emma Sparr, Sara Linse
J Biol Chem 2014 Nov;
PMID: 25425650 [PubMed - as supplied by publisher]
A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of ?-Synuclein and ?-Synuclein.
Jane R Allison, Robert C Rivers, John C Christodoulou, Michele Vendruscolo, Christopher M Dobson
Biochemistry 2014 Nov; 53(46):7170-83
PMID: 25389903 [PubMed - as supplied by publisher]
Function of ?-synuclein and PINK1 in Lewy body dementia (Review).
Akari Minami, Atsuko Nakanishi, Satoru Matsuda, Yasuko Kitagishi, Yasunori Ogura
Int J Mol Med 2015 Jan; 35(1):3-9
PMID: 25355138 [PubMed - as supplied by publisher]
Neuroprotective effect of lovastatin by inhibiting NMDA receptor1 in 6-hydroxydopamine treated PC12 cells.
Jun-Qiang Yan, Yu-Jin Ma, Jia-Chun Sun, Shu-Feng Bai, Li-Na Huang
Int J Clin Exp Med 2014 ; 7(10):3313-3319
PMID: 25419363 [PubMed - as supplied by publisher]
Therapeutic Effects of Fucoidan in 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's disease: Role of NADPH oxidase-1.
Fei-Long Zhang, Yi He, Yan Zheng, Wen-Jing Zhang, Qi Wang, Yan-Jun Jia, Hai-Long Song, Hai-Ting An, Hao-Bo Zhang, Yan-Jing Qian, Yu-Long Tong, Lin Dong, Xiao-Min Wang
CNS Neurosci Ther 2014 Dec; 20(12):1036-44
PMID: 25399812 [PubMed - as supplied by publisher]
The role of the LRRK2 gene in Parkinsonism.
Jie-Qiong Li, Lan Tan, Jin-Tai Yu
Mol Neurodegener 2014 ; 9(1):47
PMID: 25391693 [PubMed - as supplied by publisher]
The Use of (18)F-BCPP-EF as a PET Probe for Complex I Activity in the Brain.
Methods Enzymol 2014 ; 547:417-31
PMID: 25416368 [PubMed - as supplied by publisher]
Analyzing mitochondrial dynamics in mouse organotypic slice cultures.
Anh H Pham, David C Chan
Methods Enzymol 2014 ; 547:111-29
PMID: 25416355 [PubMed - as supplied by publisher]
High-Content Functional Genomic Screening to Identify Novel Regulators of the PINK1-Parkin Pathway.
Andy Cheuk-Him Ng, Stephen D Baird, Robert A Screaton
Methods Enzymol 2014 ; 547:1-20
PMID: 25416349 [PubMed - as supplied by publisher]
Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's Disease VPS35 mutation p.D620N.
L N Munsie, A J Milnerwood, P Seibler, D A Beccano-Kelly, I Tatarnikov, J Khinda, M Volta, C Kadgien, L P Cao, L Tapia, C Klein, M J Farrer
Hum Mol Genet 2014 Nov;
PMID: 25416282 [PubMed - as supplied by publisher]
?-Synuclein Protects against Manganese Neurotoxic Insult during the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson's Disease.
Dilshan S Harischandra, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy
Toxicol Sci 2014 Nov;
PMID: 25416158 [PubMed - as supplied by publisher]
An antioxidant nanozyme that uncovers the cytoprotective potential of vanadia nanowires.
Amit A Vernekar, Devanjan Sinha, Shubhi Srivastava, Prasath U Paramasivam, Patrick D'Silva, Govindasamy Mugesh
Nat Commun 2014 ; 5:5301
PMID: 25412933 [PubMed - as supplied by publisher]
p62 Deficiency Enhances ?-Synuclein Pathology in Mice.
Kunikazu Tanji, Saori Odagiri, Yasuo Miki, Atsushi Maruyama, Yoshikazu Nikaido, Junsei Mimura, Fumiaki Mori, Eiji Warabi, Toru Yanagawa, Shinya Ueno, Ken Itoh, Koichi Wakabayashi
Brain Pathol 2014 Oct;
PMID: 25412696 [PubMed - as supplied by publisher]
Glutamate Receptor Gene GRIN2A, Coffee, and Parkinson Disease.
