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What can we learn by studying genetics and Parkinson's? PDF-funded researchers Drs. Mata and Zabetian share their progress six years after launching the first large-scale survey of PD genetics in Latin America.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Level of plasma neuregulin-1 SMDF is reduced in patients with idiopathic Parkinson's disease.
Yuka Hama, Ichiro Yabe, Koichi Wakabayashi, Takahiro Kano, Makoto Hirotani, Yuriko Iwakura, Jun Utsumi, Hidenao Sasaki
Neurosci Lett 2014 Dec; 587C:17-21
PMID: 25524406 [PubMed - as supplied by publisher]

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene-environment interactions.
Michaela E Johnson, Larisa Bobrovskaya
Neurotoxicology 2014 Dec;
PMID: 25514659 [PubMed - as supplied by publisher]

JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.
Won-Seok Choi, Hyung-Wook Kim, Zhengui Xia
Toxicology 2014 Dec; 328C:75-81
PMID: 25496994 [PubMed - as supplied by publisher]

Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease.
Jesse E Hanson, Jean-Francois Pare, Lunbin Deng, Yoland Smith, Qiang Zhou
Neurobiol Dis 2014 Dec; 74C:254-262
PMID: 25484285 [PubMed - as supplied by publisher]

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy.
Victor S Van Laar, Nikita Roy, Annie Liu, Swati Rajprohat, Beth Arnold, April A Dukes, Cory D Holbein, Sarah B Berman
Neurobiol Dis 2014 Dec; 74C:180-193
PMID: 25478815 [PubMed - as supplied by publisher]

PINK1 Catalytic Activity is Regulated by Phosphorylation on Serines 228 and 402.
Liesbeth Aerts, Katleen Craessaerts, Bart De Strooper, Vanessa A Morais
J Biol Chem 2014 Dec;
PMID: 25527497 [PubMed - as supplied by publisher]

MS-275 Inhibits Aroclor 1254-Induced SH-SY5Y Neuronal Cell Toxicity by Preventing the Formation of the HDAC3/REST Complex on the Synapsin-1 Promoter.
Luigi Formisano, Natascia Guida, Giusy Laudati, Luigi Mascolo, Gianfranco Di Renzo, Lorella M T Canzoniero
J Pharmacol Exp Ther 2015 Feb; 352(2):236-43
PMID: 25467131 [PubMed - as supplied by publisher]

Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease.
Melissa Furlong, Caroline M Tanner, Samuel M Goldman, Grace S Bhudhikanok, Aaron Blair, Anabel Chade, Kathleen Comyns, Jane A Hoppin, Meike Kasten, Monica Korell, J William Langston, Connie Marras, Cheryl Meng, Marie Richards, G Webster Ross, David M Umbach, Dale P Sandler, Freya Kamel
Environ Int 2015 Feb; 75C:144-150
PMID: 25461423 [PubMed - as supplied by publisher]

Small molecule-mediated stabilization of vesicle-associated helical ?-synuclein inhibits pathogenic misfolding and aggregation.
Luis Fonseca-Ornelas, Sybille E Eisbach, Maria Paulat, Karin Giller, Claudio O Fernández, Tiago F Outeiro, Stefan Becker, Markus Zweckstetter
Nat Commun 2014 ; 5:5857
PMID: 25524885 [PubMed - as supplied by publisher]

Investigating the Validity of the Environmental Framework Underlying the Original and Modified Dynamic Gait Index.
Anne Shumway-Cook, Patricia Noritake Matsuda, Catherine Taylor
Phys Ther 2014 Dec;
PMID: 25524870 [PubMed - as supplied by publisher]

?-synuclein insertion into supported lipid bilayers as seen by in situ X-ray reflectivity.
Hendrik Hähl, Isabelle Möller, Irena Kiesel, Silvia Campioni, Roland Riek, Dorinel Verdes, Stefan Seeger
ACS Chem Neurosci 2014 Dec;
PMID: 25523270 [PubMed - as supplied by publisher]

Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells.
Kim San Tang
Lipids Health Dis 2014 Dec; 13(1):197
PMID: 25522984 [PubMed - as supplied by publisher]

