What can we learn by studying genetics and Parkinson's? PDF-funded researchers Drs. Mata and Zabetian share their progress six years after launching the first large-scale survey of PD genetics in Latin America.
PDF Grant Programs
Are you interested in furthering Parkinson's science? View PDF's open grant programs.
Causes and Pathology
PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research.
Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members? Please browse PDF's educational materials and programs - which are all available electronically or in print. Order for yourself, a loved one or in bulk for your patients or support group.
There was an error retrieving the document. Please try again.
A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress.
Peter Bou Dib, Bettina Gnägi, Fiona Daly, Virginie Sabado, Damla Tas, Dominique A Glauser, Peter Meister, Emi Nagoshi
PLoS Genet 2014 Oct; 10(10):e1004718
PMID: 25340742 [PubMed - as supplied by publisher]
Mucuna pruriens (Velvet bean) Rescues Motor, Olfactory, Mitochondrial and Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic Model of Parkinson's Disease.
Simone Poddighe, Francescaelena De Rose, Roberto Marotta, Roberta Ruffilli, Maura Fanti, Pietro Paolo Secci, Maria Cristina Mostallino, Maria Dolores Setzu, Maria Antonietta Zuncheddu, Ignazio Collu, Paolo Solla, Francesco Marrosu, Sanjay Kasture, Elio Acquas, Anna Liscia
PLoS One 2014 ; 9(10):e110802
PMID: 25340511 [PubMed - as supplied by publisher]
Nutrient deprivation induces ?-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway.
Peizhou Jiang, Ming Gan, Wen-Lang Lin, Shu-Hui C Yen
Front Aging Neurosci 2014 ; 6:268
PMID: 25339898 [PubMed - as supplied by publisher]
Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb.
Françoise Lazarini, Marie-Madeleine Gabellec, Carine Moigneu, Fabrice de Chaumont, Jean-Christophe Olivo-Marin, Pierre-Marie Lledo
J Neurosci 2014 Oct; 34(43):14430-42
PMID: 25339754 [PubMed - as supplied by publisher]
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.
Amandine Berthet, Elyssa B Margolis, Jue Zhang, Ivy Hsieh, Jiasheng Zhang, Thomas S Hnasko, Jawad Ahmad, Robert H Edwards, Hiromi Sesaki, Eric J Huang, Ken Nakamura
J Neurosci 2014 Oct; 34(43):14304-17
PMID: 25339743 [PubMed - as supplied by publisher]
Identification of the PLK2-Dependent Phosphopeptidomeby Quantitative Proteomics.
Cinzia Franchin, Luca Cesaro, Lorenzo A Pinna, Giorgio Arrigoni, Mauro Salvi
PLoS One 2014 ; 9(10):e111018
PMID: 25338102 [PubMed - as supplied by publisher]
Pure psychiatric presentation of the Lewy body disease is depression-an analysis of 60 cases verified with myocardial meta-iodobenzylguanidine study.
Katsuji Kobayashi, Hiroyuki Nakano, Noriko Akiyama, Takashi Maeda, Sanae Yamamori
Int J Geriatr Psychiatry 2014 Oct;
PMID: 25335897 [PubMed - as supplied by publisher]
A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.
Marion Szelechowski, Alexandre Bétourné, Yann Monnet, Cécile A Ferré, Anne Thouard, Charlotte Foret, Jean-Michel Peyrin, Stéphane Hunot, Daniel Gonzalez-Dunia
Nat Commun 2014 ; 5:5181
PMID: 25333748 [PubMed - as supplied by publisher]
Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event.
Jonas Kosten, Andres Binolfi, Marchel Stuiver, Silvia Verzini, Francois-Xavier Theillet, Beata Bekei, Marleen van Rossum, Philipp Selenko
ACS Chem Neurosci 2014 Oct;
PMID: 25320964 [PubMed - as supplied by publisher]
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.
Yvette C Wong, Erika L F Holzbaur
Proc Natl Acad Sci U S A 2014 Oct; 111(42):E4439-48
PMID: 25294927 [PubMed - as supplied by publisher]
Skin nerve ?-synuclein deposits: A biomarker for idiopathic Parkinson disease.
Surinder K Sharma, Vincenzo Donadio
Neurology 2014 Oct; 83(17):1582
PMID: 25332447 [PubMed - as supplied by publisher]
Impact of subunit linkages in an engineered homodimeric binding protein to ?-synuclein.
Aziz Gauhar, Hamed Shaykhalishahi, Lothar Gremer, Ewa A Mirecka, Wolfgang Hoyer
Protein Eng Des Sel 2014 Oct;
PMID: 25332193 [PubMed - as supplied by publisher]
Long-Range Correlated Dynamics in Intrinsically Disordered Proteins.
