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Featured Research

Can we predict who is at risk of facing cognitive issues in PD and address them earlier? These are the questions being pursued by Dr. Goldman of the PDF Research Center at Rush University Medical Center.

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Causes and Pathology

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members?  Please browse PDF's educational materials and programs - which are all available electronically or in print.  Order for yourself, a loved one or in bulk for your patients or support group.

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Is the Risk of Motor Neuron Disease Increased or Decreased after Cancer? An Australian Case-Control Study.
Alex Stoyanov, Roger Pamphlett
PLoS One 2014 ; 9(7):e103572
PMID: 25058637 [PubMed - as supplied by publisher]

DJ-1 interactions with ?-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.
L Zondler, L Miller-Fleming, M Repici, S Gonçalves, S Tenreiro, R Rosado-Ramos, C Betzer, K R Straatman, P H Jensen, F Giorgini, T F Outeiro
Cell Death Dis 2014 ; 5:e1350
PMID: 25058424 [PubMed - as supplied by publisher]

Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.
Suzanne Angeli, Tracy Barhydt, Ross Jacobs, David W Killilea, Gordon J Lithgow, Julie K Andersen
Metallomics 2014 Jul;
PMID: 25057947 [PubMed - as supplied by publisher]

Apoptosis and Oxidative Stress in Neurodegenerative Diseases.
Elena Radi, Patrizia Formichi, Carla Battisti, Antonio Federico
J Alzheimers Dis 2014 Jul;
PMID: 25056458 [PubMed - as supplied by publisher]

Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
John E Casida, Breanna Ford, Yunden Jinsmaa, Patti Sullivan, Adele Cooney, David S Goldstein
Chem Res Toxicol 2014 Jul;
PMID: 25045800 [PubMed - as supplied by publisher]

G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Sokhna M S Yakhine-Diop, José M Bravo-San Pedro, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Mario Rodríguez-Arribas, Vicente Climent, Ana Aiastui, Adolfo López de Munain, José M Fuentes, Rosa A González-Polo
Toxicology 2014 Jul; 324C:1-9
PMID: 25017139 [PubMed - as supplied by publisher]

CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice.
Richard L Jayaraj, Namasivayam Elangovan, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Musthafa Mohamed Essa
Chem Biol Interact 2014 Jul; 220C:149-157
PMID: 24995576 [PubMed - as supplied by publisher]

miR-16-1 Promotes the Aberrant ?-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70.
Zhelin Zhang, Yan Cheng
ScientificWorldJournal 2014 ; 2014:938348
PMID: 25054189 [PubMed - as supplied by publisher]

Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies.
Dongjun Dai, Peipei Lin, Yunliang Wang, Xingyu Zhou, Jianmin Tao, Danjie Jiang, Hanlin Zhou, Ping Ru, Guanghui Pan, Jinfeng Li, Yuzheng Zhang, Honglei Yin, Shiwei Duan
Biomed Rep 2014 Sep; 2(5):713-718
PMID: 25054016 [PubMed - as supplied by publisher]

Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats.
Rohit Bisht, Baninder Kaur, Hitu Gupta, Atish Prakash
Neurotoxicology 2014 Jun; 44C:71-79
PMID: 25053526 [PubMed - as supplied by publisher]

Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry.
John F Kellie, Richard E Higgs, John W Ryder, Anthony Major, Thomas G Beach, Charles H Adler, Kalpana Merchant, Michael D Knierman
Sci Rep 2014 ; 4:5797
PMID: 25052239 [PubMed - as supplied by publisher]

A calcineurin and NFAT-dependent pathway is involved in ?-synuclein-induced degeneration of midbrain dopaminergic neurons.
Jing Luo, Lixin Sun, Xian Lin, Guoxiang Liu, Jia Yu, Loukia Parisiadou, Chengsong Xie, Jinhui Ding, Huaibin Cai
Hum Mol Genet 2014 Jul;
PMID: 25051958 [PubMed - as supplied by publisher]

