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Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Laser Acupuncture at HT7 Acupoint Improves Cognitive Deficit, Neuronal Loss, Oxidative Stress, and Functions of Cholinergic and Dopaminergic Systems in Animal Model of Parkinson's Disease.
Jintanaporn Wattanathorn, Chatchada Sutalangka
Evid Based Complement Alternat Med 2014 ; 2014:937601
PMID: 25161693 [PubMed - as supplied by publisher]


Effect of endogenous Hsp104 chaperone in yeast models of sporadic and familial Parkinson's Disease.
Vamshidhar R Gade, Jay Kardani, Ipsita Roy
Int J Biochem Cell Biol 2014 Aug;
PMID: 25161148 [PubMed - as supplied by publisher]


The H3 receptor agonist immepip does not affect L-dopa-induced abnormal involuntary movements in 6-OHDA-lesioned rats.
Maria Papathanou, Peter Jenner, Mahmoud Iravani, Michael Jackson, Kim Stockwell, Isabel Strang, Bai-Yun Zeng, Andrew C McCreary, Sarah Rose
Eur J Pharmacol 2014 Aug;
PMID: 25160743 [PubMed - as supplied by publisher]


Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure.
Ciara A Martin, Angel Barajas, George Lawless, Hakeem O Lawal, Khadij Assani, Yosephine P Lumintang, Vanessa Nunez, David E Krantz
Neurotoxicology 2014 Aug;
PMID: 25160001 [PubMed - as supplied by publisher]


Gene Therapy for the Nervous System: Challenges and New Strategies.
Casey A Maguire, Servio H Ramirez, Steven F Merkel, Miguel Sena-Esteves, Xandra O Breakefield
Neurotherapeutics 2014 Aug;
PMID: 25159276 [PubMed - as supplied by publisher]


A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Marlène Cassar, Abdul-Raouf Issa, Thomas Riemensperger, Céline Petitgas, Thomas Rival, Hélène Coulom, Magali Iché-Torres, Kyung-An Han, Serge Birman
Hum Mol Genet 2014 Aug;
PMID: 25158689 [PubMed - as supplied by publisher]


Immunolocalization of human alpha-synuclein in the Thy1-aSyn ("Line 61") transgenic mouse line.
M Delenclos, L Carrascal, K Jensen, M Romero-Ramos
Neuroscience 2014 Aug; 277C:647-664
PMID: 25090921 [PubMed - as supplied by publisher]


SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway.
Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donmez
Front Aging Neurosci 2014 ; 6:184
PMID: 25157229 [PubMed - as supplied by publisher]


Glucocerebrosidase depletion enhances cell-to-cell transmission of ?-synuclein.
Eun-Jin Bae, Na-Young Yang, Miyoung Song, Cheol Soon Lee, Jun Sung Lee, Byung Chul Jung, He-Jin Lee, Seokjoong Kim, Eliezer Masliah, Sergio Pablo Sardi, Seung-Jae Lee
Nat Commun 2014 ; 5:4755
PMID: 25156829 [PubMed - as supplied by publisher]


Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin.
Ghazaleh Ashrafi, Julia S Schlehe, Matthew J LaVoie, Thomas L Schwarz
J Cell Biol 2014 Aug;
PMID: 25154397 [PubMed - as supplied by publisher]


Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.
Jerome A Roth
Neurotoxicology 2014 Aug;
PMID: 25149416 [PubMed - as supplied by publisher]


Parkinson disease: Detection of ?-synuclein inclusions in the gastric mucosa of patients with PD could hasten diagnosis.
Nat Rev Neurol 2014 Aug;
PMID: 25134711 [PubMed - as supplied by publisher]


?-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease.
Gheona Altarescu, Daniel Ioscovich, Roy N Alcalay, Ari Zimran, Deborah Elstein
Neurosci Lett 2014 Aug; 580C:104-107
PMID: 25111979 [PubMed - as supplied by publisher]


Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice.
S P Patil, P D Jain, P J Ghumatkar, R Tambe, S Sathaye
Neuroscience 2014 Aug; 277C:747-754
PMID: 25108167 [PubMed - as supplied by publisher]


Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.
Taku Amo, Shinji Saiki, Tadashi Sawayama, Shigeto Sato, Nobutaka Hattori
Neurosci Lett 2014 Aug; 580C:37-40
PMID: 25092611 [PubMed - as supplied by publisher]


Standardized Bacopa monnieri extract ameliorates acute paraquat-induced oxidative stress, and neurotoxicity in prepubertal mice brain.
Ravikumar Hosamani, Gokul Krishna, Muralidhara
Nutr Neurosci 2014 Aug;
PMID: 25153704 [PubMed - as supplied by publisher]


Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus].
Yang Chen, Ying-Hui Lü, Zhao-Fa Li
Yao Xue Xue Bao 2014 May; 49(5):576-81
PMID: 25151724 [PubMed - as supplied by publisher]


Role of the Akt/GSK-3?/CRMP-2 pathway in axon degeneration of dopaminergic neurons resulting from MPP+ toxicity.
Wei Fang, Guodong Gao, Haikang Zhao, Yi Xia, Xiaodong Guo, Nan Li, Yuqian Li, Yang Yang, Lei Chen, Qiang Wang, Lihong Li
Brain Res 2014 Aug;
PMID: 25150591 [PubMed - as supplied by publisher]


Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2-Nrf2 signaling pathway.
Xiao-Li Wang, Gui-Hua Xing, Bo Hong, Xiao-Ming Li, Yu Zou, Xiao-Jie Zhang, Miao-Xian Dong
Life Sci 2014 Aug;
PMID: 25132361 [PubMed - as supplied by publisher]


In vitro PAMAM, phosphorus and viologen-phosphorus dendrimers prevent rotenone-induced cell damage.
Katarzyna Milowska, Aleksandra Szwed, Maria Zablocka, Anne-Marie Caminade, Jean-Pierre Majoral, Serge Mignani, Teresa Gabryelak, Maria Bryszewska
Int J Pharm 2014 Aug; 474(1-2):42-49
PMID: 25108046 [PubMed - as supplied by publisher]


Mitochondrial acetylation and genetic models of Parkinson's disease.
Georg Auburger, Suzana Gispert, Marina Jendrach
Prog Mol Biol Transl Sci 2014 ; 127:155-82
PMID: 25149217 [PubMed - as supplied by publisher]


Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-? agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease.
Augusta Pisanu, Daniela Lecca, Giovanna Mulas, Jadwiga Wardas, Gabriella Simbula, Saturnino Spiga, Anna R Carta
Neurobiol Dis 2014 Aug;
PMID: 25134730 [PubMed - as supplied by publisher]


Automated detection of 50-kHz ultrasonic vocalizations using template matching in XBAT.
David J Barker, Christopher Herrera, Mark O West
J Neurosci Methods 2014 Aug;
PMID: 25128724 [PubMed - as supplied by publisher]


The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Manuel Rodriguez, Ingrid Morales, Clara Rodriguez-Sabate, Alberto Sanchez, Rafael Castro, Jose Miguel Brito, Magdalena Sabate
Front Neuroanat 2014 ; 8:80
PMID: 25147507 [PubMed - as supplied by publisher]


Air Pollution and Children: Neural and Tight Junction Antibodies and Combustion Metals, the Role of Barrier Breakdown and Brain Immunity in Neurodegeneration.
Lilian Calderón-Garcidueñas, Aristo Vojdani, Eleonore Blaurock-Busch, Yvette Busch, Albrecht Friedle, Maricela Franco-Lira, Partha Sarathi-Mukherjee, Su-Bin Park, Ricardo Torres-Jardón, Amedeo D'Angiulli
J Alzheimers Dis 2014 Aug;
PMID: 25147109 [PubMed - as supplied by publisher]


Group III Metabotropic Glutamate Receptors: Pharmacology, Physiology and Therapeutic Potential.
Marion S Mercier, David Lodge
Neurochem Res 2014 Aug;
PMID: 25146900 [PubMed - as supplied by publisher]