Giacomo Parigi, Nasrollah Rezaei-Ghaleh, Andrea Giachetti, Stefan Becker, Claudio Fernandez, Martin Blackledge, Christian Griesinger, Markus Zweckstetter, Claudio Luchinat
J Am Chem Soc 2014 Oct;
PMID: 25331250 [PubMed - as supplied by publisher]
The Newly Discovered Parkinson's Disease Associated Finnish Mutation (A53E) Attenuates ?-Synuclein Aggregation and Membrane Binding.
Dhiman Ghosh, Shruti Sahay, Priyatosh Ranjan, Shimul Salot, Ganesh M Mohite, Pradeep K Singh, Saumya Dwivedi, Edmund Carvalho, Rinti Banerjee, Ashutosh Kumar, Samir K Maji
Biochemistry 2014 Oct; 53(41):6419-21
PMID: 25268550 [PubMed - as supplied by publisher]
Visual signs and symptoms of multiple system atrophy.
Richard A Armstrong
Clin Exp Optom 2014 Nov; 97(6):483-91
PMID: 25256122 [PubMed - as supplied by publisher]
Besides Fibrillization: Putative Role of the Peptide Fragment 71-82 on the Structural and Assembly Behavior of ?-Synuclein.
Laurie Bédard, Thierry Lefèvre, Emilie Morin-Michaud, Michèle Auger
Biochemistry 2014 Oct; 53(41):6463-72
PMID: 25255476 [PubMed - as supplied by publisher]
Sparing of orexin-A and orexin-B neurons in the hypothalamus and of orexin fibers in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated macaques.
Manale Bensaid, Dominique Tandé, Véronique Fabre, Patrick P Michel, Etienne C Hirsch, Chantal François
Eur J Neurosci 2014 Oct;
PMID: 25328140 [PubMed - as supplied by publisher]
Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment.
Jan-Philip Schülke, Laura A McAllister, Kieran F Geoghegan, Vinod Parikh, Thomas A Chappie, Patrick R Verhoest, Christopher J Schmidt, Douglas S Johnson, Nicholas J Brandon
ACS Chem Biol 2014 Oct;
PMID: 25295858 [PubMed - as supplied by publisher]
A variety of pesticides trigger in vitro ?-synuclein accumulation, a key event in Parkinson's disease.
Areski Chorfa, Corinne Lazizzera, Dominique Bétemps, Eric Morignat, Sébastien Dussurgey, Thibault Andrieu, Thierry Baron
Arch Toxicol 2014 Oct;
PMID: 25326819 [PubMed - as supplied by publisher]
Protective Effects of Poly (butyl) Cyanoacrylate Nanoparticles Containing Vasoactive Intestinal Peptide Against 6-Hydroxydopamine-Induced Neurotoxicity In Vitro.
Zhi-Ran Xu, Wu-Fang Wang, Xin-Fang Liang, Ze-Hua Liu, Yu Liu, Liang Lin, Xuan Zhu
J Mol Neurosci 2014 Oct;
PMID: 25326789 [PubMed - as supplied by publisher]
?-Synuclein forms non-selective cation channels and stimulates KATP channels in hippocampal neurons.
Sergej L Mironov
J Physiol 2014 Oct;
PMID: 25326450 [PubMed - as supplied by publisher]
Altered synaptic architecture and glycosylated synaptomatrix composition in a Drosophila classic galactosemia disease model.
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie
Dis Model Mech 2014 Oct;
PMID: 25326312 [PubMed - as supplied by publisher]
A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation.
Tito Calì, Denis Ottolini, Maria Eugenia Soriano, Marisa Brini
Hum Mol Genet 2014 Oct;
PMID: 25305074 [PubMed - as supplied by publisher]
RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders.
Mercè Canal, Joan Romaní-Aumedes, Núria Martín-Flores, Víctor Pérez-Fernández, Cristina Malagelada
Front Cell Neurosci 2014 ; 8:313
PMID: 25324725 [PubMed - as supplied by publisher]
Parkinson Disease Genetics: A "Continuum" From Mendelian to Multifactorial Inheritance.
S Petrucci, F Consoli, E M Valente
Curr Mol Med 2014 Oct;
PMID: 25323865 [PubMed - as supplied by publisher]
Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson's Disease.
Jose L Labandeira-Garcia, Ana I Rodríguez-Perez, Begoña Villar-Cheda, Ana Borrajo, Antonio Dominguez-Meijide, Maria J Guerra
Neuroscientist 2014 Oct;
PMID: 25323761 [PubMed - as supplied by publisher]
Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease.
