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Sheng-Han Kuo, M.D.

“The PDF Côté Award [in Clinical Genetics] helped me to start my research.”

Sheng-Han Kuo, M.D.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Understanding Parkinson’s

Motor Symptoms


    Balance and Falls
    Gait or Freezing

    Nonmotor Symptoms and Complications



Sleep and Fatigue/ REM Behavior Sleep Disorder

    Gastrointestinal and Urinary Function

    Cognition and Hallucination

Impulse Control Disorder

Vision/Visual hallucination



Orthostatic Hypotension


Imaging Studies

Clinical Studies



Treating Parkinson’s

Current and potential medications/Therapies

    Surgical Treatments
Gene Therapy

Deep Brain Stimulation

Physical, Occupational and Speech Therapy



Art and Music

Complementary and Alternative Therapies

Living with a Parkinson’s Diagnosis



Care giving

Hospice/End of Life/Palliative Care

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Dimerization propensities of Synucleins are not predictive for Synuclein aggregation.
Katrin Eckermann, Sebastian Kügler, Mathias Bähr
Biochim Biophys Acta 2015 May; 1852(8):1658-1664
PMID: 25960149 [PubMed - as supplied by publisher]

Generation and characterization of novel conformation-specific monoclonal antibodies for ?-synuclein pathology.
Nishant N Vaikath, Nour K Majbour, Katerina E Paleologou, Mustafa T Ardah, Esther van Dam, Wilma D J van de Berg, Shelley L Forrest, Laura Parkkinen, Wei-Ping Gai, Nobutaka Hattori, Masashi Takanashi, Seung-Jae Lee, David M A Mann, Yuzuru Imai, Glenda M Halliday, Jia-Yi Li, Omar M A El-Agnaf
Neurobiol Dis 2015 Apr; 79:81-99
PMID: 25937088 [PubMed - as supplied by publisher]

Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells.
Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu, Yun-Cheng Wu
J Neurochem 2015 May;
PMID: 25991017 [PubMed - as supplied by publisher]

Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.
Joanna L Elson, Abi Yates, Ilse S Pienaar
Brain Struct Funct 2015 May;
PMID: 25989851 [PubMed - as supplied by publisher]

Multifaceted role of matrix metalloproteinases (MMPs).
Divya Singh, Sanjeev K Srivastava, Tapas K Chaudhuri, Ghanshyam Upadhyay
Front Mol Biosci 2015 ; 2:19
PMID: 25988186 [PubMed - as supplied by publisher]

Cytosolic PTEN-INDUCED PUTATIVE KINASE 1 is Stabilized By NF-?B Pathway and Promotes Non-Selective Mitophagy.
Grace G Y Lim, Doreen S K Chua, Adeline H Basil, Hui-Ying Chan, Chou Chai, Thiruma Arumugam, Kah-Leong Lim
J Biol Chem 2015 May;
PMID: 25987559 [PubMed - as supplied by publisher]

Gastrointestinal dysfunction in Parkinson's disease.
Alfonso Fasano, Naomi P Visanji, Louis W C Liu, Antony E Lang, Ronald F Pfeiffer
Lancet Neurol 2015 Jun; 14(6):625-639
PMID: 25987282 [PubMed - as supplied by publisher]

The emergence of Parkinson disease among patients with Gaucher disease.
Deborah Elstein, Roy Alcalay, Ari Zimran
Best Pract Res Clin Endocrinol Metab 2015 Mar; 29(2):249-259
PMID: 25987177 [PubMed - as supplied by publisher]

6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells.
Tomasz Maciej St?pkowski, Iwona Wasyk, Agnieszka Grzelak, Marcin Kruszewski
Cell Mol Neurobiol 2015 May;
PMID: 25986246 [PubMed - as supplied by publisher]

Melatonin redox activity. Its potential clinical applications in neurodegenerative disorders.
Elzbieta Miller, Agnieszka Morel, Luciano Saso, Joanna Saluk
Curr Top Med Chem 2015 ; 15(2):163-9
PMID: 25985818 [PubMed - as supplied by publisher]

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant ?-Synuclein.
Nuzhat Ahsan, Satyendra Mishra, Manish Kumar Jain, Avadhesha Surolia, Sarika Gupta
Sci Rep 2015 ; 5:9862
PMID: 25985292 [PubMed - as supplied by publisher]

Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice.
Asokan Prema, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi
Neurosci Lett 2015 May;
PMID: 25980996 [PubMed - as supplied by publisher]

Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells.
Zhen Tan, Huamin Xu, Xiaoli Shen, Hong Jiang
Peptides 2015 Apr; 69:109-114
PMID: 25937598 [PubMed - as supplied by publisher]

Clinical Features of Alzheimer Disease With and Without Lewy Bodies.
Eun Joo Chung, Ganesh M Babulal, Sarah E Monsell, Nigel J Cairns, Catherine M Roe, John C Morris
JAMA Neurol 2015 May;
PMID: 25985321 [PubMed - as supplied by publisher]

Mechanisms of Alpha-Synuclein Action on Neurotransmission: Cell-Autonomous and Non-Cell Autonomous Role.
Marco Emanuele, Evelina Chieregatti
Biomolecules 2015; 5(2):865-892
PMID: 25985082 [PubMed - as supplied by publisher]

Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis.
Sujung Yeo, Keon Sang An, Yeon-Mi Hong, Yeong-Gon Choi, Bruce Rosen, Sung-Hoon Kim, Sabina Lim
Genet Mol Biol 2015 Mar; 38(1):115-27
PMID: 25983633 [PubMed - as supplied by publisher]

?-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease.
Byung-Wook Kim, Sushruta Koppula, Hemant Kumar, Ju-Young Park, Il-Woung Kim, Sandeep V More, In-Su Kim, Sang-Don Han, Si-Kwan Kim, Sung-Hwa Yoon, Dong-Kug Choi
Neuropharmacology 2015 May;
PMID: 25983275 [PubMed - as supplied by publisher]

The walk-bicycle: A new assistive device for Parkinson's patients with freezing of gait?
Claudia Stummer, Valeria Dibilio, Sebastiaan Overeem, Vivian Weerdesteyn, Bastiaan R Bloem, Jorik Nonnekes
Parkinsonism Relat Disord 2015 Apr;
PMID: 25983112 [PubMed - as supplied by publisher]

P2X7 receptor is critical in ?-synuclein-mediated microglial NADPH oxidase activation.
Tianfang Jiang, Jake Hoekstra, Xin Heng, Wenyan Kang, Jianqing Ding, Jun Liu, Shengdi Chen, Jing Zhang
Neurobiol Aging 2015 Apr;
PMID: 25983062 [PubMed - as supplied by publisher]

Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson's Disease.
Michael J Hurley, Pascal F Durrenberger, Steve M Gentleman, Andrew F Walls, David T Dexter
J Mol Neurosci 2015 May;
PMID: 25982926 [PubMed - as supplied by publisher]

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Brice Laurens, Radu Constantinescu, Roy Freeman, Alexander Gerhard, Kurt Jellinger, Alexander Jeromin, Florian Krismer, Brit Mollenhauer, Michael G Schlossmacher, Leslie M Shaw, Marcel M Verbeek, Gregor K Wenning, Kristian Winge, Jing Zhang, Wassilios G Meissner
Neurobiol Dis 2015 May;
PMID: 25982836 [PubMed - as supplied by publisher]

Manganese Homeostasis in the Nervous System.
Pan Chen, Sudipta Chakraborty, Somshuvra Mukhopadhyay, Eunsook Lee, Monica M B Paoliello, Aaron B Bowman, Michael Aschner
J Neurochem 2015 May;
PMID: 25982296 [PubMed - as supplied by publisher]

Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Jihye Park, Chae-Seok Lim, Hyunhyo Seo, Chung-Ah Park, Min Zhuo, Bong-Kiun Kaang, Kyungmin Lee
Mol Pain 2015 May; 11(1):28
PMID: 25981600 [PubMed - as supplied by publisher]

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis.
Akvil? Jarmalavi?i?t?, Virginijus Tunaitis, Ugn? Pivorait?, Algirdas Venalis, Augustas Pivori?nas
Cytotherapy 2015 May;
PMID: 25981557 [PubMed - as supplied by publisher]

The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux.
Kang Il Lee, Min Ju Kim, Hyongjong Koh, Jin I Lee, Sim Namkoong, Won Keun Oh, Junsoo Park
Biochem Biophys Res Commun 2015 May;
PMID: 25976674 [PubMed - as supplied by publisher]

Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease.
Irene R Taravini, Celia Larramendy, Gimena Gomez, Mariano D Saborido, Floor Spaans, Cristóbal Fresno, Germán A González, Elmer Fernández, Mario Gustavo Murer, Oscar S Gershanik
Neuropharmacology 2015 May;
PMID: 25963416 [PubMed - as supplied by publisher]

