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Levodopa-induced motor complications in an incident Parkinson's disease cohort.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Nicholas W Scott, Angus D Macleod, Carl E Counsell
University of Aberdeen.
Levodopa is the mainstay of treatment for Parkinson's disease (PD) but is associated with potentially-disabling drug-induced motor fluctuations and dyskinesias. Previous studies have suggested that both of these complications develop in about 40% patients treated with levodopa for 4-6 years 1. However, most of these studies were not in truly-representative PD cohorts and there is little evidence as to which factors influence the onset of these complications.
PMID: 24108912 [PubMed - as supplied by publisher]