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Featured Research

What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

Impulse Control Disorder

Vision/Visual hallucination



Orthostatic Hypotension


Imaging Studies

Clinical Studies



Treating Parkinson’s

Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

Deep Brain Stimulation

Physical, Occupational and Speech Therapy



Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

Hospice/End of Life/Palliative Care

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?-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease.
Joel J Credle, Patrick A Forcelli, Michael Delannoy, Adam W Oaks, Eva Permaul, Deborah L Berry, Valerie Duka, Jonathan Wills, Anita Sidhu
Neurobiol Dis 2015 Feb;
PMID: 25725420 [PubMed - as supplied by publisher]

Chaperone Mediated Autophagy to the Rescue: A New-Fangled Target for the Treatment of Neurodegenerative Diseases.
Maria Xilouri, Leonidas Stefanis
Mol Cell Neurosci 2015 Feb;
PMID: 25724482 [PubMed - as supplied by publisher]

Neuroprotective Effect of Thalidomide on MPTP-induced Toxicity.
Guadalupe Palencia, Esperanza García, Laura Osorio-Rico, Cristina Trejo-Solís, Angel Escamilla-Ramírez, Julio Sotelo
Neurotoxicology 2015 Feb;
PMID: 25724264 [PubMed - as supplied by publisher]

In Vitro Studies in VCP-Associated Multisystem Proteinopathy Suggest Altered Mitochondrial Bioenergetics.
Angèle Nalbandian, Katrina J Llewellyn, Arianna Gomez, Naomi Walker, Hailing Su, Andrew Dunnigan, Marilyn Chwa, Jouni Vesa, M Cristina Kenney, Virginia E Kimonis
Mitochondrion 2015 Feb;
PMID: 25724235 [PubMed - as supplied by publisher]

Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat.
Ling-Na Han, Li Zhang, Li-Bo Li, Yi-Na Sun, Yong Wang, Li Chen, Yuan Guo, Yu-Ming Zhang, Qiao-Jun Zhang, Jian Liu
Neuropharmacology 2015 Feb; 93C:68-79
PMID: 25661701 [PubMed - as supplied by publisher]

Overview of Mouse Models of Parkinson's Disease.
Wojciech Bobela, Lu Zheng, Bernard L Schneider
Curr Protoc Mouse Biol 2014; 4(3):121-139
PMID: 25723963 [PubMed - as supplied by publisher]

From Neurodegeneration to Brain Health: An Integrated Approach.
Robert B Petersen, Frances M Lissemore, Brian Appleby, Neelum Aggarwal, Richard Boyatzis, Gemma Casadesus, Jeff Cummings, Anthony Jack, George Perry, Jiri Safar, Martha Sajatovic, Witold Surewicz, Yanming Wang, Peter Whitehouse, Alan Lerner
J Alzheimers Dis 2015 Feb;
PMID: 25720413 [PubMed - as supplied by publisher]

Postmortem Alzheimer's Disease Hippocampi Show Oxidative Phosphorylation Gene Expression Opposite that of Isolated Pyramidal Neurons.
Ann C Rice, Amy C Ladd, James P Bennett Jr
J Alzheimers Dis 2015 Feb;
PMID: 25720395 [PubMed - as supplied by publisher]

Cancer and Dementia: It's Complicated.
Mary Ganguli
Alzheimer Dis Assoc Disord 2015 Feb;
PMID: 25710132 [PubMed - as supplied by publisher]

The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders.
Jian Guan, Paul Harris, Margaret Brimble, Yang Lei, Jun Lu, Yang Yang, Alistair J Gunn
Expert Opin Ther Targets 2015 Feb; :1-9
PMID: 25652713 [PubMed - as supplied by publisher]

Nitric Oxide Induction of Parkin Translocation in PTEN-Induced Putative Kinase 1 (PINK1) Deficiency: Functional Role of Neuronal Nitric Oxide Synthase During Mitophagy.
Ji-Young Han, Min-Ji Kang, Kyung-Hee Kim, Pyung-Lim Han, Hyun-Seok Kim, Ji-Young Ha, Jin H Son
J Biol Chem 2015 Feb;
PMID: 25716315 [PubMed - as supplied by publisher]