Seon Ae Eom, Dae Won Kim, Min Jea Shin, Eun Hee Ahn, Seok Young Chung, Eun Jeong Sohn, Hyo Sang Jo, Su-Jeong Jeon, Duk-Soo Kim, Hyeok Yil Kwon, Sung-Woo Cho, Kyu Hyung Han, Jinseu Park, Won Sik Eum, Soo Young Choi
BMB Rep 2014 Oct;
PMID: 25322954 [PubMed - as supplied by publisher]
Applications of digital holographic microscopy in therapeutic evaluation of Chinese herbal medicines.
Chung-Hsin Wu, Xin-Ji Lai, Chau-Jern Cheng, Yu-Chen Yu, Chun-Yen Chang
Appl Opt 2014 Sep; 53(27):G192-7
PMID: 25322130 [PubMed - as supplied by publisher]
?-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: Implications in the pathogenesis of Parkinson's disease.
Aritri Bir, Oishimaya Sen, Shruti Anand, Vineet Kumar Khemka, Priyanjalee Banerjee, Roberto Cappai, Arghyadip Sahoo, Sasanka Chakrabarti
J Neurochem 2014 Oct;
PMID: 25319443 [PubMed - as supplied by publisher]
A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus.
Bridget A Culleton, Patrick Lall, Gemma K Kinsella, Sean Doyle, John McCaffrey, David A Fitzpatrick, Ann M Burnell
Cell Stress Chaperones 2014 Oct;
PMID: 25318690 [PubMed - as supplied by publisher]
Climate change and infectious diseases in the Arctic: establishment of a circumpolar working group.
Alan J Parkinson, Birgitta Evengard, Jan C Semenza, Nicholas Ogden, Malene L Børresen, Jim Berner, Michael Brubaker, Anders Sjöstedt, Magnus Evander, David M Hondula, Bettina Menne, Natalia Pshenichnaya, Prabhu Gounder, Tricia Larose, Boris Revich, Karsten Hueffer, Ann Albihn
Int J Circumpolar Health 2014 ; 73
PMID: 25317383 [PubMed - as supplied by publisher]
The role of DJ-1 in the oxidative stress cell death cascade after stroke.
Paolina Pantcheva, Maya Elias, Kelsey Duncan, Cesar V Borlongan, Naoki Tajiri, Yuji Kaneko
Neural Regen Res 2014 Aug; 9(15):1430-3
PMID: 25317153 [PubMed - as supplied by publisher]
Driving neural regeneration through the mammalian target of rapamycin.
Neural Regen Res 2014 Aug; 9(15):1413-7
PMID: 25317149 [PubMed - as supplied by publisher]
LIMP-2 expression is critical for ?-glucocerebrosidase activity and ?-synuclein clearance.
Michelle Rothaug, Friederike Zunke, Joseph R Mazzulli, Michaela Schweizer, Hermann Altmeppen, Renate Lüllmann-Rauch, Wouter W Kallemeijn, Paulo Gaspar, Johannes M Aerts, Markus Glatzel, Paul Saftig, Dimitri Krainc, Michael Schwake, Judith Blanz
Proc Natl Acad Sci U S A 2014 Oct;
PMID: 25316793 [PubMed - as supplied by publisher]
Repression of rRNA transcription by PARIS contributes to Parkinson's Disease.
Hojin Kang, Joo-Ho Shin
Neurobiol Dis 2014 Oct;
PMID: 25315684 [PubMed - as supplied by publisher]
PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.
Asad A Aboud, Andrew M Tidball, Kevin K Kumar, M Diana Neely, Bingying Han, Kevin C Ess, Charles C Hong, Keith M Erikson, Peter Hedera, Aaron B Bowman
Neurobiol Dis 2014 Oct;
PMID: 25315681 [PubMed - as supplied by publisher]
Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease.
L-H You, F Li, L Wang, S-E Zhao, S-M Wang, L-L Zhang, L-H Zhang, X-L Duan, P Yu, Y-Z Chang
Neuroscience 2014 Oct;
PMID: 25301748 [PubMed - as supplied by publisher]
Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP(+) toxicity.
Yi-Hsien Tsou, Ching-Ting Shih, Cheng-Hsin Ching, Jui-Yen Huang, Chauying J Jen, Lung Yu, Yu-Min Kuo, Fong-Sen Wu, Jih-Ing Chuang
Exp Neurol 2014 Oct; 263C:50-62
PMID: 25286336 [PubMed - as supplied by publisher]
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis.
Alban Ordureau, Shireen A Sarraf, David M Duda, Jin-Mi Heo, Mark P Jedrychowski, Vladislav O Sviderskiy, Jennifer L Olszewski, James T Koerber, Tiao Xie, Sean A Beausoleil, James A Wells, Steven P Gygi, Brenda A Schulman, J Wade Harper
Mol Cell 2014 Oct;
PMID: 25284222 [PubMed - as supplied by publisher]
Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson's Disease.
