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Featured Research

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Scientists are making inroads because thousands of people with Parkinson’s and their family members have donated their brains to science, including to PDF-supported programs at Columbia University Medical Center and Rush University Medical Center.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Gut feelings about smoking and coffee in Parkinson's disease.
Pascal Derkinderen, Kathleen M Shannon, Patrik Brundin
Mov Disord 2014 Apr;
PMID: 24753353 [PubMed - as supplied by publisher]


Neuropathological features of multiple system atrophy with cognitive impairment.
Yasmine T Asi, Helen Ling, Zeshan Ahmed, Andrew J Lees, Tamas Revesz, Janice L Holton
Mov Disord 2014 Apr;
PMID: 24752994 [PubMed - as supplied by publisher]


Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.
Christos Proukakis, Maryiam Shoaee, James Morris, Timothy Brier, Eleanna Kara, Una-Marie Sheerin, Gavin Charlesworth, Eduardo Tolosa, Henry Houlden, Nicholas W Wood, Anthony H Schapira
Mov Disord 2014 Apr;
PMID: 24752924 [PubMed - as supplied by publisher]


The Glutathione System: A New Drug Target in Neuroimmune Disorders.
Gerwyn Morris, George Anderson, Olivia Dean, Michael Berk, Piotr Galecki, Marta Martin-Subero, Michael Maes
Mol Neurobiol 2014 Apr;
PMID: 24752591 [PubMed - as supplied by publisher]


2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Inhibits Microglial Activation by Suppression of Nuclear Factor-Kappa B and Mitogen-Activated Protein Kinase Signaling.
Eun-A Kim, Jiyoung Choi, A Reum Han, Chang Hun Cho, Soo Young Choi, Jee-Yin Ahn, Sung-Woo Cho
J Neuroimmune Pharmacol 2014 Apr;
PMID: 24752390 [PubMed - as supplied by publisher]


Parkinson disease: Solid tissue levels of ?-synuclein could aid diagnosis of PD.
Nat Rev Neurol 2014 Apr;
PMID: 24752124 [PubMed - as supplied by publisher]


Loss of PINK1 Impairs Stress-Induced Autophagy and Cell Survival.
Dajana Parganlija, Michael Klinkenberg, Jorge Domínguez-Bautista, Miriam Hetzel, Suzana Gispert, Marthe A Chimi, Stefan Dröse, Sören Mai, Ulrich Brandt, Georg Auburger, Marina Jendrach
PLoS One 2014 ; 9(4):e95288
PMID: 24751806 [PubMed - as supplied by publisher]


The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Stéphanie Bissonnette, Sophie Muratot, Nathalie Vernoux, François Bezeau, Frédéric Calon, Sébastien S Hébert, Pershia Samadi
Eur J Neurosci 2014 Apr;
PMID: 24750443 [PubMed - as supplied by publisher]


Enteric GFAP expression and phosphorylation in Parkinson's disease.
Thomas Clairembault, Willem Kamphuis, Laurène Leclair-Visonneau, Malvyne Rolli-Derkinderen, Emmanuel Coron, Michel Neunlist, Elly M Hol, Pascal Derkinderen
J Neurochem 2014 Apr;
PMID: 24749759 [PubMed - as supplied by publisher]


The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like receptor (PAEL) receptor-mediated cell death.
Priyanka Dutta, Kara E O'Connell, S Banu Ozkan, Andreas W Sailer, Kumlesh K Dev
J Neurochem 2014 Apr;
PMID: 24749734 [PubMed - as supplied by publisher]


Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients.
Yang Song, Hui Ding, Jingfang Yang, Qingling Lin, Jinhua Xue, Yanli Zhang, Piu Chan, Yanning Cai
Neurosci Lett 2014 Apr; 569C:85-88
PMID: 24721670 [PubMed - as supplied by publisher]


Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease patients with parkin mutations.
Celia van der Merwe, Ben Loos, Chrisna Swart, Craig Kinnear, Franclo Henning, Lize van der Merwe, Komala Pillay, Nolan Muller, Dan Zaharie, Lize Engelbrecht, Jonathan Carr, Soraya Bardien
Biochem Biophys Res Commun 2014 Apr;
PMID: 24721425 [PubMed - as supplied by publisher]


Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies.
Koji Kasanuki, Eizo Iseki, Daizo Kondo, Hiroshige Fujishiro, Michiko Minegishi, Kiyoshi Sato, Omi Katsuse, Hiroaki Hino, Kenji Kosaka, Heii Arai
Neurosci Lett 2014 Apr; 569C:68-73
PMID: 24704327 [PubMed - as supplied by publisher]


?-Amyloid in CSF: A window into Parkinson disease dementia.
Andrew Siderowf, Giancarlo Logroscino
Neurology 2014 Apr;
PMID: 24748673 [PubMed - as supplied by publisher]


Regulation of Neuronal Cytoskeletal Protein Phosphorylation in Neurodegenerative Diseases.
Parvathi Rudrabhatla
J Alzheimers Dis 2014 Apr;
PMID: 24748119 [PubMed - as supplied by publisher]


PAR2-mediated epigenetic upregulation of ?-synuclein contributes to the pathogenesis of Parkinson's disease.
Ping Liu, Liang Sun, Xu-Li Zhao, Peng Zhang, Xue-Mei Zhao, Jian Zhang
Brain Res 2014 Apr;
PMID: 24747612 [PubMed - as supplied by publisher]


The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.
Mari H Savolainen, Christopher T Richie, Brandon K Harvey, Pekka T Männistö, Kathleen A Maguire-Zeiss, Timo T Myöhänen
Neurobiol Dis 2014 Apr;
PMID: 24746855 [PubMed - as supplied by publisher]


Hsp27 Suppresses the Cu(2+)-induced Amyloidogenicity, Redox Activity and Cytotoxicity of ?-Synuclein by Metal Ion Stripping.
Abhishek Asthana, Madhuri Bollapalli, Ramakrishna Tangirala, Raman Bakthisaran, Ch Mohan Rao
Free Radic Biol Med 2014 Apr;
PMID: 24746619 [PubMed - as supplied by publisher]


A novel ?-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.
Petra Pasanen, Liisa Myllykangas, Maija Siitonen, Anna Raunio, Seppo Kaakkola, Jukka Lyytinen, Pentti J Tienari, Minna Pöyhönen, Anders Paetau
Neurobiol Aging 2014 Mar;
PMID: 24746362 [PubMed - as supplied by publisher]


Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state.
D Jantas, A Greda, S Golda, M Korostynski, B Grygier, A Roman, A Pilc, W Lason
Neuropharmacology 2014 Apr; 83C:36-53
PMID: 24713472 [PubMed - as supplied by publisher]


CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
María Florencia Ogara, Laura M Belluscio, Verónica de la Fuente, Bruno G Berardino, Silvina V Sonzogni, Laura Byk, Mariela Marazita, Eduardo T Cánepa
Biochim Biophys Acta 2014 Apr; 1843(7):1309-1324
PMID: 24703879 [PubMed - as supplied by publisher]


Differential role of CSF alpha-synuclein species, tau, and A?42 in Parkinson's Disease.
Lucilla Parnetti, Lucia Farotti, Paolo Eusebi, Davide Chiasserini, Claudia De Carlo, David Giannandrea, Nicola Salvadori, Viviana Lisetti, Nicola Tambasco, Aroldo Rossi, Nour K Majbour, Omar El-Agnaf, Paolo Calabresi
Front Aging Neurosci 2014 ; 6:53
PMID: 24744728 [PubMed - as supplied by publisher]


Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.
L F Burbulla, J C Fitzgerald, K Stegen, J Westermeier, A-K Thost, H Kato, D Mokranjac, J Sauerwald, L M Martins, D Woitalla, D Rapaport, O Riess, T Proikas-Cezanne, T M Rasse, R Krüger
Cell Death Dis 2014 ; 5:e1180
PMID: 24743735 [PubMed - as supplied by publisher]


Endogenous Dopamine is Involved in the Herbicide Paraquat-Induced Dopaminergic Cell Death.
Yasuhiko Izumi, Masayuki Ezumi, Yuki Takada-Takatori, Akinori Akaike, Toshiaki Kume
Toxicol Sci 2014 Apr;
PMID: 24743698 [PubMed - as supplied by publisher]


Residue His50 Plays a Key Role in Protecting alpha-Synuclein from Aggregation at Physiological pH.
Ying-Chih Chi, Geoffrey S Armstrong, David N M Jones, Elan Z Eisenmesser, Chang-Wei Liu
J Biol Chem 2014 Apr;
PMID: 24742669 [PubMed - as supplied by publisher]


Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.
Falk Schlaudraff, Jan Gründemann, Michael Fauler, Elena Dragicevic, John Hardy, Birgit Liss
Neurobiol Aging 2014 Mar;
PMID: 24742361 [PubMed - as supplied by publisher]


Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease.
Yijiao Xu, Chunxiao Liu, Sujuan Chen, Yangjing Ye, Min Guo, Qian Ren, Lei Liu, Hai Zhang, Chong Xu, Qian Zhou, Shile Huang, Long Chen
Cell Signal 2014 Apr;
PMID: 24726895 [PubMed - as supplied by publisher]


Exosomes as mediators of neuroinflammation.
Archana Gupta, Lynn Pulliam
J Neuroinflammation 2014 ; 11(1):68
PMID: 24694258 [PubMed - as supplied by publisher]


Functional Role of Parkin against Oxidative Stress in Neural Cells.
Minyoung Hwang, Ja-Myong Lee, Younghwa Kim, Dongho Geum
Endocrinol Metab (Seoul) 2014 Mar; 29(1):62-9
PMID: 24741456 [PubMed - as supplied by publisher]


Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism.
Jayasankar Kosaraju, Santhivardhan Chinni, Partha Deb Roy, Elango Kannan, A Shanish Antony, M N Satish Kumar
Indian J Pharmacol 2014 Mar; 46(2):176-80
PMID: 24741189 [PubMed - as supplied by publisher]


Parkinson's Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration.
Elpida Tsika, Liliane Glauser, Roger Moser, Aris Fiser, Guillaume Daniel, Una-Marie Sheerin, Andrew Lees, Juan C Troncoso, Patrick A Lewis, Rina Bandopadhyay, Bernard L Schneider, Darren J Moore
Hum Mol Genet 2014 Apr;
PMID: 24740878 [PubMed - as supplied by publisher]


Co-existence of Two Different ?-Synuclein Oligomers with Different Core Structures Determined by Hydrogen/Deuterium Exchange Mass Spectrometry.
Wojciech Paslawski, Simon Mysling, Karen Thomsen, Thomas J D Jørgensen, Daniel E Otzen
Angew Chem Int Ed Engl 2014 Apr;
PMID: 24740651 [PubMed - as supplied by publisher]


PACAP Protects Against Inflammatory-Mediated Toxicity in Dopaminergic SH-SY5Y Cells: Implication for Parkinson's Disease.
Dwayne Brown, Andrea Tamas, Dora Reglodi, Yousef Tizabi
Neurotox Res 2014 Apr;
PMID: 24740430 [PubMed - as supplied by publisher]


Antidepressant and Antioxidative Effect of Ibuprofen in the Rotenone Model of Parkinson's Disease.
Tiago Zaminelli, Raísa Wendhausen Gradowski, Taysa Bervian Bassani, Janaína Kohl Barbiero, Ronise M Santiago, Daniele Maria-Ferreira, Cristiane Hatsuko Baggio, Maria A B F Vital
Neurotox Res 2014 Apr;
PMID: 24740429 [PubMed - as supplied by publisher]


A Revised Picture of the Cu(II) ?-Synuclein Complex: The Role of N-Terminal Acetylation.
Gina M Moriarty, Conceição A S A Minetti, David P Remeta, Jean Baum
Biochemistry 2014 Apr;
PMID: 24739028 [PubMed - as supplied by publisher]


Lithium and autophagy.
Yumiko Motoi, Kohei Shimada, Koichi Ishiguro, Nobutaka Hattori
ACS Chem Neurosci 2014 Apr;
PMID: 24738557 [PubMed - as supplied by publisher]


Neuroprotective Potential of Adenosine A2A and Cannabinoid CB1 Receptor Antagonists in an Animal Model of Parkinson Disease.
Silvia Cerri, Giovanna Levandis, Giulia Ambrosi, Elena Montepeloso, Gian Filippo Antoninetti, Rafael Franco, José Luis Lanciego, Younis Baqi, Christa E Müller, Annalisa Pinna, Fabio Blandini, Marie Therese Armentero
J Neuropathol Exp Neurol 2014 May; 73(5):414-24
PMID: 24709676 [PubMed - as supplied by publisher]


Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.
Joseph Amick, Simon E Schlanger, Christine Wachnowsky, Mitchell A Moseng, Corey C Emerson, Michelle Dare, Wen-I Luo, Sujay S Ithychanda, Jay C Nix, J A Cowan, Richard C Page, Saurav Misra
Protein Sci 2014 Mar;
PMID: 24687350 [PubMed - as supplied by publisher]