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models.
Qingshan Wang, Li Qian, Shih-Heng Chen, Chun-Hsien Chu, Belinda Wilson, Esteban Oyarzabal, Syed Ali, Bonnie Robinson, Deepa Rao, Jau-Shyong Hong
Brain 2015 Feb;
PMID: 25716193 [PubMed - as supplied by publisher]

Neurocytoprotective Effects of Aliphatic Hydroxamates from Lovastatin, a Secondary Metabolite from Monascus-Fermented Red Mold Rice, in 6-Hydroxydopamine (6-OHDA)-Treated Nerve Growth Factor (NGF)-Differentiated PC12 Cells.
Chien-Min Lin, Yi-Tzu Lin, Rong-Dih Lin, Wei-Jan Huang, Mei-Hsien Lee
ACS Chem Neurosci 2015 Feb;
PMID: 25692332 [PubMed - as supplied by publisher]

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease.
Emma L James, Ryan D Michalek, Gayani N Pitiyage, Alice M de Castro, Katie S Vignola, Janice Jones, Robert P Mohney, Edward D Karoly, Stephen S Prime, Eric Kenneth Parkinson
J Proteome Res 2015 Feb;
PMID: 25690941 [PubMed - as supplied by publisher]

Chemogenomic Profiling of Endogenous PARK2 Expression Using a Genome-Edited Coincidence Reporter.
Samuel A Hasson, Adam I Fogel, Chunxin Wang, Ryan MacArthur, Rajarshi Guha, Sabrina Heman-Ackah, Scott Martin, Richard J Youle, James Inglese
ACS Chem Biol 2015 Feb;
PMID: 25689131 [PubMed - as supplied by publisher]

Extracellular ?-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane.
Carla R Pacheco, Camila N Morales, Alejandra E Ramírez, Francisco J Muñoz, Scarlet S Gallegos, Pablo A Caviedes, Luis G Aguayo, Carlos M Opazo
J Neurochem 2015 Feb;
PMID: 25669123 [PubMed - as supplied by publisher]

Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson's disease.
B Macchi, D R Paola, F Marino-Merlo, M R Felice, S Cuzzocrea, A Mastino
CNS Neurol Disord Drug Targets 2015 Feb;
PMID: 25714978 [PubMed - as supplied by publisher]

New kid on the block: Does histamine get along with inflammation in amyotrophic lateral sclerosis?
C Volonté, C Parisi, S Apolloni
CNS Neurol Disord Drug Targets 2015 Feb;
PMID: 25714965 [PubMed - as supplied by publisher]

?-amyloid and ?-synuclein cooperate to block SNARE-dependent vesicle fusion.
Bong-Kyu Choi, Jae-Yeol Kim, Moon-Yong Cha, Inhee Mook-Jung, Yeon-Kyun Shin, Nam Ki Lee
Biochemistry 2015 Feb;
PMID: 25714795 [PubMed - as supplied by publisher]

Comparison of the diagnostic performance of H/M ratio between early and delayed phases for Lewy body disease.
Yasuki Maruyama, Takayuki Yamada, Kenji Murakami, Reiko Kumano
Nucl Med Commun 2015 Feb;
PMID: 25714666 [PubMed - as supplied by publisher]

Evaluation of an alpha synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson's disease.
Kenneth E Ugen, Xiaoyang Lin, Ge Bai, Zhanhua Liang, Jianfeng Cai, Kunyun Li, Shijie Song, Chuanhai Cao, Juan Sanchez-Ramos
Hum Vaccin Immunother 2015 Feb; :0
PMID: 25714663 [PubMed - as supplied by publisher]

Long-term donepezil use for dementia with Lewy bodies: results from an open-label extension of Phase III trial.
Etsuro Mori, Manabu Ikeda, Reiko Nagai, Kazutaka Matsuo, Masaki Nakagawa, Kenji Kosaka
Alzheimers Res Ther 2015 ; 7(1):5
PMID: 25713600 [PubMed - as supplied by publisher]

Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial.
Manabu Ikeda, Etsuro Mori, Kazutaka Matsuo, Masaki Nakagawa, Kenji Kosaka
Alzheimers Res Ther 2015 ; 7(1):4
PMID: 25713599 [PubMed - as supplied by publisher]

Occupational exposures and Parkinson's disease mortality in a prospective Dutch cohort.
Maartje Brouwer, Tom Koeman, Piet A van den Brandt, Hans Kromhout, Leo J Schouten, Susan Peters, Anke Huss, Roel Vermeulen
Occup Environ Med 2015 Feb;
PMID: 25713156 [PubMed - as supplied by publisher]

NADH fluorescence lifetime is an endogenous reporter of ?-synuclein aggregation in live cells.
Nicoletta Plotegher, Chiara Stringari, Sohail Jahid, Marina Veronesi, Stefania Girotto, Enrico Gratton, Luigi Bubacco
FASEB J 2015 Feb;
PMID: 25713058 [PubMed - as supplied by publisher]

Parkin Structure and Function.
Marjan Seirafi, Guennadi Kozlov, Kalle Gehring
FEBS J 2015 Feb;
PMID: 25712550 [PubMed - as supplied by publisher]

1-[2-(4-Benzyloxyphenoxy)Ethyl]Imidazole inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease.
Jin Yong Chung, Ji Won Lee, Choon Ho Ryu, Hye Kyung Min, Yeo Jin Yoon, Mi Jung Lim, Cheol Hyoung Park
J Neurosci Res 2015 Feb;
PMID: 25711470 [PubMed - as supplied by publisher]

New concepts in nutraceuticals as alternative for pharmaceuticals.
Hamid Nasri, Azar Baradaran, Hedayatollah Shirzad, Mahmoud Rafieian-Kopaei
Int J Prev Med 2014 Dec; 5(12):1487-99
PMID: 25709784 [PubMed - as supplied by publisher]

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.
Hiromi Yamazaki, Kunikazu Tanji, Koichi Wakabayashi, Shin Matsuura, Ken Itoh
Pathol Int 2015 Feb;
PMID: 25707882 [PubMed - as supplied by publisher]

Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-?B-dependent inflammation process in a mouse model of Parkinson's disease.
Eduardo Anitua, Consuelo Pascual, Rocio Pérez-Gonzalez, Gorka Orive, Eva Carro
J Control Release 2015 Feb;
PMID: 25702964 [PubMed - as supplied by publisher]

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders.
Natalia P Mena, Pamela J Urrutia, Fernanda Lourido, Carlos M Carrasco, Marco T Núñez
Mitochondrion 2015 Feb; 21C:92-105
PMID: 25667951 [PubMed - as supplied by publisher]

Irisflorentin improves ?-synuclein accumulation and attenuates 6-OHDA-induced dopaminergic neuron degeneration, implication for Parkinson's disease therapy.
Yue-Mi Chen, Shih-Ping Liu, Hsin-Lien Lin, Ming-Chia Chan, Yen-Chuan Chen, Yu-Ling Huang, Min-Chen Tsai, Ru-Huei Fu
Biomedicine (Taipei) 2015; 5(1):4
PMID: 25705584 [PubMed - as supplied by publisher]

Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease.
Huaibin Cai, Guoxiang Liu, Lixin Sun, Jinhui Ding
Transl Neurodegener 2014 ; 3:27
PMID: 25705376 [PubMed - as supplied by publisher]

Binding Interactions of Agents That Alter ?-Synuclein Aggregation.
K Sivanesam, A Byrne, M Bisaglia, L Bubacco, N Andersen
RSC Adv 2015; 5(15):11577-11590
PMID: 25705374 [PubMed - as supplied by publisher]

Apoptotic mediators are upregulated in the skeletal muscle of chronic/progressive mouse model of Parkinson's disease.
Nour S Erekat
Anat Rec (Hoboken) 2015 Feb;
PMID: 25704481 [PubMed - as supplied by publisher]

The endosomal pathway in Parkinson's disease.
Rebecca M Perrett, Zoi Alexopoulou, George K Tofaris
Mol Cell Neurosci 2015 Feb;
PMID: 25701813 [PubMed - as supplied by publisher]