Intervention with exercise restores motor deficits but not nigrostriatal loss in a progressive MPTP mouse model of Parkinson's disease.
M D Sconce, M J Churchill, R E Greene, C K Meshul
Neuroscience 2015 May; 299:156-174
PMID: 25943481 [PubMed - as supplied by publisher]

TDP-43 Pathology Progression Along the Olfactory Pathway as a Possible Substrate for Olfactory Impairment in Amyotrophic Lateral Sclerosis.
Takahiro Takeda, Mutsumi Iijima, Toshiki Uchihara, Takashi Ohashi, Danielle Seilhean, Charles Duyckaerts, Shinichiro Uchiyama
J Neuropathol Exp Neurol 2015 Jun; 74(6):547-56
PMID: 25933387 [PubMed - as supplied by publisher]

Remote His50 Acts as a Coordination Switch in the High-Affinity N-Terminal Centered Copper(II) Site of ?-Synuclein.
Riccardo De Ricco, Daniela Valensin, Simone Dell'Acqua, Luigi Casella, Pierre Dorlet, Peter Faller, Christelle Hureau
Inorg Chem 2015 May; 54(10):4744-51
PMID: 25926427 [PubMed - as supplied by publisher]

Modulation of endoplasmic reticulum stress: an opportunity to prevent neurodegeneration?
Ana I Placido, Claudia M F Pereira, Ana I Duarte, Emanuel Candeias, Sonia C Correia, Cristina Carvalho, Susana Cardoso, Catarina R Oliveira, Paula I Moreira
CNS Neurol Disord Drug Targets 2015 ; 14(4):518-33
PMID: 25921746 [PubMed - as supplied by publisher]

Multitarget intervention of Fasudil in the neuroprotection of dopaminergic neurons in MPTP-mouse model of Parkinson's disease.
Yong-Fei Zhao, Qiong Zhang, Jian-Ying Xi, Yan-Hua Li, Cun-Gen Ma, Bao-Guo Xiao
J Neurol Sci 2015 Jun; 353(1-2):28-37
PMID: 25908255 [PubMed - as supplied by publisher]

CSF proteins and resting-state functional connectivity in Parkinson disease.
Meghan C Campbell, Jonathan M Koller, Abraham Z Snyder, Chandana Buddhala, Paul T Kotzbauer, Joel S Perlmutter
Neurology 2015 May;
PMID: 25979701 [PubMed - as supplied by publisher]

The Role of ?-Synuclein and LRRK2 in Tau Phosphorylation.
Fumitaka Kawakami, Takafumi Ichikawa
Parkinsons Dis 2015 ; 2015:734746
PMID: 25977830 [PubMed - as supplied by publisher]

Recent progress of imaging agents for Parkinson's disease.
Xiaoai Wu, Huawei Cai, Ran Ge, Lin Li
Curr Neuropharmacol 2014 Dec; 12(6):551-63
PMID: 25977680 [PubMed - as supplied by publisher]

Neuropathobiology of non-motor symptoms in Parkinson disease.
Kurt A Jellinger
J Neural Transm 2015 May;
PMID: 25976432 [PubMed - as supplied by publisher]

Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB 2 Receptors.
María S Aymerich, Estefanía Rojo-Bustamante, Carmen Molina, Marta Celorrio, Juan A Sánchez-Arias, Rafael Franco
Mol Neurobiol 2015 May;
PMID: 25976369 [PubMed - as supplied by publisher]

MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim.
Huiqing Wang, Yongyi Ye, Zhiyuan Zhu, Liqian Mo, Chunnan Lin, Qifu Wang, Haoyuan Wang, Xin Gong, Xiaozheng He, Guohui Lu, Fengfei Lu, Shizhong Zhang
Brain Pathol 2015 May;
PMID: 25976060 [PubMed - as supplied by publisher]

Quantitative assessment of the association between GAK rs1564282 C/T polymorphism and the risk of Parkinson's disease.
Ze-Gang Ma, Feng He, Jian Xu
J Clin Neurosci 2015 May;
PMID: 25975492 [PubMed - as supplied by publisher]

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease.
Elvira Valera, Michael Mante, Scott Anderson, Edward Rockenstein, Eliezer Masliah
J Neuroinflammation 2015 ; 12(1):93
PMID: 25966683 [PubMed - as supplied by publisher]