Association of seven functional polymorphisms of one-carbon metabolic pathway with total plasma homocysteine levels and susceptibility to Parkinson's disease among South Indians.
Nadella Kumudini, Addepally Uma, Shaik Mohammad Naushad, Rukmini Mridula, Rupam Borgohain, Vijay Kumar Kutala
Neurosci Lett 2014 Mar; 568C:1-5
PMID: 24686188 [PubMed - as supplied by publisher]


Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment.
Dong-Ik Shin, Young J Oh
Exp Neurobiol 2014 Mar; 23(1):65-76
PMID: 24737941 [PubMed - as supplied by publisher]


Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies.
Keith A Wesnes, Dag Aarsland, Clive Ballard, Elisabet Londos
Int J Geriatr Psychiatry 2014 Apr;
PMID: 24737460 [PubMed - as supplied by publisher]


Uncovering the role of the insula in non-motor symptoms of Parkinson's disease.
Leigh Christopher, Yuko Koshimori, Anthony E Lang, Marion Criaud, Antonio P Strafella
Brain 2014 Apr;
PMID: 24736308 [PubMed - as supplied by publisher]


Parkin and PINK1: much more than mitophagy.
Leslie A Scarffe, Daniel A Stevens, Valina L Dawson, Ted M Dawson
Trends Neurosci 2014 Apr;
PMID: 24735649 [PubMed - as supplied by publisher]


Neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model.
Reza Sedaghat, Mehrdad Roghani, Mohsen Khalili
Iran J Pharm Res 2014 ; 13(1):227-34
PMID: 24734075 [PubMed - as supplied by publisher]


Gastrointestinal Involvement in Parkinson's Disease: The Horse or the Cart.
Ronald F Pfeiffer
Acta Physiol (Oxf) 2014 Apr;
PMID: 24731168 [PubMed - as supplied by publisher]


Multiple system atrophy: A prototypical synucleinopathy for disease-modifying therapeutic strategies.
Pierre-Olivier Fernagut, Benjamin Dehay, Aline Maillard, Erwan Bezard, Paul Perez, Anne Pavy-Le Traon, Olivier Rascol, Alexandra Foubert-Samier, François Tison, Wassilios G Meissner
Neurobiol Dis 2014 Apr;
PMID: 24727096 [PubMed - as supplied by publisher]


Neuroprotective effects of the andrographolide analogue AL-1 in the MPP(+)/MPTP-induced Parkinson's disease model in vitro and in mice.
Zaijun Zhang, Daoxu Lai, Liang Wang, Pei Yu, Longjun Zhu, Baojian Guo, Lipeng Xu, Libing Zhou, Yewei Sun, Simon Ming Yuen Lee, Yuqiang Wang
Pharmacol Biochem Behav 2014 Apr;
PMID: 24726706 [PubMed - as supplied by publisher]


Silencing of Hsp70 Intensifies 6-OHDA-Induced Apoptosis and Hsp90 Upregulation in PC12 Cells.
Behrang Alani, Rasoul Salehi, Payam Sadeghi, Fariba Khodagholi, Hadi Digaleh, Siamak Jabbarzadeh-Tabrizi, Mohammad Zare, Hassan Korbekandi
J Mol Neurosci 2014 Apr;
PMID: 24729093 [PubMed - as supplied by publisher]


The Novel Parkinson's Disease Linked Mutation G51D Attenuates In Vitro Aggregation and Membrane Binding of ?-Synuclein, and Enhances its Secretion and Nuclear Localization in Cells.
Mohamed-Bilal Fares, Nadine A Bouziad, Igor Dikiy, Martial K Mbefo, Ana Jovi?i?, Aoife Kiely, Janice L Holton, Seung-Jae Lee, Aaron D Gitler, David Eliezer, Hilal A Lashuel
Hum Mol Genet 2014 Apr;
PMID: 24728187 [PubMed - as supplied by publisher]


Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease.
John M Woulfe, Madison T Gray, Douglas A Gray, David G Munoz, Jaap M Middeldorp
Parkinsonism Relat Disord 2014 Mar;
PMID: 24726430 [PubMed - as supplied by publisher]