Taye H Hamza, Erin M Hill-Burns, William K Scott, Jeffrey M Vance, Stewart A Factor, Cyrus P Zabetian, Haydeh Payami
PLoS Genet 2014 Nov; 10(11):e1004774
PMID: 25411979 [PubMed - as supplied by publisher]
Eryptosis as a marker of Parkinson's disease.
Etheresia Pretorius, Albe C Swanepoel, Antoinette V Buys, Natasha Vermeulen, Wiebren Duim, Douglas B Kell
Aging (Albany NY) 2014 Oct; 6(10):788-819
PMID: 25411230 [PubMed - as supplied by publisher]
Isolating potentiated hsp104 variants using yeast proteinopathy models.
Meredith E Jackrel, Amber Tariq, Keolamau Yee, Rachel Weitzman, James Shorter
J Vis Exp 2014 ; (93)
PMID: 25407485 [PubMed - as supplied by publisher]
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.
Ianai Fishbein, Yien-Ming Kuo, Benoit I Giasson, Robert L Nussbaum
Brain 2014 Dec; 137(Pt 12):3235-47
PMID: 25351739 [PubMed - as supplied by publisher]
CSF biomarkers and clinical progression of Parkinson disease.
Sara Hall, Yulia Surova, Annika Ohrfelt, Henrik Zetterberg, Daniel Lindqvist, Oskar Hansson
Neurology 2014 Nov;
PMID: 25411441 [PubMed - as supplied by publisher]
PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.
Agne Kazlauskaite, Miratul M K Muqit
FEBS J 2014 Oct;
PMID: 25345844 [PubMed - as supplied by publisher]
Neuroprotection by Saponins.
Aijing Sun, Xianxiang Xu, Junsheng Lin, Xiuling Cui, Ruian Xu
Phytother Res 2014 Nov;
PMID: 25408503 [PubMed - as supplied by publisher]
Successful GPi stimulation in genetic Parkinson's disease caused by mosaicism of alpha-synuclein gene duplication: first description.
C Perandones, N Aráoz Olivos, G B Raina, L A Pellene, J C Giugni, D S Calvo, M Radrizzani, F Piedimonte, F E Micheli
J Neurol 2014 Nov;
PMID: 25408368 [PubMed - as supplied by publisher]
MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.
Woori Kim, Haneul Noh, Yenarae Lee, Jeha Jeon, Arthi Shanmugavadivu, Donna L McPhie, Kwang-Soo Kim, Bruce M Cohen, Hyemyung Seo, Kai C Sonntag
Mol Neurobiol 2014 Nov;
PMID: 25407931 [PubMed - as supplied by publisher]
Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.
Briana R De Miranda, Katriana A Popichak, Sean L Hammond, James A Miller, Stephen Safe, Ronald B Tjalkens
Toxicol Sci 2014 Nov;
PMID: 25406165 [PubMed - as supplied by publisher]
Glutathione redox imbalance in brain disorders.
Feng Gu, Ved Chauhan, Abha Chauhan
Curr Opin Clin Nutr Metab Care 2014 Nov;
PMID: 25405315 [PubMed - as supplied by publisher]
Role of Glucose Metabolism and ATP in Maintaining PINK1 Levels During Parkin-mediated Mitochondrial Damage Responses.
Schuyler Lee, Conggang Zhang, Xuedong Liu
J Biol Chem 2014 Nov;
PMID: 25404737 [PubMed - as supplied by publisher]
Neuroprotective Effects of ?-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway.
Sheng Zhang, Xue-Hong Gui, Li-Ping Huang, Min-Zhen Deng, Ruo-Ming Fang, Xue-Hong Ke, Yu-Ping He, Ling Li, Yong-Qi Fang
Mol Neurobiol 2014 Nov;
PMID: 25404088 [PubMed - as supplied by publisher]
Withania somnifera Alleviates Parkinsonian Phenotypes by Inhibiting Apoptotic Pathways in Dopaminergic Neurons.
Jay Prakash, Shikha Chouhan, Satyndra Kumar Yadav, Susan Westfall, Sachchida Nand Rai, Surya Pratap Singh
Neurochem Res 2014 Nov;
PMID: 25403619 [PubMed - as supplied by publisher]
Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.
