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The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease.
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Pharmacol Rep 2014 Aug; 66(4):660-9
Authors: Ilona Joniec-Maciejak, Agnieszka Ciesielska, Adriana Wawer, Anna Sznejder-Pacho?ek, Joanna Schwenkgrub, Agnieszka Cudna, Piotr Hadaczek, Kristof S Bankiewicz, Anna Cz?onkowska, Andrzej Cz?onkowski
The aim of this study was to examine the effect of AAV2-hIL-10 (vector containing cDNA for human interleukin 10) on dopaminergic system activity (measured as DA levels and TH mRNA expression in mouse striata), and other monoamine and amino acid neurotransmitters concentration as well as development of inflammatory processes (measured as TGF-?, IFN-? and GFAP mRNA expression) in a murine MPTP neurotoxicant model of Parkinson's disease.
PMID: 24948069 [PubMed - as supplied by publisher]