Adjust Text Size:change font sizechange font sizechange font sizechange font sizechange font sizechange font size

Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

Learn More

PDF Grant Programs

Are you interested in furthering Parkinson's science? View PDF's open grant programs.

Learn More


Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

There was an error retrieving the document. Please try again.

Recommendations of the Alzheimer's Disease-Related Dementias Conference.
Thomas J Montine, Walter J Koroshetz, Debra Babcock, Dennis W Dickson, Wendy R Galpern, M Maria Glymour, Steven M Greenberg, Michael L Hutton, David S Knopman, Andrey N Kuzmichev, Jennifer J Manly, Karen S Marder, Bruce L Miller, Creighton H Phelps, William W Seeley, Beth-Anne Sieber, Nina B Silverberg, Margaret Sutherland, Christine L Torborg, Salina P Waddy, Berislav V Zlokovic, Roderick A Corriveau,
Neurology 2014 Jul;
PMID: 25080517 [PubMed - as supplied by publisher]


Blood Genome-Wide Transcriptional Profiles Reflect Broad Molecular Impairments and Strong Blood-Brain Links in Alzheimer's Disease.
Bartholomew J Naughton, F Jason Duncan, Darren A Murrey, Aaron S Meadows, David E Newsom, Nicoleta Stoicea, Peter White, Douglas W Scharre, Douglas M Mccarty, Haiyan Fu
J Alzheimers Dis 2014 Jul;
PMID: 25079797 [PubMed - as supplied by publisher]


1,25-dyhydroxyvitamin D3 attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy.
Wooyoung Jang, Hee Ju Kim, Huan Li, Kwang Deog Jo, Moon Kyu Lee, Sun Hong Song, Hyun Ok Yang
Biochem Biophys Res Commun 2014 Jul;
PMID: 25078626 [PubMed - as supplied by publisher]


Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Beatriz Alvarez-Castelao, Ana Gorostidi, Javier Ruíz-Martínez, Adolfo López de Munain, José G Castańo
Front Aging Neurosci 2014 ; 6:169
PMID: 25076905 [PubMed - as supplied by publisher]


N-Alpha-Acetylation of ?-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation.
Tim Bartels, Nora C Kim, Eric S Luth, Dennis J Selkoe
PLoS One 2014 ; 9(7):e103727
PMID: 25075858 [PubMed - as supplied by publisher]


G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Sokhna M S Yakhine-Diop, José M Bravo-San Pedro, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Mario Rodríguez-Arribas, Vicente Climent, Ana Aiastui, Adolfo López de Munain, José M Fuentes, Rosa A González-Polo
Toxicology 2014 Jul; 324C:1-9
PMID: 25017139 [PubMed - as supplied by publisher]


Therapeutic potential of metabotropic glutamate receptor 4-positive allosteric modulator TAS-4 in rodent models of movement disorders.
Aakanksha Dube, Sumit Chaudhary, Tanaji Mengawade, Chandrashekhar Devidas Upasani
J Neurol Sci 2014 Jul;
PMID: 25073574 [PubMed - as supplied by publisher]


Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?
Michael Beekes, Achim Thomzig, Walter J Schulz-Schaeffer, Reinhard Burger
Acta Neuropathol 2014 Jul;
PMID: 25073522 [PubMed - as supplied by publisher]


Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model.
Sumit Sarkar, Srinivasulu Chigurupati, James Raymick, Dushyant Mann, John F Bowyer, Tom Schmitt, Richard D Beger, Joseph P Hanig, Larry C Schmued, Merle G Paule
Neurotoxicology 2014 Jul;
PMID: 25064079 [PubMed - as supplied by publisher]


NMDARs in neurological diseases: a potential therapeutic target.
Janneth Gonzalez, Juan Camilo Jurado-Coronel, Marcos Fidel Avila, Angélica Sabogal, Francisco Capani, George E Barreto
Int J Neurosci 2014 Jul;
PMID: 25051426 [PubMed - as supplied by publisher]


Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated ?-synuclein.
Misook Oh, Ji Hoon Lee, Wei Wang, Hui Sun Lee, Woo Sirl Lee, Christopher Burlak, Wonpil Im, Quyen Q Hoang, Hyun-Suk Lim
Proc Natl Acad Sci U S A 2014 Jul; 111(30):11007-12
PMID: 25024216 [PubMed - as supplied by publisher]


Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease.
Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein
Mol Neurodegener 2014 ; 9(1):27
PMID: 25011704 [PubMed - as supplied by publisher]


Functional correlates of optic flow motion processing in Parkinson's disease.
Deepti Putcha, Robert S Ross, Maya L Rosen, Daniel J Norton, Alice Cronin-Golomb, David C Somers, Chantal E Stern
Front Integr Neurosci 2014 ; 8:57
PMID: 25071484 [PubMed - as supplied by publisher]


Brain renin-angiotensin system and dopaminergic cell vulnerability.
Jose L Labandeira-García, Pablo Garrido-Gil, Jannette Rodriguez-Pallares, Rita Valenzuela, Ana Borrajo, Ana I Rodríguez-Perez
Front Neuroanat 2014 ; 8:67
PMID: 25071471 [PubMed - as supplied by publisher]


miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway.
Apostolia Fragkouli, Epaminondas Doxakis
Front Cell Neurosci 2014 ; 8:182
PMID: 25071443 [PubMed - as supplied by publisher]


Interaction of LRRK2 with kinase and GTPase signaling cascades.
Joon Y Boon, Julien Dusonchet, Chelsea Trengrove, Benjamin Wolozin
Front Mol Neurosci 2014 ; 7:64
PMID: 25071441 [PubMed - as supplied by publisher]


Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease.
Jay S Schneider, Mark E Ault, David W Anderson
Mov Disord 2014 Jul;
PMID: 25070726 [PubMed - as supplied by publisher]


Effect of electroacupuncture intervention on levels of SOD, GSH, GSH-Px, MDA, and apoptosis of dopaminergic neurons in substantia Nigra in rats with Parkinson's disease].
Jing Li, Li-Na Wang, Hong-Ling Xiao, Xia Li, Ji-Jun Yang
Zhen Ci Yan Jiu 2014 Jun; 39(3):185-91
PMID: 25069193 [PubMed - as supplied by publisher]


A calcineurin- and NFAT-dependent pathway is involved in ?-synuclein-induced degeneration of midbrain dopaminergic neurons.
Jing Luo, Lixin Sun, Xian Lin, Guoxiang Liu, Jia Yu, Loukia Parisiadou, Chengsong Xie, Jinhui Ding, Huaibin Cai
Hum Mol Genet 2014 Jul;
PMID: 25051958 [PubMed - as supplied by publisher]


Parkinson disease: A monoclonal antibody targeting misfolded ?-synuclein has therapeutic potential in Parkinson disease.
Heather Wood
Nat Rev Neurol 2014 Jul;
PMID: 25002110 [PubMed - as supplied by publisher]


Surface effects on Aggregation Kinetics of Amyloidogenic Peptides.
Robert Vacha, Sara Linse, Mikael Lund
J Am Chem Soc 2014 Jul;
PMID: 25068615 [PubMed - as supplied by publisher]


Visual cues and gait improvement in Parkinson's disease: Which piece of information are really important?
Rodrigo Vitório, Ellen Lirani-Silva, Frederico Pieruccini-Faria, Renato Moraes, Lilian T B Gobbi, Quincy J Almeida
Neuroscience 2014 Jul;
PMID: 25065625 [PubMed - as supplied by publisher]


Involvement of activation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by ?-iso-cubebenol.
Sun Young Park, Do Yeon Kim, Jong-Koo Kang, Geuntae Park, Young-Whan Choi
Neurotoxicology 2014 Jul; 44C:160-168
PMID: 24997245 [PubMed - as supplied by publisher]


