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Non-Motor Parkinsonian Pathology in Aging A53T ?-Synuclein Mice is Associated with Progressive Synucleinopathy and Altered Enzymatic Function.
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J Neurochem 2013 Oct;
Authors: Kaitlin F Farrell, Sesha Krishnamachari, Ernesto Villanueva, Haiyan Lou, Tshianda N M Alerte, Eloise Peet, Robert E Drolet, Ruth G Perez
Department of Neurology, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15260, USA.
Aging, the main risk factor for Parkinson's disease (PD), stimulates increased ?-synuclein levels in substantia nigra pars compacta (SNc). Excess ?-synuclein spurs Lewy-like pathology and dysregulates the activity of protein phosphatase 2A (PP2A). PP2A dephosphorylates many neuroproteins, including the catecholamine rate-limiting enzyme, tyrosine hydroxylase (TH). A loss of nigral dopaminergic neurons induces PD movement problems, but before those abnormalities occur, behaviors such as olfactory loss, anxiety, and constipation often manifest. Identifying mouse models with early PD behavioral changes could provide a model in which to test emerging therapeutic compounds. To this end, we evaluated A53T ?-synuclein mice for behavior and ?-synuclein pathology in olfactory bulb, adrenal gland, and gut. Aging A53T mice exhibited olfactory loss and anxiety that paralleled olfactory and adrenal ?-synuclein aggregation. PP2A activity was also diminished in olfactory and adrenal tissues harboring insoluble ?-synuclein. Low adrenal PP2A activity co-occurred with TH hyperactivity, making this the first study to link adrenal synucleinopathy to anxiety and catecholamine dysregulation. Aggregated A53T ?-synuclein recombinant protein had impaired stimulatory effects on soluble recombinant PP2A. Collectively, the data identify an excellent model in which to screen compounds for their ability to block the spread of ?-synuclein pathology associated with premotor stages of PD. This article is protected by copyright. All rights reserved.
PMID: 24117685 [PubMed - as supplied by publisher]