Intramuscular injection of ?-synuclein induces CNS ?-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.
Amanda N Sacino, Mieu Brooks, Michael A Thomas, Alex B McKinney, Sooyeon Lee, Robert W Regenhardt, Nicholas H McGarvey, Jacob I Ayers, Lucia Notterpek, David R Borchelt, Todd E Golde, Benoit I Giasson
Proc Natl Acad Sci U S A 2014 Jul; 111(29):10732-7
PMID: 25002524 [PubMed - as supplied by publisher]

Involvement of activation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by ?-iso-cubebenol.
Sun Young Park, Do Yeon Kim, Jong-Koo Kang, Geuntae Park, Young-Whan Choi
Neurotoxicology 2014 Jul; 44C:160-168
PMID: 24997245 [PubMed - as supplied by publisher]

NMDARs in neurological diseases: A potential therapeutic target.
Janneth Gonzalez, Juan Camilo Jurado-Coronel, Marcos Fidel Avila, Angélica Sabogal, Francisco Capani, George E Barreto
Int J Neurosci 2014 Jul; :1-62
PMID: 25051426 [PubMed - as supplied by publisher]

Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells.
Javier Vargas-Medrano, Sesha Krishnamachari, Ernesto Villanueva, Wesley H Godfrey, Haiyan Lou, Ramesh Chinnasamy, Jeffrey B Arterburn, Ruth G Perez
ACS Med Chem Lett 2014 Jul; 5(7):782-6
PMID: 25050165 [PubMed - as supplied by publisher]

Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts.
Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirker
Mov Disord 2014 Jul;
PMID: 25048738 [PubMed - as supplied by publisher]

Influence of Lifestyle Modifications on Age-Related Free Radical Injury to Brain.
Elaine R Peskind, Ge Li, Jane B Shofer, Steven P Millard, James B Leverenz, Chang-En Yu, Murray A Raskind, Joseph F Quinn, Douglas R Galasko, Thomas J Montine
JAMA Neurol 2014 Jul;
PMID: 25048271 [PubMed - as supplied by publisher]

Spreading of ?-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis.
Jennifer T Lamberts, Erin Hildebrandt, Patrik Brundin
Neurobiol Dis 2014 Jul;
PMID: 25046996 [PubMed - as supplied by publisher]

A cell culture model for monitoring ?-synuclein cell-to-cell transfer.
Juan F Reyes, Tomas T Olsson, Jennifer T Lamberts, Michael J Devine, Tilo Kunath, Patrik Brundin
Neurobiol Dis 2014 Jul;
PMID: 25046995 [PubMed - as supplied by publisher]

Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates.
Laura L Dugan, LinLin Tian, Kevin L Quick, Josh I Hardt, Morvarid Karimi, Chris Brown, Susan Loftin, Hugh Flores, Stephen M Moerlein, John Polich, Samer D Tabbal, Jonathan W Mink, Joel S Perlmutter
Ann Neurol 2014 Jul;
PMID: 25043598 [PubMed - as supplied by publisher]

Parkinson disease: A monoclonal antibody targeting misfolded ?-synuclein has therapeutic potential in Parkinson disease.
Heather Wood
Nat Rev Neurol 2014 Jul;
PMID: 25002110 [PubMed - as supplied by publisher]

Altered dopamine homeostasis differentially affects mitochondrial voltage-dependent anion channels turnover.
Tiziana Alberio, Cristina Mammucari, Gianluca D'Agostino, Rosario Rizzuto, Mauro Fasano
Biochim Biophys Acta 2014 Jul; 1842(9):1816-1822
PMID: 24998333 [PubMed - as supplied by publisher]

?-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Guowei Yin, Tomas Lopes da Fonseca, Sibylle E Eisbach, Ane Martín Anduaga, Carlo Breda, Maria L Orcellet, Eva M Szeg?, Patricia Guerreiro, Diana F Lázaro, Gerhard H Braus, Claudio O Fernandez, Christian Griesinger, Stefan Becker, Roger S Goody, Aymelt Itzen, Flaviano Giorgini, Tiago F Outeiro, Markus Zweckstetter
Neurobiol Dis 2014 Jun; 70C:149-161
PMID: 24983211 [PubMed - as supplied by publisher]

