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Sheng-Han Kuo, M.D.

“The PDF Côté Award [in Clinical Genetics] helped me to start my research.”

Sheng-Han Kuo, M.D.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

Impulse Control Disorder

Vision/Visual hallucination



Orthostatic Hypotension


Imaging Studies

Clinical Studies



Treating Parkinson’s

Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

Deep Brain Stimulation

Physical, Occupational and Speech Therapy



Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

Hospice/End of Life/Palliative Care

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Direct Correlation Between Ligand-Induced ?-Synuclein Oligomers and Amyloid-like Fibril Growth.
Martin Nors Perdersen, Vito Foderà, Istvan Horvath, Andreas van Maarschalkerweerd, Katrine Nørgaard Toft, Christoph Weise, Fredrik Almqvist, Magnus Wolf-Watz, Pernilla Wittung-Stafshede, Bente Vestergaard
Sci Rep 2015; 5:10422
PMID: 26020724 [PubMed - as supplied by publisher]

Transgenic LRRK2 (R1441G) rats-a model for Parkinson disease?
Komal T Shaikh, Alvin Yang, Ekaterina Youshin, Susanne Schmid
PeerJ 2015 ; 3:e945
PMID: 26020005 [PubMed - as supplied by publisher]

Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
Weili Yang, Guohao Wang, Chuan-En Wang, Xiangyu Guo, Peng Yin, Jinquan Gao, Zhuchi Tu, Zhengbo Wang, Jing Wu, Xintian Hu, Shihua Li, Xiao-Jiang Li
J Neurosci 2015 May; 35(21):8345-58
PMID: 26019347 [PubMed - as supplied by publisher]

Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways.
Yun-Lian Lin, Huey-Jen Tsay, Tzu-Hsuan Lai, Tsai-Teng Tzeng, Young-Ji Shiao
J Biomed Sci 2015; 22(1):37
PMID: 26018660 [PubMed - as supplied by publisher]

Phosphorylated ?-synuclein in skin nerve fibres differentiates Parkinson's disease from multiple system atrophy.
Leonora Zange, Cornelia Noack, Katrin Hahn, Werner Stenzel, Axel Lipp
Brain 2015 May;
PMID: 26017579 [PubMed - as supplied by publisher]

Mechanisms Underlying Neurocognitive Dysfunctions in Recurrent Major Depression.
Piotr Ga?ecki, Monika Talarowska, George Anderson, Michael Berk, Michael Maes
Med Sci Monit 2015; 21:1535-1547
PMID: 26017336 [PubMed - as supplied by publisher]

Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic ?-synuclein mutant mouse model.
Jiahui Deng, E Lv, Jian Yang, Xiaoli Gong, Wenzhong Zhang, Xibin Liang, Jiazeng Wang, Jun Jia, Xiaomin Wang
J Neuroinflammation 2015 May; 12(1):103
PMID: 26016857 [PubMed - as supplied by publisher]

Phenolic compounds prevent the oligomerization of ?-synuclein and reduce synaptic toxicity.
Ryoichi Takahashi, Kenjiro Ono, Yusaku Takamura, Mineyuki Mizuguchi, Tokuhei Ikeda, Hisao Nishijo, Masahito Yamada
J Neurochem 2015 May;
PMID: 26016728 [PubMed - as supplied by publisher]

A dysfunction of CD4+ T lymphocytes in peripheral immune system of Parkinson's disease model mice.
Yan Huang, Zhan Liu, Xiao-Qin Wang, Yi-Hua Qiu, Yu-Ping Peng
Zhongguo Ying Yong Sheng Li Xue Za Zhi 2014 Nov; 30(6):567-76
PMID: 26016368 [PubMed - as supplied by publisher]

Impaired capacity for prospection in the dementias - Theoretical and clinical implications.
Muireann Irish, Pascale Piolino
Br J Clin Psychol 2015 May;
PMID: 26014112 [PubMed - as supplied by publisher]

Rosella Abeti, Andrey Y Abramov
Pharmacol Res 2015 May;
PMID: 26013908 [PubMed - as supplied by publisher]