Latrepirdine: a systematic review of the preclinical studies].
N Cano-Cuenca, J Solis-Garcia Del Pozo, J Jordan
Rev Neurol 2015 Jan; 60(1):35-42
PMID: 25522862 [PubMed - as supplied by publisher]

Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral ?-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys.
M Chen, T Wang, F Yue, X Li, P Wang, Y Li, P Chan, S Yu
Neuroscience 2014 Dec;
PMID: 25498223 [PubMed - as supplied by publisher]

Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy.
Sungwoo Park, Seon-Guk Choi, Seung-Min Yoo, Jin H Son, Yong-Keun Jung
Autophagy 2014 Nov; 10(11):1906-20
PMID: 25483962 [PubMed - as supplied by publisher]

Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's Disease.
Janelle Drouin-Ouellet, Isabelle St-Amour, Martine Saint-Pierre, Jérôme Lamontagne-Proulx, Jasna Kriz, Roger A Barker, Francesca Cicchetti
Int J Neuropsychopharmacol 2014 Dec;
PMID: 25522431 [PubMed - as supplied by publisher]

A Novel Bio-Orthogonal Cross-Linker for Improved Protein/Protein Interaction Analysis.
Catherine Nury, Virginie Redeker, Sebastien Dautrey, Anthony Romieu, Guillaume Van Der Rest, Pierre-Yves Renard, Ronald Melki, Julia Chamot-Rooke
Anal Chem 2014 Dec;
PMID: 25522193 [PubMed - as supplied by publisher]

Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation.
Lais S Rodrigues, Adriano D S Targa, Ana Carolina D Noseda, Mariana F Aurich, Cláudio Da Cunha, Marcelo M S Lima
Front Cell Neurosci 2014 ; 8:383
PMID: 25520618 [PubMed - as supplied by publisher]

Dual effect of oxidative stress on leukemia cancer induction and treatment.
Udensi K Udensi, Paul B Tchounwou
J Exp Clin Cancer Res 2014 Dec; 33(1):106
PMID: 25519934 [PubMed - as supplied by publisher]

A Neuroprotective Function of NSF1 Sustains Autophagy and Lysosomal Trafficking in Drosophila.
Daniel T Babcock, Wei Shen, Barry Ganetzky
Genetics 2014 Dec;
PMID: 25519897 [PubMed - as supplied by publisher]

Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety.
Jacob Raber, Robert M Duvoisin
Expert Opin Investig Drugs 2014 Dec; :1-10
PMID: 25518990 [PubMed - as supplied by publisher]

Anti-inflammatory peptide regulates supply of heat shock protein 70 monomers: Implications for Aging and Age-Related Disease.
Timothy James Cunningham, Jeffrey I Greenstein, Joshua Loewenstern, Elias Degermentzidis, Lihua Yao
Rejuvenation Res 2014 Dec;
PMID: 25485461 [PubMed - as supplied by publisher]

Neuroprotection by scorpion venom heat resistant peptide in 6-hydroxydopamine rat model of early-stage Parkinson's disease.
Sheng-Ming Yin, Dan Zhao, De-Qin Yu, Sheng-Long Li, Dong An, Yan Peng, Hong Xu, Yi-Ping Sun, Dong-Mei Wang, Jie Zhao, Wan-Qin Zhang
Sheng Li Xue Bao 2014 Dec; 66(6):658-666
PMID: 25516514 [PubMed - as supplied by publisher]

Therapeutic strategies in Parkinson's disease: what we have learned from animal models.
Jorge S Valadas, Melissa Vos, Patrik Verstreken
Ann N Y Acad Sci 2014 Dec;
PMID: 25515068 [PubMed - as supplied by publisher]

Rasagiline, a Suicide Inhibitor of Monoamine Oxidases, Binds Reversibly to ?-Synuclein.
Joe Kakish, Omid Tavassoly, Jeremy S Lee
ACS Chem Neurosci 2014 Dec;
PMID: 25514361 [PubMed - as supplied by publisher]