Lorraine V Kalia, Anthony E Lang, Lili-Naz Hazrati, Shinsuke Fujioka, Zbigniew K Wszolek, Dennis W Dickson, Owen A Ross, Vivianna M Van Deerlin, John Q Trojanowski, Howard I Hurtig, Roy N Alcalay, Karen S Marder, Lorraine N Clark, Carles Gaig, Eduardo Tolosa, Javier Ruiz-Martínez, Jose F Marti-Masso, Isidre Ferrer, Adolfo López de Munain, Samuel M Goldman, Birgitt Schüle, J William Langston, Jan O Aasly, Maria T Giordana, Vincenzo Bonifati, Andreas Puschmann, Margherita Canesi, Gianni Pezzoli, Andre Maues De Paula, Kazuko Hasegawa, Charles Duyckaerts, Alexis Brice, A Jon Stoessl, Connie Marras
JAMA Neurol 2014 Nov;
PMID: 25401511 [PubMed - as supplied by publisher]
Synopsis on the Linkage of Alzheimer's and Parkinson's Disease with Chronic Diseases.
Nasimudeen R Jabir, Chelapram K Firoz, Saleh S Baeesa, Ghulam Md Ashraf, Suhail Akhtar, Warda Kamal, Mohammad A Kamal, Shams Tabrez
CNS Neurosci Ther 2014 Nov;
PMID: 25399848 [PubMed - as supplied by publisher]
Dual life of TPPP/p25 evolved in physiological and pathological conditions.
Judit Oláh, Judit Ovádi
Biochem Soc Trans 2014 Dec; 42(6):1762-7
PMID: 25399603 [PubMed - as supplied by publisher]
Early Sodium Dodecyl Sulfate Induced Collapse of ?-Synuclein Correlates with Its Amyloid Formation.
Sujit Basak, G V R Krishna Prasad, Jobin Varkey, Krishnananda Chattopadhyay
ACS Chem Neurosci 2014 Nov;
PMID: 25369246 [PubMed - as supplied by publisher]
Transglutaminase 2 and neuroinflammation.
Riccardo Ientile, Monica Currò, Daniela Caccamo
Amino Acids 2014 Nov;
PMID: 25398223 [PubMed - as supplied by publisher]
Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson's disease by reducing oxidative stress.
Rudra Pangeni, Shrestha Sharma, Gulam Mustafa, Javed Ali, Sanjula Baboota
Nanotechnology 2014 Dec; 25(48):485102
PMID: 25392203 [PubMed - as supplied by publisher]
Early and Persistent Expression of Phosphorylated ?-Synuclein in the Enteric Nervous System of A53T Mutant Human ?-Synuclein Transgenic Mice.
Anna Bencsik, Letizia Muselli, Mikael Leboidre, Latifa Lakhdar, Thierry Baron
J Neuropathol Exp Neurol 2014 Dec; 73(12):1144-51
PMID: 25383638 [PubMed - as supplied by publisher]
The Discovery of a Highly Selective 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson's Disease Model.
Paolo Di Fruscia, Emmanouil Zacharioudakis, Chang Liu, Sébastien Moniot, Sasiwan Laohasinnarong, Mattaka Khongkow, Ian F Harrison, Konstantina Koltsida, Christopher R Reynolds, Karin Schmidtkunz, Manfred Jung, Kathryn L Chapman, Clemens Steegborn, David T Dexter, Michael J E Sternberg, Eric W-F Lam, Matthew J Fuchter
ChemMedChem 2014 Nov;
PMID: 25395356 [PubMed - as supplied by publisher]
GSK-3? dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and ?-synuclein.
J J Credle, J L George, J Wills, V Duka, K Shah, Y-C Lee, O Rodriguez, T Simkins, M Winter, D Moechars, T Steckler, J Goudreau, D I Finkelstein, A Sidhu
Cell Death Differ 2014 Nov;
PMID: 25394490 [PubMed - as supplied by publisher]
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
A R Esteves, M G-Fernandes, D Santos, C Januário, S M Cardoso
Mol Neurobiol 2014 Nov;
PMID: 25394383 [PubMed - as supplied by publisher]
Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation.
