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Treatments/Pipeline

PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research. 

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Globus Pallidus Internus Deep Brain Stimulation as Rescue Therapy for Refractory Dyskinesias following Effective Subthalamic Nucleus Stimulation.
Raymond J Cook, Lyndsey Jones, George Fracchia, Nathan Anderson, Jenny Miu, Linton J Meagher, Peter A Silburn, Paul Silberstein
Stereotact Funct Neurosurg 2015 ; 93(1):25-9
PMID: 25613902 [PubMed - as supplied by publisher]


Neuropsychological Effects of Deep Brain Stimulation in Subjects with Early Stage Parkinson's Disease in a Randomized Clinical Trial.
Michael G Tramontana, Anna L Molinari, Peter E Konrad, Thomas L Davis, Scott A Wylie, Joseph S Neimat, Alexandra T May, Fenna T Phibbs, Peter Hedera, Chandler E Gill, Ronald M Salomon, Lily Wang, Yanna Song, David Charles
J Parkinsons Dis 2015 Jan;
PMID: 25613351 [PubMed - as supplied by publisher]


Dopamine agonists early monotherapy for the delay of development of levodopa-induced dyskinesias.
Pantelis Stathis, Spiridon Konitsiotis, Angelo Antonini
Expert Rev Neurother 2015 Feb; 15(2):207-213
PMID: 25578445 [PubMed - as supplied by publisher]


Association of time-to-levodopa with initial Parkinsonian medication: a retrospective cohort study.
Jens Peter Reese, Hajo Hamer, Wolfgang H Oertel, Adam Strzelczyk, Ulrich O Mueller, Christina Heilmaier, Karel Kostev
Int J Clin Pharmacol Ther 2015 Feb; 53(2):107-14
PMID: 25546160 [PubMed - as supplied by publisher]


Pharmacoeconomic aspects of using levodopa/carbidopa intestinal gel in Parkinson's disease].
A V Rudakova, E Z Yakupov
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(10):117-21
PMID: 25614914 [PubMed - as supplied by publisher]


Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats.
David Dardou, Carine Chassain, Franck Durif
Front Neurosci 2014 ; 8:437
PMID: 25610366 [PubMed - as supplied by publisher]


Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced parkinsonian rats.
Sonja Seeger-Armbruster, Clémentine Bosch-Bouju, Shane T C Little, Roseanna A Smither, Stephanie M Hughes, Brian I Hyland, Louise C Parr-Brownlie
J Neurosci 2015 Jan; 35(3):1211-6
PMID: 25609635 [PubMed - as supplied by publisher]


Effect of speech therapy and pharmacological treatment in prosody of parkinsonians.
Luciana Lemos de Azevedo, Irene Soares de Souza, Patrícia Marques de Oliveira, Francisco Cardoso
Arq Neuropsiquiatr 2015 Jan; 73(1):30-5
PMID: 25608124 [PubMed - as supplied by publisher]


Management of impulse control disorders in Parkinson's disease: Controversies and future approaches.
Michael Samuel, Maria Rodriguez-Oroz, Angelo Antonini, Jonathan M Brotchie, Kallol Ray Chaudhuri, Richard G Brown, Wendy R Galpern, Melissa J Nirenberg, Michael S Okun, Anthony E Lang
Mov Disord 2015 Jan;
PMID: 25607799 [PubMed - as supplied by publisher]


A 12-year population-based study of freezing of gait in Parkinson's disease.
E B Forsaa, J P Larsen, T Wentzel-Larsen, G Alves
Parkinsonism Relat Disord 2014 Dec;
PMID: 25603767 [PubMed - as supplied by publisher]


Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.
Anna Kubesova, Hana Tejkalova, Kamila Syslova, Petr Kacer, Jana Vondrousova, Filip Tyls, Michaela Fujakova, Tomas Palenicek, Jiri Horacek
PLoS One 2015 ; 10(1):e0115439
PMID: 25602957 [PubMed - as supplied by publisher]


The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson's disease.
Christina Tremblay, Joël Macoir, Mélanie Langlois, Léo Cantin, Michel Prud'homme, Laura Monetta
Brain Lang 2015 Feb; 141:103-9
PMID: 25577507 [PubMed - as supplied by publisher]


Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Rafael J Rojas, Dale E Edmondson, Terri Almos, Roderick Scott, Mark E Massari
Bioorg Med Chem 2015 Jan;
PMID: 25600407 [PubMed - as supplied by publisher]


Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques.
C L Bethea, A P Reddy
Mol Psychiatry 2015 Jan;
PMID: 25600110 [PubMed - as supplied by publisher]


Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.
Anke Van der Perren, Jaan Toelen, Cindy Casteels, Francesca Macchi, Anne-Sophie Van Rompuy, Sophie Sarre, Nicolas Casadei, Silke Nuber, Uwe Himmelreich, Maria Isabel Osorio Garcia, Yvette Michotte, Rudi D'Hooge, Guy Bormans, Koen Van Laere, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle Baekelandt
Neurobiol Aging 2014 Dec;
PMID: 25599874 [PubMed - as supplied by publisher]


Axial disability and deep brain stimulation in patients with Parkinson disease.
Alfonso Fasano, Camila C Aquino, Joachim K Krauss, Christopher R Honey, Bastiaan R Bloem
Nat Rev Neurol 2015 Jan;
PMID: 25582445 [PubMed - as supplied by publisher]


Spatial Topographies of Unilateral Subthalamic Nucleus Deep Brain Stimulation Efficacy for Ipsilateral, Contralateral, Midline, and Total Parkinson Disease Motor Symptoms.
Mahesh B Shenai, Andrew Romeo, Harrison C Walker, Stephanie Guthrie, Ray L Watts, Barton L Guthrie
Neurosurgery 2015 Jan;
PMID: 25599197 [PubMed - as supplied by publisher]


Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases.
Yu Tang, Weidong Le
Mol Neurobiol 2015 Jan;
PMID: 25598354 [PubMed - as supplied by publisher]


Modeling falls in Parkinson's disease: Slow gait, freezing episodes and falls in rats with extensive striatal dopamine loss.
Aaron Kucinski, Roger L Albin, Cindy Lustig, Martin Sarter
Behav Brain Res 2015 Jan;
PMID: 25595423 [PubMed - as supplied by publisher]


Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson's disease model.
Julius A Steinbeck, Se Joon Choi, Ana Mrejeru, Yosif Ganat, Karl Deisseroth, David Sulzer, Eugene V Mosharov, Lorenz Studer
Nat Biotechnol 2015 Jan;
PMID: 25580598 [PubMed - as supplied by publisher]


The ethics of deep brain stimulation (DBS).
Marcus Unterrainer, Fuat S Oduncu
Med Health Care Philos 2015 Jan;
PMID: 25597042 [PubMed - as supplied by publisher]


CSF tau and tau/A?42 predict cognitive decline in Parkinson's disease.
Changqin Liu, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, , Jing Zhang
Parkinsonism Relat Disord 2015 Jan;
PMID: 25596881 [PubMed - as supplied by publisher]


Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson's disease.
Salvatore Galati, Agnese Salvadè, Marta Pace, Simone Sarasso, Francesca Baracchi, Claudio L Bassetti, Alain Kaelin-Lang, Claudio Städler, Paolo Stanzione, Jens C Möller
Neurobiol Aging 2014 Dec;
PMID: 25596726 [PubMed - as supplied by publisher]


Glutamate and GABA concentration changes in the globus pallidus internus of Parkinson's patients during performance of implicit and declarative memory tasks: A report of two subjects.
Robert J Buchanan, Klevest Gjini, David Darrow, Georgeta Varga, Jennifer L Robinson, Zoltan Nadasdy
Neurosci Lett 2015 Jan;
PMID: 25596441 [PubMed - as supplied by publisher]


Reduction of gastrointestinal symptoms in Parkinson's disease after a switch from oral therapy to rotigotine transdermal patch: A non-interventional prospective multicenter trial.
Dirk Woitalla, Jan Kassubek, Lars Timmermann, Thomas Lauterbach, Reinhard Berkels, Frank Grieger, Thomas Müller
Parkinsonism Relat Disord 2014 Dec;
PMID: 25595315 [PubMed - as supplied by publisher]


Applying guidelines to individual patients: deep brain stimulation for early-stage Parkinson disease.
Bryn Esplin, Andre G Machado, Paul J Ford, Kara Beasley, Bryn Esplin, Andre G Machado, Paul J Ford, Kara Beasley
Virtual Mentor 2015 ; 17(1):13-22
PMID: 25594711 [PubMed - as supplied by publisher]


COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese.
Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu
Mov Disord 2015 Jan;
PMID: 25594503 [PubMed - as supplied by publisher]


Accuracy of direct magnetic resonance imaging-guided placement of drug infusion cannulae.
Prashant Chittiboina, John D Heiss, Russell R Lonser
J Neurosurg 2015 Jan; :1-7
PMID: 25594325 [PubMed - as supplied by publisher]


Gender Specific Brain Regional Variation of Neurons, Endogenous Estrogen, Neuroinflammation and Glial Cells During Rotenone Induced Mouse Model of Parkinson's Disease.
Soham Mitra, Nilkanta Chakrabarti, Spandita Seouli Dutta, Sucharit Ray, Promita Bhattacharya, Priyobrata Sinha, Arindam Bhattacharyya
Neuroscience 2015 Jan;
PMID: 25592425 [PubMed - as supplied by publisher]


Controlled striatal DOPA production from a gene delivery system in a rodent model of Parkinson's disease.
Erik Cederfjäll, Lauren Broom, Deniz Kirik
Mol Ther 2015 Jan;
PMID: 25592335 [PubMed - as supplied by publisher]


Enhanced differentiation of neural progenitor cells into neurons of the mesencephalic dopaminergic subtype on topographical patterns.
Kenneth K B Tan, Jason Y Tann, Sharvari R Sathe, Seok Hong Goh, Dongliang Ma, Eyleen L K Goh, Evelyn K F Yim
Biomaterials 2015 Mar; 43:32-43
PMID: 25591959 [PubMed - as supplied by publisher]


Bilateral coherence between motor cortices and subthalamic nuclei in patients with Parkinson's disease.
Kenji Kato, Fusako Yokochi, Makoto Taniguchi, Ryoichi Okiyama, Takashi Kawasaki, Katsuo Kimura, Junichi Ushiba
Clin Neurophysiol 2014 Dec;
PMID: 25591829 [PubMed - as supplied by publisher]


The use of stalevo in the treatment of patients with Parkinson's disease].
A S Kretova, A V Lyubimov
Zh Nevrol Psikhiatr Im S S Korsakova 2014 ; 114(10):35-8
PMID: 25591514 [PubMed - as supplied by publisher]


Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.
Joanna Ruszkiewicz, Jan Albrecht
Neurochem Int 2015 Jan;
PMID: 25576182 [PubMed - as supplied by publisher]


Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinson's disease.
Filip R??i?ka, Robert Jech, Lucie Nováková, Du?an Urgo?ík, Ond?ej Bezdí?ek, Josef Vymazal, Ev?en R??i?ka
Psychoneuroendocrinology 2015 Feb; 52:302-10
PMID: 25554999 [PubMed - as supplied by publisher]


Discharge responses of the optic tract to flash stimuli in Parkinson's disease.
Takao Hashimoto, Satoshi Katai, Tetsuya Goto
Ann Clin Transl Neurol 2014 Apr; 1(4):298-301
PMID: 25590042 [PubMed - as supplied by publisher]


Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.
Carole Carcenac, Mathieu Favier, Yvan Vachez, Emilie Lacombe, Sébastien Carnicella, Marc Savasta, Sabrina Boulet
Mov Disord 2015 Jan;
PMID: 25588931 [PubMed - as supplied by publisher]


Long-Term Safety and Maintenance of Efficacy of Levodopa-Carbidopa Intestinal Gel: An Open-Label Extension of the Double-Blind Pivotal Study in Advanced Parkinson's Disease Patients.
John T Slevin, Hubert H Fernandez, Cindy Zadikoff, Coleen Hall, Susan Eaton, Jordan Dubow, Krai Chatamra, Janet Benesh
J Parkinsons Dis 2014 Dec;
PMID: 25588353 [PubMed - as supplied by publisher]


Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Rômulo Pereira Ribeiro, João Cleverson Gasparetto, Raquel de Oliveira Vilhena, Thais Martins Guimarães de Francisco, Cleverson Antônio Ferreira Martins, Marco André Cardoso, Roberto Pontarolo
Bioanalysis 2015 Jan; 7(2):207-20
PMID: 25587837 [PubMed - as supplied by publisher]