Pathologic and therapeutic implications for the cell biology of parkin.
Rakshita A Charan, Matthew J LaVoie
Mol Cell Neurosci 2015 Feb;
PMID: 25697646 [PubMed - as supplied by publisher]

Induction of NQO1 and Neuroprotection by a Novel Compound KMS04014 in Parkinson's Disease Models.
Hyo Jin Son, Ji Hyun Choi, Ji Ae Lee, Dong Jin Kim, Kye Jung Shin, Onyou Hwang
J Mol Neurosci 2015 Feb;
PMID: 25702135 [PubMed - as supplied by publisher]

Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes.
Giovanni Smaldone, Donatella Diana, Loredano Pollegioni, Sonia Di Gaetano, Roberto Fattorusso, Emilia Pedone
FEBS Lett 2015 Feb;
PMID: 25701590 [PubMed - as supplied by publisher]

USP8 and PARK2/parkin-mediated mitophagy.
Thomas M Durcan, Edward A Fon
Autophagy 2015 Feb; :0
PMID: 25700639 [PubMed - as supplied by publisher]

The relation between ?-synuclein and microglia in Parkinson's disease: Recent developments.
V Sanchez-Guajardo, N Tentillier, M Romero-Ramos
Neuroscience 2015 Feb;
PMID: 25684748 [PubMed - as supplied by publisher]

Systems biology analysis of the proteomic alterations induced by MPP(+), a Parkinson's disease-related mitochondrial toxin.
Chiara Monti, Heather Bondi, Andrea Urbani, Mauro Fasano, Tiziana Alberio
Front Cell Neurosci 2015 ; 9:14
PMID: 25698928 [PubMed - as supplied by publisher]

Could astrocytes be the primary target of an offending agent causing the primary degenerative diseases of the human central nervous system? A hypothesis.
Roberto E Sica
Med Hypotheses 2015 Feb;
PMID: 25697116 [PubMed - as supplied by publisher]

Severe bradycardia in general anaesthesia in a patient treated with cholinesterase inhibitors for dementia.
Marlene Ersgaard Jellinge, Alan Hamilton Ferguson
Ugeskr Laeger 2015 Feb; 177(7)
PMID: 25697071 [PubMed - as supplied by publisher]

Glutathione transferases and neurodegenerative diseases.
Anna Paola Mazzetti, Maria Carmela Fiorile, Alessandra Primavera, Mario Lo Bello
Neurochem Int 2015 Feb; 82C:10-18
PMID: 25661512 [PubMed - as supplied by publisher]

Protein corona composition of gold nanoparticles/nanorods affects amyloid beta fibrillation process.
Somayeh Mirsadeghi, Rassoul Dinarvand, Mohammad Hossein Ghahremani, Mohammad Reza Hormozi-Nezhad, Zohreh Mahmoudi, Mohammad Javad Hajipour, Fatemeh Atyabi, Mahdi Ghavami, Morteza Mahmoudi
Nanoscale 2015 Feb;
PMID: 25695421 [PubMed - as supplied by publisher]

Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation.
Gregory Robison, Brendan Sullivan, Jason R Cannon, Yulia Pushkar
Metallomics 2015 Feb;
PMID: 25695229 [PubMed - as supplied by publisher]

Targeting histone deacetylases: a novel approach in Parkinson's disease.
Sorabh Sharma, Rajeev Taliyan
Parkinsons Dis 2015 ; 2015:303294
PMID: 25694842 [PubMed - as supplied by publisher]

Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.
R Nisar, P S Hanson, L He, R W Taylor, P G Blain, C M Morris
Arch Toxicol 2015 Feb;
PMID: 25693864 [PubMed - as supplied by publisher]

Resveratrol Protects from Toxin-Induced Parkinsonism: Plethora of Proofs Hitherto Petty Translational Value.
Mohd Sami Ur Rasheed, Manish Kumar Tripathi, Abhishek Kumar Mishra, Saurabh Shukla, Mahendra Pratap Singh
Mol Neurobiol 2015 Feb;
PMID: 25691456 [PubMed - as supplied by publisher]

Compromised MAPK signaling in human diseases: an update.
Eun Kyung Kim, Eui-Ju Choi
Arch Toxicol 2015 Feb;
PMID: 25690731 [PubMed - as supplied by publisher]

