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CSF ?-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.
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Parkinsonism Relat Disord 2014 Jan;
Authors: Stefania Mondello, Radu Constantinescu, Henrik Zetterberg, Ulf Andreasson, BjŲrn Holmberg, Andreas Jeromin
There is an unmet need for biomarkers for Parkinson's disease (PD) and atypical parkinsonian disorders (APD). ?-Synuclein, linked to the pathogenesis of PD, is a promising biomarker candidate in need of further investigation. The ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), a pivotal component of the ubiquitin proteasome system which seems to be disturbed in PD, may also be involved in the pathogenesis of this disorder.
PMID: 24507721 [PubMed - as supplied by publisher]