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson's disease.
Yupin Chen, Dong-Qi Zhang, Zhong Liao, Bin Wang, Suzhen Gong, Chuang Wang, Ming-Zi Zhang, Guo-Hua Wang, Huaibin Cai, Francesca-Fang Liao, Jiang-Ping Xu
Mol Neurodegener 2015 Mar; 10(1):4
PMID: 26013581 [PubMed - as supplied by publisher]

Voxel-based morphometry of the marmoset brain: in vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model.
Keigo Hikishima, Kiyoshi Ando, Yuji Komaki, Kenji Kawai, Ryutaro Yano, Takashi Inoue, Toshio Itoh, Masayuki Yamada, Suketaka Momoshima, Hirotaka J Okano, Hideyuki Okano
Neuroscience 2015 May;
PMID: 26012491 [PubMed - as supplied by publisher]

Comprehensive assessment of genetic sequence variants in the antioxidant 'master regulator' nrf2 in idiopathic Parkinson's disease.
Michael Todorovic, Jeremy R B Newman, Jianguo Shan, Steven Bentley, Stephen A Wood, Peter A Silburn, George D Mellick
PLoS One 2015 ; 10(5):e0128030
PMID: 26010367 [PubMed - as supplied by publisher]

Brain alterations with deep brain stimulation: New insight from a neuropathological case series.
Martin Kronenbuerger, Kay Wilhelm Nolte, Volker Arnd Coenen, Jean-Marc Burgunder, Joachim K Krauss, Joachim Weis
Mov Disord 2015 May;
PMID: 26011773 [PubMed - as supplied by publisher]

Plasma antioxidant status and motor features in de novo Chinese Parkinson's disease patients.
Yongsheng Yuan, Qing Tong, Li Zhang, Siming Jiang, Hong Zhou, Rui Zhang, Shu Zhang, Qinrong Xu, Daqian Li, Xiaobin Zhou, Jian Ding, Kezhong Zhang
Int J Neurosci 2015 May; :1-22
PMID: 26010212 [PubMed - as supplied by publisher]

Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to ?-synuclein in Drosophila.
Bing Wang, Qingqing Liu, Hongyun Shan, Chunlin Xia, Zhaohui Liu
Biochem Cell Biol 2015 Apr; :1-8
PMID: 26008822 [PubMed - as supplied by publisher]

The 5?-reductase inhibitor Dutasteride but not Finasteride protects dopamine neurons in the MPTP mouse model of Parkinson's disease.
Nadhir Litim, Mélanie Bourque, Sara Al Sweidi, Marc Morissette, Thérèse Di Paolo
Neuropharmacology 2015 May;
PMID: 26006269 [PubMed - as supplied by publisher]

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.
Asma Lamine, Myriam Létourneau, Ngoc Duc Doan, Julie Maucotel, Alain Couvineau, Hubert Vaudry, David Chatenet, David Vaudry, Alain Fournier
Neuropharmacology 2015 May;
PMID: 26006268 [PubMed - as supplied by publisher]

Ferulic Acid and Alzheimer's disease: promises and pitfalls.
Seyed Fazel Nabavi, Kasi Pandima Devi, Dicson Sheeja Malar, Antoni Sureda, Maria Daglia, Seyed Mohammad Nabavi
Mini Rev Med Chem 2015 ; 15(9):776-88
PMID: 26002710 [PubMed - as supplied by publisher]

A model of dopamine modulated glutamatergic synapse.
Vito Di Maio, Francesco Ventriglia, Silvia Santillo
Biosystems 2015 May;
PMID: 26001676 [PubMed - as supplied by publisher]

Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice.
Asokan Prema, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Justin Thenmozhi Arokiasamy
Neurosci Lett 2015 May; 599:12-19
PMID: 25980996 [PubMed - as supplied by publisher]

The role of poly unsaturated fatty acids and GPR40 receptor in brain.
Muhammad Zahid Khan, Ling He
Neuropharmacology 2015 May;
PMID: 26005184 [PubMed - as supplied by publisher]

Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease.
Elijah Mak, Li Su, Guy B Williams, John T O'Brien
Parkinsonism Relat Disord 2015 May;
PMID: 26004683 [PubMed - as supplied by publisher]

VIRTUALLY-induced threat in Parkinson'S: Dopaminergic interactions between anxiety and sensory-perceptual processing while WALKING.
Kaylena A Ehgoetz Martens, Colin G Ellard, Quincy J Almeida
Neuropsychologia 2015 May;
PMID: 26004056 [PubMed - as supplied by publisher]

The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux.
Kang Il Lee, Min Ju Kim, Hyongjong Koh, Jin I Lee, Sim Namkoong, Won Keun Oh, Junsoo Park
Biochem Biophys Res Commun 2015 May;
PMID: 25976674 [PubMed - as supplied by publisher]

A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections.
Hao Li, Xiaoguang Lei, Baihui Huang, Joshua D Rizak, Lichuan Yang, Shangchuan Yang, Jing Wu, Longbao Lü, Jianhong Wang, Ting Yan, Hongwei Li, Zhengbo Wang, Yingzhou Hu, Weidong Le, Xingli Deng, Jiali Li, Lin Xu, Baorong Zhang, Xintian Hu
J Neurosci Methods 2015 May;
PMID: 26003862 [PubMed - as supplied by publisher]

?-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca(2+) influx upon NMDA stimulation.
Yudong Chen, Weiwei Yang, Xin Li, Xuran Li, Hui Yang, Zhiqing Xu, Shun Yu
Neuroscience 2015 May;
PMID: 26003734 [PubMed - as supplied by publisher]

Transcriptional regulation of the ?-synuclein gene in human brain tissue.
Steffen Brenner, Christophe Wersinger, Thomas Gasser
Neurosci Lett 2015 May;
PMID: 26002080 [PubMed - as supplied by publisher]

TNF compromises lysosome acidification and reduces ?-synuclein degradation via autophagy in dopaminergic cells.
Mei-Xia Wang, Xiao-Yu Cheng, Mengmeng Jin, Yu-Lan Cao, Ya-Ping Yang, Jian-Da Wang, Qian Li, Fen Wang, Li-Fang Hu, Chun-Feng Liu
Exp Neurol 2015 May;
PMID: 26001614 [PubMed - as supplied by publisher]

?-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease.
Byung-Wook Kim, Sushruta Koppula, Hemant Kumar, Ju-Young Park, Il-Woung Kim, Sandeep V More, In-Su Kim, Sang-Don Han, Si-Kwan Kim, Sung-Hwa Yoon, Dong-Kug Choi
Neuropharmacology 2015 May;
PMID: 25983275 [PubMed - as supplied by publisher]

Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease.
Wang Tan, Cao Xue-Bin, Zhang Tian, Chen Xiao-Wu, Huang Pei-Pei, Chen Zhi-Bin, Tang Bei-Sha
Int J Neurosci 2015 May; :1-25
PMID: 26000813 [PubMed - as supplied by publisher]

Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat.
Selva Rivas-Arancibia, Luis Fernando Hernández Zimbrón, Erika Rodríguez-Martínez, Perla D Maldonado, Gabino Borgonio Pérez, María Sepúlveda-Parada
Front Aging Neurosci 2015 ; 7:65
PMID: 25999851 [PubMed - as supplied by publisher]

Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
Katharina Pukaß, Christiane Richter-Landsberg
Front Cell Neurosci 2015 ; 9:163
PMID: 25999815 [PubMed - as supplied by publisher]

How Mitochondrial Dynamism Orchestrates Mitophagy.
Orian S Shirihai, Moshi Song, Gerald W Dorn
Circ Res 2015 May; 116(11):1835-1849
PMID: 25999423 [PubMed - as supplied by publisher]

Detection of ?-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease.
Xuemei Wang, Shun Yu, Fangfei Li, Tao Feng
Neurosci Lett 2015 May;
PMID: 25998655 [PubMed - as supplied by publisher]