Silymarin improved 6-OHDA-induced motor impairment in hemi-parkisonian rats: behavioral and molecular study.
Rasool Haddadi, Alireza Mohajjel Nayebi, Safar Farajniya, Shahla Eyvari Brooshghalan, Hamdolah Sharifi
Daru 2014 Apr; 22(1):38
PMID: 24726284 [PubMed - as supplied by publisher]


Cu(II) and dopamine bind to ?-Synuclein and cause large conformational changes.
Omid Tavassoly, Sergiy Nokhrin, Oleg Y Dmitriev, Jeremy S Lee
FEBS J 2014 Apr;
PMID: 24725464 [PubMed - as supplied by publisher]


Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson's Disease.
Ian Martin, Jungwoo Wren Kim, Byoung Dae Lee, Ho Chul Kang, Jin-Chong Xu, Hao Jia, Jeannette Stankowski, Min-Sik Kim, Jun Zhong, Manoj Kumar, Shaida A Andrabi, Yulan Xiong, Dennis W Dickson, Zbigniew K Wszolek, Akhilesh Pandey, Ted M Dawson, Valina L Dawson
Cell 2014 Apr; 157(2):472-85
PMID: 24725412 [PubMed - as supplied by publisher]


Site-Specific Copper-Catalyzed Oxidation of ?-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson's Disease.
Marco C Miotto, Esaú E Rodriguez, Ariel A Valiente-Gabioud, Valentina Torres-Monserrat, Andrés Binolfi, Liliana Quintanar, Markus Zweckstetter, Christian Griesinger, Claudio O Fernández
Inorg Chem 2014 Apr;
PMID: 24725094 [PubMed - as supplied by publisher]


Reverse microdialysis of a 5-HT2A receptor antagonist alters extracellular glutamate levels in the striatum of the MPTP mouse model of Parkinson's disease.
Marcus C Ferguson, Tultul Nayyar, Twum A Ansah
Neurochem Int 2014 Apr;
PMID: 24704796 [PubMed - as supplied by publisher]


Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors.
Franck-Cyril Favre-Besse, Odile Poirel, Tiphaine Bersot, Elodie Kim-Grellier, Stephanie Daumas, Salah El Mestikawy, Francine C Acher, Nicolas Pietrancosta
Eur J Med Chem 2014 May; 78:236-47
PMID: 24686010 [PubMed - as supplied by publisher]


Activation of prelimbic 5-HT1A receptors produces antidepressant-like effects in a unilateral rat model of Parkinson's disease.
Y P Hui, Q J Zhang, L Zhang, L Chen, Y Guo, H F Qiao, Y Wang, J Liu
Neuroscience 2014 Mar; 268C:265-275
PMID: 24680938 [PubMed - as supplied by publisher]


Oxidative stress and age-related olfactory memory impairment in the honeybee Apis mellifera.
Tahira Farooqui
Front Genet 2014 ; 5:60
PMID: 24723939 [PubMed - as supplied by publisher]


Neuronal activity (c-Fos) delineating interactions of the cerebral cortex and basal ganglia.
Mei-Hong Qiu, Michael C Chen, Zhi-Li Huang, Jun Lu
Front Neuroanat 2014 ; 8:13
PMID: 24723855 [PubMed - as supplied by publisher]


Resistance of naturally secreted ?-synuclein to proteolysis.
Methodios Ximerakis, Georgios Pampalakis, Theodoros I Roumeliotis, Vasia-Samantha Sykioti, Spiros D Garbis, Leonidas Stefanis, Georgia Sotiropoulou, Kostas Vekrellis
FASEB J 2014 Apr;
PMID: 24723692 [PubMed - as supplied by publisher]


Interneurons from embryonic development to cell-based therapy.
Derek G Southwell, Cory R Nicholas, Allan I Basbaum, Michael P Stryker, Arnold R Kriegstein, John L Rubenstein, Arturo Alvarez-Buylla
Science 2014 Apr; 344(6180):1240622
PMID: 24723614 [PubMed - as supplied by publisher]


Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system.
Pamela Lopert, Manisha Patel
J Biol Chem 2014 Apr;
PMID: 24722990 [PubMed - as supplied by publisher]


Stabilization of NADH-dehydrogenase in Mitochondria by Guanosine Phosphates and Adenosine Phosphates.
M S Frolova, N L Vekshin
J Fluoresc 2014 Apr;
PMID: 24722920 [PubMed - as supplied by publisher]