Vinpocetine Attenuates MPTP-Induced Motor Deficit and Biochemical Abnormalities in Wistar Rats.
Sorabh Sharma, Rahul Deshmukh
Neuroscience 2014 Dec;
PMID: 25514048 [PubMed - as supplied by publisher]

Parkinson disease: ?-Synuclein antibodies might not be a reliable PD biomarker.
Nat Rev Neurol 2014 Dec;
PMID: 25511891 [PubMed - as supplied by publisher]

Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake.
Javier Castro-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros, Josmar Salas-Hernández, Pedro Barroso-Chinea, Rosario Moratalla, Mark J Millan, Tomás González-Hernández
Neurobiol Dis 2014 Dec;
PMID: 25511804 [PubMed - as supplied by publisher]

Stiff-person syndrome: insights into a complex autoimmune disorder.
José Fidel Baizabal-Carvallo, Joseph Jankovic
J Neurol Neurosurg Psychiatry 2014 Dec;
PMID: 25511790 [PubMed - as supplied by publisher]

Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease.
Aaron M Gusdon, Fang Fang, Jing Chen, Clayton E Mathews, Wang Li, Charleen T Chu, Jian-Qing Ding, Sheng-di Chen
Neurosci Lett 2014 Dec;
PMID: 25511548 [PubMed - as supplied by publisher]

Biomarkers of Parkinson's disease (PD): Present and future.
Diane B Miller, James P O'Callaghan
Metabolism 2014 Oct;
PMID: 25510818 [PubMed - as supplied by publisher]

Molecular mechanisms of placebo responses in humans.
M Peciña, J-K Zubieta
Mol Psychiatry 2014 Dec;
PMID: 25510510 [PubMed - as supplied by publisher]

In vitro dopaminergic neurotoxicity of pesticides: a link with neurodegeneration?
Harm J Heusinkveld, Martin van den Berg, Remco H S Westerink
Vet Q 2014 Sep; 34(3):120-31
PMID: 25506807 [PubMed - as supplied by publisher]

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing ?-synuclein.
Iddo Magen, Regina Ostritsky, Franziska Richter, Chunni Zhu, Sheila M Fleming, Vincent Lemesre, Alistair J Stewart, Bruce H Morimoto, Illana Gozes, Marie-Françoise Chesselet
Pharmacol Res Perspect 2014 Oct; 2(5):e00065
PMID: 25505609 [PubMed - as supplied by publisher]

Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism.
Sofie Degerman, Magdalena Domellöf, Mattias Landfors, Jan Linder, Mathias Lundin, Susann Haraldsson, Eva Elgh, Göran Roos, Lars Forsgren
PLoS One 2014 ; 9(12):e113387
PMID: 25501556 [PubMed - as supplied by publisher]

Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson's disease dementia.
Chao-Yu Hsu, Ching-Sui Hung, Hung-Ming Chang, Wen-Chieh Liao, Shih-Chun Ho, Ying-Jui Ho
Neuropharmacology 2014 Dec;
PMID: 25499022 [PubMed - as supplied by publisher]

Disturbed mitochondrial dynamics and neurodegenerative disorders.
Florence Burté, Valerio Carelli, Patrick F Chinnery, Patrick Yu-Wai-Man
Nat Rev Neurol 2014 Dec;
PMID: 25486875 [PubMed - as supplied by publisher]

Metabotropic glutamate receptors as drug targets: what's new?
Ferdinando Nicoletti, Valeria Bruno, Richard Teke Ngomba, Roberto Gradini, Giuseppe Battaglia
Curr Opin Pharmacol 2014 Dec; 20C:89-94
PMID: 25506748 [PubMed - as supplied by publisher]

The H50Q mutation induces a tenfold decrease in the solubility of ?-synuclein.
Riccardo Porcari, Christos Proukakis, Christopher A Waudby, Benedetta Bolognesi, P Patrizia Mangione, Jack F S Paton, Stephen Mullin, Lisa D Cabrita, Amanda Penco, Annalisa Relini, Guglielmo Verona, Michele Vendruscolo, Monica Stoppini, Gian Gaetano Tartaglia, Carlo Camilloni, John Christodoulou, Anthony H V Schapira, Vittorio Bellotti
J Biol Chem 2014 Dec;
PMID: 25505181 [PubMed - as supplied by publisher]

Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates.
Arun Singh, Li Liang, Yoshiki Kaneoke, Xuebing Cao, Stella M Papa
J Neurophysiol 2014 Dec; :jn.00910.2014
PMID: 25505120 [PubMed - as supplied by publisher]

Inhibition of i-NOS but not n-NOS protects rat primary cell cultures against MPP(+)-induced neuronal toxicity.
Monika J Brzozowski, Peter Jenner, Sarah Rose
J Neural Transm 2014 Dec;
PMID: 25503828 [PubMed - as supplied by publisher]

Levodopa: Effect on cell death and the natural history of Parkinson's disease.
C Warren Olanow
Mov Disord 2014 Dec;
PMID: 25502620 [PubMed - as supplied by publisher]

Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson's Disease: Modulation of Mitochondrial Perturbations.
Noha F Abdelkader, Marwa M Safar, Hesham A Salem
Mol Neurobiol 2014 Dec;
PMID: 25502462 [PubMed - as supplied by publisher]

The Parkinson's Disease-Related Protein DJ-1 Protects Dopaminergic Neurons in vivo and Cultured Cells from Alpha-Synuclein and 6-Hydroxydopamine Toxicity.
Sara Batelli, Roberto William Invernizzi, Alessandro Negro, Eleonora Calcagno, Serena Rodilossi, Gianluigi Forloni, Diego Albani
Neurodegener Dis 2014 Dec;
PMID: 25500798 [PubMed - as supplied by publisher]

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.
Orit Bar-Am, Tamar Amit, Lana Kupershmidt, Yuval Aluf, Danit Mechlovich, Hoda Kabha, Lena Danovitch, Vincent R Zurawski, Moussa B H Youdim, Orly Weinreb
Neurobiol Aging 2014 Oct;
PMID: 25499799 [PubMed - as supplied by publisher]

DJ-1 as a human oncogene and potential therapeutic target.
Ji Cao, Siyue Lou, Meidan Ying, Bo Yang
Biochem Pharmacol 2014 Dec;
PMID: 25498803 [PubMed - as supplied by publisher]

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M Griggs, Laura Zavala-Flores, Elsa M Reyes-Reyes, Javier Seravalli, Lia A Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franco
Neurobiol Dis 2014 Dec;
PMID: 25497688 [PubMed - as supplied by publisher]

Models of ¿-synuclein aggregation in Parkinson¿s disease.
Rosa Giráldez-Pérez, Mónica Antolín-Vallespín, María Muñoz, Amelia Sánchez-Capelo
Acta Neuropathol Commun 2014 Dec; 2(1):176
PMID: 25497491 [PubMed - as supplied by publisher]

Melatonin redox activity. It's potential clinical application in neurodegenerative disorders.
El?bieta Miller, Agnieszka Morel, Luciano Saso, Joanna Saluk
Curr Top Med Chem 2014 Dec;
PMID: 25496271 [PubMed - as supplied by publisher]

Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson¿s disease ¿ a multicenter study.
Malin von Otter, Petra Bergström, Aldo Quattrone, Elvira De Marco, Grazia Annesi, Peter Söderkvist, Stephanie Wettinger, Marek Drozdzik, Monika Bialecka, Hans Nissbrandt, Christine Klein, Michael Nilsson, Ola Hammarsten, Staffan Nilsson, Henrik Zetterberg
BMC Med Genet 2014 Dec; 15(1):131
PMID: 25496089 [PubMed - as supplied by publisher]

Differences in the Binding of Copper(I) to ?- and ?-Synuclein.
Riccardo De Ricco, Daniela Valensin, Simone Dell'Acqua, Luigi Casella, Elena Gaggelli, Gianni Valensin, Luigi Bubacco, Stefano Mangani
Inorg Chem 2014 Dec;
PMID: 25495902 [PubMed - as supplied by publisher]

