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Memantine improves goal attainment and reduces caregiver burden in Parkinson's disease with dementia.
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Int J Geriatr Psychiatry 2014 Feb;
Authors: Iracema Leroi, Richard Atkinson, Ross Overshott
Memantine, an uncompetitive antagonist of N-methyl-d-aspartate receptors, may have a role in managing symptoms associated with dementia in Parkinson's disease (PDD), although its role in improving patient-reported outcomes (PROs) has not been extensively investigated. PROs may be more sensitive than standard psychometric measures for detecting change in complex conditions such as PDD. The aim of this study was to examine the effect of memantine on PROs: individually determined goals and health-related quality of life. We also examined memantine's effect on caregiver burden.
PMID: 24510471 [PubMed - as supplied by publisher]