Koneni V Sashidhara, Ram K Modukuri, Pooja Jadiya, K Bhaskara Rao, Tanuj Sharma, Rizwanul Haque, Deependra Kumar Singh, Dibyendu Banerjee, Mohammad Imran Siddiqi, Aamir Nazir
ACS Med Chem Lett 2014 Oct; 5(10):1099-103
PMID: 25313319 [PubMed - as supplied by publisher]
Lewy body disease and dementia with Lewy bodies.
Proc Jpn Acad Ser B Phys Biol Sci 2014 ; 90(8):301-6
PMID: 25311140 [PubMed - as supplied by publisher]
Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity.
Patricia Giuliani, Patrizia Ballerini, Silvana Buccella, Renata Ciccarelli, Michel P Rathbone, Silvia Romano, Iolanda D'Alimonte, Francesco Caciagli, Patrizia Di Iorio, Mieczyslaw Pokorski
Adv Exp Med Biol 2014 Oct;
PMID: 25310956 [PubMed - as supplied by publisher]
The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease.
Ja Pyszko, Jb Strosznajder
Folia Neuropathol 2014 ; 52(3):260-9
PMID: 25310737 [PubMed - as supplied by publisher]
Human Wharton?s jelly-derived stem cells display immunomodulatory properties and transiently improve rat experimental autoimmune encephalomyelitis.
Raf Donders, Marjan Vanheusden, Jeroen Fj Bogie, Stylianos Ravanidis, Kristof Thewissen, Piet Stinissen, Wilfried Gyselaers, Jerome Ja Hendriks, Niels Hellings
Cell Transplant 2014 Oct;
PMID: 25310756 [PubMed - as supplied by publisher]
Elevated levels of cerebrospinal fluid ?-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers.
Jan O Aasly, Krisztina K Johansen, Gunnar Brønstad, Bjørg J Warø, Nour K Majbour, Shiji Varghese, Fatimah Alzahmi, Katerina E Paleologou, Dena A M Amer, Abdulmonem Al-Hayani, Omar M A El-Agnaf
Front Aging Neurosci 2014 ; 6:248
PMID: 25309429 [PubMed - as supplied by publisher]
Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.
Lars Tönges, Eva M Szegö, Patrizia Hause, Kim-Ann Saal, Lars Tatenhorst, Jan Christoph Koch, Zara D Hedouville, Vivian Dambeck, Sebastian Kügler, Christoph P Dohm, Mathias Bähr, Paul Lingor
Front Aging Neurosci 2014 ; 6:239
PMID: 25309425 [PubMed - as supplied by publisher]
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Dayne A Beccano-Kelly, Naila Kuhlmann, Igor Tatarnikov, Mattia Volta, Lise N Munsie, Patrick Chou, Li-Ping Cao, Heather Han, Lucia Tapia, Matthew J Farrer, Austen J Milnerwood
Front Cell Neurosci 2014 ; 8:301
PMID: 25309331 [PubMed - as supplied by publisher]
An association study between Heme oxygenase-1 genetic variants and Parkinson's disease.
Pedro Ayuso, Carmen Martínez, Pau Pastor, Oswaldo Lorenzo-Betancor, Antonio Luengo, Félix J Jiménez-Jiménez, Hortensia Alonso-Navarro, José A G Agúndez, Elena García-Martín
Front Cell Neurosci 2014 ; 8:298
PMID: 25309329 [PubMed - as supplied by publisher]
Edible bird's nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells.
Mei Yeng Yew, Rhun Yian Koh, Soi Moi Chye, Iekhsan Othman, Khuen Yen Ng
BMC Complement Altern Med 2014 Oct; 14(1):391
PMID: 25308934 [PubMed - as supplied by publisher]
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.
N Brehm, F Bez, T Carlsson, B Kern, S Gispert, G Auburger, M A Cenci
Mol Neurobiol 2014 Oct;
PMID: 25307288 [PubMed - as supplied by publisher]
Neuroprotective and antidepressant-like effects of melatonin in a rotenone-induced Parkinson's disease model in rats.
Taysa B Bassani, Raisa W Gradowski, Tiago Zaminelli, Janaína K Barbiero, Ronise M Santiago, Suelen L Boschen, Claudio da Cunha, Marcelo M S Lima, Roberto Andreatini, Maria A B F Vital
Brain Res 2014 Oct;
PMID: 25301688 [PubMed - as supplied by publisher]
The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease.
J Schapansky, J D Nardozzi, M J LaVoie
Neuroscience 2014 Oct;
PMID: 25284317 [PubMed - as supplied by publisher]
Induction of Pi Form of Glutathione S-Transferase by Carnosic Acid Is Mediated through PI3K/Akt/NF-?B Pathway and Protects against Neurotoxicity.