Activation of ?7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: Implications for Parkinson's disease.
Yuan Liu, Xiaoning Zeng, Yujian Hui, Chenlei Zhu, Jie Wu, Devin H Taylor, Juan Ji, Weimin Fan, Zuhu Huang, Jun Hu
Neuropharmacology 2014 Dec;
PMID: 25486621 [PubMed - as supplied by publisher]

Environmental enrichment: Evidence for an unexpected therapeutic influence.
Robert J Kotloski, Thomas P Sutula
Exp Neurol 2014 Dec;
PMID: 25483395 [PubMed - as supplied by publisher]

Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.
Wagdy K B Khalil, Naglaa Assaf, Shaimaa A ElShebiney, Neveen A Salem
Neurochem Int 2014 Dec;
PMID: 25481089 [PubMed - as supplied by publisher]

810nm near-infrared light offers neuroprotection and improves locomotor activity in MPTP-treated mice.
Florian Reinhart, Nabil El Massri, Fannie Darlot, Napoleon Torres, Daniel M Johnstone, Claude Chabrol, Thomas Costecalde, Jonathan Stone, John Mitrofanis, Alim-Louis Benabid, Cécile Moro
Neurosci Res 2014 Nov;
PMID: 25462595 [PubMed - as supplied by publisher]

Differential Co-Expression between ?-Synuclein and IFN-? Signaling Genes across Development and in Parkinson's Disease.
Noa Liscovitch, Leon French
PLoS One 2014 ; 9(12):e115029
PMID: 25493648 [PubMed - as supplied by publisher]

Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease.
Bo Ren, Yu-Xin Zhang, Hong-Xia Zhou, Fa-Wei Sun, Zuo-Feng Zhang, Zi-Feng Wei, Cheng-Yun Zhang, Dao-Wen Si
J Neurol Sci 2014 Nov;
PMID: 25491263 [PubMed - as supplied by publisher]

Purification of ?-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity.
Eric S Luth, Tim Bartels, Ulf Dettmer, Nora C Kim, Dennis J Selkoe
Biochemistry 2014 Dec;
PMID: 25490121 [PubMed - as supplied by publisher]

"Localization of ?-synuclein in teleost central nervous system: Immunohistochemical and Western blot evidence by 3D5 monoclonal antibody in the common carp Cyprinus carpio"
Rosa Vaccaro, Mattia Toni, Arianna Casini, Giorgio Vivacqua, Shun Yu, Loredana D'Este, Carla Cioni
J Comp Neurol 2014 Dec;
PMID: 25488013 [PubMed - as supplied by publisher]

Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata.
Nguyen Tuan Hiep, Jaeyoung Kwon, Dong-Woo Kim, Bang Yeon Hwang, Hak-Ju Lee, Woongchon Mar, Dongho Lee
Phytochemistry 2014 Dec;
PMID: 25487308 [PubMed - as supplied by publisher]

Autophagy functions on EMT in gastrulation of avian embryo.
Wen-Hui Lu, Guang Wang, Yan Li, Shuai Li, Xiao-Yu Song, Xiao-Yu Wang, Manli Chuai, Kenneth Ka Ho Lee, Liu Cao, Xuesong Yang
Cell Cycle 2014 Sep; 13(17):2752-64
PMID: 25486362 [PubMed - as supplied by publisher]

TNF-? regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells.
Paresh Prajapati, Sripada Lakshmi, Kritarth Singh, Khyati Bhatelia, Rochika Singh, Rajesh Singh
Biochim Biophys Acta 2014 Dec;
PMID: 25481834 [PubMed - as supplied by publisher]

Blood ?-synuclein in agricultural pesticide handlers in central Washington State.
Susan Searles Nielsen, Harvey Checkoway, Jing Zhang, Jonathan N Hofmann, Matthew C Keifer, Michael Paulsen, Federico M Farin, Travis J Cook, Christopher D Simpson
Environ Res 2015 Jan; 136:75-81
PMID: 25460623 [PubMed - as supplied by publisher]

