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Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats.
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Mol Neurodegener 2014 Jul; 9(1):26
Authors: Vez Repunte-Canonigo, Celine Lefebvre, Olivier George, Tomoya Kawamura, Marisela Morales, George Koob, Andrea Califano, Eliezer Masliah, Pietro Paolo Sanna
A thorough investigation of the neurobiology of HIV-induced neuronal dysfunction and its evolving phenotype in the setting of viral suppression has been limited by the lack of validated small animal models to probe the effects of concomitant low level expression of multiple HIV-1 products in disease-relevant cells in the CNS.
PMID: 24980976 [PubMed - as supplied by publisher]