Diana F Lázaro, Eva F Rodrigues, Ramona Langohr, Hedieh Shahpasandzadeh, Thales Ribeiro, Patrícia Guerreiro, Ellen Gerhardt, Katharina Kröhnert, Jochen Klucken, Marcos D Pereira, Blagovesta Popova, Niels Kruse, Brit Mollenhauer, Silvio O Rizzoli, Gerhard H Braus, Karin M Danzer, Tiago F Outeiro
PLoS Genet 2014 Nov; 10(11):e1004741
PMID: 25393002 [PubMed - as supplied by publisher]
In vivo markers of Parkinson's disease and dementia with Lewy bodies: current value of the 5G4 ?-synuclein antibody.
Walter Maetzler, Andrea Pilotto, Anja Apel, Christian Deuschle, Gabriele Kuebart, Sebastian Heinzel, Inga Liepelt-Scarfone, Claudia Schulte, Dorothee Reusch, Erwin Schleicher, Oliver Rothfuss, Anja Schneider, Richard Dodel, Thomas Gasser, Daniela Berg
Acta Neuropathol 2014 Dec; 128(6):893-5
PMID: 25376537 [PubMed - as supplied by publisher]
Membrane protein oxidation determines neuronal degeneration.
Parvana Hajieva, Nadhim Bayatti, Matthias Granold, Christian Behl, Bernd Moosmann
J Neurochem 2014 Nov;
PMID: 25393523 [PubMed - as supplied by publisher]
ATP13A2/PARK9 Regulates Secretion of Exosomes and ?-Synuclein.
Taiji Tsunemi, Kana Hamada, Dimitri Krainc
J Neurosci 2014 Nov; 34(46):15281-7
PMID: 25392495 [PubMed - as supplied by publisher]
Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
Adrian Flierl, Luís M A Oliveira, Lisandro J Falomir-Lockhart, Sally K Mak, Jayne Hesley, Frank Soldner, Donna J Arndt-Jovin, Rudolf Jaenisch, J William Langston, Thomas M Jovin, Birgitt Schüle
PLoS One 2014 ; 9(11):e112413
PMID: 25390032 [PubMed - as supplied by publisher]
Commentary on "Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice".
Elena Popugaeva, Ilya Bezprozvanny
Front Cell Neurosci 2014 ; 8:351
PMID: 25389389 [PubMed - as supplied by publisher]
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
Shohei Shinozaki, Kyungho Chang, Michihiro Sakai, Nobuyuki Shimizu, Marina Yamada, Tomokazu Tanaka, Harumasa Nakazawa, Fumito Ichinose, Yoshitsugu Yamada, Akihito Ishigami, Hideki Ito, Yasuyoshi Ouchi, Marlene E Starr, Hiroshi Saito, Kentaro Shimokado, Jonathan S Stamler, Masao Kaneki
Sci Signal 2014 ; 7(351):ra106
PMID: 25389371 [PubMed - as supplied by publisher]
Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of Parkinson's disease.
Min Wang, Jun Zhu, Yang Pan, Jingde Dong, Lili Zhang, Xiangrong Zhang, Li Zhang
J Neurosci Res 2014 Nov;
PMID: 25388401 [PubMed - as supplied by publisher]
The ?7 nAChR Selective Agonists as Drug Candidates for Alzheimer's Disease.
Huaimeng Fan, Ruoxu Gu, Dongqing Wei
Adv Exp Med Biol 2015 ; 827:353-65
PMID: 25387975 [PubMed - as supplied by publisher]
The role of Galectin-3 in ?-synuclein-induced microglial activation.
Antonio Boza-Serrano, Juan F Reyes, Nolwen L Rey, Hakon Leffler, Luc Bousset, Ulf Nilsson, Patrik Brundin, Jose Venero, Miguel Burguillos, Tomas Deierborg
Acta Neuropathol Commun 2014 Nov; 2(1):156
PMID: 25387690 [PubMed - as supplied by publisher]
Serum uric Acid and nigral iron deposition in Parkinson's disease: a pilot study.
