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Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration.
Zhuo Luan, Keith Reddig, Hong-Sheng Li
Exp Neurol 2014 Sep; 261C:791-801
PMID: 25205229 [PubMed - as supplied by publisher]


The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration.
David Heras-Sandoval, Jazmin M Pérez-Rojas, Jacqueline Hernández-Damián, José Pedraza-Chaverri
Cell Signal 2014 Aug; 26(12):2694-2701
PMID: 25173700 [PubMed - as supplied by publisher]


MicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA.
Doo Chul Choi, Yoon-Jee Chae, Savan Kabaria, Amrita Datta Chaudhuri, Mohit Raja Jain, Hong Li, M Maral Mouradian, Eunsung Junn
J Neurosci 2014 Sep; 34(38):12725-37
PMID: 25232110 [PubMed - as supplied by publisher]


Interplay between sumoylation and phosphorylation for protection against alpha-synuclein inclusions.
Hedieh Shahpasandzadeh, Blagovesta Popova, Alexandra Kleinknecht, Paul E Fraser, Tiago F Outeiro, Gerhard H Braus
J Biol Chem 2014 Sep;
PMID: 25231978 [PubMed - as supplied by publisher]


Effect of endogenous Hsp104 chaperone in yeast models of sporadic and familial Parkinson's disease.
Vamshidhar R Gade, Jay Kardani, Ipsita Roy
Int J Biochem Cell Biol 2014 Aug; 55C:87-92
PMID: 25161148 [PubMed - as supplied by publisher]


Regulatory Cascade of Neuronal Loss and Glucose Metabolism.
M Hassan, S A Sehgal, S Rashid
CNS Neurol Disord Drug Targets 2014 Sep;
PMID: 25230224 [PubMed - as supplied by publisher]


Ignored Avenues in Alpha-Synuclein Associated Proteopathy.
R K Chowhan, S Mittal, T A Dar, M A Kamal, L R Singh
CNS Neurol Disord Drug Targets 2014 Sep;
PMID: 25230221 [PubMed - as supplied by publisher]


Effect of monocrotophos, an organophosphorus insecticide, on the striatal dopaminergic system in a mouse model of Parkinson's disease.
Shaheen Jafri Ali, Padmanabhan Sharda Rajini
Toxicol Ind Health 2014 Sep;
PMID: 25227224 [PubMed - as supplied by publisher]


Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study.
Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Leslie A Scarffe, Valina L Dawson, Owen A Ross, Wolfdieter Springer, Ted M Dawson, Zbigniew K Wszolek
Parkinsonism Relat Disord 2014 Sep;
PMID: 25226871 [PubMed - as supplied by publisher]


Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
Elpida Tsika, Meghna Kannan, Caroline Shi-Yan Foo, Dustin Dikeman, Liliane Glauser, Sandra Gellhaar, Dagmar Galter, Graham W Knott, Ted M Dawson, Valina L Dawson, Darren J Moore
Neurobiol Dis 2014 Aug; 71C:345-358
PMID: 25174890 [PubMed - as supplied by publisher]


Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator.
João Tiago S Fernandes, Sandra Tenreiro, Andreia Gameiro, Virginia Chu, Tiago F Outeiro, João P Conde
Lab Chip 2014 Sep; 14(20):3949-57
PMID: 25167219 [PubMed - as supplied by publisher]


Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease.
YongDan Liu, Min Zhu, Li Lin, XueLi Fan, ZhongYuan Piao, XinMei Jiang
Brain Res 2014 Sep;
PMID: 25223908 [PubMed - as supplied by publisher]


Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder.
Wei Lu, Senthilkumar S Karuppagounder, Danielle A Springer, Michele D Allen, Lixin Zheng, Brittany Chao, Yan Zhang, Valina L Dawson, Ted M Dawson, Michael Lenardo
Nat Commun 2014 ; 5:4930
PMID: 25222142 [PubMed - as supplied by publisher]


Puerarin protects dopaminergic neurons in Parkinson's disease models.
X Zhang, J Xiong, S Liu, L Wang, J Huang, L Liu, J Yang, G Zhang, K Guo, Z Zhang, P Wu, D Wang, Z Lin, N Xiong, T Wang
Neuroscience 2014 Sep;
PMID: 25218963 [PubMed - as supplied by publisher]