Prodromal dementia with Lewy bodies.
Hiroshige Fujishiro, Shinichiro Nakamura, Kiyoshi Sato, Eizo Iseki
Geriatr Gerontol Int 2015 Feb;
PMID: 25690399 [PubMed - as supplied by publisher]

Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study.
Bernard Ravina, Shirley Eberly, David Oakes, Anthony E Lang, Vince Dodelet, Pieter Roos, Jennifer Harman, Ira Shoulson, Hyman M Schipper
Biomark Med 2015 Feb; 9(2):89-97
PMID: 25689898 [PubMed - as supplied by publisher]

Single Fibril Growth Kinetics of ?-Synuclein.
Michael M Wördehoff, Oliver Bannach, Hamed Shaykhalishahi, Andreas Kulawik, Stephanie Schiefer, Dieter Willbold, Wolfgang Hoyer, Eva Birkmann
J Mol Biol 2015 Feb;
PMID: 25659910 [PubMed - as supplied by publisher]

Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: A meta-analysis.
Wei Han, Yingli Liu, Yingjun Mi, Jing Zhao, Dianwu Liu, Qingbao Tian
Am J Med Genet B Neuropsychiatr Genet 2015 Mar; 168(2):123-34
PMID: 25656566 [PubMed - as supplied by publisher]

Targeting cyclin D3/CDK6 activity for treatment of Parkinson's disease.
Carolina Alquézar, Estíbaliz Barrio, Noemí Esteras, Ana de la Encarnación, Fernando Bartolomé, José A Molina, Ángeles Martín-Requero
J Neurochem 2015 Feb;
PMID: 25689470 [PubMed - as supplied by publisher]

Gut/brain axis and the microbiota.
Emeran A Mayer, Kirsten Tillisch, Arpana Gupta
J Clin Invest 2015 Feb;
PMID: 25689247 [PubMed - as supplied by publisher]

A Randomized, Placebo-Controlled Trial of AFQ056 for the Treatment of Chorea in Huntington's Disease.
Ralf Reilmann, Marie-Laure Rouzade-Dominguez, Carsten Saft, Sigurd D Süssmuth, Josef Priller, Anne Rosser, Hugh Rickards, Ludger Schöls, Nicole Pezous, Fabrizio Gasparini, Donald Johns, Georg Bernhard Landwehrmeyer, Baltazar Gomez-Mancilla
Mov Disord 2015 Feb;
PMID: 25689146 [PubMed - as supplied by publisher]

Dietary Factors in the Etiology of Parkinson's Disease.
Zeynep S Agim, Jason R Cannon
Biomed Res Int 2015; 2015:672838
PMID: 25688361 [PubMed - as supplied by publisher]

Multiple system atrophy: the application of genetics in understanding etiology.
Monica Federoff, Lucia V Schottlaender, Henry Houlden, Andrew Singleton
Clin Auton Res 2015 Feb;
PMID: 25687905 [PubMed - as supplied by publisher]

Combined Oral Supplementation of Fish Oil and Quercetin Enhances Neuroprotection in a Chronic Rotenone Rat Model: Relevance to Parkinson's Disease.
K M Denny Joseph, Muralidhara
Neurochem Res 2015 Feb;
PMID: 25687767 [PubMed - as supplied by publisher]

Interferon-?-Induced Neurotoxicity of Human Astrocytes.
S Hashioka, E G McGeer, T Miyaoka, R Wake, J Horiguchi, P L McGeer
CNS Neurol Disord Drug Targets 2015 Feb;
PMID: 25687700 [PubMed - as supplied by publisher]

Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson?s disease.
Shaoxia Wang, Haoran Jing, Hongyun Yang, Zhidong Liu, Hong Guo, Lijuan Chai, Limin Hu
J Ethnopharmacol 2015 Feb;
PMID: 25666429 [PubMed - as supplied by publisher]

Parkinson risk in idiopathic REM sleep behavior disorder: Preparing for neuroprotective trials.
Ronald B Postuma, Jean-Francois Gagnon, Josie-Anne Bertrand, Daphné Génier Marchand, Jacques Y Montplaisir
Neurology 2015 Feb;
PMID: 25681454 [PubMed - as supplied by publisher]

