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Featured Research

What can we learn by studying exercise and Parkinson's? PDF-funded researcher Kristen Pickett, Ph.D., is using magnetic resonance imaging to help find answers to improve life for people with PD.

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Treatments/Pipeline

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior.
Minerva Y Wong, Anders Borgkvist, Se Joon Choi, Eugene V Mosharov, Nigel S Bamford, David Sulzer
Neuroscience 2015 Jan;
PMID: 25637802 [PubMed - as supplied by publisher]


The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein.
Yunden Jinsmaa, Adele Cooney, Patricia Sullivan, Yehonatan Sharabi, David S Goldstein
Neurosci Lett 2015 Jan;
PMID: 25637699 [PubMed - as supplied by publisher]


Management of Parkinson's disease: current and future pharmacotherapy.
Ashish Kumar Kakkar, Neha Dahiya
Eur J Pharmacol 2015 Jan;
PMID: 25637088 [PubMed - as supplied by publisher]


Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.
Kazuya Yasuda, Hiroshi Abe, Go Koganemaru, Tetsuya Ikeda, Kazuhiko Arimori, Yasushi Ishida
Pharmacol Biochem Behav 2015 Jan; 131C:1-5
PMID: 25622778 [PubMed - as supplied by publisher]


Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors.
Xiaoqun Zhang, Karima Chergui
Neuropharmacology 2015 Jan;
PMID: 25619731 [PubMed - as supplied by publisher]


Preoperative brain metabolism and quality of life after subthalamic nucleus stimulation in Parkinson's disease.
Sophie Langner-Lemercier, Sophie Drapier, Florian Naudet, Nathalie Le Clanche, Jean-François Houvenaghel, Paul Sauleau, Pierre Jannin, Claire Haegelen, Florence Le Jeune, Marc Vérin
J Neurol 2015 Jan;
PMID: 25634679 [PubMed - as supplied by publisher]


Drug treatments for Parkinson's disease compared.
Nurs Older People 2015 Jan; 27(1):15
PMID: 25633702 [PubMed - as supplied by publisher]


Glutamate and GABA concentration changes in the globus pallidus internus of Parkinson's patients during performance of implicit and declarative memory tasks: A report of two subjects.
Robert J Buchanan, Klevest Gjini, David Darrow, Georgeta Varga, Jennifer L Robinson, Zoltan Nadasdy
Neurosci Lett 2015 Jan; 589C:73-78
PMID: 25596441 [PubMed - as supplied by publisher]


Modeling falls in Parkinson's disease: Slow gait, freezing episodes and falls in rats with extensive striatal dopamine loss.
Aaron Kucinski, Roger L Albin, Cindy Lustig, Martin Sarter
Behav Brain Res 2015 Jan; 282C:155-164
PMID: 25595423 [PubMed - as supplied by publisher]


Catechol-o-methyltransferase inhibitors in Parkinson's disease.
Thomas Müller
Drugs 2015 Feb; 75(2):157-74
PMID: 25559423 [PubMed - as supplied by publisher]


Deep brain stimulation and responsiveness of the Persian version of Parkinson's disease questionnaire with 39-items.
Gholam Ali Shahidi, Zeinab Ghaempanah, Yasaman Khalili, Marzieh Nojomi
Iran J Neurol 2014 Oct; 13(4):220-5
PMID: 25632334 [PubMed - as supplied by publisher]


Placebo effect of medication cost in Parkinson disease: A randomized double-blind study.
Alberto J Espay, Matthew M Norris, James C Eliassen, Alok Dwivedi, Matthew S Smith, Christi Banks, Jane B Allendorfer, Anthony E Lang, David E Fleck, Michael J Linke, Jerzy P Szaflarski
Neurology 2015 Jan;
PMID: 25632091 [PubMed - as supplied by publisher]


The pharmacodynamics of placebo: Expectation effects of price as a proxy for efficacy.
Peter A LeWitt, Scott Kim
Neurology 2015 Jan;
PMID: 25632090 [PubMed - as supplied by publisher]