Chia-Yuan Lin, Jing-Hsien Chen, Ru-Huei Fu, Chia-Wen Tsai
Chem Res Toxicol 2014 Oct;
PMID: 25271104 [PubMed - as supplied by publisher]
Increased plasma oligomeric alpha-synuclein in patients with lysosomal storage diseases.
S N Pchelina, E P Nuzhnyi, A K Emelyanov, T M Boukina, T S Usenko, M A Nikolaev, G N Salogub, A F Yakimovskii, E Yu Zakharova
Neurosci Lett 2014 Sep; 583C:188-193
PMID: 25265039 [PubMed - as supplied by publisher]
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Brian P Dranka, Alison Gifford, Donna McAllister, Jacek Zielonka, Joy Joseph, Crystal L O'Hara, Cheryl L Stucky, Anumantha G Kanthasamy, Balaraman Kalyanaraman
Neurosci Lett 2014 Sep; 583C:159-164
PMID: 25263790 [PubMed - as supplied by publisher]
Rab11 modulates ?-synuclein mediated defects in synaptic transmission and behaviour.
Carlo Breda, Marie L Nugent, Jasper G Estranero, Charalambos P Kyriacou, Tiago F Outeiro, Joern R Steinert, Flaviano Giorgini
Hum Mol Genet 2014 Oct;
PMID: 25305083 [PubMed - as supplied by publisher]
PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.
Hyo-Kyoung Choi, Youngsok Choi, HeeBum Kang, Eun-Jin Lim, Soo-Yeon Park, Hyun-Seob Lee, Ji-Min Park, Jisook Moon, Yoon-Jung Kim, Insup Choi, Eun-Hye Joe, Kyung-Chul Choi, Ho-Geun Yoon
Hum Mol Genet 2014 Oct;
PMID: 25305081 [PubMed - as supplied by publisher]
Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.
Qian Zhou, Chunxiao Liu, Wen Liu, Hai Zhang, Ruijie Zhang, Jia Liu, Jinfei Zhang, Chong Xu, Lei Liu, Shile Huang, Long Chen
Toxicol Sci 2014 Oct;
PMID: 25304210 [PubMed - as supplied by publisher]
L-745,870 reduces the expression of abnormal involuntary movements in the 6-OHDA-lesioned rat.
Philippe Huot, Tom H Johnston, James B Koprich, Maria C Espinosa, Maria Gabriela Reyes, Susan H Fox, Jonathan M Brotchie
Behav Pharmacol 2014 Oct;
PMID: 25303957 [PubMed - as supplied by publisher]
A Nucleoprotein-Enriched Diet Suppresses Dopaminergic Neuronal Cell Loss and Motor Deficit in Mice with MPTP-Induced Parkinson's Disease.
Keisuke Kiriyama, Hirokazu Ohtaki, Natsuki Kobayashi, Norimitsu Murai, Minako Matsumoto, Shun Sasaki, Chika Sawa, Kazue Satoh, Masaji Matsunaga, Seiji Shioda
J Mol Neurosci 2014 Oct;
PMID: 25303858 [PubMed - as supplied by publisher]
Cell cycle regulation of DNA polymerase Beta in rotenone-based Parkinson's disease models.
Hongcai Wang, Yan Chen, Jinbo Chen, Zhentao Zhang, Wansheng Lao, Xizhi Li, Jinsha Huang, Tao Wang
PLoS One 2014 ; 9(10):e109697
PMID: 25303312 [PubMed - as supplied by publisher]
The possible mechanism of Parkinson's disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine.
Renshi Xu, Yiyi Zhou, Xin Fang, Yi Lu, Jiao Li, Jie Zhang, Xia Deng, Shujuan Li
Brain Res 2014 Oct;
PMID: 25285892 [PubMed - as supplied by publisher]
Intranasal delivery of bone marrow derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer?s and Parkinson?s disease.
Lusine Danielyan, Sandra Beer-Hammer, Alexandra Stolzing, Richard Sch Fer, Georg Siegel, Claire Fabian, Philipp Kahle, Tilo Biedermann, Ali Lourhmati, Marine Buadze, Ana Novakovic, Barbara Proksch, Christoph H Gleiter, William H Frey Ii, Matthias Schwab
Cell Transplant 2014 Oct;
PMID: 25302802 [PubMed - as supplied by publisher]
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?
Gurdeep Marwarha, Othman Ghribi
Exp Gerontol 2014 Sep;
PMID: 25261765 [PubMed - as supplied by publisher]
Formation of ?-Synuclein Lewy Neurite-like aggregates in Axons Impedes the Transport of Distinct Endosomes.
