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The evolution of frontotemporal dementia due to the mapt mutation: a seventeen year natural history study.
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J Neurol Neurosurg Psychiatry 2013 Nov; 84(11):e2
Authors: Colin Mahoney, T Yeatman, Jd Rohrer, E Manning, Kk Leung, Mn Rossor, Jd Warren, N Fox
University College London.
Frontotemporal Dementia (FTD) is a common cause of early-onset dementia. A high proportion of cases are due to autosomal dominant mutations. Understanding the natural history of these disorders will be important in the development of diagnostic biomarkers and future disease modifying therapies. However, natural history studies in FTD are lacking. Here we present longitudinal clinical, neuropsychological and neuroimaging data on two members of a family followed over 17 years.
PMID: 24109072 [PubMed - as supplied by publisher]