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Tigarb causes mitochondrial dysfunction and neuronal loss in pink1 deficiency.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Oliver Bandmann
University of Sheffield.
Loss of function mutations in PINK1 typically lead to early onset Parkinson's Disease (EOPD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study neurodegenerative diseases. We used a pink1 mutant (pink-/-) zebrafish line with a premature stop mutation (Y431*) in the PINK1 kinase domain to identify molecular mechanisms leading to mitochondrial dysfunction and loss of dopaminergic neurons in PINK1 deficiency.
PMID: 24108934 [PubMed - as supplied by publisher]