Tae-Hyoung Kim, Jae-Hyeok Lee
PLoS One 2014 ; 9(11):e112512
PMID: 25386854 [PubMed - as supplied by publisher]
Effects of titanium dioxide nanoparticles on ?-synuclein aggregation and the ubiquitin-proteasome system in dopaminergic neurons.
Jie Wu, Hongjun Xie
Artif Cells Nanomed Biotechnol 2014 Nov; :1-5
PMID: 25386730 [PubMed - as supplied by publisher]
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species.
Priscila Britto Campos, Bruna S Paulsen, Stevens K Rehen
Front Aging Neurosci 2014 ; 6:292
PMID: 25386139 [PubMed - as supplied by publisher]
Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.
Neurology 2014 Nov; 83(20):1880
PMID: 25385832 [PubMed - as supplied by publisher]
Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.
William J Burke, Jeff M Bronstein, Arthur Fitzmaurice
Neurology 2014 Nov; 83(20):1879-80
PMID: 25385831 [PubMed - as supplied by publisher]
Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder.
Alex Iranzo, Heike Stockner, Mónica Serradell, Klaus Seppi, Francesc Valldeoriola, Birgit Frauscher, José Luis Molinuevo, Isabel Vilaseca, Thomas Mitterling, Carles Gaig, Dolores Vilas, Joan Santamaria, Birgit Högl, Eduard Tolosa, Werner Poewe
Mov Disord 2014 Nov;
PMID: 25384461 [PubMed - as supplied by publisher]
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.
William M Johnson, Chen Yao, Sandra L Siedlak, Wenzhang Wang, Xiongwei Zhu, Guy A Caldwell, Amy L Wilson-Delfosse, John J Mieyal, Shu G Chen
Hum Mol Genet 2014 Oct;
PMID: 25355420 [PubMed - as supplied by publisher]
Alpha-synuclein and tau: teammates in neurodegeneration?
Simon Moussaud, Daryl R Jones, Elisabeth L Moussaud-Lamodière, Marion Delenclos, Owen A Ross, Pamela J McLean
Mol Neurodegener 2014 ; 9:43
PMID: 25352339 [PubMed - as supplied by publisher]
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Dayne A Beccano-Kelly, Mattia Volta, Lise N Munsie, Sarah A Paschall, Igor Tatarnikov, Kimberley Co, Patrick Chou, Li-Ping Cao, Sabrina Bergeron, Emma Mitchell, Heather Han, Heather L Melrose, Lucia Tapia, Lynn A Raymond, Matthew J Farrer, Austen J Milnerwood
Hum Mol Genet 2014 Oct;
PMID: 25343991 [PubMed - as supplied by publisher]
Correlates of cerebrospinal fluid levels of oligomeric- and total-?-synuclein in premotor, motor and dementia stages of Parkinson's disease.
Yaroslau Compta, Tony Valente, Josep Saura, Bàrbara Segura, Alex Iranzo, Mònica Serradell, Carme Junqué, Eduard Tolosa, Francesc Valldeoriola, Esteban Muñoz, Joan Santamaria, Ana Cámara, Manel Fernández, Juan Fortea, Mariateresa Buongiorno, José Luis Molinuevo, Núria Bargalló, María José Martí
J Neurol 2014 Nov;
PMID: 25380583 [PubMed - as supplied by publisher]
Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models.
Min Sik Choi, Tomohiro Nakamura, Seung-Je Cho, Xuemei Han, Emily A Holland, Jing Qu, Gregory A Petsko, John R Yates, Robert C Liddington, Stuart A Lipton
J Neurosci 2014 Nov; 34(45):15123-31
PMID: 25378175 [PubMed - as supplied by publisher]
Pinocembrin Attenuates 6-OHDA-induced Neuronal Cell Death Through Nrf2/ARE Pathway in SH-SY5Y Cells.
Xiaohua Jin, Qian Liu, Lili Jia, Meng Li, Xuan Wang
Cell Mol Neurobiol 2014 Nov;
PMID: 25377066 [PubMed - as supplied by publisher]
PINK1-mediated Phosphorylation of Miro Inhibits Synaptic Growth and Protects Dopaminergic Neurons in Drosophila.