The Use of Cerebrospinal Fluid and Neuropathologic Studies in Neuropsychiatry Practice and Research.
Kalyani Kansal, David J Irwin
Psychiatr Clin North Am 2015 Jun; 38(2):309-322
PMID: 25998118 [PubMed - as supplied by publisher]

Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in (123)I-FP-CIT SPECT.
Norikazu Matsutomo, Akio Nagaki, Fusae Yamao, Masayuki Sasaki
Ann Nucl Med 2015 May;
PMID: 25997807 [PubMed - as supplied by publisher]

Expression of alpha-synuclein during eye development of mice (Mus musculus), chick (Gallus gallus domisticus) and fish (Ctenopharyngodon idella) in a comparison study.
Amin A Seleem
Tissue Cell 2015 Apr;
PMID: 25997379 [PubMed - as supplied by publisher]

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Brice Laurens, Radu Constantinescu, Roy Freeman, Alexander Gerhard, Kurt Jellinger, Alexander Jeromin, Florian Krismer, Brit Mollenhauer, Michael G Schlossmacher, Leslie M Shaw, Marcel M Verbeek, Gregor K Wenning, Kristian Winge, Jing Zhang, Wassilios G Meissner
Neurobiol Dis 2015 May;
PMID: 25982836 [PubMed - as supplied by publisher]

Role of ?- and ?-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies.
Akio Sekigawa, Yoshiki Takamatsu, Kazunari Sekiyama, Makoto Hashimoto
Biomolecules 2015; 5(2):1000-1011
PMID: 25996784 [PubMed - as supplied by publisher]

The genetics of Parkinson's disease.
Stephen Mullin, Anthony Schapira
Br Med Bull 2015 May;
PMID: 25995343 [PubMed - as supplied by publisher]

The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Thomas M Durcan, Edward A Fon
Genes Dev 2015 May; 29(10):989-999
PMID: 25995186 [PubMed - as supplied by publisher]

Oxidative stress derived from airborne fine and ultrafine particles and the effects on brain-nervous system: part 1.
Masaru Sagai, Tin Tin Win-Shwe
Nihon Eiseigaku Zasshi 2015 ; 70(2):127-33
PMID: 25994344 [PubMed - as supplied by publisher]

Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system.
Hong Guo, Fang Shi, Meijiao Li, Qingqing Liu, Bin Yu, Limin Hu
BMC Complement Altern Med 2015 ; 15(1):151
PMID: 25994206 [PubMed - as supplied by publisher]

Dimerization propensities of Synucleins are not predictive for Synuclein aggregation.
Katrin Eckermann, Sebastian Kügler, Mathias Bähr
Biochim Biophys Acta 2015 May; 1852(8):1658-1664
PMID: 25960149 [PubMed - as supplied by publisher]

Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.
Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu, Yun-Cheng Wu
J Neurochem 2015 May;
PMID: 25991017 [PubMed - as supplied by publisher]

Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.
Joanna L Elson, Abi Yates, Ilse S Pienaar
Brain Struct Funct 2015 May;
PMID: 25989851 [PubMed - as supplied by publisher]

Multifaceted role of matrix metalloproteinases (MMPs).
Divya Singh, Sanjeev K Srivastava, Tapas K Chaudhuri, Ghanshyam Upadhyay
Front Mol Biosci 2015 ; 2:19
PMID: 25988186 [PubMed - as supplied by publisher]

Cytosolic PTEN-INDUCED PUTATIVE KINASE 1 is Stabilized By NF-?B Pathway and Promotes Non-Selective Mitophagy.
Grace G Y Lim, Doreen S K Chua, Adeline H Basil, Hui-Ying Chan, Chou Chai, Thiruma Arumugam, Kah-Leong Lim
J Biol Chem 2015 May;
PMID: 25987559 [PubMed - as supplied by publisher]