Protective role of olesoxime against wild type alpha-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells.
C Gouarné, J Tracz, M Giraudon Paoli, V Deluca, M Seimandi, G Tardif, M Xilouri, L Stefanis, T Bordet, R M Pruss
Br J Pharmacol 2014 Sep;
PMID: 25220617 [PubMed - as supplied by publisher]


Apoptosis signal-regulating kinase 1 modulates the phenotype of ?-synuclein transgenic mice.
Kang-Woo Lee, Jong-Min Woo, Joo-Young Im, Eun S Park, Liqiang He, Hidenori Ichijo, Eunsung Junn, M Maral Mouradian
Neurobiol Aging 2014 Jul;
PMID: 25219466 [PubMed - as supplied by publisher]


Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade.
Ana Carolina D Noseda, Lais S Rodrigues, Adriano D S Targa, Mariana H Fortes, Maria A B F Vital, Cláudio Da Cunha, Marcelo M S Lima
Behav Brain Res 2014 Sep;
PMID: 25218873 [PubMed - as supplied by publisher]


Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies.
Michel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay
Curr Neurol Neurosci Rep 2014 Nov; 14(11):495
PMID: 25218483 [PubMed - as supplied by publisher]


Pharmacokinetic/pharmacodynamic evaluation of rasagiline mesylate for Parkinson's disease.
Thomas Müller
Expert Opin Drug Metab Toxicol 2014 Oct; 10(10):1423-32
PMID: 25196265 [PubMed - as supplied by publisher]


Effects of the Parkinsonian toxin MPP(+) on electrophysiological properties of nigral dopaminergic neurons.
Andrew G Yee, Sun-Min Lee, Morag R Hunter, Michelle Glass, Peter S Freestone, Janusz Lipski
Neurotoxicology 2014 Sep; 45C:1-11
PMID: 25193392 [PubMed - as supplied by publisher]


The role of transcriptional control in multiple system atrophy.
Jieqiong Chen, James D Mills, Glenda M Halliday, Michael Janitz
Neurobiol Aging 2014 Aug;
PMID: 25218777 [PubMed - as supplied by publisher]


Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS-Cu(I) interactions.
Marco C Miotto, Andrés Binolfi, Markus Zweckstetter, Christian Griesinger, Claudio O Fernández
J Inorg Biochem 2014 Sep;
PMID: 25218565 [PubMed - as supplied by publisher]


The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Daniel Santos, A Raquel Esteves, Diana F Silva, Cristina Januário, Sandra M Cardoso
Mol Neurobiol 2014 Sep;
PMID: 25218511 [PubMed - as supplied by publisher]


Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits.
Asa Hatami, Marie-Francoise Chesselet
Curr Top Behav Neurosci 2014 Sep;
PMID: 25218491 [PubMed - as supplied by publisher]


Increased neurotrophic factor levels in ventral mesencephalic cultures do not explain the protective effect of osteopontin and the synthetic 15-mer RGD domain against MPP+toxicity.
Lauren Broom, Peter Jenner, Sarah Rose
Exp Neurol 2014 Sep;
PMID: 25218309 [PubMed - as supplied by publisher]


WebBioBank: A new platform for integrating clinical forms and shared neurosignal analyses to support multi-centre studies in Parkinson's Disease.
Elena Rossi, Manuela Rosa, Lorenzo Rossi, Alberto Priori, Sara Marceglia
J Biomed Inform 2014 Sep;
PMID: 25205596 [PubMed - as supplied by publisher]


Minocycline inhibits ICAD degradation and the NF-?B activation induced by 6-OHDA in PC12 cells.
Bao-Ping Jiang, Liang Le, Li-Jia Xu, Pei-Gen Xiao
Brain Res 2014 Sep;
PMID: 25195972 [PubMed - as supplied by publisher]


Short Mitochondrial ARF Triggers Parkin/PINK1-Dependent Mitophagy.
Karl Grenier, Maria Kontogiannea, Edward A Fon
J Biol Chem 2014 Sep;
PMID: 25217637 [PubMed - as supplied by publisher]


USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Thomas M Durcan, Matthew Y Tang, Joëlle R Pérusse, Eman A Dashti, Miguel A Aguileta, Gian-Luca McLelland, Priti Gros, Thomas A Shaler, Denis Faubert, Benoit Coulombe, Edward A Fon
EMBO J 2014 Sep;
PMID: 25216678 [PubMed - as supplied by publisher]