Preventing ?-synuclein aggregation: The role of the small heat-shock molecular chaperone proteins.
Dezerae Cox, John A Carver, Heath Ecroyd
Biochim Biophys Acta 2014 Jun; 1842(9):1830-1843
PMID: 24973551 [PubMed - as supplied by publisher]

Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys.
Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérčse Di Paolo
Prog Neuropsychopharmacol Biol Psychiatry 2014 Jul;
PMID: 25046277 [PubMed - as supplied by publisher]

Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease.
Werner J Geldenhuys, Akiko Kochi, Li Lin, Vijaykumar Sutariya, Dean E Dluzen, Cornelis J Van der Schyf, Mi Hee Lim
Chembiochem 2014 Jul;
PMID: 25045125 [PubMed - as supplied by publisher]

Dopamine-induced ?-synuclein oligomers show self- and cross-propagation properties.
Matthew S Planchard, Sarah E Exley, Sarah E Morgan, Vijayaraghavan Rangachari
Protein Sci 2014 Jul;
PMID: 25044276 [PubMed - as supplied by publisher]

Peripheral alpha-synuclein and Parkinson's disease.
C Warren Olanow, Dustin R Wakeman, Jeffrey H Kordower
Mov Disord 2014 Jul; 29(8):963-6
PMID: 25043799 [PubMed - as supplied by publisher]

Genetic deletion of the GATA1-regulated protein ?-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.
Raffaele Renella, Julia S Schlehe, Dennis J Selkoe, David A Williams, Matthew J LaVoie
Am J Hematol 2014 Jul;
PMID: 25043722 [PubMed - as supplied by publisher]

Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.
Qingshan Wang, Chun-Hsien Chu, Esteban Oyarzabal, Lulu Jiang, Shih-Heng Chen, Belinda Wilson, Li Qian, Jau-Shyong Hong
Glia 2014 Jul;
PMID: 25043383 [PubMed - as supplied by publisher]

REM sleep behavior disorders in Parkinson's disease.
E A Liashenko, M G Poluéktov, O S Levin
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(6 Vypusk 2 Nevrologiia i psikhiatriia pozhilogo vozrasta):73-79
PMID: 25042507 [PubMed - as supplied by publisher]

Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila.
Juan A Navarro, Sabina Heßner, Sarat C Yenisetti, Florian Bayersdorfer, Li Zhang, Aaron Voigt, Stephan Schneuwly, Jose A Botella
J Neurochem 2014 Jul;
PMID: 25040725 [PubMed - as supplied by publisher]

Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP(+))-induced loss of mesencephalic dopaminergic neurons.
M M Khan, S Zaheer, J Nehman, A Zaheer
Neuroscience 2014 Jul;
PMID: 25016212 [PubMed - as supplied by publisher]

Endothelin-1: A potential pathological factor in Parkinson's disease? -From endoplasmic reticulum stress to beyond.
Arjun Jain
J Neurol Sci 2014 Jun;
PMID: 24998514 [PubMed - as supplied by publisher]

Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of ?-synuclein.
Nicola J Rutherford, Brenda D Moore, Todd E Golde, Benoit I Giasson
J Neurochem 2014 Jul;
PMID: 24984882 [PubMed - as supplied by publisher]

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy.
Franziska Richter, Sheila M Fleming, Melanie Watson, Vincent Lemesre, Lee Pellegrino, Brian Ranes, Chunni Zhu, Farzad Mortazavi, Caitlin K Mulligan, Pedrom C Sioshansi, Sindalana Hean, Krystal De La Rosa, Richie Khanna, John Flanagan, David J Lockhart, Brandon A Wustman, Sean W Clark, Marie-Françoise Chesselet
Neurotherapeutics 2014 Jul;
PMID: 25037721 [PubMed - as supplied by publisher]

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.
Marusela Oliveras-Salvá, Francesca Macchi, Valérie Coessens, Angélique Deleersnijder, Melanie Gérard, Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt
Neurobiol Aging 2014 Jun;
PMID: 25037286 [PubMed - as supplied by publisher]