Laura A Volpicelli-Daley, Karen L Gamble, Christine E Schultheiss, Dawn M Riddle, Andrew B West, Virginia M-Y Lee
Mol Biol Cell 2014 Oct;
PMID: 25298402 [PubMed - as supplied by publisher]
A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.
Ji Ae Lee, Ji Hyun Kim, Seo Yeon Woo, Hyo Jin Son, Se Hee Han, Bo Ko Jang, Ji Won Choi, Dong Jin Kim, Ki Duk Park, Onyou Hwang
Br J Pharmacol 2014 Oct;
PMID: 25297649 [PubMed - as supplied by publisher]
Mutant ?-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels.
Mahalakshmi Subramaniam, Daniel Althof, Suzana Gispert, Jochen Schwenk, Georg Auburger, Akos Kulik, Bernd Fakler, Jochen Roeper
J Neurosci 2014 Oct; 34(41):13586-99
PMID: 25297088 [PubMed - as supplied by publisher]
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.
Staffan Holmqvist, Oldriska Chutna, Luc Bousset, Patrick Aldrin-Kirk, Wen Li, Tomas Björklund, Zhan-You Wang, Laurent Roybon, Ronald Melki, Jia-Yi Li
Acta Neuropathol 2014 Oct;
PMID: 25296989 [PubMed - as supplied by publisher]
Potentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression.
Suzana Gispert, Nadine Brehm, Jonas Weil, Kay Seidel, Udo Rüb, Beatrice Kern, Michael Walter, Jochen Roeper, Georg Auburger
Hum Mol Genet 2014 Oct;
PMID: 25296918 [PubMed - as supplied by publisher]
Early oligomerization stages for the non-amyloid component of ?-synuclein amyloid.
Cindie Eugene, Rozita Laghaei, Normand Mousseau
J Chem Phys 2014 Oct; 141(13):135103
PMID: 25296841 [PubMed - as supplied by publisher]
Electrochemical techniques for subsecond neurotransmitter detection in live rodents.
Kevin N Hascup, Erin R Hascup
Comp Med 2014 ; 64(4):249-55
PMID: 25296011 [PubMed - as supplied by publisher]
LC-MS-Based Urinary Metabolite Signatures in Idiopathic Parkinson's Disease.
Hemi Luan, Liang-Feng Liu, Nan Meng, Zhi Tang, Ka-Kit Chua, Lei-Lei Chen, Ju-Xian Song, Vincent C T Mok, Li-Xia Xie, Min Li, Zongwei Cai
J Proteome Res 2014 Oct;
PMID: 25271123 [PubMed - as supplied by publisher]
Aptamers as Promising Molecular Recognition Elements for Diagnostics and Therapeutics in the Central Nervous System.
Erin M McConnell, Matthew R Holahan, Maria C DeRosa
Nucleic Acid Ther 2014 Oct;
PMID: 25296265 [PubMed - as supplied by publisher]
Toxicogenetics: in search of host susceptibility to environmental toxicants.
Gelareh Alam, Byron C Jones
Front Genet 2014 ; 5:327
PMID: 25295052 [PubMed - as supplied by publisher]
Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases.
William B Pratt, Jason E Gestwicki, Yoichi Osawa, Andrew P Lieberman
Annu Rev Pharmacol Toxicol 2014 Sep;
PMID: 25292434 [PubMed - as supplied by publisher]
Correlation Between 123I-FP-CIT Brain SPECT and Parkinsonism in Dementia With Lewy Bodies: Caveat for Clinical Use.
Angelo Del Sole, Giulia Perini, Michela Lecchi, Claudio Mariani, Giovanni Lucignani, Francesca Clerici
Clin Nucl Med 2014 Oct;
PMID: 25290294 [PubMed - as supplied by publisher]
In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.
