When telephone lines go down, or Internet connections are lost, our communities temporarily come to a halt. What if something similar were found to be happening in Parkinson's? This is the focus of Dr. Schmitz and her team at the PDF Research Center at Columbia University Medical Center.
PDF Grant Programs
Are you interested in furthering Parkinson's science? View PDF's open grant programs.
Iron Deficiency in Parkinsonism: Region-Specific Iron Dysregulation in Parkinson's Disease and Multiple System Atrophy.
PDF's targeted PubMed search provides you with access to journal articles from the last 90 days that may be pertinent to Parkinson's disease research.
Not what you're looking for? Do you need informational publications about Parkinson's targeted for people living with Parkinson's, caregivers and family members? Please browse PDF's educational materials and programs - which are all available electronically or in print. Order for yourself, a loved one or in bulk for your patients or support group.
J Parkinsons Dis 2013 Oct;
Authors: Naomi P Visanji, Joanna F Collingwood, Mary E Finnegan, Anurag Tandon, Emily House, Lili-Naz Hazrati
Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, ON, Canada.
Background: Alpha-synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). Regional differences in the distribution of iron are also associated with neurodegenerative diseases. The reasons for these differential distributions are unknown. Objective: Here we characterize the relationship between iron homeostasis proteins and regional concentration, distribution and form of iron in MSA and PD. Methods: In post mortem brain tissue ferritin, ferroportin and transferrin were quantified by western blot and localized by immunohistochemistry. Ferritin cores were measured by Superconducting quantum interference device (Squid) measurement of isothermal remanent magnetisation (IRM). Total iron was measured by graphite furnace analysis. Results: In PD substantia nigra, tissue iron and expression of the iron export protein ferroportin increased, while the iron storage protein ferritin expression was unchanged. In the basis pontis of MSA cases, increased total iron concentration coupled with a disproportionate increase in ferritin in dysmorphic microglia and a reduction in ferroportin expression. This is supported by isothermal remanent magnetisation evidence consistent with elevated concentrations of ferritin-bound iron in MSA basis pontis. Conclusions: Conventional opinion holds that excess iron is involved in neurodegeneration. While region-specific changes in iron are evident in both PD and MSA, the mechanisms of iron dysregulation appear distinct, with a failure to export iron from the MSA basis pontis coupling with significant intracellular accumulation of ferritin-bound iron. Our preliminary data, coupled with the widespread pathology and involvement of multiple cell types, may evidence a deficit in bioavailabile iron.
PMID: 24113558 [PubMed - as supplied by publisher]