Serotonin Impairment in CSF of PD Patients, without an Apparent Clinical Counterpart.
Enrica Olivola, Mariangela Pierantozzi, Paola Imbriani, Claudio Liguori, Mario Stampanoni Bassi, Marco Conti, Vincenza D Angelo, Nicola Biagio Mercuri, Alessandro Stefani
PLoS One 2014 ; 9(7):e101763
PMID: 25036938 [PubMed - as supplied by publisher]

New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases.
Joy Mitra, Erika N Guerrero, Pavana M Hegde, Haibo Wang, Istvan Boldogh, Kosagi Sharaf Rao, Sankar Mitra, Muralidhar L Hegde
Biomolecules 2014 ; 4(3):678-703
PMID: 25036887 [PubMed - as supplied by publisher]

Short Communication Huwe1 as a therapeutic target for neural injury.
J Zhou, Q Liu, M Mao, Y Tong
Genet Mol Res 2014 ; 13(2):4320-5
PMID: 25036176 [PubMed - as supplied by publisher]

7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo.
Jiahn-Dar Huang, Juan Amaral, Jung Wha Lee, Ignacio R Rodriguez
PLoS One 2014 ; 9(7):e100985
PMID: 25036103 [PubMed - as supplied by publisher]

Analysis of volatile organic compounds in rats with dopaminergic lesion: Possible application for early detection of Parkinson's disease.
S Khatib, J P M Finberg, F Artoul, Y Lavner, S Mahmood, U Tisch, H Haick, Y Aluf, J Vaya
Neurochem Int 2014 Jul;
PMID: 25034982 [PubMed - as supplied by publisher]

Sleep disturbance and cognitive disorder: epidemiological analysis in a cohort of 263 patients.
Michele Pistacchi, Manuela Gioulis, Franco Contin, Flavio Sanson, Sandro Zambito Marsala
Neurol Sci 2014 Jul;
PMID: 25034185 [PubMed - as supplied by publisher]

Tetranectin Knockout Mice Develop Features of Parkinson Disease.
Er-Song Wang, Xiao-Ping Zhang, Hui-Bin Yao, Gan Wang, Shi-Wen Chen, Wen-Wei Gao, Hai-Jun Yao, Yi-Rui Sun, Cai-Hua Xi, Yao-Dong Ji
Cell Physiol Biochem 2014 Jul; 34(2):277-287
PMID: 25033953 [PubMed - as supplied by publisher]

Neuroimaging characteristics of dementia with Lewy bodies.
Elijah Mak, Li Su, Guy B Williams, John T O'Brien
Alzheimers Res Ther 2014 ; 6(2):18
PMID: 25031634 [PubMed - as supplied by publisher]

Tetramethylpyrazine alleviated cytokine synthesis and dopamine deficit and improved motor dysfunction in the mice model of Parkinson's disease.
Hong Zhao, Mei-Ling Xu, Qi Zhang, Zhao-Hui Guo, Ying Peng, Zheng-Yi Qu, Yong-Nan Li
Neurol Sci 2014 Jul;
PMID: 25030124 [PubMed - as supplied by publisher]

Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.
Lars Tatenhorst, Lars Tönges, Kim-Ann Saal, Jan C Koch, Eva M Szeg?, Mathias Bähr, Paul Lingor
J Neuropathol Exp Neurol 2014 Aug; 73(8):770-9
PMID: 25003236 [PubMed - as supplied by publisher]

Plaques and tangles as well as Lewy-type alpha synucleinopathy are associated with formed visual hallucinations.
Sandra A Jacobson, Trisha Morshed, Brittany N Dugger, Thomas G Beach, Joseph G Hentz, Charles H Adler, Holly A Shill, Marwan N Sabbagh, Christine M Belden, Lucia I Sue, John N Caviness, Chengcheng Hu,
Parkinsonism Relat Disord 2014 Jun;
PMID: 25027359 [PubMed - as supplied by publisher]

CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson's Disease.
Richard L Jayaraj, Namasivayam Elangovan, Krishnan Manigandan, Sonu Singh, Shubha Shukla
Biomed Res Int 2014 ; 2014:236182
PMID: 25025041 [PubMed - as supplied by publisher]

