Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity.

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Mol Biol Rep 2009 Jul;

Authors: Xu Liangliang, Hou Yonghui, E Shunmei, Gong Shoufang, Zhou Wei, Zou Jiangying

School of Life Sciences, University of Science and Technology of China, 230027, Hefei, China.

Alpha-synuclein aggregation and cytotoxicity are widely considered to play a critical role in the process of Parkinson's disease. Heat shock proteins are a large family of cellular protective molecules in most kinds of cells. In this study, we examined the impact of dominant-positive heat shock transcription factor 1 (HSF1) on alpha-synuclein over-expression cellular model of Parkinson's disease. We found that over-expression of alpha-synuclein could form alpha-synuclein immunopositive inclusions and result in cell death; dominant-positive HSF1 dramatically increased the expression of HSP70 in SH-SY5Y cells, and significantly decreased the level and cytotoxicity of alpha-synuclein. Taken together, these data indicate that dominant-positive HSF1 plays an important role in suppressing alpha-synuclein aggregation and toxicity in SH-SY5Y cells. Parkinson's disease which is marked by alpha-synuclein aggregation may be treated by increasing a set of endogenous heat shock proteins.

PMID: 19609719 [PubMed - as supplied by publisher]

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