An open-label extension study to evaluate safety of ropinirole prolonged-release in Chinese patients with advanced Parkinson's disease.
Zhenxin Zhang, Jian Wang, Xiaoying Zhang, Shengdi Chen, Zhenfu Wang, Baorong Zhang, Chunfeng Liu, Qiumin Qu, Yan Cheng, Rongxuan Zhu, Jie Li, Jingqiu Hu, Meng Cai
Curr Med Res Opin 2015 Jan; :1-24
PMID: 25586298 [PubMed - as supplied by publisher]


Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood-brain barrier opening in vivo.
Gesthimani Samiotaki, Camilo Acosta, Shutao Wang, Elisa E Konofagou
J Cereb Blood Flow Metab 2015 Jan;
PMID: 25586140 [PubMed - as supplied by publisher]


Global long-term study on motor and non-motor symptoms and safety of levodopa-carbidopa intestinal gel in routine care of advanced Parkinson's disease patients; 12-month interim outcomes.
Angelo Antonini, Ashley Yegin, Cornelia Preda, Lars Bergmann, Werner Poewe,
Parkinsonism Relat Disord 2014 Dec;
PMID: 25585993 [PubMed - as supplied by publisher]


Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Anne Vital, Sebastien Lepreux, Claude Vital
J Peripher Nerv Syst 2015 Jan;
PMID: 25582874 [PubMed - as supplied by publisher]


The synthesis and evaluation of C7-substituted ?-tetralone derivatives as inhibitors of monoamine oxidase.
Lesetja J Legoabe, Anél Petzer, Jacobus P Petzer
Chem Biol Drug Des 2015 Jan;
PMID: 25581511 [PubMed - as supplied by publisher]


Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity.
Laura Ravani, Maria Grazia Sarpietro, Elisabetta Esposito, Antonio Di Stefano, Piera Sozio, Mariangela Calcagno, Markus Drechsler, Catia Contado, Francesco Longo, Maria Chiara Giuffrida, Francesco Castelli, Michele Morari, Rita Cortesi
Mater Sci Eng C Mater Biol Appl 2015 Mar; 48:294-300
PMID: 25579926 [PubMed - as supplied by publisher]


24 h Levodopa-carbidopa intestinal gel may reduce falls and "unresponsive" freezing of gait in Parkinson's disease.
Florence C F Chang, David S Tsui, Neil Mahant, Nigel Wolfe, Samuel D Kim, Ainhi D Ha, Melissa Drury, Jane M Griffith, Victor S C Fung
Parkinsonism Relat Disord 2014 Dec;
PMID: 25578290 [PubMed - as supplied by publisher]


Impact of mild cognitive impairment on outcome following deep brain stimulation surgery for Parkinson's disease.
Hesham Abboud, Darlene Floden, Nicolas R Thompson, Gencer Genc, Srivadee Oravivattanakul, Faisal Alsallom, Bengwei Swa, Cynthia Kubu, Mayur Pandya, Michal Gostkowski, Scott Cooper, Andre G Machado, Hubert H Fernandez
Parkinsonism Relat Disord 2014 Dec;
PMID: 25578289 [PubMed - as supplied by publisher]


Effects of Stochastic Vestibular Galvanic Stimulation and LDOPA on Balance and Motor Symptoms in Patients With Parkinson's Disease.
Ghazaleh Samoudi, Maria Jivegård, Ajitkumar P Mulavara, Filip Bergquist
Brain Stimul 2014 Dec;
PMID: 25573070 [PubMed - as supplied by publisher]


A computational model for bipolar deep brain stimulation of the subthalamic nucleus.
Maria I Iacono, Esra Neufeld, Giorgio Bonmassar, Esther Akinnagbe, Andras Jakab, Ethan Cohen, Niels Kuster, Wolfgang Kainz, Leonardo M Angelone
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:6258-61
PMID: 25571427 [PubMed - as supplied by publisher]


Single trial behavioral task classification using subthalamic nucleus local field potential signals.
Soroush Niketeghad, Adam O Hebb, Joshua Nedrud, Sara J Hanrahan, Mohammad H Mahoor
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3793-6
PMID: 25570817 [PubMed - as supplied by publisher]


Dynamic tension EMG to characterize the effects of DBS treatment of advanced Parkinson's disease.
V Ruonala, E Pekkonen, S Rissanen, O Airaksinen, G Miroshnichenko, M Kankaanpaa, P Karjalainen
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3248-51
PMID: 25570683 [PubMed - as supplied by publisher]


