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Ocular albinism 1 (OA1), a G-protein coupled receptor GPR143, is a receptor that mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.
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Br J Pharmacol 2013 Oct;
Authors: Y Hiroshima, H Miyamoto, F Nakamura, D Masukawa, T Yamamoto, H Muraoka, Marina Kamiya, N Yamashita, T Suzuki, S Matsuzaki, I Endo, Y Goshima
Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan; Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
L-3,4-dihydroxyphenylalanine (DOPA) is believed to be an inert amino acid that alleviates the symptoms of Parkinson's disease by its conversion to dopamine. We proposed that DOPA is a neurotransmitter in the central nervous system. However, specific receptors for DOPA have not been identified. Recently, the gene product of ocular albinism 1 (OA1) was shown to possess DOPA-binding activity. Herein we investigate whether OA1 is a functional receptor of DOPA in nucleus tractus solitarii (NTS).
PMID: 24117106 [PubMed - as supplied by publisher]