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated ?-synuclein.
Misook Oh, Ji Hoon Lee, Wei Wang, Hui Sun Lee, Woo Sirl Lee, Christopher Burlak, Wonpil Im, Quyen Q Hoang, Hyun-Suk Lim
Proc Natl Acad Sci U S A 2014 Jul;
PMID: 25024216 [PubMed - as supplied by publisher]

Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals.
Tam Duong, Jaetaek Kim, H Earl Ruley, Daewoong Jo
PLoS One 2014 ; 9(7):e102517
PMID: 25019626 [PubMed - as supplied by publisher]

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein.
Sudhakar Raja Subramaniam, Laurent Vergnes, Nicholas R Franich, Karen Reue, Marie-Francoise Chesselet
Neurobiol Dis 2014 Jul;
PMID: 25016198 [PubMed - as supplied by publisher]

Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP(+)-induced oxidative stress and cell death in SH-SY5Y cells.
Cheong-Meng Chong, Mingyun Shen, Zhong-Yan Zhou, Peichen Pan, Pui-Man Hoi, Shang Li, Wang Liang, Nana Ai, Lun-Qing Zhang, Cheuk-Wing Li, Huidong Yu, Tingjun Hou, Simon Ming-Yuen Lee
Free Radic Biol Med 2014 Jun;
PMID: 24973649 [PubMed - as supplied by publisher]

The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.
Ran-Der Hwang, Lyle Wiemerslage, Christopher J LaBreck, Munzareen Khan, Kavitha Kannan, Xinglong Wang, Xiongwei Zhu, Daewoo Lee, Yih-Woei C Fridell
Neurobiol Dis 2014 Sep; 69:180-91
PMID: 24965893 [PubMed - as supplied by publisher]

Mavoglurant as a treatment for Parkinson's disease.
Dmitry Petrov, Ignacio Pedros, Maria Luisa de Lemos, Mercč Pallŕs, Anna Maria Canudas, Alberto Lazarowski, Carlos Beas-Zarate, Carme Auladell, Jaume Folch, Antoni Camins
Expert Opin Investig Drugs 2014 Aug; 23(8):1165-79
PMID: 24960254 [PubMed - as supplied by publisher]

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease.
Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein
Mol Neurodegener 2014 Jul; 9(1):27
PMID: 25011704 [PubMed - as supplied by publisher]

Imaging the Role of Amyloid in PD Dementia and Dementia with Lewy Bodies.
Stephen N Gomperts
Curr Neurol Neurosci Rep 2014 Aug; 14(8):472
PMID: 25011528 [PubMed - as supplied by publisher]

Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.
Ting-Li Dai, Chan Zhang, Fang Peng, Xue-Yuan Niu, Ling Hu, Qiong Zhang, Ying Huang, Ling Chen, Lei Zhang, Weidong Zhu, Yu-Qiang Ding, Ning-Ning Song, Min Liao
Exp Ther Med 2014 Aug; 8(2):384-390
PMID: 25009587 [PubMed - as supplied by publisher]

Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.
Nicolas Dzamko, Jinxia Zhou, Yue Huang, Glenda M Halliday
Front Mol Neurosci 2014 ; 7:57
PMID: 25009465 [PubMed - as supplied by publisher]

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah
J Neurosci 2014 Jul; 34(28):9441-54
PMID: 25009275 [PubMed - as supplied by publisher]

Synucleins regulate the kinetics of synaptic vesicle endocytosis.
Karina J Vargas, Sachin Makani, Taylor Davis, Christopher H Westphal, Pablo E Castillo, Sreeganga S Chandra
J Neurosci 2014 Jul; 34(28):9364-76
PMID: 25009269 [PubMed - as supplied by publisher]

ESCRT mediated uptake and degradation of brain targeted ?-synuclein-single chain antibody attenuates neuronal degeneration in vivo.
Brian Spencer, Sharareh Emadi, Paula Desplats, Simona Eleuteri, Sarah Michael, Kori Kosberg, Jay Shen, Edward Rockenstein, Christina Patrick, Anthony Adame, Tania Gonzalez, Michael Sierks, Eliezer Masliah
Mol Ther 2014 Jul;
PMID: 25008355 [PubMed - as supplied by publisher]