Parkinson's disease assessment based on gait analysis using an innovative RGB-D camera system.
Ana Patricia Rocha, Hugo Choupina, Jose Maria Fernandes, Maria Jose Rosas, Rui Vaz, Joao Paulo Silva Cunha
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:3126-9
PMID: 25570653 [PubMed - as supplied by publisher]


Localization of subthalamic nucleus borders using macroelectrode local field potential recordings.
I Telkes, N F Ince, I Onaran, A Abosch
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:2621-4
PMID: 25570528 [PubMed - as supplied by publisher]


On modeling the neuronal activity in movement disorder patients by using the Ornstein Uhlenbeck Process.
Pitamber Shukla, Ishita Basu, Daniela Tuninetti, Daniel Graupe, Konstantin V Slavin
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:2609-12
PMID: 25570525 [PubMed - as supplied by publisher]


The study on a real-time remote monitoring system for Parkinson's disease patients with deep brain stimulators.
Yue Chen, Hongwei Hao, Hao Chen, Ye Tian, Luming Li
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:1358-61
PMID: 25570219 [PubMed - as supplied by publisher]


Sparse representation of MER signals for localizing the Subthalamic Nucleus in Parkinson's disease surgery.
Hernan Dario Vargas Cardona, Mauricio A Alvarez, Alvaro A Orozco
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:950-3
PMID: 25570117 [PubMed - as supplied by publisher]


Target coverage and selectivity in field steering brain stimulation.
Ruben Cubo, Mattias Astrom, Alexander Medvedev
Conf Proc IEEE Eng Med Biol Soc 2014 Aug; 2014:522-5
PMID: 25570011 [PubMed - as supplied by publisher]


Gene Expression Analyses Identify Narp Contribution in the Development of l-DOPA-Induced Dyskinesia.
Fanny Charbonnier-Beaupel, Marion Malerbi, Cristina Alcacer, Khadija Tahiri, Wassila Carpentier, Chuansong Wang, Matthew During, Desheng Xu, Paul F Worley, Jean-Antoine Girault, Denis Hervé, Jean-Christophe Corvol
J Neurosci 2015 Jan; 35(1):96-111
PMID: 25568106 [PubMed - as supplied by publisher]


A neuroleptic malignant-like syndrome (NMLS) in a patient with Parkinson's disease resolved with rotigotine: a case report.
Stefania Fiore, Lidia Persichino, Sabrina Anticoli, Maria Francesca De Pandis
Acta Biomed 2014 ; 85(3):281-4
PMID: 25567468 [PubMed - as supplied by publisher]


Control of abnormal synchronization in neurological disorders.
Oleksandr V Popovych, Peter A Tass
Front Neurol 2014 ; 5:268
PMID: 25566174 [PubMed - as supplied by publisher]


Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models.
Maowen Ba, Min Kong, Guozhao Ma
Drug Des Devel Ther 2015 ; 9:199-206
PMID: 25565773 [PubMed - as supplied by publisher]


Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease: a pharmacoinformatics study.
Muhammad Usman Mirza, A Hammad Mirza, Noor-Ul-Huda Ghori, Saba Ferdous
Drug Des Devel Ther 2015 ; 9:187-98
PMID: 25565772 [PubMed - as supplied by publisher]


Deep Brain Stimulation - an effective therapy not only for Parkinson's disease].
Wiebke Kathmann
Dtsch Med Wochenschr 2014 Nov; 139(48):2434-5
PMID: 25568902 [PubMed - as supplied by publisher]


Genetic control of midbrain dopaminergic neuron development.
Sandra Blaess, Siew-Lan Ang
Wiley Interdiscip Rev Dev Biol 2015 Jan;
PMID: 25565353 [PubMed - as supplied by publisher]


Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases.
Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Patrick Boissin, Edilio Borroni, Bernd Büttelmann, Simona Ceccarelli, Nicole Clemann, Beatrice David, Christoph Funk, Wolfgang Guba, Anthony Harrison, Thomas Hartung, Michael Honer, Jörg Huwyler, Martin Kuratli, Urs Niederhauser, Axel Pähler, Jens-Uwe Peters, Ann Petersen, Eric Prinssen, Antonio Ricci, Daniel Rueher, Marianne Rueher, Manfred Schneider, Paul Spurr, Theodor Stoll, Daniel Tännler, Jürgen Wichmann, Richard H Porter, Joseph G Wettstein, Lothar Lindemann
J Med Chem 2015 Jan;
PMID: 25565255 [PubMed - as supplied by publisher]