Gastrointestinal dysfunction in Parkinson's disease.
Alfonso Fasano, Naomi P Visanji, Louis W C Liu, Antony E Lang, Ronald F Pfeiffer
Lancet Neurol 2015 Jun; 14(6):625-639
PMID: 25987282 [PubMed - as supplied by publisher]

The emergence of Parkinson disease among patients with Gaucher disease.
Deborah Elstein, Roy Alcalay, Ari Zimran
Best Pract Res Clin Endocrinol Metab 2015 Mar; 29(2):249-259
PMID: 25987177 [PubMed - as supplied by publisher]

6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells.
Tomasz Maciej St?pkowski, Iwona Wasyk, Agnieszka Grzelak, Marcin Kruszewski
Cell Mol Neurobiol 2015 May;
PMID: 25986246 [PubMed - as supplied by publisher]

Melatonin redox activity. Its potential clinical applications in neurodegenerative disorders.
Elzbieta Miller, Agnieszka Morel, Luciano Saso, Joanna Saluk
Curr Top Med Chem 2015 ; 15(2):163-9
PMID: 25985818 [PubMed - as supplied by publisher]

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant ?-Synuclein.
Nuzhat Ahsan, Satyendra Mishra, Manish Kumar Jain, Avadhesha Surolia, Sarika Gupta
Sci Rep 2015 ; 5:9862
PMID: 25985292 [PubMed - as supplied by publisher]

Clinical Features of Alzheimer Disease With and Without Lewy Bodies.
Eun Joo Chung, Ganesh M Babulal, Sarah E Monsell, Nigel J Cairns, Catherine M Roe, John C Morris
JAMA Neurol 2015 May;
PMID: 25985321 [PubMed - as supplied by publisher]

Mechanisms of Alpha-Synuclein Action on Neurotransmission: Cell-Autonomous and Non-Cell Autonomous Role.
Marco Emanuele, Evelina Chieregatti
Biomolecules 2015; 5(2):865-892
PMID: 25985082 [PubMed - as supplied by publisher]

Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis.
Sujung Yeo, Keon Sang An, Yeon-Mi Hong, Yeong-Gon Choi, Bruce Rosen, Sung-Hoon Kim, Sabina Lim
Genet Mol Biol 2015 Mar; 38(1):115-27
PMID: 25983633 [PubMed - as supplied by publisher]

The walk-bicycle: A new assistive device for Parkinson's patients with freezing of gait?
Claudia Stummer, Valeria Dibilio, Sebastiaan Overeem, Vivian Weerdesteyn, Bastiaan R Bloem, Jorik Nonnekes
Parkinsonism Relat Disord 2015 Apr;
PMID: 25983112 [PubMed - as supplied by publisher]

P2X7 receptor is critical in ?-synuclein-mediated microglial NADPH oxidase activation.
Tianfang Jiang, Jake Hoekstra, Xin Heng, Wenyan Kang, Jianqing Ding, Jun Liu, Shengdi Chen, Jing Zhang
Neurobiol Aging 2015 Apr;
PMID: 25983062 [PubMed - as supplied by publisher]

Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson's Disease.
Michael J Hurley, Pascal F Durrenberger, Steve M Gentleman, Andrew F Walls, David T Dexter
J Mol Neurosci 2015 May;
PMID: 25982926 [PubMed - as supplied by publisher]

Manganese Homeostasis in the Nervous System.
Pan Chen, Sudipta Chakraborty, Somshuvra Mukhopadhyay, Eunsook Lee, Monica M B Paoliello, Aaron B Bowman, Michael Aschner
J Neurochem 2015 May;
PMID: 25982296 [PubMed - as supplied by publisher]

Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Jihye Park, Chae-Seok Lim, Hyunhyo Seo, Chung-Ah Park, Min Zhuo, Bong-Kiun Kaang, Kyungmin Lee
Mol Pain 2015 May; 11(1):28
PMID: 25981600 [PubMed - as supplied by publisher]