RE response to: "Entacapone, Parkinson's disease, "functional adrenergic denervation", and Takotsubo syndrome"
F Baldacci, A Vergallo, P Del Dotto, M Ulivi, C Palombo, G Casolo, U Bonuccelli
Parkinsonism Relat Disord 2014 Nov;
PMID: 25630888 [PubMed - as supplied by publisher]


Global long-term study on motor and non-motor symptoms and safety of levodopa-carbidopa intestinal gel in routine care of advanced Parkinson's disease patients; 12-month interim outcomes.
Angelo Antonini, Ashley Yegin, Cornelia Preda, Lars Bergmann, Werner Poewe,
Parkinsonism Relat Disord 2014 Dec;
PMID: 25585993 [PubMed - as supplied by publisher]


Face-referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease.
Shin Ying Chu, Steven M Barlow, Jaehoon Lee
J Speech Lang Hear Res 2015 Jan;
PMID: 25629806 [PubMed - as supplied by publisher]


Acupuncture Alleviated the Nonmotor Symptoms of Parkinson's Disease including Pain, Depression, and Autonomic Symptoms.
Chifumi Iseki, Taiga Furuta, Masao Suzuki, Shingo Koyama, Keiji Suzuki, Tomoko Suzuki, Akiyo Kaneko, Tadamichi Mitsuma
Case Rep Neurol Med 2014 ; 2014:953109
PMID: 25628905 [PubMed - as supplied by publisher]


Thyroid-induced worsening of parkinsonian tremor resistant to drugs and subthalamic nucleus deep brain stimulation.
Michal Minár, Peter Valkovi?
Case Rep Neurol Med 2014 ; 2014:489275
PMID: 25628904 [PubMed - as supplied by publisher]


Anticholinergic burden in older women: not seeing the wood for the trees?
Lynne Parkinson, Parker J Magin, Allison Thomson, Julie E Byles, Gillian E Caughey, Christopher Etherton-Beer, Danijela Gnjidic, Sarah N Hilmer, Thomas King Tong Lo, Colin McCowan, Rachael Moorin, C Dimity Pond
Med J Aust 2015 Feb; 202(2):91-4
PMID: 25627741 [PubMed - as supplied by publisher]


The differential effects of DBS target on motor subtypes in Parkinson's disease.
Maya Katz, Marta San Luciano, Kimberly Carlson, Ping Luo, William J Marks, Paul S Larson, Philip A Starr, Kenneth A Follett, Frances M Weaver, Matthew B Stern, Domenic J Reda, Jill L Ostrem
Ann Neurol 2015 Jan;
PMID: 25627340 [PubMed - as supplied by publisher]


Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson's Disease.
Paul B Huleatt, Mui Ling Khoo, Yi Yuan Chua, Tiong Wei Tan, Rou Shen Liew, Balázs Balogh, Ruth Deme, Flóra Gölöncsér, Kalman Magyar, David P Sheela, Han Kiat Ho, Beáta Sperlágh, Péter Mátyus, Christina L L Chai
J Med Chem 2015 Jan;
PMID: 25627172 [PubMed - as supplied by publisher]


Idiopathic intracranial hypertension following deep brain stimulation for Parkinson's disease.
Patrice Finet, Maxime Delavallée, Christian Raftopoulos
Acta Neurochir (Wien) 2015 Jan;
PMID: 25626428 [PubMed - as supplied by publisher]


Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity.
Anuj K Yadav, David L Shen, Xiaoyang Shan, Xu He, Allison R Kermode, David J Vocadlo
J Am Chem Soc 2015 Jan; 137(3):1181-9
PMID: 25562638 [PubMed - as supplied by publisher]


Treatment for advanced Parkinson's disease with intestinal levodopa/carbidopa gel: review of efficacy and safety].
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(11):145-51
PMID: 25629138 [PubMed - as supplied by publisher]


Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement.
Sabato Santaniello, Michelle M McCarthy, Erwin B Montgomery, John T Gale, Nancy Kopell, Sridevi V Sarma
Proc Natl Acad Sci U S A 2015 Jan;
PMID: 25624501 [PubMed - as supplied by publisher]


Gap junction blockers attenuate beta oscillations and improve forelimb function in hemiparkinsonian rats.
Sujoy Phookan, Alexander C Sutton, Ian Walling, Autumn Smith, Katherine A O'Connor, Joannalee C Campbell, Megan Calos, Wilson Yu, Julie G Pilitsis, Jonathan M Brotchie, Damian S Shin
Exp Neurol 2015 Jan;
PMID: 25622779 [PubMed - as supplied by publisher]


Axial disability and deep brain stimulation in patients with Parkinson disease.
Alfonso Fasano, Camila C Aquino, Joachim K Krauss, Christopher R Honey, Bastiaan R Bloem
Nat Rev Neurol 2015 Jan;
PMID: 25582445 [PubMed - as supplied by publisher]


Deep Brain Stimulation Versus Electroconvulsive Therapy in Parkinson's Disease.
Charles H Kellner, David A Kellner
J ECT 2015 Jan;
PMID: 25621543 [PubMed - as supplied by publisher]


Deep brain stimulation of the subthalamic nucleus in Parkinson's disease 2003-2013: Where are we another 10 years on?
Alexander Alamri, Ismail Ughratdar, Michael Samuel, Keyoumars Ashkan
Br J Neurosurg 2015 Jan; :1-10
PMID: 25619979 [PubMed - as supplied by publisher]


Proteomics analyses for the global proteins in the brain tissues of different human prion diseases.
Qi Shi, Li-Na Chen, Bao-Yun Zhang, Kang Xiao, Wei Zhou, Cao Chen, Xiao-Mei Zhang, Chan Tian, Chen Gao, Jing Wang, Jun Han, Xiao-Ping Dong
Mol Cell Proteomics 2015 Jan;
PMID: 25616867 [PubMed - as supplied by publisher]


Risk factors and safe dosage of levodopa for wearing-off phenomenon in Chinese patients with Parkinson's disease.
Huimin Chen, Jinping Fang, Fangfei Li, Liyan Gao, Tao Feng
Neurol Sci 2015 Jan;
PMID: 25616444 [PubMed - as supplied by publisher]


Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson's disease.
S Mitra, N Chakrabarti, S S Dutta, S Ray, P Bhattacharya, P Sinha, A Bhattacharyya
Neuroscience 2015 Jan;
PMID: 25592425 [PubMed - as supplied by publisher]


Dopamine agonists early monotherapy for the delay of development of levodopa-induced dyskinesias.
Pantelis Stathis, Spiridon Konitsiotis, Angelo Antonini
Expert Rev Neurother 2015 Feb; 15(2):207-13
PMID: 25578445 [PubMed - as supplied by publisher]


Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.
Joanna Ruszkiewicz, Jan Albrecht
Neurochem Int 2015 Jan;
PMID: 25576182 [PubMed - as supplied by publisher]


Deep brain stimulation in early stage Parkinson's disease.
David Charles, Peter E Konrad, Thomas L Davis, Joseph S Neimat, Mallory L Hacker, Stuart G Finder
Parkinsonism Relat Disord 2014 Dec;
PMID: 25547949 [PubMed - as supplied by publisher]


Globus Pallidus Internus Deep Brain Stimulation as Rescue Therapy for Refractory Dyskinesias following Effective Subthalamic Nucleus Stimulation.
Raymond J Cook, Lyndsey Jones, George Fracchia, Nathan Anderson, Jenny Miu, Linton J Meagher, Peter A Silburn, Paul Silberstein
Stereotact Funct Neurosurg 2015 ; 93(1):25-9
PMID: 25613902 [PubMed - as supplied by publisher]