Designer's microglia with novel delivery system in neurodegenerative diseases.
Abdul Mannan Baig
Med Hypotheses 2014 Aug;
PMID: 25146247 [PubMed - as supplied by publisher]


UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease.
Kai Wu, Jia Liu, Na Zhuang, Tao Wang
FASEB J 2014 Aug;
PMID: 25145627 [PubMed - as supplied by publisher]


Structural insights into amyloid oligomers of the Parkinson disease related protein ?-synuclein.
J Ignacio Gallea, M Soledad Celej
J Biol Chem 2014 Aug;
PMID: 25143382 [PubMed - as supplied by publisher]


Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells.
Hee Ju Kim, Joonki Kim, Ki Sung Kang, Keun Taik Lee, Hyun Ok Yang
Biomol Ther (Seoul) 2014 Jul; 22(4):275-81
PMID: 25143804 [PubMed - as supplied by publisher]


Potential of Cellular and Animal Models Based on a Prion-Like Propagation of ?-Synuclein for Assessing Antiparkinson Agents.
Hiroyasu Sato, Takeo Kato, Shigeki Arawaka
Mol Neurobiol 2014 Aug;
PMID: 25143237 [PubMed - as supplied by publisher]


A review of the clinical evidence for complementary and alternative therapies in Parkinson's disease.
Danny Bega, Paulina Gonzalez-Latapi, Cindy Zadikoff, Tanya Simuni
Curr Treat Options Neurol 2014 Oct; 16(10):314
PMID: 25143234 [PubMed - as supplied by publisher]


The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach.
Parveen Salahuddin, Gulam Rabbani, Rizwan Hasan Khan
Cell Mol Biol Lett 2014 Aug;
PMID: 25141979 [PubMed - as supplied by publisher]


Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding Peptide.
Nouara Yahi, Jacques Fantini
PLoS One 2014 ; 9(8):e104751
PMID: 25140899 [PubMed - as supplied by publisher]


Neuroprotective effects of cuscutae semen in a mouse model of Parkinson's disease.
Minsook Ye, Seul Gi Lee, Eun Sook Chung, Su-Jin Lim, Won Seob Kim, Heera Yoon, Sun Kwang Kim, Kwang Sung Ahn, Young Pyo Jang, Hyunsu Bae
Evid Based Complement Alternat Med 2014 ; 2014:150153
PMID: 25140184 [PubMed - as supplied by publisher]


Pharmacological Treatments Inhibiting Levodopa-Induced Dyskinesias in MPTP-Lesioned Monkeys: Brain Glutamate Biochemical Correlates.
Nicolas Morin, Thérèse Di Paolo
Front Neurol 2014 ; 5:144
PMID: 25140165 [PubMed - as supplied by publisher]


Structure activity relationship of phenolic acid inhibitors of ?-synuclein fibril formation and toxicity.
Mustafa T Ardah, Katerina E Paleologou, Guohua Lv, Salema B Abul Khair, Abdulla S Kazim, Saeed T Minhas, Taleb H Al-Tel, Abdulmonem A Al-Hayani, Mohammed E Haque, David Eliezer, Omar M A El-Agnaf
Front Aging Neurosci 2014 ; 6:197
PMID: 25140150 [PubMed - as supplied by publisher]


?-Synuclein Misfolding Versus Aggregation Relevance to Parkinson's Disease: Critical Assessment and Modeling.
Ruben Berrocal, Velmarini Vasquez, Sambasiva Rao Krs, Bharathi S Gadad, Rao Ks
Mol Neurobiol 2014 Aug;
PMID: 25139280 [PubMed - as supplied by publisher]


Neuroprotective effects of peroxisome proliferator-activated receptor alpha and gamma agonists in model of parkinsonism induced by intranigral 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine.
Janaína K Barbiero, Ronise M Santiago, Daniele Suzete Persike, Maria José da Silva Fernandes, Fernanda S Tonin, Claudio da Cunha, Suelen Boschen, Marcelo M S Lima, Maria A B F Vital
Behav Brain Res 2014 Aug;
PMID: 25127682 [PubMed - as supplied by publisher]