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis.
Akvil? Jarmalavi?i?t?, Virginijus Tunaitis, Ugn? Pivorait?, Algirdas Venalis, Augustas Pivori?nas
Cytotherapy 2015 May;
PMID: 25981557 [PubMed - as supplied by publisher]

Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease.
Irene R Taravini, Celia Larramendy, Gimena Gomez, Mariano D Saborido, Floor Spaans, Cristóbal Fresno, Germán A González, Elmer Fernández, Mario Gustavo Murer, Oscar S Gershanik
Neuropharmacology 2015 May;
PMID: 25963416 [PubMed - as supplied by publisher]

Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease.
M D Sconce, M J Churchill, R E Greene, C K Meshul
Neuroscience 2015 May; 299:156-174
PMID: 25943481 [PubMed - as supplied by publisher]

CSF proteins and resting-state functional connectivity in Parkinson disease.
Meghan C Campbell, Jonathan M Koller, Abraham Z Snyder, Chandana Buddhala, Paul T Kotzbauer, Joel S Perlmutter
Neurology 2015 May;
PMID: 25979701 [PubMed - as supplied by publisher]

The Role of ?-Synuclein and LRRK2 in Tau Phosphorylation.
Fumitaka Kawakami, Takafumi Ichikawa
Parkinsons Dis 2015 ; 2015:734746
PMID: 25977830 [PubMed - as supplied by publisher]

Recent progress of imaging agents for Parkinson's disease.
Xiaoai Wu, Huawei Cai, Ran Ge, Lin Li
Curr Neuropharmacol 2014 Dec; 12(6):551-63
PMID: 25977680 [PubMed - as supplied by publisher]

Neuropathobiology of non-motor symptoms in Parkinson disease.
Kurt A Jellinger
J Neural Transm 2015 May;
PMID: 25976432 [PubMed - as supplied by publisher]

Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB 2 Receptors.
María S Aymerich, Estefanía Rojo-Bustamante, Carmen Molina, Marta Celorrio, Juan A Sánchez-Arias, Rafael Franco
Mol Neurobiol 2015 May;
PMID: 25976369 [PubMed - as supplied by publisher]

MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim.
Huiqing Wang, Yongyi Ye, Zhiyuan Zhu, Liqian Mo, Chunnan Lin, Qifu Wang, Haoyuan Wang, Xin Gong, Xiaozheng He, Guohui Lu, Fengfei Lu, Shizhong Zhang
Brain Pathol 2015 May;
PMID: 25976060 [PubMed - as supplied by publisher]

Quantitative assessment of the association between GAK rs1564282 C/T polymorphism and the risk of Parkinson's disease.
Ze-Gang Ma, Feng He, Jian Xu
J Clin Neurosci 2015 May;
PMID: 25975492 [PubMed - as supplied by publisher]

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.
Elvira Valera, Michael Mante, Scott Anderson, Edward Rockenstein, Eliezer Masliah
J Neuroinflammation 2015 ; 12(1):93
PMID: 25966683 [PubMed - as supplied by publisher]

Thiol redox homeostasis in neurodegenerative disease.
Gethin J McBean, Mutay Aslan, Helen R Griffiths, Rita C Torrão
Redox Biol 2015 Apr; 5:186-194
PMID: 25974624 [PubMed - as supplied by publisher]

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV ?-Synuclein Rat Model of Parkinson's Disease.
Qing He, James B Koprich, Ying Wang, Wen-Bo Yu, Bao-Guo Xiao, Jonathan M Brotchie, Jian Wang
Mol Neurobiol 2015 May;
PMID: 25972237 [PubMed - as supplied by publisher]

Amyloid-? and ?-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease.
Ane Løvli Stav, Dag Aarsland, Krisztina Kunszt Johansen, Erik Hessen, Eirik Auning, Tormod Fladby
Parkinsonism Relat Disord 2015 May;
PMID: 25971633 [PubMed - as supplied by publisher]

Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy.
Ying Tang, Jiankang Liu, Jiangang Long
J Diabetes Investig 2015 May; 6(3):250-5
PMID: 25969707 [PubMed - as supplied by publisher]