High stability and cooperative unfolding of cytotoxic ?-synuclein oligomers.
Wojciech Paslawski, Maria Andreasen, Søren Bang Nielsen, Nikolai Lorenzen, Karen Thomsen, Jørn Døvling Kaspersen, Jan Skov Pedersen, Daniel Erik Otzen
Biochemistry 2014 Sep;
PMID: 25216651 [PubMed - as supplied by publisher]


A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Marlène Cassar, Abdul-Raouf Issa, Thomas Riemensperger, Céline Petitgas, Thomas Rival, Hélène Coulom, Magali Iché-Torres, Kyung-An Han, Serge Birman
Hum Mol Genet 2014 Aug;
PMID: 25158689 [PubMed - as supplied by publisher]


Down-regulating ?-synuclein for treating synucleopathies.
Mathieu Bourdenx, Benjamin Dehay, Erwan Bezard
Mov Disord 2014 Sep;
PMID: 25214445 [PubMed - as supplied by publisher]


Correlation between decreased CSF ?-synuclein and A?1-42 in Parkinson disease.
Chandana Buddhala, Meghan C Campbell, Joel S Perlmutter, Paul T Kotzbauer
Neurobiol Aging 2014 Aug;
PMID: 25212463 [PubMed - as supplied by publisher]


Chronic L-Dopa Decreases Serotonin Neurons in a Sub-region of the Dorsal Raphe Nucleus.
Branden J Stansley, Bryan K Yamamoto
J Pharmacol Exp Ther 2014 Sep;
PMID: 25212217 [PubMed - as supplied by publisher]


DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress.
Mohammad Parsanejad, Noam Bourquard, Dianbo Qu, Yi Zhang, En Huang, Maxime W C Rousseaux, Hossein Aleyasin, Isabella Irrcher, Steve Callaghan, Dominique C Vaillant, Raymond H Kim, Ruth S Slack, Tak W Mak, Srinivasa T Reddy, Daniel Figeys, David S Park
PLoS One 2014 ; 9(9):e106601
PMID: 25210784 [PubMed - as supplied by publisher]


Cross Dimerization of Amyloid-? and ?Synuclein Proteins in Aqueous Environment: A Molecular Dynamics Simulations Study.
Jaya C Jose, Prathit Chatterjee, Neelanjana Sengupta
PLoS One 2014 ; 9(9):e106883
PMID: 25210774 [PubMed - as supplied by publisher]


Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure.
Ciara A Martin, Angel Barajas, George Lawless, Hakeem O Lawal, Khadij Assani, Yosephine P Lumintang, Vanessa Nunez, David E Krantz
Neurotoxicology 2014 Aug; 44C:344-351
PMID: 25160001 [PubMed - as supplied by publisher]


Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.
Jerome A Roth
Neurotoxicology 2014 Aug; 44C:314-325
PMID: 25149416 [PubMed - as supplied by publisher]


Protein:lipid co-aggregates are formed during ?-synuclein-induced disruption of lipid bilayers.
Andreas van Maarschalkerweerd, Valeria Vetri, Annette Eva Langkilde, Vito Foderà, Bente Vestergaard
Biomacromolecules 2014 Sep;
PMID: 25210839 [PubMed - as supplied by publisher]


Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice.
Yan Liu, Yu-He Yuan, Jian-Dong Sun, Jing Li, Zhi-Peng Li, Nai-Hong Chen
F1000Res 2014 ; 3:68
PMID: 25210616 [PubMed - as supplied by publisher]


New ¿- and ¿-synuclein immunopathological lesions in human brain.
Irina Surgucheva, Kathy L Newell, Jeffrey Burns, Andrei Surguchov
Acta Neuropathol Commun 2014 Sep; 2(1):132
PMID: 25209836 [PubMed - as supplied by publisher]


Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an ?-Helical Conformation.
Marta Robotta, Hanne R Gerding, Antonia Vogel, Karin Hauser, Stefan Schildknecht, Christiaan Karreman, Marcel Leist, Vinod Subramaniam, Malte Drescher
Chembiochem 2014 Sep;
PMID: 25209675 [PubMed - as supplied by publisher]


Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase.
Qingshan Wang, Chun-Hsien Chu, Li Qian, Shih-Heng Chen, Belinda Wilson, Esteban Oyarzabal, Lulu Jiang, Syed Ali, Bonnie Robinson, Hyoung-Chun Kim, Jau-Shyong Hong
J Neurosci 2014 Sep; 34(37):12490-503
PMID: 25209287 [PubMed - as supplied by publisher]


Brain Injection of ?-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker.
Amanda N Sacino, Mieu Brooks, Alex B McKinney, Michael A Thomas, Gerry Shaw, Todd E Golde, Benoit I Giasson
J Neurosci 2014 Sep; 34(37):12368-78
PMID: 25209277 [PubMed - as supplied by publisher]


Heat shock proteins in neurodegenerative disorders and aging.
Rehana K Leak
J Cell Commun Signal 2014 Sep;
PMID: 25208934 [PubMed - as supplied by publisher]


Structural and functional imaging in parkinsonian syndromes.
Stephen M Broski, Christopher H Hunt, Geoffrey B Johnson, Robert F Morreale, Val J Lowe, Patrick J Peller
Radiographics 2014 Sep-Oct; 34(5):1273-92
PMID: 25208280 [PubMed - as supplied by publisher]


Targeted Suppression of Chaperone-Mediated Autophagy by miR-320a Promotes ?-Synuclein Aggregation.
Guobin Li, Haiying Yang, Dezhang Zhu, Hui Huang, Guoyuan Liu, Peng Lun
Int J Mol Sci 2014 ; 15(9):15845-57
PMID: 25207598 [PubMed - as supplied by publisher]


Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons.
Yunchun Tai, Ling Chen, Enping Huang, Chao Liu, Xingyi Yang, Pingming Qiu, Huijun Wang
Neural Regen Res 2014 May; 9(9):951-8
PMID: 25206917 [PubMed - as supplied by publisher]


Baicalin suppresses iron accumulation after substantia nigra injury: relationship between iron concentration and transferrin expression.
Chunyan Guo, Xin Chen, Pei Xiong
Neural Regen Res 2014 Mar; 9(6):630-6
PMID: 25206866 [PubMed - as supplied by publisher]


The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.
Ting Zou, Xiangqi Tang, Zhiling Huang, Niangui Xu, Zhiping Hu
Neural Regen Res 2014 Feb; 9(4):402-6
PMID: 25206827 [PubMed - as supplied by publisher]


Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice.
Zihua Liu, Yuhong Jing, Jie Yin, Jiying Mu, Tingting Yao, Liping Gao
Neural Regen Res 2013 Dec; 8(35):3275-83
PMID: 25206649 [PubMed - as supplied by publisher]


Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway.
Ji-Young Kim, Beom Seok Jeon, Han-Joon Kim, Tae-Beom Ahn
Neural Regen Res 2013 Dec; 8(35):3269-74
PMID: 25206648 [PubMed - as supplied by publisher]


Construction of human Fab library and screening of a single-domain antibody of amyloid-beta 42 oligomers.
Zuanning Yuan, Minge Du, Yiwen Chen, Fei Dou
Neural Regen Res 2013 Nov; 8(33):3107-15
PMID: 25206631 [PubMed - as supplied by publisher]


How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?
Shaogang Lin, Shuifen Ye, Jinmu Huang, Yun Tian, Yihui Xu, Mengqi Wu, Jingxia Wang, Songying Wu, Jing Cai
Neural Regen Res 2013 Oct; 8(30):2820-6
PMID: 25206603 [PubMed - as supplied by publisher]


Autophagy and neurodegenerative disorders.
Evangelia Kesidou, Roza Lagoudaki, Olga Touloumi, Kyriaki-Nefeli Poulatsidou, Constantina Simeonidou
Neural Regen Res 2013 Aug; 8(24):2275-83
PMID: 25206537 [PubMed - as supplied by publisher]


Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.
Xingrong Ma, Zhikun Sun, Yanru Liu, Yanjie Jia, Boai Zhang, Jiewen Zhang
Neural Regen Res 2013 Aug; 8(22):2050-9
PMID: 25206513 [PubMed - as supplied by publisher]


Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
Ming-Kai Pan, Chun-Hwei Tai, Wen-Chuan Liu, Ju-Chun Pei, Wen-Sung Lai, Chung-Chin Kuo
J Clin Invest 2014 Sep;
PMID: 25202982 [PubMed - as supplied by publisher]