Fluorescence quenched substrates for live cell imaging of human glucocerebrosidase activity.
Anuj K Yadav, David Shen, Xiaoyang Shan, Xu He, Allison R Kermode, David J Vocadlo
J Am Chem Soc 2015 Jan;
PMID: 25562638 [PubMed - as supplied by publisher]


Deep Brain Stimulation for Parkinson Disease: The 2014 Lasker-DeBakey Clinical Medical Research Award.
Maxime W C Rousseaux, Huda Y Zoghbi
JAMA Neurol 2015 Jan;
PMID: 25560048 [PubMed - as supplied by publisher]


Catechol-O-Methyltransferase Inhibitors in Parkinson's Disease.
Thomas Müller
Drugs 2015 Jan;
PMID: 25559423 [PubMed - as supplied by publisher]


A Review of the Potential Role of Nano-Enabled Drug Delivery Technologies in Amyotrophic Lateral Sclerosis: Lessons Learned from Other Neurodegenerative Disorders.
Zamanzima Mazibuko, Yahya E Choonara, Pradeep Kumar, Lisa C Du Toit, Girish Modi, Dinesh Naidoo, Viness Pillay
J Pharm Sci 2015 Jan;
PMID: 25559087 [PubMed - as supplied by publisher]


Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease.
Daniel Weiss, Rosa Klotz, Rathinaswamy B Govindan, Marlieke Scholten, Georgios Naros, Ander Ramos-Murguialday, Friedemann Bunjes, Christoph Meisner, Christian Plewnia, Rejko Krüger, Alireza Gharabaghi
Brain 2015 Jan;
PMID: 25558877 [PubMed - as supplied by publisher]


New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases.
Christian Hölscher
Neural Regen Res 2014 Nov; 9(21):1870-3
PMID: 25558231 [PubMed - as supplied by publisher]


The link between the SNCA gene and parkinsonism.
Wei Xu, Lan Tan, Jin-Tai Yu
Neurobiol Aging 2014 Dec;
PMID: 25554495 [PubMed - as supplied by publisher]


Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Ilse S Pienaar, Cecilia Heyne Lee, Joanna L Elson, Louisa McGuinness, Stephen M Gentleman, Raj N Kalaria, David T Dexter
Neurobiol Dis 2014 Dec; 74C:392-405
PMID: 25533682 [PubMed - as supplied by publisher]


Psychiatric aspects of Parkinson's disease.
Sandeep Grover, Mansi Somaiya, Santhosh Kumar, Ajit Avasthi
J Neurosci Rural Pract 2015 Jan; 6(1):65-76
PMID: 25552854 [PubMed - as supplied by publisher]


Deep brain stimulation in early stage Parkinson's disease.
David Charles, Peter E Konrad, Thomas L Davis, Joseph S Neimat, Mallory L Hacker, Stuart G Finder
Parkinsonism Relat Disord 2014 Dec;
PMID: 25547949 [PubMed - as supplied by publisher]


Melatonin Redox Activity. Its Potential Clinical Application in Neurodegenerative Disorders.
El?bieta Miller, Agnieszka Morel, Luciano Saso, Joanna Saluk
Curr Top Med Chem 2014 Dec;
PMID: 25547102 [PubMed - as supplied by publisher]


An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents.
Florian Kolbl, Gilles N'Kaoua, Frederic Naudet, Florent Berthier, Emilie Faggiani, Sylvie Renaud, Abdelhamid Benazzouz, Noelle Lewis
IEEE Trans Biomed Circuits Syst 2014 Dec;
PMID: 25546861 [PubMed - as supplied by publisher]


Stem cell reprogramming: Basic implications and future perspective for movement disorders.
Björn Brändl, Susanne A Schneider, Jeanne F Loring, John Hardy, Philip Gribbon, Franz-Josef Müller
Mov Disord 2014 Dec;
PMID: 25546831 [PubMed - as supplied by publisher]


Progression of gait dysfunction in incident Parkinson's disease: Impact of medication and phenotype.
Brook Galna, Sue Lord, David J Burn, Lynn Rochester
Mov Disord 2014 Dec;
PMID: 25546558 [PubMed - as supplied by publisher]


Predictors of response to a cognitive behavioral intervention for impulse control behaviors in Parkinson's disease.
David Okai, Sally Askey-Jones, Michael Samuel, Anthony S David, Richard G Brown
Mov Disord 2014 Dec;
PMID: 25546340 [PubMed - as supplied by publisher]