Activation of MyD88-dependent TLR1/2 signaling by misfolded ?-synuclein, a protein linked to neurodegenerative disorders.
Stefano G Daniele, Dawn Béraud, Connor Davenport, Kui Cheng, Hang Yin, Kathleen A Maguire-Zeiss
Sci Signal 2015 ; 8(376):ra45
PMID: 25969543 [PubMed - as supplied by publisher]

Antagonistic pleiotropic effects of nitric oxide in Parkinson's disease pathophysiology.
Debasmita Tripathy, Joy Chakraborty, Kochupurackal P Mohanakumar
Free Radic Res 2015 May; :1-43
PMID: 25968946 [PubMed - as supplied by publisher]

Neuroprotective effects of ginkgetin against neuro-injury in Parkinson's disease model induced by MPTP via chelating iron.
Yue-Qi Wang, Mei-Yue Wang, Xue-Rui Fu, Peng- Yu, Guo-Fen Gao, Yu-Mei Fan, Xiang-Lin Duan, Bao-Lu Zhao, Yan-Zhong Chang, Zhen-Hua Shi
Free Radic Res 2015 May; :1-39
PMID: 25968939 [PubMed - as supplied by publisher]

Alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
Michela Zaltieri, Jessica Grigoletto, Francesca Longhena, Laura Navarria, Gaia Favero, Stefania Castrezzati, Maria Alessandra Colivicchi, Laura Della Corte, Rita Rezzani, Marina Pizzi, Fabio Benfenati, Maria Grazia Spillantini, Cristina Missale, PierFranco Spano, Arianna Bellucci
J Cell Sci 2015 May;
PMID: 25967550 [PubMed - as supplied by publisher]

Normalization of Overexpressed ?-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference.
Masaki Takahashi, Mari Suzuki, Masashi Fukuoka, Nobuhiro Fujikake, Shoko Watanabe, Miho Murata, Keiji Wada, Yoshitaka Nagai, Hirohiko Hohjoh
Mol Ther Nucleic Acids 2015 ; 4:e241
PMID: 25965551 [PubMed - as supplied by publisher]

Folic Acid Supplementation Ameliorates Oxidative Stress, Metabolic Functions and Developmental Anomalies in a Novel Fly Model of Parkinson's Disease.
Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, Saripella Srikrishna
Neurochem Res 2015 May;
PMID: 25963948 [PubMed - as supplied by publisher]

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.
Marie-Therese Fuzzati-Armentero, Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gianfilippo Antoninetti, Fabio Blandini, Younis Baqi, Christa E Müller, Rosaria Volpini, Giulia Costa, Nicola Simola, Annalisa Pinna
J Neurochem 2015 May;
PMID: 25962878 [PubMed - as supplied by publisher]

Plasma Oligomeric Alpha-Synuclein Is Associated With Glucocerebrosidase Activity in Gaucher Disease.
Evgenii Nuzhnyi, Anton Emelyanov, Tatyana Boukina, Tatiana Usenko, Andrey Yakimovskii, Ekaterina Zakharova, Sofya Pchelina
Mov Disord 2015 May;
PMID: 25962734 [PubMed - as supplied by publisher]

Impaired heart rate variability in patients with dementia with Lewy bodies: Efficacy of electrocardiogram as a supporting diagnostic marker.
Koji Kasanuki, Eizo Iseki, Hiroshige Fujishiro, Shuntaro Ando, Hideki Sugiyama, Maiko Kitazawa, Yuhei Chiba, Kiyoshi Sato, Heii Arai
Parkinsonism Relat Disord 2015 May;
PMID: 25962552 [PubMed - as supplied by publisher]

SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.
Yue Huang, Gang Wang, Dominic Rowe, Ying Wang, John B J Kwok, Qin Xiao, Frank Mastaglia, Jun Liu, Sheng-Di Chen, Glenda Halliday
Biomed Res Int 2015 ; 2015:135674
PMID: 25960998 [PubMed - as supplied by publisher]