Pei-I Tsai, Meredith M Course, Jonathan R Lovas, Chung-Han Hsieh, Milos Babic, Konrad E Zinsmaier, Xinnan Wang
Sci Rep 2014 ; 4:6962
PMID: 25376463 [PubMed - as supplied by publisher]
Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin.
Thomas R Caulfield, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Daniel F A R Dourado, Samuel C Flores, Wolfdieter Springer
PLoS Comput Biol 2014 Nov; 10(11):e1003935
PMID: 25375667 [PubMed - as supplied by publisher]
Implication of matrix metalloproteinases in regulating neuronal disorder.
Abhishek Mukherjee, Snehasikta Swarnakar
Mol Biol Rep 2014 Nov;
PMID: 25374425 [PubMed - as supplied by publisher]
Cyclosporine A and MnTMPyP Alleviate ?-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism.
Sonal Agrawal, Anubhuti Dixit, Ashish Singh, Pratibha Tripathi, Dhirendra Singh, Devendra Kumar Patel, Mahendra Pratap Singh
Mol Neurobiol 2014 Nov;
PMID: 25370934 [PubMed - as supplied by publisher]
Head injury, ?-synuclein genetic variability and Parkinson's disease.
P C Lee, Y Bordelon, J Bronstein, J S Sinsheimer, M Farrer, B Ritz
Eur J Neurol 2014 Nov;
PMID: 25370538 [PubMed - as supplied by publisher]
Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.
Phillip M Rappold, Mei Cui, Jonathan C Grima, Rebecca Z Fan, Karen L de Mesy-Bentley, Linan Chen, Xiaoxi Zhuang, William J Bowers, Kim Tieu
Nat Commun 2014 ; 5:5244
PMID: 25370169 [PubMed - as supplied by publisher]
-NMDA R/+VDR pharmacological phenotype as a novel therapeutic target in relieving motor-cognitive impairments in Parkinsonism.
Olalekan Michael Ogundele, Ednar Tarebi Nanakumo, Azeez Olakunle Ishola, Oluwafemi Michael Obende, Linus Anderson Enye, Wasiu Gbolahan Balogun, Ansa Emmanuel Cobham, Amin Abdulbasit
Drug Chem Toxicol 2014 Nov; :1-13
PMID: 25367720 [PubMed - as supplied by publisher]
Functional imaging in pre-motor Parkinson's disease.
D Arnaldi, S Morbelli, A Picco, M Ferrara, A Buschiazzo, F Famà, F De Carli, F M Nobili
Q J Nucl Med Mol Imaging 2014 Nov;
PMID: 25366709 [PubMed - as supplied by publisher]
Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.
Sayinthen Vivekanantham, Savan Shah, Rizwan Dewji, Abbas Dewji, Chetan Khatri, Rele Ologunde
Int J Neurosci 2014 Nov; :1-17
PMID: 25364880 [PubMed - as supplied by publisher]
Mutual exacerbation of PGC-1? deregulation and ?-synuclein oligomerization.
Judith Eschbach, Björn von Einem, Kathrin Müller, Hanna Bayer, Annika Scheffold, Bradley E Morrison, K Lenhard Rudolph, Dietmar R Thal, Anke Witting, Patrick Weydt, Markus Otto, Michael Fauler, Birgit Liss, Pamela J McLean, Albert R La Spada, Albert C Ludolph, Jochen H Weishaupt, Karin M Danzer
Ann Neurol 2014 Nov;
PMID: 25363075 [PubMed - as supplied by publisher]
Neuroprotective Effects of Angiotensin Receptor Blockers.
Sonia Villapol, Juan M Saavedra
Am J Hypertens 2014 Oct;
PMID: 25362113 [PubMed - as supplied by publisher]
Selegiline promotes NOTCH-JAGGED signaling in astrocytes of the peri-infarct region and improves the functional integrity of the neurovascular unit in a rat model of focal ischemia.
Sándor Nardai, Arpád Dobolyi, Gabriella Pál, Judit Skopál, Nándor Pintér, Kinga Lakatos, Béla Merkely, Zoltán Nagy
Restor Neurol Neurosci 2014 Oct;
PMID: 25361607 [PubMed - as supplied by publisher]
LRRK2 Transport Is Regulated by Its Novel Interacting Partner Rab32.