Cerebrospinal fluid Alpha-synuclein as A Biomarker for Parkinson's disease Diagnosis: A Systematic review and Meta-analysis.
Liang Gao, Hongmei Tang, Kun Nie, Limin Wang, Jiehao Zhao, Rong Gan, Jing Huang, Ruiming Zhu, Shujun Feng, Zhenpeng Duan, Yuhu Zhang, Lijuan Wang
Int J Neurosci 2014 Sep; :1-26
PMID: 25202803 [PubMed - as supplied by publisher]


Phosphatidylethanolamine deficiency disrupts ?-synuclein homeostasis in yeast and worm models of Parkinson disease.
Shaoxiao Wang, Siyuan Zhang, Liang-Chun Liou, Qun Ren, Zhaojie Zhang, Guy A Caldwell, Kim A Caldwell, Stephan N Witt
Proc Natl Acad Sci U S A 2014 Sep;
PMID: 25201965 [PubMed - as supplied by publisher]


Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Hyun Jin Cho, Jia Yu, Chengsong Xie, Parvathi Rudrabhatla, Xi Chen, Junbing Wu, Loukia Parisiadou, Guoxiang Liu, Lixin Sun, Bo Ma, Jinhui Ding, Zhihua Liu, Huaibin Cai
EMBO J 2014 Sep;
PMID: 25201882 [PubMed - as supplied by publisher]


Testosterone as the missing link between pesticides, Alzheimer disease, and Parkinson disease-reply.
Jason R Richardson
JAMA Neurol 2014 Sep; 71(9):1190
PMID: 25200543 [PubMed - as supplied by publisher]


Testosterone as the missing link between pesticides, Alzheimer disease, and Parkinson disease.
Ralph Martins, Malcolm Carruthers
JAMA Neurol 2014 Sep; 71(9):1189-90
PMID: 25200541 [PubMed - as supplied by publisher]


Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging.
Ananda S Prasad
J Trace Elem Med Biol 2014 Aug;
PMID: 25200490 [PubMed - as supplied by publisher]


Antibodies and protein misfolding: From structural research tools to therapeutic strategies.
Erwin De Genst, Anne Messer, Christopher M Dobson
Biochim Biophys Acta 2014 Sep;
PMID: 25194824 [PubMed - as supplied by publisher]


Mutations in the ATP13A2 Gene and Parkinsonism: A Preliminary Review.
Xinglong Yang, Yanming Xu
Biomed Res Int 2014 ; 2014:371256
PMID: 25197640 [PubMed - as supplied by publisher]


Hippocampal proliferation is increased in presymptomatic Parkinson's disease and due to microglia.
Karlijn J Doorn, Benjamin Drukarch, Anne-Marie van Dam, Paul J Lucassen
Neural Plast 2014 ; 2014:959154
PMID: 25197578 [PubMed - as supplied by publisher]


Fractalkine Over Expression Suppresses ?-Synuclein mediated Neurodegeneration.
Kevin R Nash, Peter Moran, Dylan Finneran, Charles Hudson, Jesse Robinson, Dave Morgan, Paula C Bickford
Mol Ther 2014 Sep;
PMID: 25195598 [PubMed - as supplied by publisher]


PRDX6 Exacerbates Dopaminergic Neurodegeneration in a MPTP Mouse Model of Parkinson's Disease.
Hyung-Mun Yun, Dong Young Choi, Ki Wan Oh, Jin Tae Hong
Mol Neurobiol 2014 Sep;
PMID: 25193021 [PubMed - as supplied by publisher]


Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury.
Kai Kysenius, Cecilia A Brunello, Henri J Huttunen
PLoS One 2014 ; 9(9):e107129
PMID: 25192195 [PubMed - as supplied by publisher]


Rectifying rectifier channels in Huntington disease.
Juliane Proft, Norbert Weiss
Commun Integr Biol 2014 ; 7:e29410
PMID: 25191533 [PubMed - as supplied by publisher]


The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light.
Joanna F Collingwood, Mark R Davidson
Front Pharmacol 2014 ; 5:191
PMID: 25191270 [PubMed - as supplied by publisher]


TREM2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in postmortem temporal cortices.
Lih-Fen Lue, Christopher T Schmitz, Geidy Sorrano, Lucia I Sue, Thomas G Beach, Douglas G Walker
Brain Pathol 2014 Sep;
PMID: 25186950 [PubMed - as supplied by publisher]