Autonomic involvement in Parkinsonian carriers of PARK2 gene mutations.
Beatriz Tijero, Iñigo Gabilondo, Elena Lezcano, Nuria Teran-Villagrá, Verónica Llorens, Javier Ruiz-Martinez, Jose Felix Marti-Masso, M Carmona, Maria Rosario Luquin, Koldo Berganzo, Ivan Fernandez, Manuel Fernandez, Juan José Zarranz, Juan Carlos Gómez-Esteban
Parkinsonism Relat Disord 2015 Apr;
PMID: 25960264 [PubMed - as supplied by publisher]

Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines.
Andrew F Fischer, Kathryn Mansfield Matera
Neurochem Res 2015 May;
PMID: 25956992 [PubMed - as supplied by publisher]

The mechanobiology of drug-induced cardiac valve disease.
Ngoc Thien Lam, Kartik Balachandran
J Long Term Eff Med Implants 2015 ; 25(1-2):27-40
PMID: 25955005 [PubMed - as supplied by publisher]

Role of ??synuclein in cognitive dysfunction: Studies in Drosophila melanogaster.
Xiaofeng Zhao, Xicui Sun, Song Cai, Dongzhi Ran, Ying Yan, Zhong Pei
Mol Med Rep 2015 May;
PMID: 25954925 [PubMed - as supplied by publisher]

A new role for ?-Synuclein in Parkinson's disease: Alteration of ER-Mitochondrial communication.
Cristina Guardia-Laguarta, Estela Area-Gomez, Eric A Schon, Serge Przedborski
Mov Disord 2015 May;
PMID: 25952565 [PubMed - as supplied by publisher]

Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.
Ashutosh Kumar, Fabian Leinisch, Maria B Kadiiska, Jean Corbett, Ronald P Mason
Mol Neurobiol 2015 May;
PMID: 25952542 [PubMed - as supplied by publisher]

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.
Keiko Nakamura, Fumiaki Mori, Kunikazu Tanji, Yasuo Miki, Masahito Yamada, Akiyoshi Kakita, Hitoshi Takahashi, Jun Utsumi, Hidenao Sasaki, Koichi Wakabayashi
Neuropathology 2015 May;
PMID: 25950736 [PubMed - as supplied by publisher]

Neuroaxonal dystrophy in PLA2G6 knockout mice.
Hisae Sumi-Akamaru, Goichi Beck, Shinsuke Kato, Hideki Mochizuki
Neuropathology 2015 May;
PMID: 25950622 [PubMed - as supplied by publisher]

Protective effect of curculigo orchioides extract on cyclophosphamide-induced neurotoxicity in murine model.
Dipica Ramchandani, Aditya Ganeshpurkar, Divya Bansal, Manvendra Singh Karchuli, Nazneen Dubey
Toxicol Int 2014 Sep-Dec; 21(3):232-5
PMID: 25948959 [PubMed - as supplied by publisher]

Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability.
Chuen-Lin Huang, Chih-Chang Chao, Yi-Chao Lee, Mei-Kuang Lu, Jing-Jy Cheng, Ying-Chen Yang, Vin-Chi Wang, Wen-Chang Chang, Nai-Kuei Huang
Mol Neurobiol 2015 May;
PMID: 25947082 [PubMed - as supplied by publisher]

Clinical Utility of Skin Biopsy in Differentiating between Parkinson's Disease and Multiple System Atrophy.
Rie Haga, Kazuhiro Sugimoto, Haruo Nishijima, Yasuo Miki, Chieko Suzuki, Koichi Wakabayashi, Masayuki Baba, Soroku Yagihashi, Masahiko Tomiyama
Parkinsons Dis 2015 ; 2015:167038
PMID: 25945280 [PubMed - as supplied by publisher]

Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson's Disease.
Musthafa Mohamed Essa, Selvaraju Subash, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Samir Al-Adawi, Gilles J Guillemin, Arokiasamy Justin Thenmozhi
Neurochem Res 2015 May;
PMID: 25944473 [PubMed - as supplied by publisher]