Dieter Waschbüsch, Helen Michels, Swantje Strassheim, Edith Ossendorf, Daniel Kessler, Christian Johannes Gloeckner, Angelika Barnekow
PLoS One 2014 ; 9(10):e111632
PMID: 25360523 [PubMed - as supplied by publisher]
Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice.
Sara E Gombash, Christopher J Cowley, Julie A Fitzgerald, Jodie C E Hall, Christian Mueller, Fedias L Christofi, Kevin D Foust
Front Mol Neurosci 2014 ; 7:81
PMID: 25360081 [PubMed - as supplied by publisher]
Pros and cons of drugs for motor symptom control.
Nurs Older People 2014 Oct; 26(9):13
PMID: 25358990 [PubMed - as supplied by publisher]
Lower urinary tract function in dementia with Lewy bodies (DLB).
Fuyuki Tateno, Ryuji Sakakibara, Tsuyoshi Ogata, Masahiko Kishi, Yohei Tsuyusaki, Osamu Takahashi, Megumi Sugiyama, Akihiko Tateno
Mov Disord 2014 Oct;
PMID: 25356960 [PubMed - as supplied by publisher]
?-Synuclein inclusions in the skin of Parkinson's disease and parkinsonism.
Ildefonso Rodríguez-Leyva, Ana Laura Calderón-Garcidueñas, María E Jiménez-Capdeville, Ana Arely Rentería-Palomo, Héctor Gerardo Hernandez-Rodriguez, Rodrigo Valdés-Rodríguez, Cornelia Fuentes-Ahumada, Bertha Torres-Álvarez, Julio Sepúlveda-Saavedra, Adolfo Soto-Domínguez, Martha E Santoyo, José Ildefonso Rodriguez-Moreno, Juan Pablo Castanedo-Cázares
Ann Clin Transl Neurol 2014 Jul; 1(7):471-8
PMID: 25356418 [PubMed - as supplied by publisher]
LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.
Hui-Fang Liu, Song Lu, Philip Wing-Lok Ho, Ho-Man Tse, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, Jessica Wing-Man Ho, David B Ramsden, Zhong-Jun Zhou, Shu-Leong Ho
Ann Clin Transl Neurol 2014 Mar; 1(3):199-208
PMID: 25356398 [PubMed - as supplied by publisher]
The regulation of catalase activity by PPAR ? is affected by ?-synuclein.
Eugenia Yakunin, Haya Kisos, Willem Kulik, Jessica Grigoletto, Ronald J A Wanders, Ronit Sharon
Ann Clin Transl Neurol 2014 Mar; 1(3):145-59
PMID: 25356396 [PubMed - as supplied by publisher]
Evaluation of Levodopa and Carbidopa Antioxidant Activity in Normal Human Lymphocytes In Vitro: Implication for Oxidative Stress in Parkinson's Disease.
Monica Colamartino, Massimo Santoro, Guglielmo Duranti, Stefania Sabatini, Roberta Ceci, Antonella Testa, Luca Padua, Renata Cozzi
Neurotox Res 2014 Oct;
PMID: 25355370 [PubMed - as supplied by publisher]
Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study.
Cyril C Curtain, Nigel M Kirby, Haydyn D T Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan
Mol Biosyst 2014 Oct;
PMID: 25352253 [PubMed - as supplied by publisher]
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.
Yusuke Kageyama, Masahiko Hoshijima, Kinya Seo, Djahida Bedja, Polina Sysa-Shah, Shaida A Andrabi, Weiran Chen, Ahmet Höke, Valina L Dawsn, Ted M Dawson, Kathleen Gabrielson, David A Kass, Miho Iijima, Hiromi Sesaki
EMBO J 2014 Oct;
PMID: 25349190 [PubMed - as supplied by publisher]
Potential Neuroprotective Activity of Ginseng in Parkinson's Disease: A Review.
Elena González-Burgos, Carlos Fernandez-Moriano, M Pilar Gómez-Serranillos
J Neuroimmune Pharmacol 2014 Oct;
PMID: 25349145 [PubMed - as supplied by publisher]
T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson's Disease.
