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Amantadine and cognitive flexibility: decision making in Parkinson's patients with severe pathological gambling and other impulse control disorders.

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Neuropsychiatr Dis Treat 2014 ; 10:1093-101

Authors: Nicoletta Cera, Stefania Bifolchetti, Giovanni Martinotti, Francesco Gambi, Gianna Sepede, Marco Onofrj, Massimo Di Giannantonio, Astrid Thomas

Dopamine replacement therapy for Parkinson's disease (PD) was recently linked to the development of impulse control disorders such as pathological gambling (PG), hypersexuality, compulsive shopping, and binge or compulsive eating. Antiglutamatergic agents including amantadine (Ama) reduce these behaviors in PD and non-PD patients. The aim of our study is to evaluate the changes in executive functions, emotions, and reward/loss processing during Ama treatment in PD patients.

PMID: 24971012 [PubMed - as supplied by publisher]

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