Role of Aldehyde Dehydrogenase 2 in 1-Methy-4-Phenylpyridinium Ion-Induced Aldehyde Stress and Cytotoxicity in PC12 Cells.
Ai-Hua Chen, Ping Zhang, Wei-Lan Yin, Li Wang, Wei Zou, Xiao-Qing Tang
Neurochem Res 2014 Jul;
PMID: 25005621 [PubMed - as supplied by publisher]

Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.
Kelly M Lohr, Alison I Bernstein, Kristen A Stout, Amy R Dunn, Carlos R Lazo, Shawn P Alter, Minzheng Wang, Yingjie Li, Xueliang Fan, Ellen J Hess, Hong Yi, Laura M Vecchio, David S Goldstein, Thomas S Guillot, Ali Salahpour, Gary W Miller
Proc Natl Acad Sci U S A 2014 Jul; 111(27):9977-82
PMID: 24979780 [PubMed - as supplied by publisher]

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.
Jose Bras, Rita Guerreiro, Lee Darwent, Laura Parkkinen, Olaf Ansorge, Valentina Escott-Price, Dena G Hernandez, Michael A Nalls, Lorraine N Clark, Lawrence S Honig, Karen Marder, Wiesje M Van Der Flier, Afina Lemstra, Philip Scheltens, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Sara Ortega-Cubero, Pau Pastor, Tanis J Ferman, Neill R Graff-Radford, Owen A Ross, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Walter Maetzler, Daniela Berg, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Yaroslau Compta, Tamas Revesz, Andrew Lees, Nigel Cairns, Glenda M Halliday, David Mann, Stuart Pickering-Brown, Dennis W Dickson, Andrew Singleton, John Hardy
Hum Mol Genet 2014 Jun;
PMID: 24973356 [PubMed - as supplied by publisher]

A 6.4 Mb Duplication of the ?-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism: Phenotype-Genotype Correlations.
Eleanna Kara, Aoife P Kiely, Christos Proukakis, Nicola Giffin, Seth Love, Jason Hehir, Khadija Rantell, Amelie Pandraud, Dena G Hernandez, Elizabeth Nacheva, Alan M Pittman, Mike A Nalls, Andrew B Singleton, Tamas Revesz, Kailash P Bhatia, Niall Quinn, John Hardy, Janice L Holton, Henry Houlden
JAMA Neurol 2014 Jul;
PMID: 25003242 [PubMed - as supplied by publisher]

Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
Patrick Aldrin-Kirk, Marcus Davidsson, Staffan Holmqvist, Jia-Yi Li, Tomas Björklund
PLoS One 2014 ; 9(7):e100869
PMID: 24999658 [PubMed - as supplied by publisher]

Computational Prediction of a Putative Binding Site on Drp1: Implications for Antiparkinsonian Therapy.
Hanumanthappa Pradeep, G Krishnamurthy Rajanikant
J Chem Inf Model 2014 Jul;
PMID: 24977305 [PubMed - as supplied by publisher]

Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease.
Min Shi, Changqin Liu, Travis J Cook, Kristin M Bullock, Yanchun Zhao, Carmen Ginghina, Yanfei Li, Patrick Aro, Romel Dator, Chunmei He, Michael J Hipp, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, William A Banks, Jing Zhang
Acta Neuropathol 2014 Jul;
PMID: 24997849 [PubMed - as supplied by publisher]

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease.
Anke A Dijkstra, Pieter Voorn, Henk W Berendse, Henk J Groenewegen, , Annemieke J M Rozemuller, Wilma D J van de Berg
Mov Disord 2014 Jul;
PMID: 24996051 [PubMed - as supplied by publisher]

Diet-induced obesity accelerates the onset of terminal phenotypes in ?-synuclein transgenic mice.
Carola Rotermund, Felicia M Truckenmüller, Heinrich Schell, Philipp J Kahle
J Neurochem 2014 Jul;
PMID: 24995537 [PubMed - as supplied by publisher]