Extracellular ?-Synuclein Leads to Microtubule Destabilization via GSK-3?-Dependent Tau Phosphorylation in PC12 Cells.
Magdalena G?ssowska, Grzegorz A Czapski, Beata Paj?k, Magdalena Cie?lik, Anna M Lenkiewicz, Agata Adamczyk
PLoS One 2014 ; 9(4):e94259
PMID: 24722055 [PubMed - as supplied by publisher]


Effects of 6-Hydroxydopamine Exposure on Motor Activity and Biochemical Expression in Zebrafish (Danio Rerio) Larvae.
Chien-Wei Feng, Zhi-Hong Wen, Shi-Ying Huang, Han-Chun Hung, Chun-Hong Chen, San-Nan Yang, Nan-Fu Chen, Hui-Min Wang, Chung-Der Hsiao, Wu-Fu Chen
Zebrafish 2014 Apr;
PMID: 24720843 [PubMed - as supplied by publisher]


Neuroprotective Effects of Tetramethylpyrazine against Dopaminergic Neuron Injury in a Rat Model of Parkinson's Disease Induced by MPTP.
Chen Lu, Jin Zhang, Xiaopeng Shi, Shan Miao, Linlin Bi, Song Zhang, Qian Yang, Xuanxuan Zhou, Meng Zhang, Yanhua Xie, Qing Miao, Siwang Wang
Int J Biol Sci 2014 ; 10(4):350-7
PMID: 24719552 [PubMed - as supplied by publisher]


Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
Indranil Basak, Ramavati Pal, Ketan S Patil, Aisling Dunne, Hsin-Pin Ho, Sungsu Lee, Diluka Peiris, Jodi Maple-Grødem, Mark Odell, Emmanuel J Chang, Jan Petter Larsen, Simon G Møller
J Biol Chem 2014 Apr;
PMID: 24719325 [PubMed - as supplied by publisher]


2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) is Selectively Toxic to Primary Dopaminergic Neurons In Vitro.
Amy M Griggs, Zeynep S Agim, Vartika R Mishra, Mitali A Tambe, Alison E Director-Myska, Kenneth W Turteltaub, George P McCabe, Jean-Christophe Rochet, Jason R Cannon
Toxicol Sci 2014 Apr;
PMID: 24718704 [PubMed - as supplied by publisher]


PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer's disease and Lewy body disorders.
Andrew Siderowf, Michael J Pontecorvo, Holly A Shill, Mark A Mintun, Anupa Arora, Abhinay D Joshi, Ming Lu, Charles H Adler, Douglas Galasko, Carolyn Liebsack, Daniel M Skovronsky, Marwan N Sabbagh
BMC Neurol 2014 Apr; 14(1):79
PMID: 24716655 [PubMed - as supplied by publisher]


Dysautonomia in Parkinson disease.
David S Goldstein
Compr Physiol 2014 Apr; 4(2):805-26
PMID: 24715569 [PubMed - as supplied by publisher]


The brain-uterus connection: brain derived neurotrophic factor (BDNF) and its receptor (ntrk2) are conserved in the Mammalian uterus.
Jocelyn M Wessels, Liang Wu, Nicholas A Leyland, Hongmei Wang, Warren G Foster
PLoS One 2014 ; 9(4):e94036
PMID: 24714156 [PubMed - as supplied by publisher]


Alpha-synuclein in Parkinson's disease].
Anna Oczkowska, Wojciech Kozubski, Jolanta Dorszewska
Przegl Lek 2014 ; 71(1):26-32
PMID: 24712265 [PubMed - as supplied by publisher]


Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease.
Rainer Hoffmann, Sven H Stüwe, Oliver Goetze, Matthias Banasch, Peter Klotz, Carsten Lukas, Martin Tegenthoff, Christian Beste, Michael Orth, Carsten Saft
Mov Disord 2014 Apr;
PMID: 24710776 [PubMed - as supplied by publisher]


Complexation of amyloid fibrils with charged conjugated polymers.
Dhiman Ghosh, Paulami Dutta, Chanchal Chakraborty, Pradeep K Singh, A Anoop, Narendra Nath Jha, Reeba S Jacob, Mrityunjoy Mondal, Shruti Mankar, Subhadeep Das, Sudip Malik, Samir K Maji
Langmuir 2014 Apr; 30(13):3775-86
PMID: 24678792 [PubMed - as supplied by publisher]