Copper Binding to the N-Terminally Acetylated, Naturally Occurring Form of Alpha-Synuclein Induces Local Helical Folding.
Marco C Miotto, Ariel A Valiente-Gabioud, Giulia Rossetti, Markus Zweckstetter, Paolo Carloni, Philipp Selenko, Christian Griesinger, Andres Binolfi, Claudio O Fernández
J Am Chem Soc 2015 May;
PMID: 25939020 [PubMed - as supplied by publisher]

Phytic acid attenuates inflammatory responses and the levels of NF-?B and p-ERK in MPTP-induced Parkinson's disease model of mice.
Yuqiang Lv, Zheng Zhang, Lin Hou, Li Zhang, Jinyu Zhang, Yuehua Wang, Cun Liu, Pingping Xu, Lu Liu, Xiaoying Gai, Tingxiu Lu
Neurosci Lett 2015 Apr; 597:132-136
PMID: 25929185 [PubMed - as supplied by publisher]

Thiol redox homeostasis in neurodegenerative disease.
Gethin J McBean, Mutay Aslan, Helen R Griffiths, Rita C Torrão
Redox Biol 2015 Apr; 5:186-194
PMID: 25974624 [PubMed - as supplied by publisher]

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV ?-Synuclein Rat Model of Parkinson's Disease.
Qing He, James B Koprich, Ying Wang, Wen-Bo Yu, Bao-Guo Xiao, Jonathan M Brotchie, Jian Wang
Mol Neurobiol 2015 May;
PMID: 25972237 [PubMed - as supplied by publisher]

Amyloid-? and ?-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease.
Ane Løvli Stav, Dag Aarsland, Krisztina Kunszt Johansen, Erik Hessen, Eirik Auning, Tormod Fladby
Parkinsonism Relat Disord 2015 May;
PMID: 25971633 [PubMed - as supplied by publisher]

Oligomers of Parkinson's Disease-Related ?-Synuclein Mutants Have Similar Structures but Distinctive Membrane Permeabilization Properties.
Anja N D Stefanovic, Saskia Lindhoud, Slav A Semerdzhiev, Mireille M A E Claessens, Vinod Subramaniam
Biochemistry 2015 May;
PMID: 25909158 [PubMed - as supplied by publisher]

Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy.
Ying Tang, Jiankang Liu, Jiangang Long
J Diabetes Investig 2015 May; 6(3):250-5
PMID: 25969707 [PubMed - as supplied by publisher]

Activation of MyD88-dependent TLR1/2 signaling by misfolded ?-synuclein, a protein linked to neurodegenerative disorders.
Stefano G Daniele, Dawn Béraud, Connor Davenport, Kui Cheng, Hang Yin, Kathleen A Maguire-Zeiss
Sci Signal 2015 ; 8(376):ra45
PMID: 25969543 [PubMed - as supplied by publisher]

Antagonistic pleiotropic effects of nitric oxide in Parkinson's disease pathophysiology.
Debasmita Tripathy, Joy Chakraborty, Kochupurackal P Mohanakumar
Free Radic Res 2015 May; :1-43
PMID: 25968946 [PubMed - as supplied by publisher]

Neuroprotective effects of ginkgetin against neuro-injury in Parkinson's disease model induced by MPTP via chelating iron.
Yue-Qi Wang, Mei-Yue Wang, Xue-Rui Fu, Peng- Yu, Guo-Fen Gao, Yu-Mei Fan, Xiang-Lin Duan, Bao-Lu Zhao, Yan-Zhong Chang, Zhen-Hua Shi
Free Radic Res 2015 May; :1-39
PMID: 25968939 [PubMed - as supplied by publisher]

Alpha-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
Michela Zaltieri, Jessica Grigoletto, Francesca Longhena, Laura Navarria, Gaia Favero, Stefania Castrezzati, Maria Alessandra Colivicchi, Laura Della Corte, Rita Rezzani, Marina Pizzi, Fabio Benfenati, Maria Grazia Spillantini, Cristina Missale, PierFranco Spano, Arianna Bellucci
J Cell Sci 2015 May;
PMID: 25967550 [PubMed - as supplied by publisher]

Normalization of Overexpressed ?-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference.
Masaki Takahashi, Mari Suzuki, Masashi Fukuoka, Nobuhiro Fujikake, Shoko Watanabe, Miho Murata, Keiji Wada, Yoshitaka Nagai, Hirohiko Hohjoh
Mol Ther Nucleic Acids 2015 ; 4:e241
PMID: 25965551 [PubMed - as supplied by publisher]