Genetic Dys-regulation of Astrocytic Glutamate Transporter EAAT2 and its Implications in Neurological Disorders and Manganese Toxicity.
Pratap Karki, Keisha Smith, James Johnson, Michael Aschner, Eunsook Y Lee
Neurochem Res 2014 Jul;
PMID: 25064045 [PubMed - as supplied by publisher]


Altered dopamine homeostasis differentially affects mitochondrial voltage-dependent anion channels turnover.
Tiziana Alberio, Cristina Mammucari, Gianluca D'Agostino, Rosario Rizzuto, Mauro Fasano
Biochim Biophys Acta 2014 Jul; 1842(9):1816-1822
PMID: 24998333 [PubMed - as supplied by publisher]


CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice.
Richard L Jayaraj, Namasivayam Elangovan, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Musthafa Mohamed Essa
Chem Biol Interact 2014 Jul; 220C:149-157
PMID: 24995576 [PubMed - as supplied by publisher]


A novel computerized algorithm to detect microstructural brainstem pathology in Parkinson's disease using standard 3 Tesla MR imaging.
Kai Boelmans, Lothar Spies, Jan Sedlacik, Jens Fiehler, Holger Jahn, Christian Gerloff, Alexander Münchau
J Neurol 2014 Jul;
PMID: 25063366 [PubMed - as supplied by publisher]


Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival.
Yusuke Toyoda, Cihan Erkut, Francisco Pan-Montojo, Sebastian Boland, Martin P Stewart, Daniel J Müller, Wolfgang Wurst, Anthony A Hyman, Teymuras V Kurzchalia
Biol Open 2014 Jul;
PMID: 25063200 [PubMed - as supplied by publisher]


The Co-Occurrence of Alzheimer's Disease and Huntington's Disease: A Neuropathological Study of 15 Elderly Huntington's Disease Subjects.
Marie Y Davis, C Dirk Keene, Suman Jayadev, Thomas Bird
J Huntingtons Dis 2014 Jan; 3(2):209-17
PMID: 25062863 [PubMed - as supplied by publisher]


Aquatherapy for neurodegenerative disorders.
Alyson R Plecash, Blair R Leavitt
J Huntingtons Dis 2014 Jan; 3(1):5-11
PMID: 25062761 [PubMed - as supplied by publisher]


Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
Hélčne Hall, Stefanie Reyes, Natalie Landeck, Chris Bye, Giampiero Leanza, Kay Double, Lachlan Thompson, Glenda Halliday, Deniz Kirik
Brain 2014 Jul;
PMID: 25062696 [PubMed - as supplied by publisher]


Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
Meredith E Jackrel, James Shorter
Dis Model Mech 2014 Jul;
PMID: 25062688 [PubMed - as supplied by publisher]


Cudarflavone B Provides Neuroprotection against Glutamate-Induced Mouse Hippocampal HT22 Cell Damage through the Nrf2 and PI3K/Akt Signaling Pathways.
Dong-Sung Lee, Wonmin Ko, Dong-Cheol Kim, Youn-Chul Kim, Gil-Saeng Jeong
Molecules 2014 ; 19(8):10818-31
PMID: 25061726 [PubMed - as supplied by publisher]


Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats.
Rohit Bisht, Baninder Kaur, Hitu Gupta, Atish Prakash
Neurotoxicology 2014 Jun; 44C:71-79
PMID: 25053526 [PubMed - as supplied by publisher]


Spreading of ?-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis.
Jennifer T Lamberts, Erin Hildebrandt, Patrik Brundin
Neurobiol Dis 2014 Jul;
PMID: 25046996 [PubMed - as supplied by publisher]


Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys.
Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérčse Di Paolo
Prog Neuropsychopharmacol Biol Psychiatry 2014 Jul;
PMID: 25046277 [PubMed - as supplied by publisher]


Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein.
Sudhakar Raja Subramaniam, Laurent Vergnes, Nicholas R Franich, Karen Reue, Marie-Francoise Chesselet
Neurobiol Dis 2014 Jul; 70C:204-213
PMID: 25016198 [PubMed - as supplied by publisher]


Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network.
Mustafa Sertba?, Kutlu Ulgen, Tunahan Cak?r
FEBS Open Bio 2014 ; 4:542-53
PMID: 25061554 [PubMed - as supplied by publisher]


Genetics and genomics of Parkinson's disease.
Michelle K Lin, Matthew J Farrer
Genome Med 2014 ; 6(6):48
PMID: 25061481 [PubMed - as supplied by publisher]


Genetic Susceptibility Model of Parkinson's Disease Resulting from Exposure of DJ-1 Deficient Mice to MPTP: Evaluation of Neuroprotection by Ubisol-Q10.
Krithika Muthukumaran, Jessica Smith, Harshil Jasra, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Daniel Lopatin, Siyaram Pandey
J Parkinsons Dis 2014 Jul;
PMID: 25061060 [PubMed - as supplied by publisher]


MPTP/MPP+ Suppresses Activation of Protein C in Parkinson's Disease.
Teng Chen, Ruihua Hou, Chao Li, Chengyuan Wu, Shujun Xu
J Alzheimers Dis 2014 Jul;
PMID: 25061051 [PubMed - as supplied by publisher]


Correlations between plasma levels of amino acids and nonmotor symptoms in Parkinson's disease.
Qing Tong, Qinrong Xu, Qiang Xia, Yongsheng Yuan, Li Zhang, Hongbin Sun, Han Shan, Kezhong Zhang
J Neural Transm 2014 Jul;
PMID: 25059457 [PubMed - as supplied by publisher]


Selective increase of in vivo firing frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain.
Mahalakshmi Subramaniam, Beatrice Kern, Simone Vogel, Verena Klose, Gaby Schneider, Jochen Roeper
Eur J Neurosci 2014 Jul;
PMID: 25059097 [PubMed - as supplied by publisher]


Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study.
Alex Stoyanov, Roger Pamphlett
PLoS One 2014 ; 9(7):e103572
PMID: 25058637 [PubMed - as supplied by publisher]


DJ-1 interactions with ?-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.
L Zondler, L Miller-Fleming, M Repici, S Gonçalves, S Tenreiro, R Rosado-Ramos, C Betzer, K R Straatman, P H Jensen, F Giorgini, T F Outeiro
Cell Death Dis 2014 ; 5:e1350
PMID: 25058424 [PubMed - as supplied by publisher]


Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.
Suzanne Angeli, Tracy Barhydt, Ross Jacobs, David W Killilea, Gordon J Lithgow, Julie K Andersen
Metallomics 2014 Jul;
PMID: 25057947 [PubMed - as supplied by publisher]


Apoptosis and Oxidative Stress in Neurodegenerative Diseases.
Elena Radi, Patrizia Formichi, Carla Battisti, Antonio Federico
J Alzheimers Dis 2014 Jul;
PMID: 25056458 [PubMed - as supplied by publisher]


Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
John E Casida, Breanna Ford, Yunden Jinsmaa, Patti Sullivan, Adele Cooney, David S Goldstein
Chem Res Toxicol 2014 Jul;
PMID: 25045800 [PubMed - as supplied by publisher]


miR-16-1 Promotes the Aberrant ?-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70.
Zhelin Zhang, Yan Cheng
ScientificWorldJournal 2014 ; 2014:938348
PMID: 25054189 [PubMed - as supplied by publisher]


Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
Dongjun Dai, Peipei Lin, Yunliang Wang, Xingyu Zhou, Jianmin Tao, Danjie Jiang, Hanlin Zhou, Ping Ru, Guanghui Pan, Jinfeng Li, Yuzheng Zhang, Honglei Yin, Shiwei Duan
Biomed Rep 2014 Sep; 2(5):713-718
PMID: 25054016 [PubMed - as supplied by publisher]


Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry.
John F Kellie, Richard E Higgs, John W Ryder, Anthony Major, Thomas G Beach, Charles H Adler, Kalpana Merchant, Michael D Knierman
Sci Rep 2014 ; 4:5797
PMID: 25052239 [PubMed - as supplied by publisher]


Intramuscular injection of ?-synuclein induces CNS ?-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.
Amanda N Sacino, Mieu Brooks, Michael A Thomas, Alex B McKinney, Sooyeon Lee, Robert W Regenhardt, Nicholas H McGarvey, Jacob I Ayers, Lucia Notterpek, David R Borchelt, Todd E Golde, Benoit I Giasson
Proc Natl Acad Sci U S A 2014 Jul; 111(29):10732-7
PMID: 25002524 [PubMed - as supplied by publisher]


Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells.
Javier Vargas-Medrano, Sesha Krishnamachari, Ernesto Villanueva, Wesley H Godfrey, Haiyan Lou, Ramesh Chinnasamy, Jeffrey B Arterburn, Ruth G Perez
ACS Med Chem Lett 2014 Jul; 5(7):782-6
PMID: 25050165 [PubMed - as supplied by publisher]


Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts.
Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirker
Mov Disord 2014 Jul;
PMID: 25048738 [PubMed - as supplied by publisher]


Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain.
Elaine R Peskind, Ge Li, Jane B Shofer, Steven P Millard, James B Leverenz, Chang-En Yu, Murray A Raskind, Joseph F Quinn, Douglas R Galasko, Thomas J Montine
JAMA Neurol 2014 Jul;
PMID: 25048271 [PubMed - as supplied by publisher]


A cell culture model for monitoring ?-synuclein cell-to-cell transfer.
Juan F Reyes, Tomas T Olsson, Jennifer T Lamberts, Michael J Devine, Tilo Kunath, Patrik Brundin
Neurobiol Dis 2014 Jul;
PMID: 25046995 [PubMed - as supplied by publisher]


Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates.
Laura L Dugan, LinLin Tian, Kevin L Quick, Josh I Hardt, Morvarid Karimi, Chris Brown, Susan Loftin, Hugh Flores, Stephen M Moerlein, John Polich, Samer D Tabbal, Jonathan W Mink, Joel S Perlmutter
Ann Neurol 2014 Jul;
PMID: 25043598 [PubMed - as supplied by publisher]


Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease.
Werner J Geldenhuys, Akiko Kochi, Li Lin, Vijaykumar Sutariya, Dean E Dluzen, Cornelis J Van der Schyf, Mi Hee Lim
Chembiochem 2014 Jul;
PMID: 25045125 [PubMed - as supplied by publisher]


Dopamine-induced ?-synuclein oligomers show self- and cross-propagation properties.
Matthew S Planchard, Sarah E Exley, Sarah E Morgan, Vijayaraghavan Rangachari
Protein Sci 2014 Jul;
PMID: 25044276 [PubMed - as supplied by publisher]


Peripheral alpha-synuclein and Parkinson's disease.
C Warren Olanow, Dustin R Wakeman, Jeffrey H Kordower
Mov Disord 2014 Jul; 29(8):963-6
PMID: 25043799 [PubMed - as supplied by publisher]


Genetic deletion of the GATA1-regulated protein ?-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.
Raffaele Renella, Julia S Schlehe, Dennis J Selkoe, David A Williams, Matthew J LaVoie
Am J Hematol 2014 Jul;
PMID: 25043722 [PubMed - as supplied by publisher]


Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.
Qingshan Wang, Chun-Hsien Chu, Esteban Oyarzabal, Lulu Jiang, Shih-Heng Chen, Belinda Wilson, Li Qian, Jau-Shyong Hong
Glia 2014 Jul;
PMID: 25043383 [PubMed - as supplied by publisher]


REM sleep behavior disorders in Parkinson's disease.
E A Liashenko, M G Poluéktov, O S Levin
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(6 Vypusk 2 Nevrologiia i psikhiatriia pozhilogo vozrasta):73-79
PMID: 25042507 [PubMed - as supplied by publisher]


Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.
Juan A Navarro, Sabina Heßner, Sarat C Yenisetti, Florian Bayersdorfer, Li Zhang, Aaron Voigt, Stephan Schneuwly, Jose A Botella
J Neurochem 2014 Jul;
PMID: 25040725 [PubMed - as supplied by publisher]


Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP(+))-induced loss of mesencephalic dopaminergic neurons.
M M Khan, S Zaheer, J Nehman, A Zaheer
Neuroscience 2014 Jul;
PMID: 25016212 [PubMed - as supplied by publisher]


Endothelin-1: A potential pathological factor in Parkinson's disease? -From endoplasmic reticulum stress to beyond.
Arjun Jain
J Neurol Sci 2014 Jun;
PMID: 24998514 [PubMed - as supplied by publisher]


A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy.
Franziska Richter, Sheila M Fleming, Melanie Watson, Vincent Lemesre, Lee Pellegrino, Brian Ranes, Chunni Zhu, Farzad Mortazavi, Caitlin K Mulligan, Pedrom C Sioshansi, Sindalana Hean, Krystal De La Rosa, Richie Khanna, John Flanagan, David J Lockhart, Brandon A Wustman, Sean W Clark, Marie-Françoise Chesselet
Neurotherapeutics 2014 Jul;
PMID: 25037721 [PubMed - as supplied by publisher]


Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.
Marusela Oliveras-Salvá, Francesca Macchi, Valérie Coessens, Angélique Deleersnijder, Melanie Gérard, Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt
Neurobiol Aging 2014 Jun;
PMID: 25037286 [PubMed - as supplied by publisher]


Serotonin Impairment in CSF of PD Patients, without an Apparent Clinical Counterpart.
Enrica Olivola, Mariangela Pierantozzi, Paola Imbriani, Claudio Liguori, Mario Stampanoni Bassi, Marco Conti, Vincenza D Angelo, Nicola Biagio Mercuri, Alessandro Stefani
PLoS One 2014 ; 9(7):e101763
PMID: 25036938 [PubMed - as supplied by publisher]


New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases.
Joy Mitra, Erika N Guerrero, Pavana M Hegde, Haibo Wang, Istvan Boldogh, Kosagi Sharaf Rao, Sankar Mitra, Muralidhar L Hegde
Biomolecules 2014 ; 4(3):678-703
PMID: 25036887 [PubMed - as supplied by publisher]


Short Communication Huwe1 as a therapeutic target for neural injury.
J Zhou, Q Liu, M Mao, Y Tong
Genet Mol Res 2014 ; 13(2):4320-5
PMID: 25036176 [PubMed - as supplied by publisher]


7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo.
Jiahn-Dar Huang, Juan Amaral, Jung Wha Lee, Ignacio R Rodriguez
PLoS One 2014 ; 9(7):e100985
PMID: 25036103 [PubMed - as supplied by publisher]


Analysis of volatile organic compounds in rats with dopaminergic lesion: Possible application for early detection of Parkinson's disease.
S Khatib, J P M Finberg, F Artoul, Y Lavner, S Mahmood, U Tisch, H Haick, Y Aluf, J Vaya
Neurochem Int 2014 Jul;
PMID: 25034982 [PubMed - as supplied by publisher]


Sleep disturbance and cognitive disorder: epidemiological analysis in a cohort of 263 patients.
Michele Pistacchi, Manuela Gioulis, Franco Contin, Flavio Sanson, Sandro Zambito Marsala
Neurol Sci 2014 Jul;
PMID: 25034185 [PubMed - as supplied by publisher]


Tetranectin Knockout Mice Develop Features of Parkinson Disease.
Er-Song Wang, Xiao-Ping Zhang, Hui-Bin Yao, Gan Wang, Shi-Wen Chen, Wen-Wei Gao, Hai-Jun Yao, Yi-Rui Sun, Cai-Hua Xi, Yao-Dong Ji
Cell Physiol Biochem 2014 Jul; 34(2):277-287
PMID: 25033953 [PubMed - as supplied by publisher]