The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies.
Kay Seidel, Josefine Mahlke, Sonny Siswanto, Reijko Krüger, Helmut Heinsen, Georg Auburger, Mohamed Bouzrou, Lt Grinberg, Helmut Wicht, Horst-Werner Korf, Wilfred den Dunnen, Udo Rüb
Brain Pathol 2014 Jul;
PMID: 24995389 [PubMed - as supplied by publisher]

Treatment effect of memantine on survival in dementia with Lewy bodies and Parkinson's disease with dementia: a prospective study.
Kajsa Stubendorff, Victoria Larsson, Clive Ballard, Lennart Minthon, Dag Aarsland, Elisabet Londos
BMJ Open 2014 ; 4(7):e005158
PMID: 24993765 [PubMed - as supplied by publisher]

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.
R A Charan, B N Johnson, S Zaganelli, J D Nardozzi, M J LaVoie
Cell Death Dis 2014 ; 5:e1313
PMID: 24991765 [PubMed - as supplied by publisher]

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease.
Laurie H Sanders, Jennifer McCoy, Xiaoping Hu, Pier G Mastroberardino, Bryan C Dickinson, Christopher J Chang, Charleen T Chu, Bennett Van Houten, J Timothy Greenamyre
Neurobiol Dis 2014 Jun;
PMID: 24981012 [PubMed - as supplied by publisher]

Latest treatment options for Alzheimer's disease, Parkinson's disease dementia and dementia with Lewy bodies.
Martin Broadstock, Clive Ballard, Anne Corbett
Expert Opin Pharmacother 2014 Jul; :1-14
PMID: 24992196 [PubMed - as supplied by publisher]

Sleep Disorders in Parkinsonian Macaques: Effects of l-Dopa Treatment and Pedunculopontine Nucleus Lesion.
Hayat Belaid, Joëlle Adrien, Elodie Laffrat, Dominique Tandé, Carine Karachi, David Grabli, Isabelle Arnulf, Stewart D Clark, Xavier Drouot, Etienne C Hirsch, Chantal François
J Neurosci 2014 Jul; 34(27):9124-33
PMID: 24990932 [PubMed - as supplied by publisher]

A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases.
William B Pratt, Yoshihiro Morishima, Jason E Gestwicki, Andrew P Lieberman, Yoichi Osawa
Exp Biol Med (Maywood) 2014 Jul;
PMID: 24990484 [PubMed - as supplied by publisher]

Defective Autophagy in Parkinson's Disease: Lessons from Genetics.
H Zhang, C Duan, H Yang
Mol Neurobiol 2014 Jul;
PMID: 24990317 [PubMed - as supplied by publisher]

Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.
Xiao-Min Zhang, Ming Yin, Min-Hua Zhang
Acta Pharmacol Sin 2014 Jul; 35(7):945-56
PMID: 24989254 [PubMed - as supplied by publisher]

Elevation of striatal urate in experimental models of Parkinson's disease: a compensatory mechanism triggered by dopaminergic nigrostriatal degeneration?
Maria Antonietta De Luca, Omar Cauli, Micaela Morelli, Nicola Simola
J Neurochem 2014 Jul;
PMID: 24989117 [PubMed - as supplied by publisher]

Update on SPECT and PET in parkinsonism - part 2: biomarker imaging of cognitive impairment in Lewy-body diseases.
Philipp T Meyer, Lars Frings, Sabine Hellwig
Curr Opin Neurol 2014 Aug; 27(4):398-404
PMID: 24978635 [PubMed - as supplied by publisher]

Levels of cerebrospinal fluid ?-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease.
Oskar Hansson, Sara Hall, Annika Ohrfelt, Henrik Zetterberg, Kaj Blennow, Lennart Minthon, Katarina Nägga, Elisabet Londos, Shiji Varghese, Nour K Majbour, Abdulmonem Al-Hayani, Omar Ma El-Agnaf
Alzheimers Res Ther 2014 ; 6(3):25
PMID: 24987465 [PubMed - as supplied by publisher]

Upstream deregulation of calcium signaling in Parkinson's disease.
Pilar Rivero-Ríos, Patricia Gómez-Suaga, Elena Fdez, Sabine Hilfiker
Front Mol Neurosci 2014 ; 7:53
PMID: 24987329 [PubMed - as supplied by publisher]