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson's disease.
Guillaume Grolez, Caroline Moreau, Bernard Sablonnière, Guillaume Garçon, Jean-Christophe Devedjian, Sayah Meguig, Patrick Gelé, Christine Delmaire, Regis Bordet, Luc Defebvre, Ioav Z Cabantchik, David Devos
BMC Neurol 2015 ; 15:74
PMID: 25943368 [PubMed - as supplied by publisher]

Targeting ?-arrestin2 in the treatment of l-DOPA-induced dyskinesia in Parkinson's disease.
Nikhil M Urs, Simone Bido, Sean M Peterson, Tanya L Daigle, Caroline E Bass, Raul R Gainetdinov, Erwan Bezard, Marc G Caron
Proc Natl Acad Sci U S A 2015 May; 112(19):E2517-26
PMID: 25918399 [PubMed - as supplied by publisher]

Effect of serotonin transporter blockade on L-DOPA-induced dyskinesia in animal models of Parkinson's disease.
C Fidalgo, W K D Ko, E Tronci, Q Li, R Stancampiano, Q Chuan, E Bezard, M Carta
Neuroscience 2015 Apr; 298:389-396
PMID: 25907446 [PubMed - as supplied by publisher]

Folic Acid Supplementation Ameliorates Oxidative Stress, Metabolic Functions and Developmental Anomalies in a Novel Fly Model of Parkinson's Disease.
Saurabh Srivastav, Sandeep Kumar Singh, Amarish Kumar Yadav, Saripella Srikrishna
Neurochem Res 2015 May;
PMID: 25963948 [PubMed - as supplied by publisher]

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease.
Marie-Therese Fuzzati-Armentero, Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gianfilippo Antoninetti, Fabio Blandini, Younis Baqi, Christa E Müller, Rosaria Volpini, Giulia Costa, Nicola Simola, Annalisa Pinna
J Neurochem 2015 May;
PMID: 25962878 [PubMed - as supplied by publisher]

Plasma Oligomeric Alpha-Synuclein Is Associated With Glucocerebrosidase Activity in Gaucher Disease.
Evgenii Nuzhnyi, Anton Emelyanov, Tatyana Boukina, Tatiana Usenko, Andrey Yakimovskii, Ekaterina Zakharova, Sofya Pchelina
Mov Disord 2015 May;
PMID: 25962734 [PubMed - as supplied by publisher]

Impaired heart rate variability in patients with dementia with Lewy bodies: Efficacy of electrocardiogram as a supporting diagnostic marker.
Koji Kasanuki, Eizo Iseki, Hiroshige Fujishiro, Shuntaro Ando, Hideki Sugiyama, Maiko Kitazawa, Yuhei Chiba, Kiyoshi Sato, Heii Arai
Parkinsonism Relat Disord 2015 May;
PMID: 25962552 [PubMed - as supplied by publisher]

SNCA Gene, but Not MAPT, Influences Onset Age of Parkinson's Disease in Chinese and Australians.
Yue Huang, Gang Wang, Dominic Rowe, Ying Wang, John B J Kwok, Qin Xiao, Frank Mastaglia, Jun Liu, Sheng-Di Chen, Glenda Halliday
Biomed Res Int 2015 ; 2015:135674
PMID: 25960998 [PubMed - as supplied by publisher]

Autonomic involvement in Parkinsonian carriers of PARK2 gene mutations.
Beatriz Tijero, Iñigo Gabilondo, Elena Lezcano, Nuria Teran-Villagrá, Verónica Llorens, Javier Ruiz-Martinez, Jose Felix Marti-Masso, M Carmona, Maria Rosario Luquin, Koldo Berganzo, Ivan Fernandez, Manuel Fernandez, Juan José Zarranz, Juan Carlos Gómez-Esteban
Parkinsonism Relat Disord 2015 Apr;
PMID: 25960264 [PubMed - as supplied by publisher]

Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines.
Andrew F Fischer, Kathryn Mansfield Matera
Neurochem Res 2015 May;
PMID: 25956992 [PubMed - as supplied by publisher]

The mechanobiology of drug-induced cardiac valve disease.
Ngoc Thien Lam, Kartik Balachandran
J Long Term Eff Med Implants 2015 ; 25(1-2):27-40
PMID: 25955005 [PubMed - as supplied by publisher]