The Cardiovascular Actions of DOPA Mediated by the Gene Product of ocular albinism 1.
Yoshio Goshima, Fumio Nakamura, Daiki Masukawa, Sandy Chen, Motokazu Koga
J Pharmacol Sci 2014 Sep;
PMID: 25185585 [PubMed - as supplied by publisher]


Proliferating Cell Nuclear Antigen Binds DNA Polymerase-? and Mediates 1-Methyl-4-Phenylpyridinium-Induced Neuronal Death.
Zhentao Zhang, Zhaohui Zhang, Hongcai Wang, Guoxin Zhang, Dan Hu, Jing Xiong, Nian Xiong, Tao Wang, Xuebing Cao, Ling Mao
PLoS One 2014 ; 9(9):e106669
PMID: 25184665 [PubMed - as supplied by publisher]


Cerebellum in levodopa-induced dyskinesias: the unusual suspect in the motor network.
Asha Kishore, Traian Popa
Front Neurol 2014 ; 5:157
PMID: 25183959 [PubMed - as supplied by publisher]


G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Noemí Esteras, Carolina Alquézar, Fernando Bartolomé, Ana de la Encarnación, Félix Bermejo-Pareja, José Antonio Molina, Angeles Martín-Requero
Mol Neurobiol 2014 Sep;
PMID: 25182869 [PubMed - as supplied by publisher]


I716F A?PP Mutation Associates with the Deposition of Oligomeric Pyroglutamate Amyloid-? and ?-Synucleinopathy with Lewy Bodies.
Evelyn Sieczkowski, Ivan Milenkovic, Vivek Venkataramani, Regina Giera, Thomas Ströbel, Romana Höftberger, Pawe? P Liberski, Eduard Auff, Oliver Wirths, Thomas A Bayer, Gabor G Kovacs
J Alzheimers Dis 2014 Sep;
PMID: 25182745 [PubMed - as supplied by publisher]


Methods to Characterize Spontaneous and Startle-induced Locomotion in a Rotenone-induced Parkinson's Disease Model of Drosophila.
Jennifer Liao, Laura W Morin, S Tariq Ahmad
J Vis Exp 2014 ; (90)
PMID: 25178101 [PubMed - as supplied by publisher]


Subthalamotomy-induced changes in dopamine receptors in parkinsonian monkeys.
Vincent A Jourdain, Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérèse Di Paolo
Exp Neurol 2014 Aug;
PMID: 25172808 [PubMed - as supplied by publisher]


Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin.
Ghazaleh Ashrafi, Julia S Schlehe, Matthew J LaVoie, Thomas L Schwarz
J Cell Biol 2014 Sep; 206(5):655-70
PMID: 25154397 [PubMed - as supplied by publisher]


Influence of Deep Breathing on Heart Rate Variability in Parkinson's Disease: Co-relation with Severity of Disease and Non-Motor Symptom Scale Score.
Mukta Pritam Bidikar, Gayatri J Jagtap, Rahul T Chakor
J Clin Diagn Res 2014 Jul; 8(7):BC01-3
PMID: 25177554 [PubMed - as supplied by publisher]


Lysosomes and ?-synuclein form a dangerous duet leading to neuronal cell death.
Mathieu Bourdenx, Erwan Bezard, Benjamin Dehay
Front Neuroanat 2014 ; 8:83
PMID: 25177278 [PubMed - as supplied by publisher]


P38 MAPK signaling pathway regulates nuclear factor-?B and inducible nitric oxide synthase expressions in the substantia nigra in a mouse model of Parkinson's disease].
Qian Wang, Hui Zhang, Ming Liu, Zuofeng Zhang, Zifeng Wei, Na Sun, Tongyao Mao, Yuxin Zhang
Nan Fang Yi Ke Da Xue Xue Bao 2014 Jul; 34(8):1176-80
PMID: 25176090 [PubMed - as supplied by publisher]


Adenosine receptor control of cognition in normal and disease.
Jiang-Fan Chen
Int Rev Neurobiol 2014 ; 119:257-307
PMID: 25175970 [PubMed - as supplied by publisher]


Effects of the Adenosine A2A Receptor Antagonist on Cognitive Dysfunction in Parkinson's Disease.
Shin-Ichi Uchida, Takako Kadowaki-Horita, Tomoyuki Kanda
Int Rev Neurobiol 2014 ; 119:169-89
PMID: 25175966 [PubMed - as supplied by publisher]