Reduced cortical innervation of the subthalamic nucleus in MPTP-treated parkinsonian monkeys.
Abraham Mathai, Yuxian Ma, Jean-Francois Paré, Rosa M Villalba, Thomas Wichmann, Yoland Smith
Brain 2015 Feb;
PMID: 25681412 [PubMed - as supplied by publisher]

Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition.
Jorge Antolio Dominguez-Bautista, Michael Klinkenberg, Nadine Brehm, Mahalakshmi Subramaniam, Beatrice Kern, Jochen Roeper, Georg Auburger, Marina Jendrach
Eur J Cell Biol 2015 Jan;
PMID: 25681212 [PubMed - as supplied by publisher]

The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated ?-Synuclein Dimerisation.
Su Ling Leong, Mark G Hinds, Andrea R Connor, David P Smith, Eva Illes-Toth, Chi L L Pham, Kevin J Barnham, Roberto Cappai
PLoS One 2015 ; 10(2):e0116497
PMID: 25679387 [PubMed - as supplied by publisher]

The S-Nitrosylation Status of PCNA Localized in Cytosol Impacts the Apoptotic Pathway in a Parkinson's Disease Paradigm.
Liang Yin, Yingying Xie, Songyue Yin, Xiaolei Lv, Jia Zhang, Zezong Gu, Haidan Sun, Siqi Liu
PLoS One 2015 ; 10(2):e0117546
PMID: 25675097 [PubMed - as supplied by publisher]

Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson's disease.
Xiu-Qi Bao, Liang-Yu Wu, Xiao-Liang Wang, Hua Sun, Dan Zhang
Naunyn Schmiedebergs Arch Pharmacol 2015 Feb;
PMID: 25678053 [PubMed - as supplied by publisher]

Parkinson's disease as a result of aging.
Manuel Rodriguez, Clara Rodriguez-Sabate, Ingrid Morales, Alberto Sanchez, Magdalena Sabate
Aging Cell 2015 Feb;
PMID: 25677794 [PubMed - as supplied by publisher]

Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization.
Yujeong Lee, Hee Ra Park, Hye Jeong Chun, Jaewon Lee
J Neurosci Res 2015 Feb;
PMID: 25677261 [PubMed - as supplied by publisher]

Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies.
Urmi Sengupta, Marcos J Guerrero-Muñoz, Diana L Castillo-Carranza, Cristian A Lasagna-Reeves, Julia E Gerson, Adriana A Paulucci-Holthauzen, Shashirekha Krishnamurthy, Malika Farhed, George R Jackson, Rakez Kayed
Biol Psychiatry 2015 Jan;
PMID: 25676491 [PubMed - as supplied by publisher]

Validity of the MPTP-Treated Mouse as a Model for Parkinson's Disease.
Cornelius J H M Klemann, Gerard J M Martens, Geert Poelmans, Jasper E Visser
Mol Neurobiol 2015 Feb;
PMID: 25676140 [PubMed - as supplied by publisher]

MicroRNA Association with Synucleinopathy Conversion in REM Behavior Disorder.
Rubén Fernández-Santiago, Alex Iranzo, Carles Gaig, Mónica Serradell, Manel Fernández, Eduardo Tolosa, Joan Santamaría, Mario Ezquerra
Ann Neurol 2015 Feb;
PMID: 25675938 [PubMed - as supplied by publisher]

The association of Parkinson's disease pathogenesis with inflammation].
Shinji Saiki
Rinsho Shinkeigaku 2014 ; 54(12):1125-7
PMID: 25672726 [PubMed - as supplied by publisher]

Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.
Julie Vallortigara, Sindhoo Rangarajan, David Whitfield, Amani Alghamdi, David Howlett, Tibor Hortobágyi, Mary Johnson, Johannes Attems, Clive Ballard, Alan Thomas, John O'Brien, Dag Aarsland, Paul Francis
F1000Res 2014 ; 3:108
PMID: 25671083 [PubMed - as supplied by publisher]