Neuropsychological Effects of Deep Brain Stimulation in Subjects with Early Stage Parkinson's Disease in a Randomized Clinical Trial.
Michael G Tramontana, Anna L Molinari, Peter E Konrad, Thomas L Davis, Scott A Wylie, Joseph S Neimat, Alexandra T May, Fenna T Phibbs, Peter Hedera, Chandler E Gill, Ronald M Salomon, Lily Wang, Yanna Song, David Charles
J Parkinsons Dis 2015 Jan;
PMID: 25613351 [PubMed - as supplied by publisher]


Pharmacoeconomic aspects of using levodopa/carbidopa intestinal gel in Parkinson's disease].
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(10):117-21
PMID: 25614914 [PubMed - as supplied by publisher]


Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats.
David Dardou, Carine Chassain, Franck Durif
Front Neurosci 2014 ; 8:437
PMID: 25610366 [PubMed - as supplied by publisher]


Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced parkinsonian rats.
Sonja Seeger-Armbruster, Clémentine Bosch-Bouju, Shane T C Little, Roseanna A Smither, Stephanie M Hughes, Brian I Hyland, Louise C Parr-Brownlie
J Neurosci 2015 Jan; 35(3):1211-6
PMID: 25609635 [PubMed - as supplied by publisher]


Effect of speech therapy and pharmacological treatment in prosody of parkinsonians.
Luciana Lemos de Azevedo, Irene Soares de Souza, Patrícia Marques de Oliveira, Francisco Cardoso
Arq Neuropsiquiatr 2015 Jan; 73(1):30-5
PMID: 25608124 [PubMed - as supplied by publisher]


Management of impulse control disorders in Parkinson's disease: Controversies and future approaches.
Michael Samuel, Maria Rodriguez-Oroz, Angelo Antonini, Jonathan M Brotchie, Kallol Ray Chaudhuri, Richard G Brown, Wendy R Galpern, Melissa J Nirenberg, Michael S Okun, Anthony E Lang
Mov Disord 2015 Jan;
PMID: 25607799 [PubMed - as supplied by publisher]


A 12-year population-based study of freezing of gait in Parkinson's disease.
E B Forsaa, J P Larsen, T Wentzel-Larsen, G Alves
Parkinsonism Relat Disord 2014 Dec;
PMID: 25603767 [PubMed - as supplied by publisher]


Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.
Anna Kubesova, Hana Tejkalova, Kamila Syslova, Petr Kacer, Jana Vondrousova, Filip Tyls, Michaela Fujakova, Tomas Palenicek, Jiri Horacek
PLoS One 2015 ; 10(1):e0115439
PMID: 25602957 [PubMed - as supplied by publisher]


The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson's disease.
Christina Tremblay, Joël Macoir, Mélanie Langlois, Léo Cantin, Michel Prud'homme, Laura Monetta
Brain Lang 2015 Feb; 141:103-9
PMID: 25577507 [PubMed - as supplied by publisher]


Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Rafael J Rojas, Dale E Edmondson, Terri Almos, Roderick Scott, Mark E Massari
Bioorg Med Chem 2015 Jan;
PMID: 25600407 [PubMed - as supplied by publisher]


Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]


Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2014 Dec;
PMID: 25599874 [PubMed - as supplied by publisher]


Spatial Topographies of Unilateral Subthalamic Nucleus Deep Brain Stimulation Efficacy for Ipsilateral, Contralateral, Midline, and Total Parkinson Disease Motor Symptoms.
Mahesh B Shenai, Andrew Romeo, Harrison C Walker, Stephanie Guthrie, Ray L Watts, Barton L Guthrie
Neurosurgery 2015 Jan;
PMID: 25599197 [PubMed - as supplied by publisher]


Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.
Yu Tang, Weidong Le
Mol Neurobiol 2015 Jan;
PMID: 25598354 [PubMed - as supplied by publisher]


Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson's disease model.
Julius A Steinbeck, Se Joon Choi, Ana Mrejeru, Yosif Ganat, Karl Deisseroth, David Sulzer, Eugene V Mosharov, Lorenz Studer
Nat Biotechnol 2015 Jan;
PMID: 25580598 [PubMed - as supplied by publisher]


