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Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
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BMC Genomics 2014 ; 15(1):118
Authors: Erin M Hill-Burns, William T Wissemann, Taye H Hamza, Stewart A Factor, Cyrus P Zabetian, Haydeh Payami
Parkinson's disease (PD) is complex and heterogeneous. The numerous susceptibility loci that have been identified reaffirm the complexity of PD but do not fully explain it; e.g., it is not known if any given PD susceptibility gene is associated with all PD or a disease subtype. We also suspect that important disease genes may have escaped detection because of this heterogeneity. We used presence/absence of family history to subdivide the cases and performed genome-wide association studies (GWAS) in Sporadic-PD and Familial-PD separately. The aim was to uncover new genes and gain insight into the genetic architecture of PD.
PMID: 24511991 [PubMed - as supplied by publisher]