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Measuring dopaminergic function in the 6-OHDA-lesioned rat: a comparison of PET and microdialysis.
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EJNMMI Res 2013 Oct; 3(1):69
Authors: Matthew D Walker, Katherine Dinelle, Rick Kornelsen, Anna Lee, Matthew J Farrer, A Jon Stoessl, Vesna Sossi
[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microdialysis to aid in the interpretation of data from both techniques.
PMID: 24088510 [PubMed - as supplied by publisher]