Differentiating between visual hallucination-free dementia with Lewy bodies and corticobasal syndrome on the basis of neuropsychology and perfusion single-photon emission computed tomography.
Michael R Misch, Sara Mitchell, Philip L Francis, Kayla Sherborn, Katayoun Meradje, Alicia A McNeely, Kie Honjo, Jiali Zhao, Christopher Jm Scott, Curtis B Caldwell, Lisa Ehrlich, Prathiba Shammi, Bradley J MacIntosh, Juan M Bilbao, Anthony E Lang, Sandra E Black, Mario Masellis
Alzheimers Res Ther 2014 ; 6(9):71
PMID: 25484929 [PubMed - as supplied by publisher]

The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis.
Paul C Donaghy, Ian G McKeith
Alzheimers Res Ther 2014 ; 6(4):46
PMID: 25484925 [PubMed - as supplied by publisher]

Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment.
Anne-Maria Poehler, Wei Xiang, Philipp Spitzer, Verena May, Holger Meixner, Edward Rockenstein, Oldriska Chutna, Tiago Outeiro, Juergen Winkler, Eliezer Masliah, Jochen Klucken
Autophagy 2014 Oct; :e36436
PMID: 25484190 [PubMed - as supplied by publisher]

Autophagy and ethanol neurotoxicity.
Jia Luo
Autophagy 2014 Nov; :0
PMID: 25484085 [PubMed - as supplied by publisher]

Spermidine protects against ?-synuclein neurotoxicity.
Sabrina Büttner, Filomena Broeskamp, Cornelia Sommer, Maria Markaki, Lukas Habernig, Ali Alavian-Ghavanini, Didac Carmona-Gutierrez, Tobias Eisenberg, Eva Michael, Guido Kroemer, Nektarios Tavernarakis, Stephan J Sigrist, Frank Madeo
Cell Cycle 2014 Oct; :0
PMID: 25483063 [PubMed - as supplied by publisher]

Astrocytic Dynamin-Like Protein 1 Regulates Neuronal Protection against Excitotoxicity in Parkinson Disease.
Jake G Hoekstra, Travis J Cook, Tessandra Stewart, Hayley Mattison, Max T Dreisbach, Zachary S Hoffer, Jing Zhang
Am J Pathol 2014 Dec;
PMID: 25482923 [PubMed - as supplied by publisher]

Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.
Gael Le Douaron, Fanny Schmidt, Majid Amar, Hanane Kadar, Lucila Debortoli, Alexandra Latini, Blandine Séon-Méniel, Laurent Ferrié, Patrick Pierre Michel, David Touboul, Alain Brunelle, Rita Raisman-Vozari, Bruno Figadère
Eur J Med Chem 2015 Jan; 89:467-79
PMID: 25462259 [PubMed - as supplied by publisher]

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.
Ming Gan, Simon Moussaud, Peizhou Jiang, Pamela J McLean
Neurobiol Aging 2014 Nov;
PMID: 25480524 [PubMed - as supplied by publisher]

Increased DJ-1 in Urine Exosome of Korean Males with Parkinson's Disease.
Dong Hwan Ho, Sanghak Yi, Hyemyung Seo, Ilhong Son, Wongi Seol
Biomed Res Int 2014 ; 2014:704678
PMID: 25478574 [PubMed - as supplied by publisher]

Oleanolic Acid enhances the beneficial effects of preconditioning on PC12 cells.
Babongile C Ndlovu, Willie M U Daniels, Musa V Mabandla
Parkinsons Dis 2014 ; 2014:929854
PMID: 25478286 [PubMed - as supplied by publisher]

Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias?
Greg J Elder, John-Paul Taylor
Alzheimers Res Ther 2014 ; 6(9):74
PMID: 25478032 [PubMed - as supplied by publisher]

Biomarkers in biological fluids for dementia with Lewy bodies.
Sebastian Schade, Brit Mollenhauer
Alzheimers Res Ther 2014 ; 6(5-8):72
PMID: 25478030 [PubMed - as supplied by publisher]