Trends in mitochondrial therapeutics for neurological disease.
Ana Leitão-Rocha, Pedro Guedes-Dias, Brígida R Pinho, Jorge M A Oliveira
Curr Med Chem 2015 Feb;
PMID: 25666789 [PubMed - as supplied by publisher]

The E3 Ubiquitin ligase parkin is recruited to the 26S proteasome via the proteasomal ubiquitin receptor Rpn13.
Miguel A Aguileta, Jelena Korac, Thomas M Durcan, Jean-François Trempe, Michael Haber, Kalle Gehring, Suzanne Elsasser, Oliver Waidmann, Edward A Fon, Koraljka Husnjak
J Biol Chem 2015 Feb;
PMID: 25666615 [PubMed - as supplied by publisher]

Angiotensin II Triggers Apoptosis Via Enhancement of NADPH Oxidase-Dependent Oxidative Stress in a Dopaminergic Neuronal Cell Line.
Hong-Rui Zhao, Teng Jiang, You-Yong Tian, Qing Gao, Zhang Li, Yang Pan, Liang Wu, Jie Lu, Ying-Dong Zhang
Neurochem Res 2015 Feb;
PMID: 25666589 [PubMed - as supplied by publisher]

Peptides as Modulators of ?-Synuclein Aggregation.
Matteo Gazziero, Maria De Marchi, Giada Massalongo, Anna Marchiani, Ida Autero, Isabella Tessari, Luigi Bubacco, Andrea Calderan, Paolo Ruzza
Protein Pept Lett 2015 Feb;
PMID: 25666040 [PubMed - as supplied by publisher]

Beneficial antioxidant properties of betaine against oxidative stress mediated by levodopa/benserazide in the brain of rats.
Masoud Alirezaei, Zeynab Khoshdel, Omid Dezfoulian, Marzyeh Rashidipour, Vahideh Taghadosi
J Physiol Sci 2015 Feb;
PMID: 25665954 [PubMed - as supplied by publisher]

Biophysics of ?-synuclein induced membrane remodelling.
Zheng Shi, Jonathan N Sachs, Elizabeth Rhoades, Tobias Baumgart
Phys Chem Chem Phys 2015 Feb;
PMID: 25665896 [PubMed - as supplied by publisher]

Parkinson disease with REM sleep behavior disorder: Features, ?-synuclein, and inflammation.
Yang Hu, Shu-Yang Yu, Li-Jun Zuo, Chen-Jie Cao, Fang Wang, Ze-Jie Chen, Yang Du, Teng-Hong Lian, Ya-Jie Wang, Piu Chan, Sheng-Di Chen, Xiao-Min Wang, Wei Zhang
Neurology 2015 Feb;
PMID: 25663225 [PubMed - as supplied by publisher]

Amino acid supplementation in l-dopa treated Parkinson's disease patients.
A Cucca, S Mazzucco, A Bursomanno, L Antonutti, F G Di Girolamo, G Pizzolato, N Koscica, G L Gigli, M Catalan, G Biolo
Clin Nutr 2014 Dec;
PMID: 25660414 [PubMed - as supplied by publisher]

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an ?-synuclein-based rat model for Parkinson's disease.
Anke Van der Perren, Francesca Macchi, Jaan Toelen, Marianne S Carlon, Michael Maris, Henriette de Loor, Dirk R J Kuypers, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2015 Jan;
PMID: 25660193 [PubMed - as supplied by publisher]

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric ?-Synuclein.
Cristine Betzer, A James Movius, Min Shi, Wei-Ping Gai, Jing Zhang, Poul Henning Jensen
PLoS One 2015 ; 10(2):e0116473
PMID: 25659148 [PubMed - as supplied by publisher]

Anti-Human ?-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-?-Synuclein Rat Model of Parkinson's Disease.
Md Shahaduzzaman, Kevin Nash, Charles Hudson, Masroor Sharif, Bethany Grimmig, Xiaoyang Lin, Ge Bai, Hui Liu, Kenneth E Ugen, Chuanhai Cao, Paula C Bickford
PLoS One 2015 ; 10(2):e0116841
PMID: 25658425 [PubMed - as supplied by publisher]