Effects of rasagiline on the progression of nonmotor scores of the MDS-UPDRS.
Werner Poewe, Robert A Hauser, Anthony Lang
Mov Disord 2014 Dec;
PMID: 25545629 [PubMed - as supplied by publisher]


Levodopa-carbidopa intestinal gel in advanced Parkinson's disease: Final 12-month, open-label results.
Hubert H Fernandez, David G Standaert, Robert A Hauser, Anthony E Lang, Victor S C Fung, Fabian Klostermann, Mark F Lew, Per Odin, Malcolm Steiger, Eduard Z Yakupov, Sylvain Chouinard, Oksana Suchowersky, Jordan Dubow, Coleen M Hall, Krai Chatamra, Weining Z Robieson, Janet A Benesh, Alberto J Espay
Mov Disord 2014 Dec;
PMID: 25545465 [PubMed - as supplied by publisher]


Selective changes of ocular vestibular myogenic potentials in Parkinson's disease.
Monika Pötter-Nerger, Sendhil Govender, Günther Deuschl, Jens Volkmann, J G Colebatch
Mov Disord 2014 Dec;
PMID: 25545048 [PubMed - as supplied by publisher]


Caffeine As A Lead Compound For The Design Of Therapeutic Agents For The Treatment Of Parkinson's Disease.
Jacobus P Petzer, Anél Petzer
Curr Med Chem 2014 Dec;
PMID: 25544641 [PubMed - as supplied by publisher]


Parkinson's disease severity and use of dopaminergic medications.
John Y Fang, Adriana Pérez, Chadwick W Christine, Maureen Leehey, Michael J Aminoff, James T Boyd, John C Morgan, Rohit Dhall, Anthony P Nicholas, Ivan Bodis-Wollner, Richard M Zweig, John L Goudreau,
Parkinsonism Relat Disord 2014 Dec;
PMID: 25541182 [PubMed - as supplied by publisher]


Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD.
Tao Xie, Julie Vigil, Ellen MacCracken, Arunas Gasparaitis, Joan Young, Wenjun Kang, Jacqueline Bernard, Peter Warnke, Un J Kang
Neurology 2014 Dec;
PMID: 25540305 [PubMed - as supplied by publisher]


Management of constipation in Parkinson's disease.
Malco Rossi, Marcelo Merello, Santiago Perez-Lloret
Expert Opin Pharmacother 2014 Dec; :1-11
PMID: 25539892 [PubMed - as supplied by publisher]


Pedunculopontine Nucleus Stimulation: Where are We Now and What Needs to be Done to Move the Field Forward?
Hokuto Morita, Chris J Hass, Elena Moro, Atchar Sudhyadhom, Rajeev Kumar, Michael S Okun
Front Neurol 2014 ; 5:243
PMID: 25538673 [PubMed - as supplied by publisher]


Prevalence and clinical correlates of drooling in Parkinson disease: A study on 518 Chinese patients.
Ruwei Ou, Xiaoyan Guo, Qianqian Wei, Bei Cao, Jing Yang, Wei Song, Na Shao, Bi Zhao, Xueping Chen, Huifang Shang
Parkinsonism Relat Disord 2014 Dec;
PMID: 25537930 [PubMed - as supplied by publisher]


Liver Growth Factor as a tissue regenerating factor in neurodegenerative diseases.
Rafael Gonzalo-Gobernado, Lucia Calatrava-Ferreras, Juan Perucho, Diana Reimers, María José Casarejos, Antonio S Herranz, Adriano Jiménez-Escrig, Juan José Díaz-Gil, Eulalia Bazán
Recent Pat CNS Drug Discov 2014 Dec;
PMID: 25537484 [PubMed - as supplied by publisher]


The therapeutic plasma concentrations of antiparkinson dopamine agonists and their in vitro pharmacology at dopamine receptors].
Yoshihiro Tadori, Hiroyuki Kobayashi
Nihon Shinkei Seishin Yakurigaku Zasshi 2014 Nov; 34(5-6):127-32
PMID: 25536763 [PubMed - as supplied by publisher]