Opposite Effects of Bone Marrow-Derived Cells Transplantation in MPTP-rat Model of Parkinson's Disease: A Comparison Study of Mononuclear and Mesenchymal Stem Cells.
Caroline Santos Capitelli, Carolina Salomão Lopes, Angélica Cristina Alves, Janaína Barbiero, Lucas Felipe Oliveira, Valdo José Dias da Silva, Maria Aparecida Barbato Frazão Vital
Int J Med Sci 2014 ; 11(10):1049-64
PMID: 25136260 [PubMed - as supplied by publisher]


Cardiac Sympathetic Denervation in 6-OHDA-Treated Nonhuman Primates.
Valerie Joers, Kristine Dilley, Shahrose Rahman, Corinne Jones, Jeanette Shultz, Heather Simmons, Marina E Emborg
PLoS One 2014 ; 9(8):e104850
PMID: 25133405 [PubMed - as supplied by publisher]


Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity.
Pratap Karki, Keisha Smith, James Johnson, Michael Aschner, Eunsook Lee
Neurochem Int 2014 Aug;
PMID: 25128239 [PubMed - as supplied by publisher]


In vivo gastric detection of ?-synuclein inclusions in Parkinson's disease.
Alvaro Sánchez-Ferro, Alberto Rábano, María José Catalán, Fernando Canga Rodríguez-Valcárcel, Servando Fernández Díez, Jaime Herreros-Rodríguez, Elvira García-Cobos, Marina Mata Alvarez-Santullano, Lydia López-Manzanares, Antonio J Mosqueira, Lydia Vela Desojo, Juan José López-Lozano, Eva López-Valdés, Rafael Sánchez-Sánchez, José Antonio Molina-Arjona
Mov Disord 2014 Aug;
PMID: 25113060 [PubMed - as supplied by publisher]


Molecular Imaging Insights into Neurodegeneration: Focus on ?-Synuclein Radiotracers.
Maliha Shah, John Seibyl, Anna Cartier, Ram Bhatt, Ana M Catafau
J Nucl Med 2014 Aug;
PMID: 25091474 [PubMed - as supplied by publisher]


Detection of disease-associated ?-synuclein in the cerebrospinal fluid: a feasibility study.
Ursula Unterberger, Ingolf Lachmann, Till Voigtländer, Walter Pirker, Anna S Berghoff, Katharina Flach, Uta Wagner, Aline Geneste, Armand Perret-Liaudet, Gabor G Kovacs
Clin Neuropathol 2014 Sep-Oct; 33(5):329-34
PMID: 25131945 [PubMed - as supplied by publisher]


Clinical Neuropathology image 5-2014: ?-synuclein pathology in the ependyma in Parkinson's disease.
Gabor G Kovacs
Clin Neuropathol 2014 Sep-Oct; 33(5):328
PMID: 25131944 [PubMed - as supplied by publisher]


Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis.
Helen R Broom, Jessica A O Rumfeldt, Elizabeth M Meiering
Essays Biochem 2014 Aug; 56(1):149-65
PMID: 25131593 [PubMed - as supplied by publisher]


Oligomers of ?-synuclein: picking the culprit in the line-up.
Nikolai Lorenzen, Daniel E Otzen
Essays Biochem 2014 Aug; 56(1):137-48
PMID: 25131592 [PubMed - as supplied by publisher]


Role of ?-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease.
Shun Yu, Piu Chan
Essays Biochem 2014 Aug; 56(1):125-35
PMID: 25131591 [PubMed - as supplied by publisher]


From yeast to patient neurons and back again: A powerful new discovery platform.
Daniel F Tardiff, Vikram Khurana, Chee Yeun Chung, Susan Lindquist
Mov Disord 2014 Aug;
PMID: 25131316 [PubMed - as supplied by publisher]


Cognitive and neuroprotective effects of chlorogenic acid.
Erin Heitman, Donald K Ingram
Nutr Neurosci 2014 Aug;
PMID: 25130715 [PubMed - as supplied by publisher]


SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population.
Xiao Yan Guo, Yong Ping Chen, Wei Song, Bi Zhao, Bei Cao, Qian Qian Wei, Ru Wei Ou, Yuan Yang, Li Xing Yuan, Hui-Fang Shang
Neurobiol Aging 2014 Jul;
PMID: 25129240 [PubMed - as supplied by publisher]


Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism.
Xiaocui Qin, Qiaoqi Wu, Lifang Lin, Aimin Sun, Shuhu Liu, Xiaowen Li, Xiong Cao, Tianming Gao, Pengcheng Luo, Xinhong Zhu, Xuemin Wang
Mol Neurobiol 2014 Aug;
PMID: 25128026 [PubMed - as supplied by publisher]


D-beta-hydroxybutyrate extends lifespan in C. elegans.
Clare Edwards, John Canfield, Neil Copes, Muhammad Rehan, David Lipps, Patrick C Bradshaw
Aging (Albany NY) 2014 Aug;
PMID: 25127866 [PubMed - as supplied by publisher]


Disease-Modifying Effect of Adiponectin in Model of ?-Synucleinopathies.
Kazunari Sekiyama, Masaaki Waragai, Hiroyasu Akatsu, Shuei Sugama, Takato Takenouchi, Yoshiki Takamatsu, Masayo Fujita, Akio Sekigawa, Edward Rockenstein, Satoshi Inoue, Albert R La Spada, Eliezer Masliah, Makoto Hashimoto
Ann Clin Transl Neurol 2014 Jul; 1(7):479-489
PMID: 25126588 [PubMed - as supplied by publisher]


Is Brain Copper Deficiency in Alzheimer's, Lewy Body, and Creutzfeldt Jakob Diseases the Common Key for a Free Radical Mechanism and Oxidative Stress-Induced Damage?
Roger Deloncle, Olivier Guillard
J Alzheimers Dis 2014 Aug;
PMID: 25125459 [PubMed - as supplied by publisher]


May the thyroid gland and thyroperoxidase participate in nitrosylation of serum proteins and sporadic Parkinson's disease?
Emilio Fernandez, Jose-Manuel Garcia-Moreno, Angel Martin de Pablos, Jose Chacon
Antioxid Redox Signal 2014 Aug;
PMID: 25125346 [PubMed - as supplied by publisher]


Trehalose Alleviates PC12 Neuronal Death Mediated by Lipopolysaccharide-Stimulated BV-2 Cells via Inhibiting Nuclear Transcription Factor NF-?B and AP-1 Activation.
Qing He, Ying Wang, Wei Lin, Qiong Zhang, Jue Zhao, Feng-Tao Liu, Yi-Lin Tang, Bao-Guo Xiao, Jian Wang
Neurotox Res 2014 Aug;
PMID: 25125332 [PubMed - as supplied by publisher]


GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.
S Bellani, A Mescola, G Ronzitti, H Tsushima, S Tilve, C Canale, F Valtorta, E Chieregatti
Cell Death Differ 2014 Aug;
PMID: 25124556 [PubMed - as supplied by publisher]


Metabolism in HD: Still a relevant mechanism?
Wenzhen Duan, Mali Jiang, Jing Jin
Mov Disord 2014 Aug;
PMID: 25124273 [PubMed - as supplied by publisher]


The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat.
Kobra Zare, Akram Eidi, Mehrdad Roghani, Ali Haeri Rohani
Metab Brain Dis 2014 Aug;
PMID: 25123753 [PubMed - as supplied by publisher]


Addition of exogenous ?-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous ?-synuclein to Lewy body and Lewy neurite-like aggregates.
Laura A Volpicelli-Daley, Kelvin C Luk, Virginia M-Y Lee
Nat Protoc 2014 Sep; 9(9):2135-46
PMID: 25122523 [PubMed - as supplied by publisher]


Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease.
Lei Lu, LE Tang, Wenshi Wei, Yunyi Hong, Heyu Chen, Weihai Ying, Shengdi Chen
Exp Ther Med 2014 Sep; 8(3):943-950
PMID: 25120628 [PubMed - as supplied by publisher]


Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.
Jean-Marc Taymans, Veerle Baekelandt, Kirsten Harvey
Front Mol Neurosci 2014 ; 7:71
PMID: 25120428 [PubMed - as supplied by publisher]


Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.
Pascal F Durrenberger, Francesca S Fernando, Samira N Kashefi, Tim P Bonnert, Danielle Seilhean, Brahim Nait-Oumesmar, Andrea Schmitt, Peter J Gebicke-Haerter, Peter Falkai, Edna Grünblatt, Miklos Palkovits, Thomas Arzberger, Hans Kretzschmar, David T Dexter, Richard Reynolds
J Neural Transm 2014 Aug;
PMID: 25119539 [PubMed - as supplied by publisher]


The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.
S Saez-Atienzar, L Bonet-Ponce, J R Blesa, F J Romero, M P Murphy, J Jordan, M F Galindo
Cell Death Dis 2014 ; 5:e1368
PMID: 25118928 [PubMed - as supplied by publisher]


Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture.
K Radad, D Scheller, W-D Rausch, H Reichmann, G Gille
Folia Neuropathol 2014 ; 52(2):179-86
PMID: 25118903 [PubMed - as supplied by publisher]


The Effect of Lentivirus-Mediated PSPN Genetic Engineering Bone Marrow Mesenchymal Stem Cells on Parkinson's Disease Rat Model.
Xiaofeng Yin, Huamin Xu, Yunxia Jiang, Wenshuai Deng, Zeyu Wu, Hengwei Xiang, Peng Sun, Junxia Xie
PLoS One 2014 ; 9(8):e105118
PMID: 25118697 [PubMed - as supplied by publisher]


VPS35 dysfunction impairs lysosomal degradation of ?-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.
Emiko Miura, Takafumi Hasegawa, Masatoshi Konno, Mari Suzuki, Naoto Sugeno, Nobuhiro Fujikake, Sven Geisler, Mitsuaki Tabuchi, Ryuji Oshima, Akio Kikuchi, Toru Baba, Keiji Wada, Yoshitaka Nagai, Atsushi Takeda, Masashi Aoki
Neurobiol Dis 2014 Aug;
PMID: 25107340 [PubMed - as supplied by publisher]


Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.
Fang Du, Zhong-Ming Qian, Qianqian Luo, Wing-Ho Yung, Ya Ke
Mol Neurobiol 2014 Aug;
PMID: 25115800 [PubMed - as supplied by publisher]


Walking Deficits and Centrophobism in an Alpha-Synuclein Fly Model of Parkinson's Disease.
Alex Y Chen, Paul Wilburn, Xue Hao, Tim Tully
Genes Brain Behav 2014 Aug;
PMID: 25113870 [PubMed - as supplied by publisher]


Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence.
Jane A Driver
Biogerontology 2014 Aug;
PMID: 25113739 [PubMed - as supplied by publisher]


Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.
J Mark Cooper, P B Oscar Wiklander, Joel Z Nordin, Raya Al-Shawi, Matthew J Wood, Mansi Vithlani, Anthony H V Schapira, J Paul Simons, Samir El-Andaloussi, Lydia Alvarez-Erviti
Mov Disord 2014 Aug;
PMID: 25112864 [PubMed - as supplied by publisher]


Ceftriaxone Protects Astrocytes from MPP(+) via Suppression of NF-?B/JNK/c-Jun Signaling.
Yunlong Zhang, Xiuping Zhang, Shaogang Qu
Mol Neurobiol 2014 Aug;
PMID: 25112679 [PubMed - as supplied by publisher]


Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology.
Suzana Gispert, Alexander Kurz, Nadine Brehm, Katrin Rau, Michael Walter, Olaf Riess, Georg Auburger
Mol Neurobiol 2014 Aug;
PMID: 25112678 [PubMed - as supplied by publisher]