Nocturnal Manifestations of Atypical Parkinsonian Disorders.
Roongroj Bhidayasiri, Onanong Jitkritsadakul, Carlo Colosimo
J Parkinsons Dis 2014 Apr;
PMID: 24705593 [PubMed - as supplied by publisher]


Effects of ultrafine diesel exhaust particles on oxidative stress generation and dopamine metabolism in PC-12 cells.
Yong-Dae Kim, Susan M Lantz-McPeak, Syed F Ali, Michael T Kleinman, Young-Sook Choi, Heon Kim
Environ Toxicol Pharmacol 2014 Mar; 37(3):954-959
PMID: 24705343 [PubMed - as supplied by publisher]


EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population.
Kenya Nishioka, Manabu Funayama, Carles Vilariño-Güell, Kotaro Ogaki, Yuanzhe Li, Ryogen Sasaki, Yasumasa Kokubo, Shigeki Kuzuhara, Jennifer M Kachergus, Stephanie A Cobb, Hirohide Takahashi, Yoshikuni Mizuno, Matthew J Farrer, Owen A Ross, Nobutaka Hattori
Parkinsonism Relat Disord 2014 Mar;
PMID: 24704100 [PubMed - as supplied by publisher]


The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease.
Angelique Camilleri, Neville Vassallo
CNS Neurosci Ther 2014 Apr;
PMID: 24703487 [PubMed - as supplied by publisher]


Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review.
N Malek, D Swallow, K A Grosset, O Anichtchik, M Spillantini, D G Grosset
Acta Neurol Scand 2014 Apr;
PMID: 24702516 [PubMed - as supplied by publisher]


Measuring attention in a Parkinson's disease rat model using the 5-arm maze test.
Shih-Chun Ho, Chih-Chuan Hsu, Ching-Han Yu, Wen-Nung Huang, Maria A Tikhonova, Ming-Chou Ho, Fu-Ying Wu, Tamara G Amstislavskaya, Ying-Jui Ho
Physiol Behav 2014 Mar;
PMID: 24690450 [PubMed - as supplied by publisher]


Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion.
Shinji Oikawa, Hatasu Kobayashi, Yuki Kitamura, Hong Zhu, Kumi Obata, Yoshio Minabe, Maryia Dazortsava, Kyoko Ohashi, Saeko Tada-Oikawa, Hitoshi Takahashi, Kenichiro Yata, Mariko Murata, Tetsumori Yamashima
Free Radic Res 2014 Apr;
PMID: 24697733 [PubMed - as supplied by publisher]


Preconditioning as a Potential Strategy for the Prevention of Parkinson's Disease.
Mojtaba Golpich, Behrouz Rahmani, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond, Abolhassan Ahmadiani
Mol Neurobiol 2014 Apr;
PMID: 24696268 [PubMed - as supplied by publisher]


Therapeutic options for nocturnal problems in Parkinson's disease and atypical parkinsonian disorders.
Lisa Klingelhoefer, Elisaveta Sokolov, K Ray Chaudhuri
J Neural Transm 2014 Apr;
PMID: 24696217 [PubMed - as supplied by publisher]


Visuomotor adaptation in Parkinson's disease: Effects of perturbation type and medication state.
Jennifer A Semrau, Joel S Perlmutter, Kurt A Thoroughman
J Neurophysiol 2014 Apr;
PMID: 24694937 [PubMed - as supplied by publisher]


Pharmacological studies on neurodegenerative diseases focusing on refolding and degradation of unfolded proteins in the endoplasmic reticulum.
Yasuyuki Nomura
Yakugaku Zasshi 2014 ; 134(4):537-43
PMID: 24694815 [PubMed - as supplied by publisher]


Reversing deleterious protein aggregation with re-engineered protein disaggregases.
Meredith E Jackrel, James Shorter
Cell Cycle 2014 Apr; 13(9)
PMID: 24694655 [PubMed - as supplied by publisher]


Genomic and pharmacogenomic biomarkers of Parkinson's disease.
Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Elena Garcia-Martin, Jose A G Agundez
Curr Drug Metab 2014 Feb; 15(2):129-81
PMID: 24694231 [PubMed - as supplied by publisher]


Neuroprotective Potential of Peroxisome Proliferator Activated Receptor- ? Agonist in Cognitive Impairment in Parkinson's Disease: Behavioral, Biochemical, and PBPK Profile.
Dedeepya Uppalapati, Nihar R Das, Rahul P Gangwal, Mangesh V Damre, Abhay T Sangamwar, Shyam S Sharma
PPAR Res 2014 ; 2014:753587
PMID: 24693279 [PubMed - as supplied by publisher]