Neuroimaging characteristics of dementia with Lewy bodies.
Elijah Mak, Li Su, Guy B Williams, John T O'Brien
Alzheimers Res Ther 2014 ; 6(2):18
PMID: 25031634 [PubMed - as supplied by publisher]


Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease.
Hong Zhao, Mei-Ling Xu, Qi Zhang, Zhao-Hui Guo, Ying Peng, Zheng-Yi Qu, Yong-Nan Li
Neurol Sci 2014 Jul;
PMID: 25030124 [PubMed - as supplied by publisher]


Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Lars Tatenhorst, Lars Tönges, Kim-Ann Saal, Jan C Koch, Eva M Szeg?, Mathias Bähr, Paul Lingor
J Neuropathol Exp Neurol 2014 Aug; 73(8):770-9
PMID: 25003236 [PubMed - as supplied by publisher]


Plaques and tangles as well as Lewy-type alpha synucleinopathy are associated with formed visual hallucinations.
Sandra A Jacobson, Trisha Morshed, Brittany N Dugger, Thomas G Beach, Joseph G Hentz, Charles H Adler, Holly A Shill, Marwan N Sabbagh, Christine M Belden, Lucia I Sue, John N Caviness, Chengcheng Hu,
Parkinsonism Relat Disord 2014 Jun;
PMID: 25027359 [PubMed - as supplied by publisher]


CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson's Disease.
Richard L Jayaraj, Namasivayam Elangovan, Krishnan Manigandan, Sonu Singh, Shubha Shukla
Biomed Res Int 2014 ; 2014:236182
PMID: 25025041 [PubMed - as supplied by publisher]


Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals.
Tam Duong, Jaetaek Kim, H Earl Ruley, Daewoong Jo
PLoS One 2014 ; 9(7):e102517
PMID: 25019626 [PubMed - as supplied by publisher]


Imaging the role of amyloid in PD dementia and dementia with Lewy bodies.
Stephen N Gomperts
Curr Neurol Neurosci Rep 2014 Aug; 14(8):472
PMID: 25011528 [PubMed - as supplied by publisher]


Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.
Ting-Li Dai, Chan Zhang, Fang Peng, Xue-Yuan Niu, Ling Hu, Qiong Zhang, Ying Huang, Ling Chen, Lei Zhang, Weidong Zhu, Yu-Qiang Ding, Ning-Ning Song, Min Liao
Exp Ther Med 2014 Aug; 8(2):384-390
PMID: 25009587 [PubMed - as supplied by publisher]


Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.
Nicolas Dzamko, Jinxia Zhou, Yue Huang, Glenda M Halliday
Front Mol Neurosci 2014 ; 7:57
PMID: 25009465 [PubMed - as supplied by publisher]


Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah
J Neurosci 2014 Jul; 34(28):9441-54
PMID: 25009275 [PubMed - as supplied by publisher]


Synucleins regulate the kinetics of synaptic vesicle endocytosis.
Karina J Vargas, Sachin Makani, Taylor Davis, Christopher H Westphal, Pablo E Castillo, Sreeganga S Chandra
J Neurosci 2014 Jul; 34(28):9364-76
PMID: 25009269 [PubMed - as supplied by publisher]


ESCRT mediated uptake and degradation of brain targeted ?-synuclein-single chain antibody attenuates neuronal degeneration in vivo.
Brian Spencer, Sharareh Emadi, Paula Desplats, Simona Eleuteri, Sarah Michael, Kori Kosberg, Jay Shen, Edward Rockenstein, Christina Patrick, Anthony Adame, Tania Gonzalez, Michael Sierks, Eliezer Masliah
Mol Ther 2014 Jul;
PMID: 25008355 [PubMed - as supplied by publisher]