Human Olfactory Bulb Neural Stem Cells Mitigate Movement Disorders in a Rat Model of Parkinson's disease.
Hany E S Marei, Samah Lashen, Amany Farag, Asma Althani, Nahla Afifi, A Abd-Elmaksoud, Shaymaa Rezk, Roberto Pallini, Patrizia Casalbore, Carlo Cenciarelli
J Cell Physiol 2014 Dec;
PMID: 25536543 [PubMed - as supplied by publisher]


Enhanced efficacy of human brain-derived neural stem cells by transplantation of cell aggregates in a rat model of Parkinson's disease.
Eun Sil Shin, Onyou Hwang, Yu-Shik Hwang, Jun-Kyo Francis Suh, Young Il Chun, Sang Ryong Jeon
J Korean Neurosurg Soc 2014 Nov; 56(5):383-9
PMID: 25535514 [PubMed - as supplied by publisher]


Vitamin C Facilitates Dopamine Neuron Differentiation in Fetal Midbrain Through Tet1- aND Jmjd3-Dependent Epigenetic Control Manner.
Xi-Biao He, Mirang Kim, Seon-Young Kim, Sang-Hoon Yi, Yong-Hee Rhee, Taeho Kim, Eun-Hye Lee, Chang-Hwan Park, Shilpy Dixit, Fiona E Harrison, Sang-Hun Lee
Stem Cells 2014 Dec;
PMID: 25535150 [PubMed - as supplied by publisher]


Potential transbuccal delivery of l-DOPA methylester prodrug: stability in the environment of the oral cavity and ability to cross the mucosal tissue.
Anna Lisa Scaturro, Viviana De Caro, Giuseppina Campisi, Libero Italo Giannola
Drug Deliv 2014 Dec; :1-8
PMID: 25533875 [PubMed - as supplied by publisher]


Progressive brain metabolic changes under deep brain stimulation of subthalamic nucleus in parkinsonian rats.
Christophe Melon, Carine Chassain, Guy Bielicki, Jean-Pierre Renou, Lydia Kerkerian-Le Goff, Pascal Salin, Franck Durif
J Neurochem 2014 Dec;
PMID: 25533782 [PubMed - as supplied by publisher]


TMS Enhances Retention of a Motor Skill in Parkinson's Disease.
Clara Moisello, Daniella Blanco, Cecilia Fontanesi, Jing Lin, Milton Biagioni, Pawan Kumar, Miroslaw Brys, Andrea Loggini, Lucio Marinelli, Giovanni Abbruzzese, Angelo Quartarone, Giulio Tononi, Alessandro Di Rocco, Maria Felice Ghilardi,
Brain Stimul 2014 Nov;
PMID: 25533243 [PubMed - as supplied by publisher]


Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings.
Martina Svensson, Jan Lexell, Tomas Deierborg
Neurorehabil Neural Repair 2014 Dec;
PMID: 25527485 [PubMed - as supplied by publisher]


Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline.
Aysegul Gunduz, Hokuto Morita, P Justin Rossi, William L Allen, Ron L Alterman, Helen Bronte-Stewart, Christopher R Butson, David Charles, Sjaak Deckers, Coralie de Hemptinne, Mahlon DeLong, Darin Dougherty, Jens Ellrich, Kelly D Foote, James Giordano, Wayne Goodman, Benjamin D Greenberg, David Greene, Robert Gross, Jack W Judy, Edward Karst, Alexander Kent, Brian Kopell, Anthony Lang, Andres Lozano, Codrin Lungu, Kelly E Lyons, Andre Machado, Hubert Martens, Cameron McIntyre, Hoon-Ki Min, Joseph Neimat, Jill Ostrem, Sat Pannu, Francisco Ponce, Nader Pouratian, Donnie Reymers, Lauren Schrock, Sameer Sheth, Ludy Shih, Scott Stanslaski, G Karl Steinke, Paul Stypulkowski, Alexander I Tröster, Leo Verhagen, Harrison Walker, Michael S Okun
Int J Neurosci 2014 Dec; :1-31
PMID: 25526555 [PubMed - as supplied by publisher]


Small molecule-mediated stabilization of vesicle-associated helical ?-synuclein inhibits pathogenic misfolding and aggregation.
Luis Fonseca-Ornelas, Sybille E Eisbach, Maria Paulat, Karin Giller, Claudio O Fernández, Tiago F Outeiro, Stefan Becker, Markus Zweckstetter
Nat Commun 2014 ; 5:5857
PMID: 25524885 [PubMed - as supplied by publisher]