Hua-Shan Wang, Joanne Toh, Patrick Ho, Murni Tio, Yi Zhao, Eng-King Tan
Mol Brain 2014 Oct; 7(1):73
PMID: 25288323 [PubMed - as supplied by publisher]
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
, M C Cornelis, E M Byrne, T Esko, M A Nalls, A Ganna, N Paynter, K L Monda, N Amin, K Fischer, F Renstrom, J S Ngwa, V Huikari, A Cavadino, I M Nolte, A Teumer, K Yu, P Marques-Vidal, R Rawal, A Manichaikul, M K Wojczynski, J M Vink, J H Zhao, G Burlutsky, J Lahti, V Mikkilä, R N Lemaitre, J Eriksson, S K Musani, T Tanaka, F Geller, J Luan, J Hui, R Mägi, M Dimitriou, M E Garcia, W-K Ho, M J Wright, L M Rose, P K E Magnusson, N L Pedersen, D Couper, B A Oostra, A Hofman, M A Ikram, H W Tiemeier, A G Uitterlinden, F J A van Rooij, I Barroso, I Johansson, L Xue, M Kaakinen, L Milani, C Power, H Snieder, R P Stolk, S E Baumeister, R Biffar, F Gu, F Bastardot, Z Kutalik, D R Jacobs, N G Forouhi, E Mihailov, L Lind, C Lindgren, K Michaëlsson, A Morris, M Jensen, K-T Khaw, R N Luben, J J Wang, S Männistö, M-M Perälä, M Kähönen, T Lehtimäki, J Viikari, D Mozaffarian, K Mukamal, B M Psaty, A Döring, A C Heath, G W Montgomery, N Dahmen, T Carithers, K L Tucker, L Ferrucci, H A Boyd, M Melbye, J L Treur, D Mellström, J J Hottenga, I Prokopenko, A Tönjes, P Deloukas, S Kanoni, M Lorentzon, D K Houston, Y Liu, J Danesh, A Rasheed, M A Mason, A B Zonderman, L Franke, B S Kristal, , , , J Karjalainen, D R Reed, H-J Westra, M K Evans, D Saleheen, T B Harris, G Dedoussis, G Curhan, M Stumvoll, J Beilby, L R Pasquale, B Feenstra, S Bandinelli, J M Ordovas, A T Chan, U Peters, C Ohlsson, C Gieger, N G Martin, M Waldenberger, D S Siscovick, O Raitakari, J G Eriksson, P Mitchell, D J Hunter, P Kraft, E B Rimm, D I Boomsma, I B Borecki, R J F Loos, N J Wareham, P Vollenweider, N Caporaso, H J Grabe, M L Neuhouser, B H R Wolffenbuttel, F B Hu, E Hyppönen, M-R Järvelin, L A Cupples, P W Franks, P M Ridker, C M van Duijn, G Heiss, A Metspalu, K E North, E Ingelsson, J A Nettleton, R M van Dam, D I Chasman
Mol Psychiatry 2014 Oct;
PMID: 25288136 [PubMed - as supplied by publisher]
Involvement of the sodium-calcium exchanger 3 (NCX3) in ziram-induced calcium dysregulation and toxicity.
J Jin, A J Lao, M Katsura, A Caputo, F E Schweizer, S Sokolow
Neurotoxicology 2014 Oct;
PMID: 25284465 [PubMed - as supplied by publisher]
AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo.
Kim-Ann Saal, Jan C Koch, Lars Tatenhorst, Eva M Szeg?, Vinicius Toledo Ribas, Uwe Michel, Mathias Bähr, Lars Tönges, Paul Lingor
Neurobiol Dis 2014 Oct;
PMID: 25283984 [PubMed - as supplied by publisher]
Alpha synuclein is transported into and out of the brain by the blood-brain barrier.
Yu-Ting Sui, Kristin M Bullock, Michelle A Erickson, Jing Zhang, W A Banks
Peptides 2014 Sep;
PMID: 25278492 [PubMed - as supplied by publisher]
Microencapsulation of dopamine neurons derived from human induced pluripotent stem cells.
Shuhei Konagaya, Hiroo Iwata
Biochim Biophys Acta 2014 Oct;
PMID: 25281770 [PubMed - as supplied by publisher]
Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice.
Michelle S Antunes, André T R Goes, Silvana P Boeira, Marina Prigol, Cristiano R Jesse
Nutrition 2014 Nov-Dec; 30(11-12):1415-22
PMID: 25280422 [PubMed - as supplied by publisher]
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
Ching-Chi Chiu, Tu-Hsueh Yeh, Szu-Chia Lai, Yah-Huei Wu-Chou, Che-Hong Chen, Daria Mochly-Rosen, Yin-Cheng Huang, Yu-Jie Chen, Chao-Lang Chen, Ya-Ming Chang, Hung-Li Wang, Chin-Song Lu
Exp Neurol 2014 Sep;
PMID: 25263579 [PubMed - as supplied by publisher]
Parkinson's disease and age: The obvious but largely unexplored link.
Rashed Abdullah, Indranil Basak, Ketan S Patil, Guido Alves, Jan Petter Larsen, Simon Geir Møller
Exp Gerontol 2014 Sep;
PMID: 25261764 [PubMed - as supplied by publisher]
E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity.
Jacob W Zyskind, Ying Wang, Giyong Cho, Jenhao H Ting, Dennis L Kolson, David R Lynch, Kelly L Jordan-Sciutto
J Neurochem 2014 Oct;
PMID: 25279448 [PubMed - as supplied by publisher]
Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2.