The small GTPase Rab11 co-localizes with ?-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Oldriska Chutna, Susana Gonçalves, Anna Villar-Piqué, Patrícia Guerreiro, Zrinka Marijanovic, Tiago Mendes, José Ramalho, Evangelia Emmanouilidou, Salvador Ventura, Jochen Klucken, Duarte C Barral, Flaviano Giorgini, Kostas Vekrellis, Tiago F Outeiro
Hum Mol Genet 2014 Aug;
PMID: 25092884 [PubMed - as supplied by publisher]


Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease.
Ajay Gupta, Baptiste Lacoste, Paul J Pistel, Donald K Ingram, Edith Hamel, Moulay A Alaoui-Jamali, Walter A Szarek, Jason Z Vlahakis, Su Jie, Wei Song, Hyman M Schipper
J Neurochem 2014 Aug;
PMID: 25111043 [PubMed - as supplied by publisher]


Magnetic Resonance Spectroscopy in the Diagnosis of Dementia with Lewy Bodies.
Radoslaw Magierski, Tomasz Sobow
Biomed Res Int 2014 ; 2014:809503
PMID: 25110697 [PubMed - as supplied by publisher]


Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells.
Rita Perfeito, Diana F Lázaro, Tiago F Outeiro, A Cristina Rego
Mol Cell Neurosci 2014 Aug;
PMID: 25109238 [PubMed - as supplied by publisher]


Upregulation of human PINK1 gene expression by NF¿B signalling.
Xiaoling Duan, Jade Tong, Qin Xu, Yili Wu, Fang Cai, Tingyu Li, Weihong Song
Mol Brain 2014 Aug; 7(1):57
PMID: 25108683 [PubMed - as supplied by publisher]


A new pathway for mitochondrial quality control: mitochondrial-derived vesicles.
Ayumu Sugiura, Gian-Luca McLelland, Edward A Fon, Heidi M McBride
EMBO J 2014 Aug;
PMID: 25107473 [PubMed - as supplied by publisher]


The Paths to Neurodegeneration in Genetic Parkinson's Disease.
O E Abdel-Salam
CNS Neurol Disord Drug Targets 2014 Aug;
PMID: 25106632 [PubMed - as supplied by publisher]


Animal Models for Parkinson's Disease.
Dilip Ashok Patil, Vishal Ashok Patil, Sanjay Baburao Bari, Sanjay J Surana, Pravin Onkar Patil
CNS Neurol Disord Drug Targets 2014 Aug;
PMID: 25106631 [PubMed - as supplied by publisher]


BAG1 is Neuroprotective in In Vivo and In Vitro Models of Parkinson's Disease.
Pawel Kermer, Anja Köhn, Marlena Schnieder, Paul Lingor, Mathias Bähr, Jan Liman, Christoph Peter Dohm
J Mol Neurosci 2014 Aug;
PMID: 25106480 [PubMed - as supplied by publisher]


CDK5-mediated phosphorylation and autophagy of RKIP regulate neuronal death in Parkinson's disease.
Zheng Wen, Yang Shu, Caiyun Gao, Xuemin Wang, Guangjian Qi, Pei Zhang, Man Li, Jing Shi, Bo Tian
Neurobiol Aging 2014 Jun;
PMID: 25104559 [PubMed - as supplied by publisher]


Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.
David R Whitfield, Julie Vallortigara, Amani Alghamdi, David Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Stephen Newhouse, Clive Ballard, Alan J Thomas, John T O'Brien, Dag Aarsland, Paul T Francis
Neurobiol Aging 2014 Jun;
PMID: 25104558 [PubMed - as supplied by publisher]


Occupational exposure to pesticides and endotoxin and Parkinson disease in the Netherlands.
Marianne van der Mark, Roel Vermeulen, Peter C G Nijssen, Wim M Mulleners, Antonetta M G Sas, Teus van Laar, Maartje Brouwer, Anke Huss, Hans Kromhout
Occup Environ Med 2014 Aug;
PMID: 25104429 [PubMed - as supplied by publisher]


