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Diffusion mr correlates of motor function recovery after stroke: a systematic review.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Dheeraj Kalladka, Keith Muir
University of Glasgow, Southern General Hospital, Glasgow.
Corticospinal tract (CST) integrity predicts the capacity for motor recovery after stroke and can be studied by diffusion-weighted MRI (DWI) sequences which measure random motion of water molecules along multiple directional gradients. By applying a diffusion tensor mathematical model at every brain voxel, several metrics can be derived that provide information on white matter tract microstructural integrity, including Fractional Anisotropy (FA), Apparent Diffusion Coefficient (ADC), Mean diffusivity (MD) and tractography. Neuroimaging parameters of CST integrity on its own, or along with functional MRI (fMRI) to investigate grey matter reorganisation, are proposed to aid patient selection for clinical trials (or in future, individualise rehabilitative or regenerative therapy selection), and serve as biomarkers of clinical change.
PMID: 24109060 [PubMed - as supplied by publisher]