Christopher J Wheeler, Akop Seksenyan, Yosef Koronyo, Altan Rentsendorj, Danielle Sarayba, Henry Wu, Ashley Gragg, Emily Siegel, Deborah Thomas, Andres Espinosa, Kerry Thompson, Keith Black, Maya Koronyo-Hamaoui, Robert Pechnick, Dwain K Irvin
J Neurol Neurophysiol 2014 May; 5(3)
PMID: 25346865 [PubMed - as supplied by publisher]
Putting reins on the brain. How the body and environment use it.
Dobromir G Dotov
Front Hum Neurosci 2014 ; 8:795
PMID: 25346675 [PubMed - as supplied by publisher]
?-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved.
Alicia Flores-Cuadrado, Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Carlos de la Rosa-Prieto, Alino Martinez-Marcos
Eur J Neurosci 2014 Oct;
PMID: 25345880 [PubMed - as supplied by publisher]
The study of telomere length in patients with Parkinson's disease].
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(8):58-61
PMID: 25345632 [PubMed - as supplied by publisher]
The Parkinson's Disease-Associated Protein ?-Synuclein Disrupts Stress Signaling - A Possible Implication for Methamphetamine Use?
Shaoxiao Wang, Stephan N Witt
Microb Cell 2014 Apr; 1(4):131-132
PMID: 25343141 [PubMed - as supplied by publisher]
Histone Hyperacetylation Upregulates PKC? in Dopaminergic Neurons to Induce Cell Death: Relevance to Epigenetic Mechanisms of Neurodegeneration in Parkinson's Disease.
Huajun Jin, Arthi Kanthasamy, Dilshan S Harischandra, Naveen Kondru, Anamitra Ghosh, Nikhil Panicker, Vellareddy Anantharam, Ajay Rana, Anumantha G Kanthasamy
J Biol Chem 2014 Oct;
PMID: 25342743 [PubMed - as supplied by publisher]
Pharmacological Strategies for the Management of Levodopa-Induced Dyskinesia in Patients with Parkinson's Disease.
Eva Schaeffer, Andrea Pilotto, Daniela Berg
CNS Drugs 2014 Oct;
PMID: 25342080 [PubMed - as supplied by publisher]
A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress.
Peter Bou Dib, Bettina Gnägi, Fiona Daly, Virginie Sabado, Damla Tas, Dominique A Glauser, Peter Meister, Emi Nagoshi
PLoS Genet 2014 Oct; 10(10):e1004718
PMID: 25340742 [PubMed - as supplied by publisher]
Mucuna pruriens (Velvet bean) Rescues Motor, Olfactory, Mitochondrial and Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic Model of Parkinson's Disease.
Simone Poddighe, Francescaelena De Rose, Roberto Marotta, Roberta Ruffilli, Maura Fanti, Pietro Paolo Secci, Maria Cristina Mostallino, Maria Dolores Setzu, Maria Antonietta Zuncheddu, Ignazio Collu, Paolo Solla, Francesco Marrosu, Sanjay Kasture, Elio Acquas, Anna Liscia
PLoS One 2014 ; 9(10):e110802
PMID: 25340511 [PubMed - as supplied by publisher]
Nutrient deprivation induces ?-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway.
Peizhou Jiang, Ming Gan, Wen-Lang Lin, Shu-Hui C Yen
Front Aging Neurosci 2014 ; 6:268
PMID: 25339898 [PubMed - as supplied by publisher]
Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb.
Françoise Lazarini, Marie-Madeleine Gabellec, Carine Moigneu, Fabrice de Chaumont, Jean-Christophe Olivo-Marin, Pierre-Marie Lledo
J Neurosci 2014 Oct; 34(43):14430-42
PMID: 25339754 [PubMed - as supplied by publisher]
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
Amandine Berthet, Elyssa B Margolis, Jue Zhang, Ivy Hsieh, Jiasheng Zhang, Thomas S Hnasko, Jawad Ahmad, Robert H Edwards, Hiromi Sesaki, Eric J Huang, Ken Nakamura
J Neurosci 2014 Oct; 34(43):14304-17
PMID: 25339743 [PubMed - as supplied by publisher]