Association of Parkinson's disease with altered serum levels of lead and transition metals among South Indian subjects.
Yalavarthy Prameela Devi, Shaik Mohammad Naushad, Rukmini Mridula, Rupam Borgohain, Kumar Kutala Vijay
Indian J Biochem Biophys 2014 Apr; 51(2):121-6
PMID: 24980015 [PubMed - as supplied by publisher]

The role of alpha-synuclein in Parkinson's disease].
Ildiko Miklya, Noemi Pencz, Florencia Hafenscher, Patricia Goltl
Neuropsychopharmacol Hung 2014 Jun; 16(2):77-84
PMID: 24978050 [PubMed - as supplied by publisher]

The role of parkin in Parkinson's disease].
Ildiko Miklya, Patricia Goltl, Florencia Hafenscher, Noemi Pencz
Neuropsychopharmacol Hung 2014 Jun; 16(2):67-76
PMID: 24978049 [PubMed - as supplied by publisher]

Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease.
Naoto Kadoguchi, Shinji Okabe, Yukio Yamamura, Misaki Shono, Tatsuya Fukano, Akie Tanabe, Hironori Yokoyama, Jiro Kasahara
BMC Neurosci 2014 ; 15:79
PMID: 24965042 [PubMed - as supplied by publisher]

The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model.
Diana Fernández-Suárez, Marta Celorrio, José Ignacio Riezu-Boj, Ana Ugarte, Rodrigo Pacheco, Hugo González, Julen Oyarzabal, Cecilia J Hillard, Rafael Franco, María S Aymerich
Neurobiol Aging 2014 May;
PMID: 24973119 [PubMed - as supplied by publisher]

A rapid and simple method for the determination of 3,4-dihydroxyphenylacetic acid, norepinephrine, dopamine, and serotonin in mouse brain homogenate by HPLC with fluorimetric detection.
Giuseppe Egidio De Benedetto, Daniela Fico, Antonio Pennetta, Cosimino Malitesta, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco De Nuccio, Velia La Pesa
J Pharm Biomed Anal 2014 Jun; 98C:266-270
PMID: 24971521 [PubMed - as supplied by publisher]

Transglutaminase 2 exacerbates ?-synuclein toxicity in mice and yeast.
Hilary Grosso, Jong-Min Woo, Kang-Woo Lee, Joo-Young Im, Eliezer Masliah, Eunsung Junn, M Maral Mouradian
FASEB J 2014 Jun;
PMID: 24970392 [PubMed - as supplied by publisher]

Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease: a preliminary investigation in the postmortem human brain.
Balázs Gulyás, Judit Sovago, Baltazar Gomez-Mancilla, Zhisheng Jia, Csaba Szigeti, Károly Gulya, Martin Schumacher, Ralph Paul Maguire, Fabrizio Gasparini, Christer Halldin
Brain Struct Funct 2014 Jun;
PMID: 24969128 [PubMed - as supplied by publisher]

The role of dopamine in huntington's disease.
Carlos Cepeda, Kerry P S Murphy, Martin Parent, Michael S Levine
Prog Brain Res 2014 ; 211:235-54
PMID: 24968783 [PubMed - as supplied by publisher]

The neurogenetics of atypical parkinsonian disorders.
Brent L Fogel, Mary C Clark, Daniel H Geschwind
Semin Neurol 2014 Apr; 34(2):217-24
PMID: 24963681 [PubMed - as supplied by publisher]

Neuropathologic changes of multiple system atrophy and diffuse lewy body disease.
Etty Paola Cortes Ramirez, Jean Paul G Vonsattel
Semin Neurol 2014 Apr; 34(2):210-6
PMID: 24963680 [PubMed - as supplied by publisher]

Dementia with lewy bodies.
Mary Catherine Mayo, Yvette Bordelon
Semin Neurol 2014 Apr; 34(2):182-8
PMID: 24963677 [PubMed - as supplied by publisher]

High-throughput Functional Screening using a Homemade Dual-glow Luciferase Assay.
Jessica M Baker, Frederick M Boyce
J Vis Exp 2014 ; (88)
PMID: 24962249 [PubMed - as supplied by publisher]