Role of ??synuclein in cognitive dysfunction: Studies in Drosophila melanogaster.
Xiaofeng Zhao, Xicui Sun, Song Cai, Dongzhi Ran, Ying Yan, Zhong Pei
Mol Med Rep 2015 May;
PMID: 25954925 [PubMed - as supplied by publisher]

A new role for ?-Synuclein in Parkinson's disease: Alteration of ER-Mitochondrial communication.
Cristina Guardia-Laguarta, Estela Area-Gomez, Eric A Schon, Serge Przedborski
Mov Disord 2015 May;
PMID: 25952565 [PubMed - as supplied by publisher]

Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease.
Ashutosh Kumar, Fabian Leinisch, Maria B Kadiiska, Jean Corbett, Ronald P Mason
Mol Neurobiol 2015 May;
PMID: 25952542 [PubMed - as supplied by publisher]

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.
Keiko Nakamura, Fumiaki Mori, Kunikazu Tanji, Yasuo Miki, Masahito Yamada, Akiyoshi Kakita, Hitoshi Takahashi, Jun Utsumi, Hidenao Sasaki, Koichi Wakabayashi
Neuropathology 2015 May;
PMID: 25950736 [PubMed - as supplied by publisher]

Neuroaxonal dystrophy in PLA2G6 knockout mice.
Hisae Sumi-Akamaru, Goichi Beck, Shinsuke Kato, Hideki Mochizuki
Neuropathology 2015 May;
PMID: 25950622 [PubMed - as supplied by publisher]

Protective effect of curculigo orchioides extract on cyclophosphamide-induced neurotoxicity in murine model.
Dipica Ramchandani, Aditya Ganeshpurkar, Divya Bansal, Manvendra Singh Karchuli, Nazneen Dubey
Toxicol Int 2014 Sep-Dec; 21(3):232-5
PMID: 25948959 [PubMed - as supplied by publisher]

Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability.
Chuen-Lin Huang, Chih-Chang Chao, Yi-Chao Lee, Mei-Kuang Lu, Jing-Jy Cheng, Ying-Chen Yang, Vin-Chi Wang, Wen-Chang Chang, Nai-Kuei Huang
Mol Neurobiol 2015 May;
PMID: 25947082 [PubMed - as supplied by publisher]

Paeonolum protects against MPP(+)-induced neurotoxicity in zebrafish and PC12 cells.
Xi-Lin Lu, Yue-Hao Lin, Qi Wu, Feng-Juan Su, Cheng-Hui Ye, Lei Shi, Bai-Xuan He, Fei-Wen Huang, Zhong Pei, Xiao-Li Yao
BMC Complement Altern Med 2015 ; 15(1):137
PMID: 25925762 [PubMed - as supplied by publisher]

Clinical Utility of Skin Biopsy in Differentiating between Parkinson's Disease and Multiple System Atrophy.
Rie Haga, Kazuhiro Sugimoto, Haruo Nishijima, Yasuo Miki, Chieko Suzuki, Koichi Wakabayashi, Masayuki Baba, Soroku Yagihashi, Masahiko Tomiyama
Parkinsons Dis 2015 ; 2015:167038
PMID: 25945280 [PubMed - as supplied by publisher]

Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson's Disease.
Musthafa Mohamed Essa, Selvaraju Subash, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Samir Al-Adawi, Gilles J Guillemin, Arokiasamy Justin Thenmozhi
Neurochem Res 2015 May;
PMID: 25944473 [PubMed - as supplied by publisher]

Animal models for prion-like diseases.
Natalia Fernández-Borges, Hasier Eraña, Vanesa Venegas, Saioa R Elezgarai, Chafik Harrathi, Joaquín Castilla
Virus Res 2015 Apr;
PMID: 25907990 [PubMed - as supplied by publisher]

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.
Robert D Leone, Ying-Chun Lo, Jonathan D Powell
Comput Struct Biotechnol J 2015 ; 13:265-72
PMID: 25941561 [PubMed - as supplied by publisher]

The dormant blood microbiome in chronic, inflammatory diseases.
Marnie Potgieter, Janette Bester, Douglas B Kell, Etheresia Pretorius
FEMS Microbiol Rev 2015 May;
PMID: 25940667 [PubMed - as supplied by publisher]

Groundwater Pesticide Levels and the Association With Parkinson Disease.
Katherine A James, Deborah A Hall
Int J Toxicol 2015 May;
PMID: 25939349 [PubMed - as supplied by publisher]

