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Modulation of corticomotor excitability after maximal or sustainable-rate repetitive finger movement is impaired in Parkinson's disease and is reversed by levodopa.
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Clin Neurophysiol 2013 Oct;
Authors: Wei-Peng Teo, Julian P Rodrigues, Frank L Mastaglia, Gary W Thickbroom
Australian Neuro-Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Western Australia, Australia.
In healthy subjects, fatiguing exercises induce a period of post-exercise corticomotor depression (PECD) that is absent in Parkinson's disease (PD). Our objective is to determine the time-course of corticomotor excitability changes following a 10-s repetitive index finger flexion-extension task performed at maximal voluntary rate (MVR) and a slower sustainable rate (MSR) in PD patients OFF and ON levodopa.
PMID: 24095151 [PubMed - as supplied by publisher]