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Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias.

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Parkinsonism Relat Disord 2014 May;

Authors: Olivier Rascol, Susan Fox, Fabrizio Gasparini, Christopher Kenney, Thérèse Di Paolo, Baltazar Gomez-Mancilla

Modulation of metabotropic glutamate receptors may be a novel therapeutic approach to manage l-Dopa-induced dyskinesias in patients with Parkinson's disease. This article reviews the rationale for use of metabotropic glutamate 5-receptor antagonists in experimental and clinical l-Dopa-induced dyskinesias.

PMID: 24951359 [PubMed - as supplied by publisher]

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