Regional Multiple Pathology Scores are Associated with Cognitive Decline in Lewy Body Dementias.
David R Howlett, David Whitfield, Mary Johnson, Johannes Attems, John T O'Brien, Dag Aarsland, Mitchell Kp Lai, Jasinda H Lee, Christopher Chen, Clive Ballard, Tibor Hortobágyi, Paul T Francis
Brain Pathol 2014 Aug;
PMID: 25103200 [PubMed - as supplied by publisher]


Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.
J Romaní-Aumedes, M Canal, N Martín-Flores, X Sun, V Pérez-Fernández, S Wewering, R Fernández-Santiago, M Ezquerra, C Pont-Sunyer, A Lafuente, J Alberch, H Luebbert, E Tolosa, O A Levy, L A Greene, C Malagelada
Cell Death Dis 2014 ; 5:e1364
PMID: 25101677 [PubMed - as supplied by publisher]


Gene-Gene and Gene-Environment Interaction on the Risk of Parkinson's Disease.
Neeraj Kumar Singh, B D Banerjee, Kiran Bala, Mitra Basu, Neelam Chhillar
Curr Aging Sci 2014 Aug;
PMID: 25101650 [PubMed - as supplied by publisher]


Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases.
Antonio Paoli, Antonino Bianco, Ernesto Damiani, Gerardo Bosco
Biomed Res Int 2014 ; 2014:474296
PMID: 25101284 [PubMed - as supplied by publisher]


Genetic Convergence of Parkinson's Disease and Lysosomal Storage Disorders.
Hao Deng, Xiaofei Xiu, Joseph Jankovic
Mol Neurobiol 2014 Aug;
PMID: 25099932 [PubMed - as supplied by publisher]


Acupuncture mechanism and redox equilibrium.
Xiang-Hong Zeng, Qian-Qian Li, Qian Xu, Fang Li, Cun-Zhi Liu
Evid Based Complement Alternat Med 2014 ; 2014:483294
PMID: 25097658 [PubMed - as supplied by publisher]


Pesticides and Parkinson's disease: is it in your genes?
Lisa M Barnhill, Jeff M Bronstein
Neurodegener Dis Manag 2014 Jun; 4(3):197-200
PMID: 25095814 [PubMed - as supplied by publisher]


Pathological alpha-synuclein propagates through neural networks.
Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Maki Kubo, Aki Shimozawa, Haruhiko Akiyama, Masato Hasegawa
Acta Neuropathol Commun 2014 Aug; 2(1):88
PMID: 25095794 [PubMed - as supplied by publisher]


Protective effect of alkaloids from Piper longum in rat dopaminergic neuron injury of 6-OHDA-induced Parkinson's disease].
Li Zheng, Hao Wang, Yin-Ying Ba, Hao-Long Liu, Meng Wang, Wei-Wei Guo, Xia Wu, Hui Yang
Zhongguo Zhong Yao Za Zhi 2014 May; 39(9):1660-5
PMID: 25095380 [PubMed - as supplied by publisher]


Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons.
Shan Liu, Xing Wang, Yun Li, Lei Xu, Xiaoliang Yu, Lin Ge, Jun Li, Yongjin Zhu, Sudan He
Biomed Res Int 2014 ; 2014:290182
PMID: 25093162 [PubMed - as supplied by publisher]


Brain disposition of ?-Synuclein: roles of brain barrier systems and implications for Parkinson's disease.
Christopher A Bates, Wei Zheng
Fluids Barriers CNS 2014 ; 11:17
PMID: 25093076 [PubMed - as supplied by publisher]


Late stages of hematopoiesis and B cell lymphopoiesis are regulated by ?-synuclein, a key player in Parkinson's disease.
Wenbin Xiao, Afshin Shameli, Clifford V Harding, Howard J Meyerson, Robert W Maitta
Immunobiology 2014 Jul;
PMID: 25092570 [PubMed - as supplied by publisher]


Genetic analysis of SNCA coding mutation in Chinese Han patients with Parkinson disease.
Sheng Deng, Xiong Deng, Lamei Yuan, Zhi Song, Zhijian Yang, Wei Xiong, Hao Deng
Acta Neurol Belg 2014 Aug;
PMID: 25092551 [PubMed - as supplied by publisher]