The ethics of deep brain stimulation (DBS).
Marcus Unterrainer, Fuat S Oduncu
Med Health Care Philos 2015 Jan;
PMID: 25597042 [PubMed - as supplied by publisher]


CSF tau and tau/A?42 predict cognitive decline in Parkinson's disease.
Changqin Liu, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, , Jing Zhang
Parkinsonism Relat Disord 2015 Jan;
PMID: 25596881 [PubMed - as supplied by publisher]


Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson's disease.
Salvatore Galati, Agnese Salvadč, Marta Pace, Simone Sarasso, Francesca Baracchi, Claudio L Bassetti, Alain Kaelin-Lang, Claudio Städler, Paolo Stanzione, Jens C Möller
Neurobiol Aging 2014 Dec;
PMID: 25596726 [PubMed - as supplied by publisher]


Reduction of gastrointestinal symptoms in Parkinson's disease after a switch from oral therapy to rotigotine transdermal patch: A non-interventional prospective multicenter trial.
Dirk Woitalla, Jan Kassubek, Lars Timmermann, Thomas Lauterbach, Reinhard Berkels, Frank Grieger, Thomas Müller
Parkinsonism Relat Disord 2014 Dec;
PMID: 25595315 [PubMed - as supplied by publisher]


Applying guidelines to individual patients: deep brain stimulation for early-stage Parkinson disease.
Bryn Esplin, Andre G Machado, Paul J Ford, Kara Beasley, Bryn Esplin, Andre G Machado, Paul J Ford, Kara Beasley
Virtual Mentor 2015 ; 17(1):13-22
PMID: 25594711 [PubMed - as supplied by publisher]


COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese.
Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu
Mov Disord 2015 Jan;
PMID: 25594503 [PubMed - as supplied by publisher]


Accuracy of direct magnetic resonance imaging-guided placement of drug infusion cannulae.
Prashant Chittiboina, John D Heiss, Russell R Lonser
J Neurosurg 2015 Jan; :1-7
PMID: 25594325 [PubMed - as supplied by publisher]


Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
Erik Cederfjäll, Lauren Broom, Deniz Kirik
Mol Ther 2015 Jan;
PMID: 25592335 [PubMed - as supplied by publisher]


Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns.
Kenneth K B Tan, Jason Y Tann, Sharvari R Sathe, Seok Hong Goh, Dongliang Ma, Eyleen L K Goh, Evelyn K F Yim
Biomaterials 2015 Mar; 43:32-43
PMID: 25591959 [PubMed - as supplied by publisher]


Bilateral coherence between motor cortices and subthalamic nuclei in patients with Parkinson's disease.
Kenji Kato, Fusako Yokochi, Makoto Taniguchi, Ryoichi Okiyama, Takashi Kawasaki, Katsuo Kimura, Junichi Ushiba
Clin Neurophysiol 2014 Dec;
PMID: 25591829 [PubMed - as supplied by publisher]


The use of stalevo in the treatment of patients with Parkinson's disease].
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(10):35-8
PMID: 25591514 [PubMed - as supplied by publisher]


Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinson's disease.
Filip R??i?ka, Robert Jech, Lucie Nováková, Du?an Urgo?ík, Ond?ej Bezdí?ek, Josef Vymazal, Ev?en R??i?ka
Psychoneuroendocrinology 2015 Feb; 52:302-10
PMID: 25554999 [PubMed - as supplied by publisher]


Discharge responses of the optic tract to flash stimuli in Parkinson's disease.
Takao Hashimoto, Satoshi Katai, Tetsuya Goto
Ann Clin Transl Neurol 2014 Apr; 1(4):298-301
PMID: 25590042 [PubMed - as supplied by publisher]


Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.
Carole Carcenac, Mathieu Favier, Yvan Vachez, Emilie Lacombe, Sébastien Carnicella, Marc Savasta, Sabrina Boulet
Mov Disord 2015 Jan;
PMID: 25588931 [PubMed - as supplied by publisher]


Long-Term Safety and Maintenance of Efficacy of Levodopa-Carbidopa Intestinal Gel: An Open-Label Extension of the Double-Blind Pivotal Study in Advanced Parkinson's Disease Patients.
John T Slevin, Hubert H Fernandez, Cindy Zadikoff, Coleen Hall, Susan Eaton, Jordan Dubow, Krai Chatamra, Janet Benesh
J Parkinsons Dis 2014 Dec;
PMID: 25588353 [PubMed - as supplied by publisher]


Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Rômulo Pereira Ribeiro, Joăo Cleverson Gasparetto, Raquel de Oliveira Vilhena, Thais Martins Guimarăes de Francisco, Cleverson Antônio Ferreira Martins, Marco André Cardoso, Roberto Pontarolo
Bioanalysis 2015 Jan; 7(2):207-20
PMID: 25587837 [PubMed - as supplied by publisher]


An open-label extension study to evaluate safety of ropinirole prolonged-release in Chinese patients with advanced Parkinson's disease.
Zhenxin Zhang, Jian Wang, Xiaoying Zhang, Shengdi Chen, Zhenfu Wang, Baorong Zhang, Chunfeng Liu, Qiumin Qu, Yan Cheng, Rongxuan Zhu, Jie Li, Jingqiu Hu, Meng Cai
Curr Med Res Opin 2015 Jan; :1-24
PMID: 25586298 [PubMed - as supplied by publisher]


Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood-brain barrier opening in vivo.
Gesthimani Samiotaki, Camilo Acosta, Shutao Wang, Elisa E Konofagou
J Cereb Blood Flow Metab 2015 Jan;
PMID: 25586140 [PubMed - as supplied by publisher]


Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Anne Vital, Sebastien Lepreux, Claude Vital
J Peripher Nerv Syst 2015 Jan;
PMID: 25582874 [PubMed - as supplied by publisher]


The synthesis and evaluation of C7-substituted ?-tetralone derivatives as inhibitors of monoamine oxidase.
Lesetja J Legoabe, Anél Petzer, Jacobus P Petzer
Chem Biol Drug Des 2015 Jan;
PMID: 25581511 [PubMed - as supplied by publisher]


Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity.
Laura Ravani, Maria Grazia Sarpietro, Elisabetta Esposito, Antonio Di Stefano, Piera Sozio, Mariangela Calcagno, Markus Drechsler, Catia Contado, Francesco Longo, Maria Chiara Giuffrida, Francesco Castelli, Michele Morari, Rita Cortesi
Mater Sci Eng C Mater Biol Appl 2015 Mar; 48:294-300
PMID: 25579926 [PubMed - as supplied by publisher]


24 h Levodopa-carbidopa intestinal gel may reduce falls and "unresponsive" freezing of gait in Parkinson's disease.
Florence C F Chang, David S Tsui, Neil Mahant, Nigel Wolfe, Samuel D Kim, Ainhi D Ha, Melissa Drury, Jane M Griffith, Victor S C Fung
Parkinsonism Relat Disord 2014 Dec;
PMID: 25578290 [PubMed - as supplied by publisher]


Impact of mild cognitive impairment on outcome following deep brain stimulation surgery for Parkinson's disease.
Hesham Abboud, Darlene Floden, Nicolas R Thompson, Gencer Genc, Srivadee Oravivattanakul, Faisal Alsallom, Bengwei Swa, Cynthia Kubu, Mayur Pandya, Michal Gostkowski, Scott Cooper, Andre G Machado, Hubert H Fernandez
Parkinsonism Relat Disord 2014 Dec;
PMID: 25578289 [PubMed - as supplied by publisher]