Adenosine A2A Receptor Antagonists in Parkinson's Disease: Progress in Clinical Trials from the Newly Approved Istradefylline to Drugs in Early Development and Those Already Discontinued.
Annalisa Pinna
CNS Drugs 2014 Apr;
PMID: 24687255 [PubMed - as supplied by publisher]


BAX channel activity mediates lysosomal disruption linked to Parkinson disease.
Jordi Bové, Marta Martínez-Vicente, Benjamin Dehay, Celine Perier, Ariadna Recasens, Agnes Bombrun, Bruno Antonsson, Miquel Vila
Autophagy 2014 Mar; 10(5)
PMID: 24686337 [PubMed - as supplied by publisher]


Mitochondrial pharmacology: energy, injury and beyond.
S M Davidson, G D Lopaschuk, M Spedding, P M Beart
Br J Pharmacol 2014 Apr; 171(8):1795-7
PMID: 24684388 [PubMed - as supplied by publisher]


N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities.
Reza Bavarsad Shahripour, Mark R Harrigan, Andrei V Alexandrov
Brain Behav 2014 Mar; 4(2):108-122
PMID: 24683506 [PubMed - as supplied by publisher]


Can fall of blood pressure prevent falls in Parkinson disease?
Peter Hedera, Joseph H Friedman
Neurology 2014 Mar;
PMID: 24682972 [PubMed - as supplied by publisher]


Association of glycogen synthase kinase?3? with Parkinson's disease (Review).
Da-Wei Li, Zhi-Qiang Liu, Wei Chen, Min Yao, Guang-Ren Li
Mol Med Rep 2014 Mar;
PMID: 24681994 [PubMed - as supplied by publisher]


Patterns of cortical thinning in idiopathic rapid eye movement sleep behavior disorder.
Shady Rahayel, Jacques Montplaisir, Oury Monchi, Christophe Bedetti, Ronald B Postuma, Simona Brambati, Julie Carrier, Sven Joubert, Véronique Latreille, Thomas Jubault, Jean-François Gagnon
Mov Disord 2014 Feb;
PMID: 24676967 [PubMed - as supplied by publisher]


Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis.
Tiziana Alberio, Heather Bondi, Flavia Colombo, Isabella Alloggio, Luisa Pieroni, Andrea Urbani, Mauro Fasano
Mol Biosyst 2014 Mar;
PMID: 24675778 [PubMed - as supplied by publisher]


Copper and Copper Proteins in Parkinson's Disease.
Sergio Montes, Susana Rivera-Mancia, Araceli Diaz-Ruiz, Luis Tristan-Lopez, Camilo Rios
Oxid Med Cell Longev 2014 ; 2014:147251
PMID: 24672633 [PubMed - as supplied by publisher]


Mechanisms of Dopamine D1 Receptor-Mediated ERK1/2 Activation in the Parkinsonian Striatum and Their Modulation by Metabotropic Glutamate Receptor Type 5.
Tim Fieblinger, Irene Sebastianutto, Cristina Alcacer, Zisis Bimpisidis, Natallia Maslava, Sabina Sandberg, David Engblom, M Angela Cenci
J Neurosci 2014 Mar; 34(13):4728-40
PMID: 24672017 [PubMed - as supplied by publisher]


K27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.
Nicol Birsa, Rosalind Norkett, Tobias Wauer, Tycho E T Mevissen, Hsiu-Chuan Wu, Thomas Foltynie, Kailash Bhatia, Warren D Hirst, David Komander, Helene Plun-Favreau, Josef T Kittler
J Biol Chem 2014 Mar;
PMID: 24671417 [PubMed - as supplied by publisher]


Structural Characterization of Heparin-induced GAPDH Protofibrils Preventing ?-synuclein Oligomeric Species Toxicity.
César L Avila, Clarisa M Torres-Bugeau, Leandro R S Barbosa, Elisa Morandé Sales, Mohand O Ouidja, Sergio B Socías, M Soledad Celej, Rita Raisman-Vozari, Dulce Papy-Garcia, Rosangela Itri, Rosana N Chehin
J Biol Chem 2014 Mar;
PMID: 24671416 [PubMed - as supplied by publisher]