Role of Aldehyde Dehydrogenase 2 in 1-Methy-4-Phenylpyridinium Ion-Induced Aldehyde Stress and Cytotoxicity in PC12 Cells.
Ai-Hua Chen, Ping Zhang, Wei-Lan Yin, Li Wang, Wei Zou, Xiao-Qing Tang
Neurochem Res 2014 Jul;
PMID: 25005621 [PubMed - as supplied by publisher]


A 6.4 Mb Duplication of the ?-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism: Phenotype-Genotype Correlations.
Eleanna Kara, Aoife P Kiely, Christos Proukakis, Nicola Giffin, Seth Love, Jason Hehir, Khadija Rantell, Amelie Pandraud, Dena G Hernandez, Elizabeth Nacheva, Alan M Pittman, Mike A Nalls, Andrew B Singleton, Tamas Revesz, Kailash P Bhatia, Niall Quinn, John Hardy, Janice L Holton, Henry Houlden
JAMA Neurol 2014 Jul;
PMID: 25003242 [PubMed - as supplied by publisher]


Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklund
PLoS One 2014 ; 9(7):e100869
PMID: 24999658 [PubMed - as supplied by publisher]


Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease.
Min Shi, Changqin Liu, Travis J Cook, Kristin M Bullock, Yanchun Zhao, Carmen Ginghina, Yanfei Li, Patrick Aro, Romel Dator, Chunmei He, Michael J Hipp, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, William A Banks, Jing Zhang
Acta Neuropathol 2014 Jul;
PMID: 24997849 [PubMed - as supplied by publisher]


Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.
Anke A Dijkstra, Pieter Voorn, Henk W Berendse, Henk J Groenewegen, , Annemieke J M Rozemuller, Wilma D J van de Berg
Mov Disord 2014 Jul;
PMID: 24996051 [PubMed - as supplied by publisher]


Diet-induced obesity accelerates the onset of terminal phenotypes in ?-synuclein transgenic mice.
Carola Rotermund, Felicia M Truckenmüller, Heinrich Schell, Philipp J Kahle
J Neurochem 2014 Jul;
PMID: 24995537 [PubMed - as supplied by publisher]


The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.
Kay Seidel, Josefine Mahlke, Sonny Siswanto, Reijko Krüger, Helmut Heinsen, Georg Auburger, Mohamed Bouzrou, Lt Grinberg, Helmut Wicht, Horst-Werner Korf, Wilfred den Dunnen, Udo Rüb
Brain Pathol 2014 Jul;
PMID: 24995389 [PubMed - as supplied by publisher]


Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study.
Kajsa Stubendorff, Victoria Larsson, Clive Ballard, Lennart Minthon, Dag Aarsland, Elisabet Londos
BMJ Open 2014 ; 4(7):e005158
PMID: 24993765 [PubMed - as supplied by publisher]


Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.
R A Charan, B N Johnson, S Zaganelli, J D Nardozzi, M J LaVoie
Cell Death Dis 2014 ; 5:e1313
PMID: 24991765 [PubMed - as supplied by publisher]


Latest treatment options for Alzheimer's disease, Parkinson's disease dementia and dementia with Lewy bodies.
Martin Broadstock, Clive Ballard, Anne Corbett
Expert Opin Pharmacother 2014 Jul; :1-14
PMID: 24992196 [PubMed - as supplied by publisher]


Sleep Disorders in Parkinsonian Macaques: Effects of l-Dopa Treatment and Pedunculopontine Nucleus Lesion.
Hayat Belaid, Joëlle Adrien, Elodie Laffrat, Dominique Tandé, Carine Karachi, David Grabli, Isabelle Arnulf, Stewart D Clark, Xavier Drouot, Etienne C Hirsch, Chantal François
J Neurosci 2014 Jul; 34(27):9124-33
PMID: 24990932 [PubMed - as supplied by publisher]


A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases.
William B Pratt, Yoshihiro Morishima, Jason E Gestwicki, Andrew P Lieberman, Yoichi Osawa
Exp Biol Med (Maywood) 2014 Jul;
PMID: 24990484 [PubMed - as supplied by publisher]