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The yield from testing voltage-gated potassium channel antibodies in patients with cramp.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Sonam Ansel, Maria E Farrugia
University of Glasgow; Institute of Neurological Sciences, Southern General Hospital.
Muscle cramp, twitching and stiffness are common symptoms reported by patients attending the neuromuscular clinic. In a proportion of patients, these symptoms may be due to an acquired peripheral nerve hyperexcitabilty syndrome, including benign cramp fasciculation syndrome (BCFS) and disabling neuromyotonia (NMT) or Isaac's syndrome. Antibodies to voltage-gated potassium channels (VGKC) can be detected in approximately 40% of patients with NMT. Recent literature highlights that antibodies which bind to VGKC-associated proteins may also be involved. We reviewed a cohort of patients attending the muscle clinic, who had their sera tested for VGKC-antibodies based on their symptoms and examination findings.
PMID: 24108915 [PubMed - as supplied by publisher]