Interaction of adenosine receptors with other receptors from therapeutic perspective in Parkinson's disease.
Nicolas Morin, Thérèse Di Paolo
Int Rev Neurobiol 2014 ; 119:151-67
PMID: 25175965 [PubMed - as supplied by publisher]


Mode of Action of Adenosine A2A Receptor Antagonists as Symptomatic Treatment for Parkinson's Disease.
Akihisa Mori
Int Rev Neurobiol 2014 ; 119:87-116
PMID: 25175962 [PubMed - as supplied by publisher]


Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats.
Jang-Won Lee, Victor Tapias, Roberto Di Maio, J Timothy Greenamyre, Jason R Cannon
Neurobiol Aging 2014 Jul;
PMID: 25174649 [PubMed - as supplied by publisher]


Guanosine exerts neuroprotective effects by reversing mitochondrial dysfunction in a cellular model of Parkinson's disease.
Da-Wei Li, Min Yao, Yan-Hua Dong, Min-Na Tang, Wei Chen, Guang-Ren Li, Bi-Quan Sun
Int J Mol Med 2014 Aug;
PMID: 25174304 [PubMed - as supplied by publisher]


Improvement of Neurological Dysfunctions in Aphakia Mice, a Model of Parkinson's Disease, after Transplantation of ES Cell-Derived Dopaminergic Neuronal Precursors.
Sangmi Chung, Jisook Moon, Kwang-Soo Kim
Methods Mol Biol 2014 ; 1213:285-91
PMID: 25173391 [PubMed - as supplied by publisher]


AQW051, a novel and selective nicotinic acetylcholine receptor ?7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys.
Thérèse Di Paolo, Laurent Grégoire, Dominik Feuerbach, Walid Elbast, Markus Weiss, Baltazar Gomez-Mancilla
Parkinsonism Relat Disord 2014 May;
PMID: 25172125 [PubMed - as supplied by publisher]


Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.
Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Birgit Schüle, Jeff Alexander, William Wallace, Glenda M Halliday, J William Langston, Scott Braxton, Ted Yednock, Thomas Shaler, Jennifer A Johnston
PLoS One 2014 ; 9(8):e102909
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Laser Acupuncture at HT7 Acupoint Improves Cognitive Deficit, Neuronal Loss, Oxidative Stress, and Functions of Cholinergic and Dopaminergic Systems in Animal Model of Parkinson's Disease.
Jintanaporn Wattanathorn, Chatchada Sutalangka
Evid Based Complement Alternat Med 2014 ; 2014:937601
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Gene Therapy for the Nervous System: Challenges and New Strategies.
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Neurotherapeutics 2014 Aug;
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SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway.
Lei Liu, Anirudh Arun, Lakia Ellis, Carina Peritore, Gizem Donmez
Front Aging Neurosci 2014 ; 6:184
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Glucocerebrosidase depletion enhances cell-to-cell transmission of ?-synuclein.
Eun-Jin Bae, Na-Young Yang, Miyoung Song, Cheol Soon Lee, Jun Sung Lee, Byung Chul Jung, He-Jin Lee, Seokjoong Kim, Eliezer Masliah, Sergio Pablo Sardi, Seung-Jae Lee
Nat Commun 2014 ; 5:4755
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Standardized Bacopa monnieri extract ameliorates acute paraquat-induced oxidative stress, and neurotoxicity in prepubertal mice brain.
Ravikumar Hosamani, Gokul Krishna, Muralidhara
Nutr Neurosci 2014 Aug;
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Advances in the application of gene therapy for Parkinson's disease with adeno-associated virus].
Yang Chen, Ying-Hui Lü, Zhao-Fa Li
Yao Xue Xue Bao 2014 May; 49(5):576-81
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Mitochondrial acetylation and genetic models of Parkinson's disease.
Georg Auburger, Suzana Gispert, Marina Jendrach
Prog Mol Biol Transl Sci 2014 ; 127:155-82
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The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
Manuel Rodriguez, Ingrid Morales, Clara Rodriguez-Sabate, Alberto Sanchez, Rafael Castro, Jose Miguel Brito, Magdalena Sabate
Front Neuroanat 2014 ; 8:80
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