Camelid single-domain antibody fragments: Uses and prospects to investigate protein misfolding and aggregation, and to treat diseases associated with these phenomena.
Coralie Pain, Janice Dumont, Mireille Dumoulin
Biochimie 2015 Feb;
PMID: 25656912 [PubMed - as supplied by publisher]

Deep brain light stimulation effects on glutamate and dopamine concentration.
Jinn-Rung Kuo, Shih-Shian Lin, Janelle Liu, Shih-How Chen, Chung-Chin Chio, Jhi-Joung Wang, Jia-Ming Liu
Biomed Opt Express 2015 Jan; 6(1):23-31
PMID: 25657871 [PubMed - as supplied by publisher]

The Parkinson's Disease Mutant E46K Enhances Alpha-Synuclein Phosphorylation in Mammalian Cell-Lines, in Yeast and In Vivo.
Martial Mbefo, Mohamed-Bilal Fares, Katerina Paleologou, Abid Oueslati, Guowei Yin, Sanda Tenreiro, Madalena Pinto, Tiago Outeiro, Markus Zweckstetter, Eliezer Masliah, Hilal A Lashuel
J Biol Chem 2015 Feb;
PMID: 25657004 [PubMed - as supplied by publisher]

Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats.
Jun Wang, Mingxia Bi, Junxia Xie
Cell Mol Neurobiol 2015 Feb;
PMID: 25656940 [PubMed - as supplied by publisher]

Balance Dysfunction in Parkinson's Disease.
Steno Rinalduzzi, Carlo Trompetto, Lucio Marinelli, Alessia Alibardi, Paolo Missori, Francesco Fattapposta, Francesco Pierelli, Antonio Currà
Biomed Res Int 2015; 2015:434683
PMID: 25654100 [PubMed - as supplied by publisher]

Is Parkinson's disease truly a prion-like disorder? An appraisal of current evidence.
Aneesha Chauhan, Alexander F Jeans
Neurol Res Int 2015 ; 2015:345285
PMID: 25653875 [PubMed - as supplied by publisher]

Environmental modulations of the number of midbrain dopamine neurons in adult mice.
Doris Tomas, Augustinus H Prijanto, Emma L Burrows, Anthony J Hannan, Malcolm K Horne, Tim D Aumann
J Vis Exp 2015 ; (95)
PMID: 25650697 [PubMed - as supplied by publisher]

Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer's disease.
Elijah Mak, Li Su, Guy B Williams, Rosie Watson, Michael J Firbank, Andrew M Blamire, John T O'Brien
Neurobiol Aging 2015 Jan;
PMID: 25649023 [PubMed - as supplied by publisher]

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease.
Eleonora Carboni, Paul Lingor
Metallomics 2015 Feb;
PMID: 25648629 [PubMed - as supplied by publisher]

Adipose Tissue Derived Stem Cells in Neural Regenerative Medicine.
Da-Chuan Yeh, Tzu-Min Chan, Horng-Jyh Harn, Tzyy-Wen Chiou, Hsin-Shui Chen, Zung-Sheng Lin, Shinn-Zong Lin
Cell Transplant 2015 Feb;
PMID: 25647067 [PubMed - as supplied by publisher]

Free radicals: properties, sources, targets, and their implication in various diseases.
Alugoju Phaniendra, Dinesh Babu Jestadi, Latha Periyasamy
Indian J Clin Biochem 2015 Jan; 30(1):11-26
PMID: 25646037 [PubMed - as supplied by publisher]

Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease.
Renu Wadhwa, Jihoon Ryu, Hyo Min Ahn, Nishant Saxena, Anupama Chaudhary, Chae-Ok Yun, Sunil C Kaul
J Biol Chem 2015 Feb;
PMID: 25645922 [PubMed - as supplied by publisher]

Rotenone Decreases Intracellular Aldehyde Dehydrogenase Activity: Implications for the Pathogenesis of Parkinson Disease.
David S Goldstein, Patti Sullivan, Adele Cooney, Yunden Jinsmaa, Irwin J Kopin, Yehonatan Sharabi
J Neurochem 2015 Jan;
PMID: 25645689 [PubMed - as supplied by publisher]