Effects of impaired membrane interactions on ?-synuclein aggregation and neurotoxicity.
Daniel Ysselstein, Mehul Joshi, Vartika Mishra, Amy M Griggs, Josephat M Asiago, George P McCabe, Lia A Stanciu, Carol Beth Post, Jean-Christophe Rochet
Neurobiol Dis 2015 Apr;
PMID: 25931201 [PubMed - as supplied by publisher]

Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations.
Zsuzsanna Bohár, József Toldi, Ferenc Fülöp, László Vécsei
Int J Mol Sci 2015; 16(5):9772-9793
PMID: 25938971 [PubMed - as supplied by publisher]

Controlled and impaired mitochondrial quality in neurons: Molecular physiology and prospective pharmacology.
Ivana Matic, Daniela Strobbe, Michele Frison, Michelangelo Campanella
Pharmacol Res 2015 Apr;
PMID: 25917207 [PubMed - as supplied by publisher]

Hydrogen sulfide in pharmacology and medicine - An update.
Jerzy Be?towski
Pharmacol Rep 2015 Jun; 67(3):647-658
PMID: 25933982 [PubMed - as supplied by publisher]

Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
Vincent A Jourdain, Nicolas Morin, Laurent Grégoire, Marc Morissette, Thérèse Di Paolo
J Neurosurg 2015 May; :1-11
PMID: 25932606 [PubMed - as supplied by publisher]

Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism.
Gabriela da Rocha Lindner, Danúbia Bonfanti Santos, Dirleise Colle, Eduardo Luiz Gasnhar Moreira, Rui Daniel Prediger, Marcelo Farina, Najeh Maissar Khalil, Rubiana Mara Mainardes
Nanomedicine (Lond) 2015 Apr; 10(7):1127-38
PMID: 25929569 [PubMed - as supplied by publisher]

Comparative quantitative study of 'signature' pathological lesions in the hippocampus and adjacent gyri of 12 neurodegenerative disorders.
Richard A Armstrong, Nigel J Cairns
J Neural Transm 2015 May;
PMID: 25929331 [PubMed - as supplied by publisher]

Transcranial Direct Current Stimulation Ameliorates Behavioral Deficits and Reduces Oxidative Stress in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Model of Parkinson's Disease.
Chengbiao Lu, Yun Wei, Rui Hu, Yong Wang, Kun Li, Xiaoli Li
Neuromodulation 2015 May;
PMID: 25929279 [PubMed - as supplied by publisher]

Roles of Ca(2+)/calmodulin-dependent protein kinase II in subcellular expression of striatal N-methyl-D-aspartate receptors in l-3, 4-dihydroxyphenylalanine-induced dyskinetic rats.
Jing Gan, Chen Qi, Zhenguo Liu
Drug Des Devel Ther 2015 ; 9:2119-28
PMID: 25926720 [PubMed - as supplied by publisher]

CypD: The Key to the Death Door.
S M Fayaz, Y Raj Vijay, G K Rajanikant
CNS Neurol Disord Drug Targets 2015 Apr;
PMID: 25921742 [PubMed - as supplied by publisher]

Relating gas phase to solution conformations: Lessons from disordered proteins.
Rebecca Beveridge, Ashley S Phillips, Laetitia Denbigh, Hassan M Saleem, Cait E MacPhee, Perdita E Barran
Proteomics 2015 Apr;
PMID: 25920945 [PubMed - as supplied by publisher]

Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report.
Hiroshige Fujishiro, Shuji Iritani, Hirotaka Sekiguchi, Chikako Habuchi, Youta Torii, Shinji Matsunaga, Norio Ozaki, Mari Yoshida, Kiyoshi Fujita
Psychogeriatrics 2015 Apr;
PMID: 25919332 [PubMed - as supplied by publisher]

Mitochondrial Dysfunction and ?-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
Michela Zaltieri, Francesca Longhena, Marina Pizzi, Cristina Missale, PierFranco Spano, Arianna Bellucci
Parkinsons Dis 2015 ; 2015:108029
PMID: 25918668 [PubMed - as supplied by publisher]

Posttranslational Modifications and Clearing of ?-Synuclein Aggregates in Yeast.
Blagovesta Popova, Alexandra Kleinknecht, Gerhard H Braus
Biomolecules 2015; 5(2):617-634
PMID: 25915624 [PubMed - as supplied by publisher]

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases.
Miguel Chin-Chan, Juliana Navarro-Yepes, Betzabet Quintanilla-Vega
Front Cell Neurosci 2015 ; 9:124
PMID: 25914621 [PubMed - as supplied by publisher]