Sarah Cahill-Smith, Jian-Mei Li
Br J Clin Pharmacol 2014 Sep; 78(3):441-53
PMID: 25279404 [PubMed - as supplied by publisher]
Maneb-induced dopaminergic neuronal death is not affected by loss of mitochondrial complex I activity: results from primary mesencephalic dopaminergic neurons cultured from individual Ndufs4+/+ and Ndufs4-/- mouse embryos.
Won-Seok Choi, Zhengui Xia
Neuroreport 2014 Oct;
PMID: 25275677 [PubMed - as supplied by publisher]
Methylglyoxal increased dopamine level and led to oxidative stress in SH-SY5Y cells.
Bingjie Xie, Fankai Lin, Lei Peng, Kaleem Ullah, Hanyan Wu, Hong Qing, Yulin Deng
Acta Biochim Biophys Sin (Shanghai) 2014 Oct;
PMID: 25274329 [PubMed - as supplied by publisher]
Acute increase of ?-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.
David J Busch, Paul A Oliphint, Rylie B Walsh, Susan M L Banks, Wendy S Woods, Julia M George, Jennifer R Morgan
Mol Biol Cell 2014 Oct;
PMID: 25273557 [PubMed - as supplied by publisher]
Mechanism of the beneficial effect of melatonin in experimental Parkinson's disease.
Fatos Belgin Yildirim, Ozlem Ozsoy, Gamze Tanriover, Yasemin Kaya, Eren Ogut, Burcu Gemici, Sayra Dilmac, Ayse Ozkan, Aysel Agar, Mutay Aslan
Neurochem Int 2014 Sep;
PMID: 25263280 [PubMed - as supplied by publisher]
Clinical workout for the early detection of cognitive decline and dementia.
Eur J Clin Nutr 2014 Oct;
PMID: 25271010 [PubMed - as supplied by publisher]
Cypermethrin alters the status of oxidative stress in the peripheral blood: relevance to Parkinsonism.
Pratibha Tripathi, Ashish Singh, Sonal Agrawal, Om Prakash, Mahendra Pratap Singh
J Physiol Biochem 2014 Oct;
PMID: 25270427 [PubMed - as supplied by publisher]
Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
A Ledonne, A Nobili, E C Latagliata, V Cavallucci, E Guatteo, S Puglisi-Allegra, M D'Amelio, N B Mercuri
Mol Psychiatry 2014 Sep;
PMID: 25266126 [PubMed - as supplied by publisher]
Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP.
Joon Ho Moon, Ji Ho Kim, Hyung-Jun Im, Dong Soo Lee, Eun Jung Park, Kilyoung Song, Hyun Ju Oh, Su Bin Hyun, Sang Chul Kang, Hyunil Kim, Hyo Eun Moon, Hyung Woo Park, Hong Jae Lee, Eun Ji Kim, Seokjoong Kim, Byeong Chun Lee, Sun Ha Paek
Exp Neurobiol 2014 Sep; 23(3):258-65
PMID: 25258574 [PubMed - as supplied by publisher]
Reduced alpha-synuclein in cerebrospinal fluid in synucleinopathies: Evidence from a meta-analysis.
Wataru Sako, Nagahisa Murakami, Yuishin Izumi, Ryuji Kaji
Mov Disord 2014 Sep;
PMID: 25258345 [PubMed - as supplied by publisher]
Interactions between Calcium and Alpha-Synuclein in Neurodegeneration.
Alex Rcom-H'cheo-Gauthier, Jacob Goodwin, Dean L Pountney
Biomolecules 2014 ; 4(3):795-811
PMID: 25256602 [PubMed - as supplied by publisher]
Air pollution and your brain: what do you need to know right now.
Lilian Calderón-Garcidueñas, Ana Calderón-Garcidueñas, Ricardo Torres-Jardón, José Avila-Ramírez, Randy J Kulesza, Amedeo D Angiulli
Prim Health Care Res Dev 2014 Sep; :1-17
PMID: 25256239 [PubMed - as supplied by publisher]
Stimulation of ? Opioid Receptor and Blockade of Nociceptin/Orphanin FQ Receptor Synergistically Attenuate Parkinsonism.
Omar S Mabrouk, Riccardo Viaro, Mattia Volta, Ada Ledonne, Nicola Mercuri, Michele Morari
J Neurosci 2014 Sep; 34(39):12953-62
PMID: 25253844 [PubMed - as supplied by publisher]
Neuroprotective effect of Buddleja cordata methanolic extract in the 1-methyl-4-phenylpyridinium Parkinson's disease rat model.
Gabriela Pérez-Barrón, José Guillermo Avila-Acevedo, Ana María García-Bores, Sergio Montes, Sara García-Jiménez, Ismael León-Rivera, Moisés Rubio-Osornio, Antonio Monroy-Noyola
J Nat Med 2014 Sep;
PMID: 25253176 [PubMed - as supplied by publisher]