Effects of Stochastic Vestibular Galvanic Stimulation and LDOPA on Balance and Motor Symptoms in Patients With Parkinson's Disease.
Ghazaleh Samoudi, Maria Jivegĺrd, Ajitkumar P Mulavara, Filip Bergquist
Brain Stimul 2014 Dec;
PMID: 25573070 [PubMed - as supplied by publisher]


A computational model for bipolar deep brain stimulation of the subthalamic nucleus.
Maria I Iacono, Esra Neufeld, Giorgio Bonmassar, Esther Akinnagbe, Andras Jakab, Ethan Cohen, Niels Kuster, Wolfgang Kainz, Leonardo M Angelone
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:6258-61
PMID: 25571427 [PubMed - as supplied by publisher]


Single trial behavioral task classification using subthalamic nucleus local field potential signals.
Soroush Niketeghad, Adam O Hebb, Joshua Nedrud, Sara J Hanrahan, Mohammad H Mahoor
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3793-6
PMID: 25570817 [PubMed - as supplied by publisher]


Dynamic tension EMG to characterize the effects of DBS treatment of advanced Parkinson's disease.
V Ruonala, E Pekkonen, S Rissanen, O Airaksinen, G Miroshnichenko, M Kankaanpaa, P Karjalainen
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3248-51
PMID: 25570683 [PubMed - as supplied by publisher]


Parkinson's disease assessment based on gait analysis using an innovative RGB-D camera system.
Ana Patricia Rocha, Hugo Choupina, Jose Maria Fernandes, Maria Jose Rosas, Rui Vaz, Joao Paulo Silva Cunha
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3126-9
PMID: 25570653 [PubMed - as supplied by publisher]


Localization of subthalamic nucleus borders using macroelectrode local field potential recordings.
I Telkes, N F Ince, I Onaran, A Abosch
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:2621-4
PMID: 25570528 [PubMed - as supplied by publisher]


On modeling the neuronal activity in movement disorder patients by using the Ornstein Uhlenbeck Process.
Pitamber Shukla, Ishita Basu, Daniela Tuninetti, Daniel Graupe, Konstantin V Slavin
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:2609-12
PMID: 25570525 [PubMed - as supplied by publisher]


The study on a real-time remote monitoring system for Parkinson's disease patients with deep brain stimulators.
Yue Chen, Hongwei Hao, Hao Chen, Ye Tian, Luming Li
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:1358-61
PMID: 25570219 [PubMed - as supplied by publisher]


Sparse representation of MER signals for localizing the Subthalamic Nucleus in Parkinson's disease surgery.
Hernan Dario Vargas Cardona, Mauricio A Alvarez, Alvaro A Orozco
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:950-3
PMID: 25570117 [PubMed - as supplied by publisher]


Target coverage and selectivity in field steering brain stimulation.
Ruben Cubo, Mattias Astrom, Alexander Medvedev
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:522-5
PMID: 25570011 [PubMed - as supplied by publisher]


Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.
Fanny Charbonnier-Beaupel, Marion Malerbi, Cristina Alcacer, Khadija Tahiri, Wassila Carpentier, Chuansong Wang, Matthew During, Desheng Xu, Paul F Worley, Jean-Antoine Girault, Denis Hervé, Jean-Christophe Corvol
J Neurosci 2015 Jan; 35(1):96-111
PMID: 25568106 [PubMed - as supplied by publisher]


A neuroleptic malignant-like syndrome (NMLS) in a patient with Parkinson's disease resolved with rotigotine: a case report.
Stefania Fiore, Lidia Persichino, Sabrina Anticoli, Maria Francesca De Pandis
Acta Biomed 2014 ; 85(3):281-4
PMID: 25567468 [PubMed - as supplied by publisher]


Control of abnormal synchronization in neurological disorders.
Oleksandr V Popovych, Peter A Tass
Front Neurol 2014 ; 5:268
PMID: 25566174 [PubMed - as supplied by publisher]


Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models.
Maowen Ba, Min Kong, Guozhao Ma
Drug Des Devel Ther 2015 ; 9:199-206
PMID: 25565773 [PubMed - as supplied by publisher]


Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease: a pharmacoinformatics study.
Muhammad Usman Mirza, A Hammad Mirza, Noor-Ul-Huda Ghori, Saba Ferdous
Drug Des Devel Ther 2015 ; 9:187-98
PMID: 25565772 [PubMed - as supplied by publisher]


Deep Brain Stimulation - an effective therapy not only for Parkinson's disease].
Wiebke Kathmann
Dtsch Med Wochenschr 2014 Nov; 139(48):2434-5
PMID: 25568902 [PubMed - as supplied by publisher]


Genetic control of midbrain dopaminergic neuron development.
Sandra Blaess, Siew-Lan Ang
Wiley Interdiscip Rev Dev Biol 2015 Jan;
PMID: 25565353 [PubMed - as supplied by publisher]


Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases.
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Patrick Boissin, Edilio Borroni, Bernd Büttelmann, Simona Ceccarelli, Nicole Clemann, Beatrice David, Christoph Funk, Wolfgang Guba, Anthony Harrison, Thomas Hartung, Michael Honer, Jörg Huwyler, Martin Kuratli, Urs Niederhauser, Axel Pähler, Jens-Uwe Peters, Ann Petersen, Eric Prinssen, Antonio Ricci, Daniel Rueher, Marianne Rueher, Manfred Schneider, Paul Spurr, Theodor Stoll, Daniel Tännler, Jürgen Wichmann, Richard H Porter, Joseph G Wettstein, Lothar Lindemann
J Med Chem 2015 Jan;
PMID: 25565255 [PubMed - as supplied by publisher]


Deep Brain Stimulation for Parkinson Disease: The 2014 Lasker-DeBakey Clinical Medical Research Award.
Maxime W C Rousseaux, Huda Y Zoghbi
JAMA Neurol 2015 Jan;
PMID: 25560048 [PubMed - as supplied by publisher]


A Review of the Potential Role of Nano-Enabled Drug Delivery Technologies in Amyotrophic Lateral Sclerosis: Lessons Learned from Other Neurodegenerative Disorders.
Zamanzima Mazibuko, Yahya E Choonara, Pradeep Kumar, Lisa C Du Toit, Girish Modi, Dinesh Naidoo, Viness Pillay
J Pharm Sci 2015 Jan;
PMID: 25559087 [PubMed - as supplied by publisher]


Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease.
Daniel Weiss, Rosa Klotz, Rathinaswamy B Govindan, Marlieke Scholten, Georgios Naros, Ander Ramos-Murguialday, Friedemann Bunjes, Christoph Meisner, Christian Plewnia, Rejko Krüger, Alireza Gharabaghi
Brain 2015 Jan;
PMID: 25558877 [PubMed - as supplied by publisher]


New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases.
Christian Hölscher
Neural Regen Res 2014 Nov; 9(21):1870-3
PMID: 25558231 [PubMed - as supplied by publisher]


The link between the SNCA gene and parkinsonism.
Wei Xu, Lan Tan, Jin-Tai Yu
Neurobiol Aging 2014 Dec;
PMID: 25554495 [PubMed - as supplied by publisher]


Psychiatric aspects of Parkinson's disease.
Sandeep Grover, Mansi Somaiya, Santhosh Kumar, Ajit Avasthi
J Neurosci Rural Pract 2015 Jan; 6(1):65-76
PMID: 25552854 [PubMed - as supplied by publisher]


Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders.
El?bieta Miller, Agnieszka Morel, Luciano Saso, Joanna Saluk
Curr Top Med Chem 2014 Dec;
PMID: 25547102 [PubMed - as supplied by publisher]


An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents.
Florian Kolbl, Gilles N'Kaoua, Frederic Naudet, Florent Berthier, Emilie Faggiani, Sylvie Renaud, Abdelhamid Benazzouz, Noelle Lewis
IEEE Trans Biomed Circuits Syst 2014 Dec;
PMID: 25546861 [PubMed - as supplied by publisher]