Cabergoline protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture.
J Meinel, K Radad, W-D Rausch, H Reichmann, G Gille
Folia Neuropathol 2015 ; 53(1):29-40
PMID: 25909873 [PubMed - as supplied by publisher]

Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease.
S García, Rm Coral-Vázquez, M P Gallegos-Arreola, L A Montes-Almanza, P Canto, F A García-Martínez, G Chavira-Hernández, C Palma-Flores, L Dávila-Maldonado, C F Cuevas-García, L B López Hernández
Folia Neuropathol 2015 ; 53(1):24-8
PMID: 25909872 [PubMed - as supplied by publisher]

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
Emily M Rocha, Gaynor A Smith, Eric Park, Hongmei Cao, Eilish Brown, Penelope Hallett, Ole Isacson
Ann Clin Transl Neurol 2015 Apr; 2(4):433-8
PMID: 25909088 [PubMed - as supplied by publisher]

Variants associated with Gaucher disease in multiple system atrophy.
Jun Mitsui, Takashi Matsukawa, Hidenao Sasaki, Ichiro Yabe, Masaaki Matsushima, Alexandra Dürr, Alexis Brice, Hiroshi Takashima, Akio Kikuchi, Masashi Aoki, Hiroyuki Ishiura, Tsutomu Yasuda, Hidetoshi Date, Budrul Ahsan, Atsushi Iwata, Jun Goto, Yaeko Ichikawa, Yasuo Nakahara, Yoshio Momose, Yuji Takahashi, Kenju Hara, Akiyoshi Kakita, Mitsunori Yamada, Hitoshi Takahashi, Osamu Onodera, Masatoyo Nishizawa, Hirohisa Watanabe, Mizuki Ito, Gen Sobue, Kinya Ishikawa, Hidehiro Mizusawa, Kazuaki Kanai, Takamichi Hattori, Satoshi Kuwabara, Kimihito Arai, Shigeru Koyano, Yoshiyuki Kuroiwa, Kazuko Hasegawa, Tatsuhiko Yuasa, Kenichi Yasui, Kenji Nakashima, Hijiri Ito, Yuishin Izumi, Ryuji Kaji, Takeo Kato, Susumu Kusunoki, Yasushi Osaki, Masahiro Horiuchi, Tomoyoshi Kondo, Shigeo Murayama, Nobutaka Hattori, Mitsutoshi Yamamoto, Miho Murata, Wataru Satake, Tatsushi Toda, Alessandro Filla, Thomas Klockgether, Ullrich Wüllner, Garth Nicholson, Sid Gilman, Caroline M Tanner, Walter A Kukull, Mathew B Stern, Virginia M-Y Lee, John Q Trojanowski, Eliezer Masliah, Phillip A Low, Paola Sandroni, Laurie J Ozelius, Tatiana Foroud, Shoji Tsuji
Ann Clin Transl Neurol 2015 Apr; 2(4):417-26
PMID: 25909086 [PubMed - as supplied by publisher]

The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning.
David H Jang, Joshua W Lampe, Lance B Becker
J Med Toxicol 2015 Apr;
PMID: 25907836 [PubMed - as supplied by publisher]

Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1.
Ya-Nan Wang, Liang Zhou, Yun-Hong Li, Zhen Wang, Ying-Cong Li, Ya-Wen Zhang, Yin Wang, Gang Liu, Ying Shen
J Neurosci 2015 Apr; 35(16):6429-43
PMID: 25904794 [PubMed - as supplied by publisher]

Parkinson's disease.
Lorraine V Kalia, Anthony E Lang
Lancet 2015 Apr;
PMID: 25904081 [PubMed - as supplied by publisher]

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats.
Andrea Ferrigno, Mariapia Vairetti, Giulia Ambrosi, Vittoria Rizzo, Plinio Richelmi, Fabio Blandini, Marie-Therese Armentero
Clin Exp Pharmacol Physiol 2015 Apr;
PMID: 25904005 [PubMed - as supplied by publisher]

Activation of Autophagy Contributes to the Angiotensin II-Triggered Apoptosis in a Dopaminergic Neuronal Cell Line.
Qing Gao, Teng Jiang, Hong-Rui Zhao, Liang Wu, You-Yong Tian, Zhou Ou, Li Zhang, Yang Pan, Jie Lu, Ying-Dong Zhang
Mol Neurobiol 2015 Apr;
PMID: 25902863 [PubMed - as supplied by publisher]