The cortico-pallidal projection: An additional route for cortical regulation of the basal ganglia circuitry.
Yoland Smith, Thomas Wichmann
Mov Disord 2014 Dec;
PMID: 25476969 [PubMed - as supplied by publisher]

Gut microbiota are related to Parkinson's disease and clinical phenotype.
Filip Scheperjans, Velma Aho, Pedro A B Pereira, Kaisa Koskinen, Lars Paulin, Eero Pekkonen, Elena Haapaniemi, Seppo Kaakkola, Johanna Eerola-Rautio, Marjatta Pohja, Esko Kinnunen, Kari Murros, Petri Auvinen
Mov Disord 2014 Dec;
PMID: 25476529 [PubMed - as supplied by publisher]

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering.
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai
PLoS Genet 2014 Dec; 10(12):e1004861
PMID: 25474007 [PubMed - as supplied by publisher]

Parkinson's disease as a member of Prion-like disorders.
Maria Eugenia Herva, Maria Grazia Spillantini
Virus Res 2014 Nov;
PMID: 25456401 [PubMed - as supplied by publisher]

102 supplementation with estradiol cypionate at the onset of a synchronized proestrus alters the uterine gene expression of suckled anestrous beef cows.
M F Sá Filho, G Pugliesi, A M Gonella-Diaza, M Sponchiado, M F Mendanha, R S Ramos, S C S Andrade, G Gasperin, M D Goissis, F S Mesquita, L L Coutinho, P S Baruselli, M Binelli
Reprod Fertil Dev 2014 Dec; 27(1):144
PMID: 25472151 [PubMed - as supplied by publisher]

Zirconium oxide ceramic foam: a promising supporting biomaterial for massive production of glial cell line-derived neurotrophic factor.
Zhong-Wei Liu, Wen-Qiang Li, Jun-Kui Wang, Xian-Cang Ma, Chen Liang, Peng Liu, Zheng Chu, Yong-Hui Dang
J Zhejiang Univ Sci B 2014 Dec; 15(12):1013-22
PMID: 25471830 [PubMed - as supplied by publisher]

Noninvasive Bioluminescence Imaging of ?-Synuclein Oligomerization in Mouse Brain Using Split Firefly Luciferase Reporters.
Sarah-Ann Aelvoet, Abdelilah Ibrahimi, Francesca Macchi, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
J Neurosci 2014 Dec; 34(49):16518-32
PMID: 25471588 [PubMed - as supplied by publisher]

Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays.
Sebastian Heinzel, Maike Gold, Christian Deuschle, Felix Bernhard, Walter Maetzler, Daniela Berg, Richard Dodel
PLoS One 2014 ; 9(12):e114566
PMID: 25470145 [PubMed - as supplied by publisher]

Ida-1, the Caenorhabditis elegans Orthologue of Mammalian Diabetes Autoantigen IA-2, Potentially Acts as a Common Modulator between Parkinson's Disease and Diabetes: Role of Daf-2/Daf-16 Insulin Like Signalling Pathway.
Soobiya Fatima, Rizwanul Haque, Pooja Jadiya, Shamsuzzama, Lalit Kumar, Aamir Nazir
PLoS One 2014 ; 9(12):e113986
PMID: 25469508 [PubMed - as supplied by publisher]

Induction of GADD45? protects M17 neuroblastoma cells against MPP*
Xiao-Feng Wang, Qing-Gan Zeng, Yan Zeng, Rong-Yong Man, Bing-Xun Lu, Yi-Feng Luo
IUBMB Life 2014 Dec;
PMID: 25469469 [PubMed - as supplied by publisher]

Brain-derived neurotrophic factor expression increases after enzyme replacement therapy in Gaucher disease.
Filippo Vairo, Fernanda Sperb-Ludwig, Matheus Wilke, Kristiane Michellin-Tirelli, Cristina Netto, Eurico Camargo Neto, Ida Vanessa Doederlein Schwartz
J Neuroimmunol 2014 Nov;
PMID: 25468270 [PubMed - as supplied by publisher]

Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.
Wenting Jia, Huamin Xu, Xixun Du, Hong Jiang, Junxia Xie
Neurobiol Aging 2014 Oct;
PMID: 25467637 [PubMed - as supplied by publisher]

Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous ?-synuclein fibrils.
Atsushi Tsujimura, Katsutoshi Taguchi, Yoshihisa Watanabe, Harutsugu Tatebe, Takahiko Tokuda, Toshiki Mizuno, Masaki Tanaka
Neurobiol Dis 2014 Oct; 73C:244-253
PMID: 25466281 [PubMed - as supplied by publisher]

The neuroprotective effect of erythropoietin on experimental Parkinson model in rats.
Oytun Erba?, Bilge Piri C?nar, Volkan Solmaz, Türker Cavu?o?lu, Utku Ate?
Neuropeptides 2014 Oct;
PMID: 25464888 [PubMed - as supplied by publisher]

REM sleep behaviour disorder: How useful is it for the differential diagnosis of parkinsonism?
Renato P Munhoz, Helio A Teive
Clin Neurol Neurosurg 2014 Dec; 127:71-4
PMID: 25459246 [PubMed - as supplied by publisher]

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1.
Richard G Carroll, Emilie Hollville, Seamus J Martin
Cell Rep 2014 Nov; 9(4):1538-53
PMID: 25456142 [PubMed - as supplied by publisher]

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson's Disease.
Chris M Woodard, Brian A Campos, Sheng-Han Kuo, Melissa J Nirenberg, Michael W Nestor, Matthew Zimmer, Eugene V Mosharov, David Sulzer, Hongyan Zhou, Daniel Paull, Lorraine Clark, Eric E Schadt, Sergio Pablo Sardi, Lee Rubin, Kevin Eggan, Mathew Brock, Scott Lipnick, Mahendra Rao, Stephen Chang, Aiqun Li, Scott A Noggle
Cell Rep 2014 Nov; 9(4):1173-82
PMID: 25456120 [PubMed - as supplied by publisher]

Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease.
Marianne Amalric
Curr Opin Pharmacol 2014 Nov; 20C:29-34
PMID: 25462289 [PubMed - as supplied by publisher]

Targeting glutamatergic synapses in Parkinson's disease.
Fabrizio Gardoni, Monica Di Luca
Curr Opin Pharmacol 2014 Nov; 20C:24-28
PMID: 25462288 [PubMed - as supplied by publisher]

Anti-fibrillation potency of caffeic acid against an antidepressant induced fibrillogenesis of human ?-synuclein: Implications for Parkinson's disease.
Naveed Ahmad Fazili, Aabgeena Naeem
Biochimie 2014 Nov;
PMID: 25461276 [PubMed - as supplied by publisher]

?-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9).
Guillaume Daniel, Alessandra Musso, Elpida Tsika, Aris Fiser, Liliane Glauser, Olga Pletnikova, Bernard L Schneider, Darren J Moore
Neurobiol Dis 2014 Oct; 73C:229-243
PMID: 25461191 [PubMed - as supplied by publisher]

M. paratuberculosis and Parkinson's disease - Is this a trigger.
Coad Thomas Dow
Med Hypotheses 2014 Oct; 83(6):709-712
PMID: 25459140 [PubMed - as supplied by publisher]

Do genetic factors protect against Parkinson's disease? What I can learn from my healthy grandma.
Khashayar Dashtipour
Med Hypotheses 2014 Oct; 83(6):637-639
PMID: 25459129 [PubMed - as supplied by publisher]

Peripheral nervous system involvement in Parkinson's disease: Evidence and controversies.
C Comi, L Magistrelli, G D Oggioni, M Carecchio, T Fleetwood, R Cantello, F Mancini, A Antonini
Parkinsonism Relat Disord 2014 Oct; 20(12):1329-1334
PMID: 25457816 [PubMed - as supplied by publisher]

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.
Jose A Morales-Garcia, Diana Aguilar-Morante, Elena Hernandez-Encinas, Sandra Alonso-Gil, Carmen Gil, Ana Martinez, Angel Santos, Ana Perez-Castillo
Neurobiol Aging 2014 Oct;
PMID: 25457552 [PubMed - as supplied by publisher]